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Pesquisa : G03.500 [Categoria DeCS]
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Id: biblio-1370072
Autor: Pimentel, Letícia Freitas; Martins, Letícia Maria Perdigão; Portela, Juliana Gomes; Gurgel, Maria Helane Costa; Esmeraldo, Arthur Rafhael Amorim Alves.
Título: Avaliação do perfil metabólico dos pacientes transplantados do coração no Hospital de Messejana / Evaluation of the metabolic profile of heart transplant patients at the Hospital de Messejana
Fonte: J. Health Biol. Sci. (Online);9(1):1-6, 2021. tab, graf.
Idioma: pt.
Resumo: Objetivo: Este estudo visa avaliar o perfil metabólico de pacientes que foram submetidos a TxC em um centro de referência do estado do Ceará. Métodos: Trata-se de um estudo transversal, quantitativo, em que se avaliaram 110 pacientes receptores de TxC no Hospital de Messejana de Fortaleza, no período de 2011 a 2018, por meio de uma ficha clínica. Resultados: observou-se que a maioria dos pacientes era do gênero masculino (76,5%), e a média de idade foi de 46,26 ± 12,73 anos. Entre os pacientes, observou-se que previamente à cirurgia, 42,5% tinham histórico familiar de doença cardíaca, 40,1% estavam com sobrepeso e 15% eram diabéticos. A classe de medicação mais utilizada para as doenças de bases foram os diuréticos, inibidores da enzima conversora da angiotensina e bloqueadores de receptores da angiotensina. A principal etiologia que levou à necessidade do TxC foi a miocardiopatia isquêmica. Conclusões: Nesta amostra, a doença de base com maior prevalência que levou ao transplante foi a miocardiopatia isquêmica. A maioria dos pacientes apresentou rejeição ao enxerto em algum momento do período estudado. Todos os pacientes que apresentaram descompensação glicêmica fizeram uso de insulina.

Objective: This study aims to assess the metabolic profile of patients who underwent HT at a referral center in the state of Ceará. Methods: This is a cross-sectional, quantitative study, in which 110 patients receiving HT were evaluated at the Hospital de Messejana in Fortaleza, from 2011 to 2018, through a clinical form. Results: It was observed that the majority of patients were male (76.5%) and the mean age was 46.26 ± 12.73 years. Among the patients, it was observed that prior to surgery, 42.5% had a family history of heart disease, 40.1% were overweight, and 15% were diabetic. The most used class of medication for underlying diseases were diuretics, angiotensin-converting-enzyme inhibitors, and angiotensin receptor blockers. The main etiology leading to the need for HT was ischemic cardiomyopathy. Conclusions: In this sample, the most prevalent underlying disease leading to transplantation was ischemic cardiomyopathy. Most patients presented graft rejection at some point during the study period. All patients who presented glycemic decompensation used insulin.
Descritores: Transplantes
Transplantados
-Diuréticos
Inibidores Enzimáticos
Metaboloma
Coração
Cardiomiopatias
Responsável: BR1780.2


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Id: biblio-900082
Autor: Farfán, Mauricio J; Torres, Juan Pablo.
Título: Diagnóstico en medicina en la era de las "omicas" / Diagnostics in medicine in the "omics" era
Fonte: Rev. chil. pediatr;89(2):163-165, abr. 2018. graf.
Idioma: es.
Projeto: FONDECYT.
Descritores: Técnicas e Procedimentos Diagnósticos/tendências
Proteoma
Genômica/métodos
Genômica/tendências
Metaboloma
Transcriptoma
Limites: Humanos
Tipo de Publ: Editorial
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1142570
Autor: Rodrigues, I C; Grandi, C; Simões, V M F; Batista, R F L; Rodrigues, L S; Cardoso, V C.
Título: Metabolic profile during pregnancy in BRISA birth cohorts of Ribeirão Preto and São Luís, Brazil
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;54(1):e10253, 2021. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: During pregnancy, metabolic changes that develop in women may increase the risk of diseases and conditions that may also harm the life of the growing fetus. The aim of the present study was to identify and compare the metabolic profile (MP) during pregnancy in two birth cohorts in 2010 in the cities of Ribeirão Preto (RP) and São Luís (SL), Brazil. Pregnant women (1393 in RP and 1413 in SL) were studied; information was obtained through questionnaires in addition to anthropometric, biochemical, and blood pressure measurements. Data are presented as means and proportions. To compare the characteristics of pregnant women in both cities, chi-squared and Student's t-tests were applied, with 5% significance level. Ribeirão Preto presented higher mean values than SL for pre-gestational body mass index (24.5 vs 23 kg/m2, P<0.001), systolic (108.4 vs 102.8 mmHg, P<0.001) and diastolic (65.9 vs 61.8 mmHg, P<0.001) blood pressure, total cholesterol (226.3 vs 213.7 mg/dL, P<0.001) and fractions, and glycemia (84.5 vs 80.2 mg/dL, P<0.001), except for triglycerides (P=0.135). Women from RP also showed higher rates of pre-gestational overweight and obesity compared with SL (40.1 vs 25.8%). In the present study, pregnant women in RP had a worse gestational metabolic profile than those in SL, with higher pre-gestational excess weight, indicating that nutritional transition was more advanced in the more developed city.
Descritores: Gravidez/metabolismo
Metaboloma
-Fatores Socioeconômicos
Brasil/epidemiologia
Índice de Massa Corporal
Estudos de Coortes
Cidades
Limites: Humanos
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-950780
Autor: Habu, Josiah Bitrus; Ibeh, Bartholomew Okechukwu.
Título: In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract
Fonte: Biol. Res;48:1-10, 2015. graf, tab.
Idioma: en.
Resumo: BACKGROUND: The aim of the present study was to evaluate the in vitro antioxidant and free radical scavenging capacity of bioactive metabolites present in Newbouldia laevis leaf extract. RESULTS: Chromatographic and spectrophotometric methods were used in the study and modified where necessary in the study. Bioactivity of the extract was determined at 10 µg/ml, 50 µg/ml, 100 µg/ml, 200 µg/ml and 400 µg/ml concentrations expressed in % inhibition. The yield of the ethanolic leaf extract of N.laevis was 30.3 g (9.93%). Evaluation of bioactive metabolic constituents gave high levels of ascorbic acid (515.53 ± 12 IU/100 g [25.7 mg/100 g]), vitamin E (26.46 ± 1.08 IU/100 g), saponins (6.2 ± 0.10), alkaloids (2.20 ± 0.03), cardiac glycosides(1.48 ± 0.22), amino acids and steroids (8.01 ± 0.04) measured in mg/100 g dry weight; moderate levels of vitamin A (188.28 ± 6.19 IU/100 g), tannins (0.09 ± 0.30), terpenoids (3.42 ± 0.67); low level of flavonoids (1.01 ± 0.34 mg/100 g) and absence of cyanogenic glycosides, carboxylic acids and aldehydes/ketones. The extracts percentage inhibition of DPPH, hydroxyl radical (OH.), superoxide anion (O2 .-), iron chelating, nitric oxide radical (NO), peroxynitrite (ONOO-), singlet oxygen (1O2), hypochlorous acid (HOCl), lipid peroxidation (LPO) and FRAP showed a concentration-dependent antioxidant activity with no significant difference with the controls. Though, IC50 of the extract showed significant difference only in singlet oxygen (1O2) and iron chelating activity when compared with the controls. CONCLUSIONS: The extract is a potential source of antioxidants/free radical scavengers having important metabolites which maybe linked to its ethno-medicinal use.
Descritores: Extratos Vegetais/isolamento & purificação
Sequestradores de Radicais Livres/isolamento & purificação
Folhas de Planta/química
Bignoniaceae/química
Metaboloma/fisiologia
Antioxidantes/isolamento & purificação
-Fenóis/análise
Vitaminas/isolamento & purificação
Vitaminas/metabolismo
Flavonoides/análise
Extratos Vegetais/farmacologia
Peroxidação de Lipídeos/fisiologia
Quelantes de Ferro/isolamento & purificação
Espécies Reativas de Oxigênio/isolamento & purificação
Radical Hidroxila/análise
Concentração Inibidora 50
Metabolismo Secundário/fisiologia
Nigéria
Óxido Nítrico/metabolismo
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1116909
Autor: Sedlinsky, Claudia.
Título: Ritmos circadianos, sueño y salud ósea / Circadian rhythms, sleep and bone health
Fonte: Actual. osteol;13(3):195-197, Sept - DIc. 2017.
Idioma: es.
Descritores: Sono/fisiologia
Osso e Ossos/fisiologia
Ritmo Circadiano/fisiologia
Relógios Circadianos/fisiologia
-Privação do Sono
Osteocalcina/metabolismo
Ritmo Circadiano/genética
Metaboloma/fisiologia
Peptídeos e Proteínas de Sinalização do Ritmo Circadiano/metabolismo
Relógios Circadianos/genética
Limites: Humanos
Animais
Camundongos
Tipo de Publ: Editorial
Responsável: AR2.1 - Biblioteca Central


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Id: biblio-1041239
Autor: Aguiar-Bloemer, Ana Carolina; Agliussi, Rosina Gabriela; Pinho, Thiago Maehara Pereira; Furtado, Erikson Felipe; Diez-Garcia, Rosa Wanda.
Título: Eating behavior of schizophrenic patients / Comportamento alimentar de pacientes com esquizofrenia
Fonte: Rev. Nutr. (Online);31(1):13-24, Jan.-Feb. 2018. tab.
Idioma: en.
Resumo: ABSTRACT Objective To assess the eating behavior, food practices, nutritional and metabolic profiles of patients with schizophrenia undergoing treatment. Methods Cross-sectional exploratory descriptive qualitative study used a semi-structured questionnaire on the eating behavior, food practices, and perception of changes after the initiation of drug therapy and a quantitative method using anthropometric and body composition measurements, metabolic parameters, and 5-day dietary records to analyze nutrient ingestion of patients with schizophrenia in an outpatient clinic at a tertiary hospital (n=33). The qualitative data were analyzed and coded by three researchers and quantitative data were analyzed using descriptive exploratory statistics. Results The results of this study showed that schizophrenic patients presented high prevalence of excess weight (71.0%), metabolic syndrome (42.0%), dyslipidemia (62.0%), changes in appetite (76.0%), and increase in energy intake (74.2%), associated with important irregularities in eating behavior and food practices (such as irregularity of meals, emotional intake, high carbohydrate and fat intake, and low energy expenditure) and lifestyle (changes in social and work routines). Conclusion This eating profile may interact synergistically with psychotropic drugs to contribute to weight gain and metabolic changes in schizophrenia. Nutrition education may prevent and monitor the risk of metabolic and nutrition problems, irrespective of the medications used.

RESUMO Objetivo Avaliar o comportamento e as práticas alimentares, o perfil nutricional e metabólico de pacientes com esquizofrenia em tratamento ambulatorial de um hospital terciário. Métodos Trata-se de estudo descritivo exploratório transversal com abordagem qualitativa utilizando questionário semi-estruturado sobre comportamentos alimentares, práticas alimentares e percepção de mudanças após o início da terapia medicamentosa e abordagem quantitativa usando medidas antropométricas e de composição corporal, parâmetros metabólicos e registros alimentares por cinco dias para analisar a ingestão de nutrientes em pacientes com esquizofrenia (n=33). Os dados qualitativos foram analisados e codificados por três pesquisadores e os dados quantitativos foram analisados utilizando estatísticas exploratórias descritivas. Resultados Os resultados deste estudo mostraram que os pacientes com esquizofrenia apresentaram uma alta prevalência de excesso de peso (71,0%), síndrome metabólica (42,0%) e dislipidemia (62,0%), com alterações no apetite (76,0%), consumo excessivo de energia (74,2%), associado à irregularidades no comportamento alimentar e nas práticas alimentares (como a irregularidade das refeições, o consumo emocional, a ingestão elevada de carboidratos e gorduras e o baixo gasto de energia) e o estilo de vida (mudanças nas rotinas sociais e de trabalho). Conclusão Esse perfil alimentar pode interagir sinergicamente com às drogas psicotrópicas utilizadas o tratamento de esquizofrenia contribuindo com o ganho de peso e alterações metabólicas após o diagnóstico da doença. Nesse sentido, acredita-se que a educação nutricional pode prevenir e monitorar o risco de problema metabólico e nutricional, independentemente dos medicamentos utilizados.
Descritores: Esquizofrenia
-Psicotrópicos
Composição Corporal
Inquéritos e Questionários
Ingestão de Alimentos
Metaboloma
Comportamento Alimentar
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Ensaio Clínico
Responsável: BR13.3 - Biblioteca das Faculdades de Odontologia e Nutrição


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Id: biblio-1040357
Autor: Freemark, Michael.
Título: Endothelial dysfunction and cardiovascular disease in childhood obesity / Disfunção endotelial e doença cardiovascular na obesidade infantil
Fonte: J. pediatr. (Rio J.);95(5):503-505, Sept.-Oct. 2019.
Idioma: en.
Descritores: Doenças Cardiovasculares
Obesidade Pediátrica
-Aptidão Física
Adipocinas
Metaboloma
Limites: Humanos
Criança
Tipo de Publ: Comentário
Responsável: BR1.1 - BIREME


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Id: biblio-828208
Autor: Munaganti, Rajesh Kumar; Muvva, Vijayalakshmi; Konda, Saidulu; Naragani, Krishna; Mangamuri, Usha Kiranmayi; Dorigondla, Kumar Reddy; Akkewar, Dattatray. M.
Título: Antimicrobial profile of Arthrobacter kerguelensis VL-RK_09 isolated from Mango orchards
Fonte: Braz. j. microbiol;47(4):1030-1038, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract An actinobacterial strain VL-RK_09 having potential antimicrobial activities was isolated from a mango orchard in Krishna District, Andhra Pradesh (India) and was identified as Arthrobacter kerguelensis. The strain A. kerguelensis VL-RK_09 exhibited a broad spectrum of in vitro antimicrobial activity against bacteria and fungi. Production of bioactive metabolites by the strain was the highest in modified yeast extract malt extract dextrose broth, as compared to other media tested. Lactose (1%) and peptone (0.5%) were found to be the most suitable carbon and nitrogen sources, respectively, for the optimum production of the bioactive metabolites. The maximum production of the bioactive metabolites was detected in the culture medium with an initial pH of 7, in which the strain was incubated for five days at 30 °C under shaking conditions. Screening of secondary metabolites obtained from the culture broth led to the isolation of a compound active against a wide variety of Gram-positive and negative bacteria and fungi. The structure of the first active fraction was elucidated using Fourier transform infrared spectroscopy, electrospray ionization mass spectrometry, 1H and 13C nuclear magnetic resonance spectroscopy. The compound was identified as S,S-dipropyl carbonodithioate. This study is the first report of the occurrence of this compound in the genus Arthrobacter.
Descritores: Arthrobacter/isolamento & purificação
Arthrobacter/metabolismo
Mangifera/microbiologia
Anti-Infecciosos/metabolismo
Anti-Infecciosos/farmacologia
-Sais/metabolismo
Temperatura
Carbono/metabolismo
Testes de Sensibilidade Microbiana
Metaboloma
Metabolômica/métodos
Concentração de Íons de Hidrogênio
Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/química
Minerais/metabolismo
Nitrogênio/metabolismo
Responsável: BR1.1 - BIREME


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Id: lil-788960
Autor: Lazim, Zainab Mat; Hadibarata, Tony.
Título: Ligninolytic fungus Polyporus sp. S133 mediated metabolic degradation of fluorene
Fonte: Braz. j. microbiol;47(3):610-616, July-Sept. 2016. tab, graf.
Idioma: en.
Projeto: Fundamental Research Grant Scheme; . Universiti Teknologi Malaysia.
Resumo: ABSTRACT This study aimed to investigate the impact of nonionic surfactants on the efficacy of fluorine degradation by Polyporus sp. S133 in a liquid culture. Fluorene was observed to be degraded in its entirety by Polyporus sp. S133 subsequent to a 23-day incubation period. The fastest cell growth rate was observed in the initial 7 days in the culture that was supplemented with Tween 80. The degradation process was primarily modulated by the activity of two ligninolytic enzymes, laccase and MnP. The highest laccase activity was stimulated by the addition of Tween 80 (2443 U/L) followed by mixed surfactant (1766 U/L) and Brij 35 (1655 U/L). UV-vis spectroscopy, TLC analysis and mass spectrum analysis of samples subsequent to the degradation process in the culture medium confirmed the biotransformation of fluorene. Two metabolites, 9-fluorenol (λmax 270, tR 8.0 min and m/z 254) and protocatechuic acid (λmax 260, tR 11.3 min and m/z 370), were identified in the treated medium.
Descritores: Polyporus/metabolismo
Fluorenos/metabolismo
-Solubilidade
Biodegradação Ambiental
Biotransformação
Biomassa
Poluentes Ambientais/metabolismo
Redes e Vias Metabólicas
Polyporus/enzimologia
Metaboloma
Metabolômica/métodos
Fluorenos/química
Responsável: BR1.1 - BIREME


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Id: biblio-889230
Autor: Wang, Yongqiang; Zhang, Wenju; Nie, Cunxi; Chen, Cheng; Zhang, Xiaoyang; Hu, Jianhe.
Título: Evaluation of sample extracting methods of FCSM by Lactobacillus acidophilus based on a UPLC-Q-TOF-MS global metabolomics analysis
Fonte: Braz. j. microbiol;49(2):392-400, Apr.-June 2018. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Graduate Research & Innovation Project in Xinjiang Autonomous Region of China.
Resumo: Abstract The study of metabolomics requires extracting as many metabolites as possible from a biological sample. This study aimed to determine the optimal method for the extraction of metabolites from solid-state fermented cottonseed meal (FCSM). The UPLC-Q-TOF-MS global metabolomics technology was used to detect the metabolites in FCSM, and the extraction quantity and extraction efficiency of seven different extraction methods, specifically the WA, 50MeOH, 50MeOHB, 50MeCNB, 80MeOHB, 80MeOH and AMF methods were evaluated. The results showed that the number of VIP metabolites extracted by AMF method are 196 and 184 in ESI+ and ESI- mode respectively, it is the largest number of all exacted methods; and the AMF methods also provided a higher extraction efficiency compared with the other methods, especially in indoleacrylic acid, dl-tryptophan and epicatechin (p < 0.01). As a result, AMF/-4 °C method was identified as the best method for the extraction of metabolites from FCSM by Lactobacillus acidophilus. Our study establishes a technical basis for future metabolomics research of fermented feed.
Descritores: Sementes/metabolismo
Extratos Vegetais/química
Gossypium/metabolismo
Metaboloma
Lactobacillus acidophilus/metabolismo
Lactobacillus acidophilus/química
-Espectrometria de Massas
Cromatografia
Metabolômica
Responsável: BR1.1 - BIREME



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