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Id: biblio-1055096
Autor: Alegre, Patricia; Mathias, Livia; Lourenço, Maria Angelica; Santos, Priscila Portugal dos; Gonçalves, Andrea; Fernandes, Ana Angélica; Gaiolla, Paula Schmidt Azevedo; Minicucci, Marcos Ferreira; Zornoff, Leonardo; Paiva, Sergio Alberto Rupp; Polegato, Bertha Furlan.
Título: Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats / Euterpe Oleracea Mart. (Açaí) Reduz o Estresse Oxidativo e Melhora o Metabolismo Energético da Lesão de Isquemia-Reperfusão Miocárdica Em Ratos
Fonte: Arq. bras. cardiol;114(1):78-86, Jan. 2020. tab, graf.
Idioma: en.
Resumo: Abstract Background: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury. Objective: To evaluate the influence of açaí in global ischemia-reperfusion model in rats. Methods: Wistar rats were assigned to 2 groups: Control (C: receiving standard chow; n = 9) and Açaí (A: receiving standard chow supplemented with 5% açaí; n = 10). After six weeks, the animals were subjected to the global ischemia-reperfusion protocol and an isolated heart study to evaluate left ventricular function. Level of significance adopted: 5%. Results: There was no difference between the groups in initial body weight, final body weight and daily feed intake. Group A presented lower lipid hydroperoxide myocardial concentration and higher catalase activity, superoxide dismutase and glutathione peroxidase than group C. We also observed increased myocardial activity of b-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. The systolic function was similar between the groups, and the A group presented poorer diastolic function than the C group. We did not observe any difference between the groups in relation to myocardial infarction area, total and phosphorylated NF-kB, total and acetylated FOXO1, SIRT1 and Nrf-2 protein expression. Conclusion: despite improving energy metabolism and attenuating oxidative stress, açai supplementation did not decrease the infarcted area or improve left ventricular function in the global ischemia-reperfusion model.

Resumo Fundamento: Euterpe oleracea Mart. (açaí) é uma fruta com alta capacidade antioxidante e pode ser uma estratégia adjuvante para atenuar a lesão de isquemia-reperfusão. Objetivo: Avaliar a influência do açaí no modelo global de isquemia-reperfusão em ratos. Metodologia: Ratos Wistar foram divididos em 2 grupos: Controle (C: recebendo ração padrão; n = 9) e Açaí (A: recebendo ração padrão suplementada com 5% de açaí; n = 10). Após seis semanas, os animais foram submetidos ao protocolo global de isquemia-reperfusão e a estudo do coração isolado para avaliar a função ventricular esquerda. Nível de significância adotado: 5%. Resultados: Não houve diferença entre os grupos quanto ao peso corporal inicial e final, e a ingestão diária de ração. O grupo A apresentou menor concentração miocárdica de hidroperóxido lipídico e maior atividade de catalase, superóxido dismutase e glutationa peroxidase do que o grupo C. Também observamos aumento da atividade miocárdica da b-hidroxiacil coenzima-A desidrogenase, piruvato desidrogenase, citrato sintase, complexo I, complexo II e ATP sintase no grupo A, bem como menor atividade das enzimas lactato desidrogenase e fosfofructoquinase. A função sistólica foi semelhante entre os grupos, e o grupo A apresentou função diastólica pior que C. Não foram observadas diferenças entre os grupos em relação à área de infarto do miocárdio, e expressão proteica de NF-kB total e fosforilado, e das proteínas FOXO1, SIRT1 e Nrf-2. Conclusão: apesar de melhorar o metabolismo energético e atenuar o estresse oxidativo, a suplementação de açaí não diminuiu a área infartada nem melhorou a função ventricular esquerda no modelo global de isquemia-reperfusão.
Descritores: Extratos Vegetais/farmacologia
Traumatismo por Reperfusão Miocárdica/fisiopatologia
Estresse Oxidativo/efeitos dos fármacos
Metabolismo Energético/efeitos dos fármacos
Euterpe/química
-Estresse Oxidativo/fisiologia
Modelos Animais de Doenças
Metabolismo Energético/fisiologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1131478
Autor: Silva, I. M; Broch, J; Wachholz, L; Souza, C. de; Pires Filho, I. C; Eyng, C; Tsutsumi, C. Y; Nunes, R. V.
Título: Valores energéticos e composição bromatológica do resíduo seco de fecularia associado a carboidrases para frangos de corte em fase de crescimento / [Energy value and bromatological composition of dry residue of cassava associated with carbohydrases for grower broilers]
Fonte: Arq. bras. med. vet. zootec. (Online);72(4):1504-1510, July-Aug. 2020. tab.
Idioma: pt.
Resumo: Foram determinados os valores energéticos e a composição bromatológica do resíduo seco de fecularia (RSF) para frangos de corte, na fase de crescimento, utilizando ou não enzimas carboidrases. Os tratamentos foram distribuídos em esquema fatorial 2x4 + ração referência, sendo uma RR sem adição de RSF e quatro tratamentos experimentais com 10%, 20%, 30% e 40% de inclusão do RSF e a suplementação ou não com carboidrases. A composição química encontrada para o RSF, na MN, foi de 89,86% de matéria seca, 0,98% de proteína bruta, 3519kcal kg-1 de energia bruta, 0,19% de extrato etéreo, 27% de fibra em detergente neutro, 19,5% de fibra em detergente ácido, 0,33% de cálcio, 0,43% de fósforo, 0,46% de potássio e 0,12% de magnésio. O uso de carboidrases proporcionou um aumento de 173 e 213kcal kg-1 nos valores de EMA e EMAn, respectivamente, resultando em 1828kcal kg-1 EMA e 1840kcal kg-1 EMAn. Concluiu-se que os maiores níveis de EMA e EMAn foram encontrados para o nível de inclusão médio do RSF de 35% e que a suplementação enzimática pode promover aumento desses parâmetros em até 12% em dietas para frangos de corte na fase de crescimento.(AU)

The energetic values and the bromatological composition of the dry residue of cassava (DRC) were determined for growing broilers with or without carbohydrase enzymes. The treatments were distributed in a 2x4 + reference diet factorial scheme, with one RD without addition of DRC and four experimental treatments with 10, 20, 30 and 40% inclusion levels of RSF and supplementation or not with carbohydrases. The chemical composition found for DRC in natural matter was 89.86% dry matter, 0.98% crude protein, 3519kcal kg-1 gross energy, 0.19% ether extract, 27% neutral detergent fiber, 19.5% of acid detergent fiber, 0.33% of calcium, 0.43% of phosphorus, 0.46% of potassium and 0.12% of magnesium. The use of carbohydrase resulted in an increase of 173 and 213kcal kg-1 in EMA and EMAn values, respectively, resulting in 1828kcal kg-1 EMA and 1840kcal kg-1 EMAn. It was concluded that the highest levels of AME and AMEn were found for the mean inclusion level of the DRC of 35% and that enzymatic supplementation may promote the increase of these parameters by up to 12% in broiler diets in the growth phase.(AU)
Descritores: Fibras na Dieta/administração & dosagem
Galinhas/crescimento & desenvolvimento
Dieta/veterinária
Amidos e Féculas
Ração Animal/análise
-Metabolismo Energético
Glicosídeo Hidrolases/administração & dosagem
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1042193
Autor: Perdigão, Marcela Maria de Melo; Rodrigues, Andrea Bezerra; Magalhães, Tayanne de Lima; Freitas, Fernanda Macedo Cartaxo; Bravo, Lia Guedes; Oliveira, Patrícia Peres de.
Título: Educational technology for fatigue management related to antineoplastic chemotherapy / Tecnología educativa en el manejo de la fatiga relacionada con la quimioterapia antineoplásica / Tecnologia educativa para manejo da fadiga relacionada à quimioterapia antineoplásica
Fonte: Rev. bras. enferm;72(6):1519-1525, Nov.-Dec. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: To construct and validate an educational technology (ET) on fatigue and non-pharmacological strategies for the management of this symptom in people with cancer undergoing outpatient antineoplastic chemotherapy. Method: This is a methodological study composed of three stages: 1) elaboration of the ET using the theoretical-methodological model of Doak, Doak and Root; 2) validation of content and appearance by seven nurses via the content validity index (CVI); and 3) a pilot test with 10 patients. Results: The ET "Knowing and coping with fatigue" contemplates the definition of fatigue, its causes and the interventions of physical exercise practice, sleep hygiene, energy conservation and behavioral intervention. The overall CVI obtained with the judges was 0.95. Conclusion: The ET presented content and appearance validity for health education regarding fatigue related to antineoplastic chemotherapy in outpatient cancer patients.

RESUMEN Objetivo: Construir y validar una tecnología educativa (TE) sobre fatiga y estrategias no farmacológicas para el manejo del síntoma en personas con cáncer en tratamiento quimioterápico antineoplásico ambulatorio. Método: Estudio metodológico que consta de tres etapas: 1) elaboración de la TE utilizando el modelo teórico-metodológico de Doak, Doak y Root; 2) validación de contenido y apariencia por siete jueces enfermeros, por medio del índice de validez de contenido (IVC); y 3) realización de una prueba piloto con 10 pacientes. Resultados: La TE "Conociendo y lidiando con la fatiga" contempla la definición de fatiga, sus causas y las intervenciones con la práctica de ejercicios físicos, la higiene del sueño, la conservación de energía y la intervención comportamental. El IVC total obtenido con los jueces fue de 0,95. Conclusión: La TE presentó validez de contenido y apariencia para la educación en salud con relación a la fatiga relacionada a la quimioterapia antineoplásica en pacientes oncológicos ambulatorios.

RESUMO Objetivo: Construir e validar tecnologia educativa (TE) sobre fadiga e estratégias não farmacológicas para manejo desse sintoma em pessoas com câncer em tratamento quimioterápico antineoplásico ambulatorial. Método: Estudo metodológico composto por três etapas: 1) elaboração da TE, utilizando o modelo teórico-metodológico de Doak, Doak e Root; 2) validação de conteúdo e aparência por sete juízes enfermeiros, por meio do índice de validade de conteúdo (IVC); e 3) realização de teste piloto com 10 pacientes. Resultados: A TE "Conhecendo e lidando com a fadiga" contempla a definição de fadiga, suas causas e as intervenções de prática de exercícios físicos, higiene do sono, conservação de energia e intervenção comportamental. O IVC global obtido com os juízes foi de 0,95. Conclusão: A TE apresentou validade de conteúdo e aparência para a educação em saúde com relação à fadiga relacionada à quimioterapia antineoplásica em pacientes oncológicos ambulatoriais.
Descritores: Tecnologia Educacional/métodos
Fadiga/induzido quimicamente
Fadiga/terapia
Neoplasias/tratamento farmacológico
Antineoplásicos/efeitos adversos
-Pacientes Ambulatoriais
Projetos Piloto
Reprodutibilidade dos Testes
Metabolismo Energético
Terapia por Exercício
Higiene do Sono
Limites: Humanos
Adulto
Tipo de Publ: Estudo de Validação
Responsável: BR1.1 - BIREME


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Id: lil-782159
Autor: Moehlecke, Milene; Canani, Luis Henrique; Silva, Lucas Oliveira Junqueira e; Trindade, Manoel Roberto Maciel; Friedman, Rogerio; Leitão, Cristiane Bauermann.
Título: Determinants of body weight regulation in humans
Fonte: Arch. endocrinol. metab. (Online);60(2):152-162, Apr. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Body weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery. Weight maintenance requires a balance between energy intake and energy expenditure. Although several components that participate in energy homeostasis have been identified, there is a need to know in more detail their actions as well as their interactions with environmental and psychosocial factors in the development of human obesity. In this review, we examine the role of systemic mediators such as leptin, ghrelin and insulin, which act in the central nervous system by activating or inhibiting neuropeptide Y, Agouti-related peptide protein, melanocortin, transcript related to cocaine and amphetamine, and others. As a result, modifications in energy homeostasis occur through regulation of appetite and energy expenditure. We also examine compensatory changes in the circulating levels of several peripheral hormones after diet-induced weight loss.
Descritores: Peso Corporal/fisiologia
Ingestão de Energia/fisiologia
Metabolismo Energético/fisiologia
-Tecido Adiposo/metabolismo
Ilustração Médica
Obesidade/etiologia
Obesidade/metabolismo
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-838414
Autor: Moraes, Camila de; Oliveira, Camila Andrea de; Amaral, Maria Esméria Corezola do; Landini, Gabriela Arcurio; Catisti, Rosana.
Título: Liver metabolic changes induced by conjugated linoleic acid in calorie-restricted rats
Fonte: Arch. endocrinol. metab. (Online);61(1):45-53, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: ABSTRACT Objective Complexes like conjugated linoleic acid (CLA) reduce the percentage of body fat by increasing energy expenditure, fat oxidation, or both. The aim of this study was to verify if CLA is able to mimic caloric restriction (CR), and determine the effects of CLA on liver metabolic profile of young adult male Wistar rats. Materials and methods We divided 36 animals into the following groups: 1) Control; 2) CLA (1% of daily food intake, 21 days, orogastric intubation); 3) Restr (fed 60% of the diet offered to controls); and 4) CLA Restr. Liver tissues were processed for biochemical and molecular or mitochondrial isolation (differential centrifugation) and blood samples were collected for biochemical analyses. Results Treatment of the animals for 21 days with 1% CLA alone or combined with CR increased liver weight and respiration rates of liver mitochondria suggesting significant mitochondrial uncoupling. We observed a decrease in adipose tissue leading to insulin resistance, hyperinsulinemia, and hepatic steatosis due to increased liver cholesterol and triacylglycerol levels, but no significant effects on body mass. The expression of hepatic cellular connexins (43 and 26) was significantly higher in the CLA group compared with the Control or Restr groups. Conclusion CLA does not seem to be a safe compound to induce mass loss because it upregulates the mRNA expression of connexins and induces hepatic mitochondrial changes and lipids disorders.
Descritores: Restrição Calórica
Ácidos Linoleicos Conjugados/administração & dosagem
Metabolismo Energético
Fígado Gorduroso/prevenção & controle
Fígado/metabolismo
-Fatores de Tempo
Ratos Wistar
Metabolismo dos Lipídeos
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-838419
Autor: Batista, Gisele Almeida; Souza, Aglécio Luiz de; Marin, Daniela Miguel; Sider, Marina; Melhado, Vaneska Carvalho; Fernandes, Arlete Maria; Alegre, Sarah Monte.
Título: Body composition, resting energy expenditure and inflammatory markers: impact in users of depot medroxyprogesterone acetate after 12 months follow-up
Fonte: Arch. endocrinol. metab. (Online);61(1):70-75, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers. Subjects and methods Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed. Results After 12 months of evaluation, we could observe a significant increase in the DMPA group in weight (3,01 kg) and BMI, while the IUD group’s only significant increase was observed in the BMI. Relative to REE there was an increase of basal metabolic rate (BMR) in both groups after one year. The sub-group DMPA that gained < 3 kg had increased significant weight, BMI and body surface (BS) with respiratory quotient (RQ) reduction, while the sub-group that gained ≥ 3 kg had a significant increase in weight, BMI, BS, fat-free mass, fat mass, BMR, Leptin, HOMA-IR and waist circumference, with RQ significantly reduced. Conclusion Our study found significant changes in weight, body composition and metabolic profile of the population studied in the first 12 months of contraceptive use. These changes mainly increased body weight, leptin levels and HOMA-IR which can contribute to the development of some chronic complications, including obesity, insulin resistance and diabetes mellitus.
Descritores: Composição Corporal/efeitos dos fármacos
Biomarcadores/sangue
Ganho de Peso/efeitos dos fármacos
Acetato de Medroxiprogesterona/farmacologia
Metabolismo Energético/efeitos dos fármacos
-Metabolismo Basal/efeitos dos fármacos
Calorimetria Indireta
Índice de Massa Corporal
Seguimentos
Interleucina-6/sangue
Fator de Necrose Tumoral alfa/sangue
Leptina/sangue
Adiponectina/sangue
Nicotinamida Fosforribosiltransferase/sangue
Glucose/análise
Insulina/sangue
Limites: Humanos
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-887559
Autor: del Re, Mariana Pantaleão; Melo, Camila Maria de; Santos, Marcus Vinicius dos; Tufik, Sergio; Mello, Marco Túlio de.
Título: Applicability of predictive equations for resting energy expenditure in obese patients with obstructive sleep apnea
Fonte: Arch. endocrinol. metab. (Online);61(3):257-262, May-June 2017. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: ABSTRACT Objective To investigate the applicability of predictive equations for resting energy expenditure (REE) in obese individuals with obstructive sleep apnea (OSA) and the effects of OSA severity on REE. Materials and methods Twenty-nine obese men, 41.5 ± 7 years old, with moderate and severe OSA were recruited. All subjects were submitted to a clinical polysomnography, body composition, and indirect calorimetry measurements. REE was also predicted by three different equations: Harris and Benedict (1919), Cunningham (1990), and DRI (2002). Results No effects of OSA severity on REE were found. The measured REE (2416.0 ± 447.1 kcal/day) and the REE predicted by equations were different from each other (F = 2713.88; p < 0.05): Harris and Benedict (2128.0 ± 245.8 kcal/day), Cunningham (1789.1 ± 167.8 kcal/day) and DRI (2011.1 ± 181.4 kcal/day). Pearson correlations showed a moderate positive correlation between the REE measured and predicted by all equations. Conclusion Our findings suggest that predictive equations for REE underestimate the energy expenditure in obese patients with sleep apnea. Also, no effects of OSA severity on REE were found.
Descritores: Descanso/fisiologia
Algoritmos
Apneia Obstrutiva do Sono/metabolismo
Metabolismo Energético/fisiologia
Obesidade/fisiopatologia
Obesidade/metabolismo
-Valores de Referência
Fatores de Tempo
Índice de Gravidade de Doença
Composição Corporal/fisiologia
Calorimetria Indireta/métodos
Antropometria
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Análise de Variância
Polissonografia
Apneia Obstrutiva do Sono/fisiopatologia
Limites: Humanos
Masculino
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-887597
Autor: Santos, Willian dos; Tureck, Luciane Viater; Saliba, Louise Farah; Schenknecht, Caroline Schovanz; Scaraboto, Débora; Souza, Ricardo Lehtonen R; Furtado-Alle, Lupe.
Título: Effects of energetic restriction diet on butyrylcholinesterase in obese women from southern Brazil - A longitudinal study
Fonte: Arch. endocrinol. metab. (Online);61(5):484-489, Sept.-Oct. 2017. tab.
Idioma: en.
Resumo: Objective Butyrylcholinesterase (BChE) activity has been associated with obesity, lipid concentrations, and CHE2 locus phenotypes. This, the aim of this study was to evaluate the effects of an energetic restriction diet intervention on anthropometrical and biochemical variables and on absolute and relative BChE activity in CHE2 C5+ and CHE2 C5- individuals. Subjects and methods One hundred eleven premenopausal obese women from Southern Brazil participated in an energetic restriction diet intervention (deficit of 2500 kJ/day) for 8 weeks. Their anthropometric and biochemical parameters were evaluated before and after the intervention. Plasma BChE activity was measured, and BChE bands in plasma and CHE2 locus phenotypes were detected by electrophoresis. Results The dietetic intervention decreased anthropometric and biochemical parameters as well as absolute BChE activity and relative activity of the G4 band. The CHE2 C5+ phenotype presented a different effect when compared with the CHE2 C5- phenotype. The CHE2 C5+ phenotype showed an effect in absolute BChE activity and in the relative activity of the G4 form, maintaining higher BChE activity regardless of the metabolic changes. Conclusion In our study, 8 weeks was not sufficient time to lower the body mass index to normal, but it was enough to significantly reduce the absolute BChE activity, which became similar to the levels in nonobese individuals. CHE2 C5+ individuals were resistant to the decrease in BChE activity compared to CHE2 C5- individuals. This shows that the diet did not affect the CHE2 and G4 fraction complex and that the products of the CHE2 locus in association with BChE have a role in energy metabolism, maintaining high levels of enzymatic activity even after dietary intervention.
Descritores: Butirilcolinesterase/metabolismo
Restrição Calórica
Obesidade/dietoterapia
Obesidade/enzimologia
-Fenótipo
Brasil
Análise de Regressão
Estudos Longitudinais
Metabolismo Energético
Limites: Humanos
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-950070
Autor: Ferraz-de-Souza, Bruno.
Título: The elusive clinical significance of osteocalcin actions in energy metabolism in humans
Fonte: Arch. endocrinol. metab. (Online);62(3):271-272, May-June 2018.
Idioma: en.
Descritores: Osso e Ossos/metabolismo
Osteocalcina/fisiologia
Metabolismo Energético/fisiologia
-Osteogênese/fisiologia
Limites: Humanos
Tipo de Publ: Editorial
Responsável: BR1.1 - BIREME


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Id: biblio-1088771
Autor: Oliveira, Daiane Teixeira de; Fernandes, Isabela da Costa; Sousa, Graziele Galdino de; Santos, Talita Adriana Pereira dos; Paiva, Nívia Carolina Nogueira de; Carneiro, Cláudia Martins; Evangelista, Elísio Alberto; Barboza, Natália Rocha; Guerra-Sá, Renata.
Título: High-sugar diet leads to obesity and metabolic diseases in ad libitum -fed rats irrespective of caloric intake
Fonte: Arch. endocrinol. metab. (Online);64(1):71-81, Jan.-Feb. 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective Provide a comprehensive view of the events surrounding the sugar consumption, under conditions of energy equivalence; through the analysis of behavioral aspects of intake, and of biochemical, metabolic and physiological parameters, as well as the effect of this nutrient on the plasticity of adipose tissue. Materials and methods Newly weaned male Wistar rats were classified in two groups and subjected to the following normocaloric diets: standard chow diet or to high-sugar diet (HSD) ad libitum for 18 weeks. Results The animals submitted to the HSD were associated with a lower caloric intake during the 18 weeks of experimentation. However, the HSD induced a significant increase in body weight, white adipose tissue weight, adiposity index, Lee index, and the levels of triglycerides and very low-density lipoprotein in the serum. In addition, it induced glucose intolerance, insulin resistance and compensatory increase of insulin secretion by pancreatic β-cells. Also increased heart rate and induced hyperplasia, and hypertrophy of retroperitoneal visceral adipose tissue. In the liver, the HSD was associated with increased hepatic lipid content (i.e., triglycerides and cholesterol) and hepatomegaly. Conclusion The post-weaning consumption of HSD induces an adaptive response in metabolism; however, such an event is not enough to reverse the homeostatic imbalance triggered by the chronic consumption of this macronutrient, leading to the development of metabolic syndrome, irrespective of caloric intake. These findings corroborate recent evidence indicating that sugar is a direct contributor to metabolic diseases independent of a positive energy balance. Arch Endocrinol Metab. 2020;64(1):71-81
Descritores: Ingestão de Energia
Tecido Adiposo/metabolismo
Metabolismo Energético
Açúcares da Dieta/metabolismo
Doenças Metabólicas/metabolismo
Obesidade/metabolismo
-Ratos Wistar
Açúcares da Dieta/efeitos adversos
Açúcares da Dieta/sangue
Doenças Metabólicas/sangue
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde