Base de dados : LILACS
Pesquisa : G02.700 [Categoria DeCS]
Referências encontradas : 221 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 23 ir para página                         

  1 / 221 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-899353
Autor: Mardini, Victor; Rohde, Luis A; Ceresér, Keila M; Gubert, Carolina M; Silva, Emily G da; Xavier, Fernando; Parcianello, Rodrigo; Röhsig, Liane M; Pechansky, Flávio; Szobot, Claudia M.
Título: TBARS and BDNF levels in newborns exposed to crack/cocaine during pregnancy: a comparative study
Fonte: Rev. bras. psiquiatr;39(3):263-266, July-Sept. 2017. tab.
Idioma: en.
Resumo: Objectives: To compare levels of a marker of lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and brain-derived neurotrophic factor (BDNF) in umbilical cord blood (UCB) between newborns exposed to crack/cocaine in utero (exposed newborns [EN], n=57) and non-exposed newborns (NEN, n=99), as well as in maternal peripheral blood at delivery. Methods: This was a cross-sectional study. Potential confounders, including perinatal parameters, psychopathology, and use of other substances, were assessed. Results: After adjusting for potential confounders, adjusted mean BDNF was significantly higher in EN (3.86 ng/mL, 95% confidence interval [95%CI] 2.29-5.43) than in NEN (0.85 ng/mL, 95%CI 0.47-1.23; p < 0.001; Cohen effect size: 1.12), and significantly lower in crack/cocaine mothers than in control mothers (4.03 ng/mL, 95%CI 2.87-5.18 vs. 6.67 ng/mL, 95%CI 5.60-7.74; p = 0.006). The adjusted mean TBARS level was significantly lower in EN (63.97 µM MDA, 95%CI 39.43-88.50) than NEN (177.04 µM MDA, 95%CI 140.93-213.14; p < 0.001; effect size = 0.84), with no difference between mother groups (p = 0.86). Conclusions: The changes in TBARS levels observed in EN suggest that fetuses exposed to cocaine mobilize endogenous antioxidant routes since very early stages of development. The increase in BDNF levels in EN might indicate changes in fetal development, whereas the changes in BDNF levels in mothers provide evidence of the complex metabolic processes involved in drug use during pregnancy.
Descritores: Cocaína Crack/farmacologia
Substâncias Reativas com Ácido Tiobarbitúrico/análise
Fator Neurotrófico Derivado do Encéfalo/sangue
Sangue Fetal/química
-Oxirredução/efeitos dos fármacos
Estudos Transversais
Transtornos Relacionados ao Uso de Cocaína/sangue
Período Pós-Parto/sangue
Limites: Humanos
Feminino
Gravidez
Recém-Nascido
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


  2 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1095900
Autor: Sorroche, Patricia.
Título: Subclases de HDL, sus alteraciones en diabetes / Subclasses of HDL, its alterations in diabetes
Fonte: Rev. Hosp. Ital. B. Aires (2004);37(4):153-154, dic. 2017.
Idioma: es.
Descritores: Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/sangue
HDL-Colesterol/metabolismo
HDL-Colesterol/sangue
-Oxirredução
Glicemia/metabolismo
Hemoglobina A Glicada/metabolismo
Estresse Oxidativo/fisiologia
Índice Glicêmico/fisiologia
Dislipidemias/metabolismo
Dislipidemias/sangue
Hipoalfalipoproteinemias/metabolismo
Hipoalfalipoproteinemias/sangue
Lipoproteínas LDL/sangue
Antioxidantes/metabolismo
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


  3 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Costa Rica
Texto completo
Texto completo
Id: biblio-1002562
Autor: Carvajal Carvajal, Carlos.
Título: Especies reactivas del oxígeno: formación, funcion y estrés oxidativo / Reactive oxygen species: training, function and oxidative stress
Fonte: Med. leg. Costa Rica;36(1):91-100, ene.-mar. 2019.
Idioma: es.
Resumo: Resumen Las especies reactivas del oxígeno (ROS) son producidas como una consecuencia del metabolismo aeróbico fisiológico normal. La cadena de transporte de electrones de la mitocondria, los peroxisomas, la NADPH oxidasa, la óxido nítrico sintetasa desacoplada y el sistema del citocromo P450 son las fuentes más importantes de producción de los ROS. El desbalance entre la producción de los ROS y el sistema de defensa antioxidante en los sistemas vivos ocasiona una ruptura de la función celular y daño. Este desbalance ocurre por una sobreproducción de ROS y una reducción del mecanismo de defensa antioxidante. Las acciones protectoras contra los ROS son llevadas a cabo por varias enzimas (superóxido dismutasa, catalasa y glutatión peroxidasa) y también por compuestos no enzimáticos (vitamina E, ascorbato, glutatión, transferrina, ceruloplasmina, etc.). Los ROS son moduladores cruciales de las funciones celulares. A bajas concentraciones, los ROS son participantes esenciales en la señalización celular, la inducción de la respuesta mitogénica, la defensa contra agentes infecciosos, mientras que el exceso de los ROS puede alterar la función celular normal y promover el daño irreversible a lípidos, ácidos nucleicos y a proteínas celulares. Los ROS, especialmente el H2O2, sirven como moléculas mensajeras por medio de la modificación oxidativa de proteínas de señalización. Entonces, un balance entre la producción de los ROS y su remoción permite una función celular normal, mientras que un desequilibrio causa estrés oxidativo con consecuencias patológicas.

Abstract Reactive oxigen species (ROS) are produced as the consequence of the normal aerobic physiological metabolism. The electron transport chain in mitochondrial, peroxisomes, NADPH oxidases, uncoupled nitric oxide synthase (NOS) and cytochrome P450 system are the most important sources of ROS production. The imbalance of the ROS production and antioxidants defense system in the living systems causes oxidative stress brings to cellular function disruption and damage. This imbalance occurs due to over production of ROS and reduction of the antioxidant defense mechanism. Protective actions against ROS are performed by several enzymes (superoxide dismutase, catalase and glutation peroxidase) as well as nonenzimatic compounds (vitamin E, ascorbate, glutathione, transferrin, ceruloplasmin, etc). ROS are crucial modulators of cellular functions. At low concentrations, ROS are essential participants in cell signaling, induction of mitogenic response, involvement in defense against infectious agents, whereas excess ROS can disrupt normal cellular function and promote irreversible damage to cellular lipids, nucleic acids, and proteins. ROS, especially H2O2, serve as a signal molecule through oxidative modification of signaling proteins. Thus, a balance between ROS production and their removal allows for normal cellular function, whereas an imbalance causes oxidative stress with pathological consequences.
Descritores: Oxirredução
Espécies Reativas de Oxigênio
Estresse Oxidativo
Radicais Livres
Antioxidantes
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


  4 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-886269
Autor: Wang, Zhishun; Han, Qi; Guo, Yong-lian; Liu, Xiu-heng; Qiu, Tao.
Título: Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation
Fonte: Acta cir. bras;33(3):238-249, Mar. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effect of ozone oxidative preconditioning (OzoneOP) on inflammation and oxidative stress injury in rat model of renal transplantation. Methods: Thirty six male Sprague Dawley (SD) rats were randomly divided into three groups. Sham group: rats were treated with opening and closing abdomen. Kidney transplantation group (KT group): SD rat received the donor's left kidney derived from another SD rat. Ozone oxidative preconditioning and kidney transplantation (OOP+KT group): donor SD rats received OzoneOP treatments by transrectal insufflations before kidney transplantation. After transplantation, parameters of renal function of recipients were determined. Morphology and pathological changes of renal allograft were examined. Expression of NF-κBp65, HMGB-1 were also determined by Western-blot. Results: Compared to KT group, the morphology and pathological damages of renal allograft were less serious in OOP+KT group. Meanwhile, levels of SOD and GSH-Px of renal allograft in OOP+KT group were higher than those in KT group respectively. Western-blot showed that the expressions of NF-κBp65 and HMGB-1 in OOP+KT group were obviously less than those in KT group. Conclusion: Ozone oxidative preconditioning could attenuate the inflammatory reaction and oxidative stress injury in renal allograft, which might be related with the enhancement of anti-oxidative system and suppression of inflammatory reaction.
Descritores: Ozônio/administração & dosagem
Transplante de Rim/métodos
Precondicionamento Isquêmico/métodos
Inflamação/prevenção & controle
-Oxirredução/efeitos dos fármacos
Superóxido Dismutase/metabolismo
Traumatismo por Reperfusão/prevenção & controle
Western Blotting
Transplante de Rim/efeitos adversos
Ratos Sprague-Dawley
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais
Inflamação/etiologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  5 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1001088
Autor: Eken, Hüseyin; Cimen, Orhan; Cimen, Ferda Keskin; Kurnaz, Eray; Yildirim, Murat; Tasova, Volkan; Kurt, Nezahat; Pehlivanoglu, Kamil; Onk, Didem; Bilgin, Asli Ozbek.
Título: Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
Fonte: Acta cir. bras;34(4):e201900404, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.
Descritores: Quercetina/análogos & derivados
Traumatismo por Reperfusão/prevenção & controle
Anti-Inflamatórios não Esteroides/uso terapêutico
Mucosa Gástrica/lesões
-Oxirredução/efeitos dos fármacos
Quercetina/uso terapêutico
Artéria Celíaca/cirurgia
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais de Doenças
Ligadura
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  6 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-828191
Autor: Costa, Bruna Zucoloto da; Rodrigues, Viviane Drumond; Oliveira, Valéria Maia de; Ottoboni, Laura Maria Mariscal; Marsaioli, Anita Jocelyne.
Título: Enzymatic potential of heterotrophic bacteria from a neutral copper mine drainage
Fonte: Braz. j. microbiol;47(4):846-852, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Copper mine drainages are restricted environments that have been overlooked as sources of new biocatalysts for bioremediation and organic syntheses. Therefore, this study aimed to determine the enzymatic activities (esterase, epoxide hydrolase and monooxygenase) of 56 heterotrophic bacteria isolated from a neutral copper mine drainage (Sossego Mine, Canaã dos Carajás, Brazil). Hydrolase and monooxygenase activities were detected in 75% and 20% of the evaluated bacteria, respectively. Bacterial strains with good oxidative performance were also evaluated for biotransformation of organic sulfides. Fourteen strains with good enzymatic activity were identified by 16S rRNA gene sequencing, revealing the presence of three genera: Bacillus, Pseudomonas and Stenotrophomonas. The bacterial strains B. megaterium (SO5-4 and SO6-2) and Pseudomonas sp. (SO5-9) efficiently oxidized three different organic sulfides to their corresponding sulfoxides. In conclusion, this study revealed that neutral copper mine drainages are a promising source of biocatalysts for ester hydrolysis and sulfide oxidation/bioremediation. Furthermore, this is a novel biotechnological overview of the heterotrophic bacteria from a copper mine drainage, and this report may support further microbiological monitoring of this type of mine environment.
Descritores: Bactérias/classificação
Bactérias/enzimologia
Cobre
Microbiologia Ambiental
-Oxirredução
Filogenia
Sulfetos/metabolismo
Bactérias/isolamento & purificação
Bactérias/genética
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Enzimas
Esterases/genética
Esterases/metabolismo
Oxigenases de Função Mista/genética
Oxigenases de Função Mista/metabolismo
Mineração
Responsável: BR1.1 - BIREME


  7 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-788982
Autor: Rosa, Juliana Pacheco da; Tibúrcio, Samyra Raquel Gonçalves; Marques, Joana Montezano; Seldin, Lucy; Coelho, Rosalie Reed Rodrigues.
Título: Streptomyces lunalinharesii 235 prevents the formation of a sulfate-reducing bacterial biofilm
Fonte: Braz. j. microbiol;47(3):603-609, July-Sept. 2016. graf.
Idioma: en.
Resumo: ABSTRACT Streptomyces lunalinharesii strain 235 produces an antimicrobial substance that is active against sulfate reducing bacteria, the major bacterial group responsible for biofilm formation and biocorrosion in petroleum reservoirs. The use of this antimicrobial substance for sulfate reducing bacteria control is therefore a promising alternative to chemical biocides. In this study the antimicrobial substance did not interfere with the biofilm stability, but the sulfate reducing bacteria biofilm formation was six-fold smaller in carbon steel coupons treated with the antimicrobial substance when compared to the untreated control. A reduction in the most probable number counts of planktonic cells of sulfate reducing bacteria was observed after treatments with the sub-minimal inhibitory concentration, minimal inhibitory concentration, and supra-minimal inhibitory concentration of the antimicrobial substance. Additionally, when the treated coupons were analyzed by scanning electron microscopy, the biofilm formation was found to be substantially reduced when the supra-minimal inhibitory concentration of the antimicrobial substance was used. The coupons used for the biofilm formation had a small weight loss after antimicrobial substance treatment, but corrosion damage was not observed by scanning electron microscopy. The absence of the dsrA gene fragment in the scraped cell suspension after treatment with the supra-minimal inhibitory concentration of the antimicrobial substance suggests that Desulfovibrio alaskensis was not able to adhere to the coupons. This is the first report on an antimicrobial substance produced by Streptomyces active against sulfate reducing bacteria biofilm formation. The application of antimicrobial substance as a potential biocide for sulfate reducing bacteria growth control could be of great interest to the petroleum industry.
Descritores: Oxirredução
Streptomyces/fisiologia
Sulfatos/metabolismo
Biofilmes
Antibiose
-Streptomyces/efeitos dos fármacos
Streptomyces/ultraestrutura
Testes de Sensibilidade Microbiana
Biofilmes/crescimento & desenvolvimento
Biofilmes/efeitos dos fármacos
Antibacterianos/farmacologia
Responsável: BR1.1 - BIREME


  8 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-780847
Autor: Ismaiel, Mostafa Mahmoud Sami; El-Ayouty, Yassin Mahmoud; Piercey-Normore, Michele.
Título: Role of pH on antioxidants production by Spirulina (Arthrospira) platensis
Fonte: Braz. j. microbiol;47(2):298-304, Apr.-June 2016. tab, graf.
Idioma: en.
Resumo: Abstract Algae can tolerate a broad range of growing conditions but extreme conditions may lead to the generation of highly dangerous reactive oxygen species (ROS), which may cause the deterioration of cell metabolism and damage cellular components. The antioxidants produced by algae alleviate the harmful effects of ROS. While the enhancement of antioxidant production in blue green algae under stress has been reported, the antioxidant response to changes in pH levels requires further investigation. This study presents the effect of pH changes on the antioxidant activity and productivity of the blue green alga Spirulina (Arthrospira) platensis. The algal dry weight (DW) was greatly enhanced at pH 9.0. The highest content of chlorophyll a and carotenoids (10.6 and 2.4 mg/g DW, respectively) was recorded at pH 8.5. The highest phenolic content (12.1 mg gallic acid equivalent (GAE)/g DW) was recorded at pH 9.5. The maximum production of total phycobiliprotein (159 mg/g DW) was obtained at pH 9.0. The antioxidant activities of radical scavenging activity, reducing power and chelating activity were highest at pH 9.0 with an increase of 567, 250 and 206% compared to the positive control, respectively. Variation in the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) was also reported. While the high alkaline pH may favor the overproduction of antioxidants, normal cell metabolism and membrane function is unaffected, as shown by growth and chlorophyll content, which suggests that these conditions are suitable for further studies on the harvest of antioxidants from S. platensis.
Descritores: Spirulina/metabolismo
Antioxidantes/metabolismo
-Oxirredução
Fenóis/metabolismo
Fenóis/química
Clorofila/metabolismo
Spirulina/crescimento & desenvolvimento
Spirulina/química
Ficobiliproteínas/metabolismo
Ficobiliproteínas/química
Concentração de Íons de Hidrogênio
Antioxidantes/química
Responsável: BR1.1 - BIREME


  9 / 221 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-886225
Autor: Costa, Beatriz Pinto da; Gonçalves, Ana Cristina; Abrantes, Ana Margarida; Matafome, Paulo; Seiça, Raquel; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena; Castro-Sousa, Francisco.
Título: Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats
Fonte: Acta cir. bras;32(8):648-661, Aug. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the inflammatory and redox responses to teduglutide on an animal model of laparotomy and intestinal anastomosis. Methods: Wistar rats (n=62) were allocated into four groups: "Ileal Resection and Anastomosis" vs. "Laparotomy", each one split into "Postoperative Teduglutide Administration" vs. "No Treatment"; and euthanized at the third or the seventh day. Ileal and blood samples were recovered at the baseline and at the euthanasia. Flow cytometry was used to study the inflammatory response (IL-1α, MCP-1, TNF-α, IFN-γ and IL-4 levels), oxidative stress (cytosolic peroxides, mitochondrial reactive species, intracellular glutathione and mitochondrial membrane potential) and cellular viability and death (annexin V/propidium iodide double staining). Results: Postoperative teduglutide treatment was associated with higher cellular viability index and lower early apoptosis ratio at the seventh day; higher cytosolic peroxides level at the third day and mitochondrial overgeneration of reactive species at the seventh day; higher tissue concentration of IL-4 and lower local pro-to-anti-inflammatory cytokines ratio at the seventh day. Conclusion: Those findings suggest an intestinal pro-oxidative and anti-inflammatory influence of teduglutide on the peri-operative context with a potential interference in the intestinal anastomotic healing.
Descritores: Oxirredução/efeitos dos fármacos
Peptídeos/farmacologia
Íleo/cirurgia
Íleo/efeitos dos fármacos
Íleo/patologia
Anti-Inflamatórios/farmacologia
-Fatores de Tempo
Cicatrização/efeitos dos fármacos
Anastomose Cirúrgica
Distribuição Aleatória
Sobrevivência Celular/efeitos dos fármacos
Reprodutibilidade dos Testes
Citocinas/sangue
Resultado do Tratamento
Ratos Wistar
Apoptose
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais de Doenças
Citometria de Fluxo
Íleo/metabolismo
Laparotomia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  10 / 221 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1008708
Autor: Valdebenito-Rolack, Emky; Ruiz-Tagle, Nathaly; Abarzúa, Leslie; Aroca, Germán; Urrutia, Homero.
Título: Characterization of a hyperthermophilic sulphur-oxidizing biofilm produced by archaea isolated from a hot spring
Fonte: Electron. j. biotechnol;25:58-63, ene. 2017. tab, graf, ilus.
Idioma: en.
Projeto: FONDECYT.
Resumo: Background: Sulphur-oxidizing microorganisms are widely used in the biofiltration of total reduced sulphur compounds (odorous and neurotoxic) produced by industries such as the cellulose and petrochemical industries, which include high-temperature process steps. Some hyperthermophilic microorganisms have the capability to oxidize these compounds at high temperatures (N60°C), and archaea of this group, for example, Sulfolobus metallicus, are commonly used in biofiltration technology. Results: In this study, a hyperthermophilic sulphur-oxidizing strain of archaea was isolated from a hot spring (Chillán, Chile) and designated as M1. It was identified as archaea of the genus Sulfolobus (99% homology with S. solfataricus 16S rDNA). Biofilms of this culture grown on polyethylene rings showed an elemental sulphur oxidation rate of 95.15 ± 15.39 mg S l-1 d-1, higher than the rate exhibited by the biofilm of the sulphur-oxidizing archaea S. metallicus (56.8 ± 10.91 mg l-1 d-1). Conclusions: The results suggest that the culture M1 is useful for the biofiltration of total reduced sulphur gases at high temperatures and for other biotechnological applications.
Descritores: Sulfetos/metabolismo
Archaea/metabolismo
Biofilmes
-Oxirredução
Filogenia
Reação em Cadeia da Polimerase
Sulfolobus
Archaea/isolamento & purificação
Archaea/genética
Polietileno
Fontes Termais/microbiologia
Eletroforese
Filtração
Extremófilos
Temperatura Alta
Responsável: CL1.1 - Biblioteca Central



página 1 de 23 ir para página                         
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde