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Souccar, Caden
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Id: lil-623957
Autor: Fischman, Lygia A; Skorupa, L. A; Souccar, Caden; Lapa, A. J.
Título: The water extract of Coleus barbatus Benth decreases gastric secretion in rats
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):141-143, 1991. ilus, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Coleus barbatus (Labiatae) Benth is popularly used in Brazil "for the healing of liver and stomach diseases". The water extract (WE 1 to 10 g/Kg, p.o.) of stem and leaves given to rats and mice did not induce signs of intoxication. Preveious treatment of mice with WE (1 g/kg, p.o.) shortened the sleeping time induced by pentobarbital (50 mg/Kg, i.p.) by 37 por cento, althoyugh the extract alone did not increase the spontaneous activity nor did it induce hyperexcitability. In mice WE (2 g/Kg, p.o.) increased the intestinal transit of charcoal by 30 por cento, while reduced gastric secretions ion rats treated with WE (2g/Kg intraduodenal) 3,9 ± 1.0 to 0.5 ± 0.2 ml/4h, respectively). The treatment also reduced the total acid secretion from 34.4 ± 11.0 to 2.7 ± 0.5 mEq/l and raisedgastric pH from 2.2 ± 0.3 to 6.5 ± 0.8. Treatment with WE (2g/Kg, p.o.) protected against gastric ulcers induced by stress (5.3 ± 1.6 and 1.5 ± 0.5 ulcers/cm²), but did nor protect against indonethacin induced ulcers. The results show that the water extract of C barbatus Benth produces mild stimulation of thecentral nervous system and increases intestinal movements. The extract also reduces gastric secretion indicating an antidyspeptic activity, and protects against gastric ulcers induced by stress.
Descritores: Taxa Secretória/efeitos dos fármacos
Úlcera Gástrica/prevenção & controle
Comportamento Animal/efeitos dos fármacos
Extratos Vegetais/farmacologia
Ácido Gástrico/enzimologia
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/metabolismo
Motilidade Gastrointestinal/efeitos dos fármacos
-Brasil
Avaliação de Medicamentos
Limites: Animais
Camundongos
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-900291
Autor: Aitken-Saavedra, Juan Pablo; Olid, Cristobal; Escobar, Alejandro; Parry, Yoshua; Duarte da Silva, Karine; Morales-Bozo, Irene.
Título: Características salivales y estado sistémico de sujetos con xerostomía / Salivary characteristics and systemic status of subjects with xerostomia
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);10(2):118-120, ago. 2017. tab, graf.
Idioma: es.
Projeto: FONIS.
Resumo: RESUMEN: Xerostomía o sensación de boca es una afección que afecta severamente la calidad de vida de quienes la padecen. Si bien se relaciona con la reducción del flujo salival (hiposalivación), existe evidencia contradictoria y se sugiere evaluar características cualitativas salivales y estado sistémico de los afectados para comprender su etiología y mejorar terapias asociadas. El objetivo de este estudio fue comparar pH y concentración de proteínas en saliva y estado sistémico entre sujetos xerostómicos con y sin hiposialia. Se midió pH, concentración de proteínas salivales y se consignaron antecedentes sistémicos y uso de fármacos en 27 individuos xerostómicos, que fueron divididos en hiposiálicos y no hiposiálicos. Se compararon las variables mencionadas usando test no paramétrico de Mann-Whitney y test Chi-Cuadrado. Se aceptaron diferencias estadísticamente significativas con error alfa igual o menor a 5 %. Sujetos xerostómicos con hiposialia presentaron mayor prevalencia de Artritis Reumatoide y Síndrome de Sjögren en comparación con xerostómicos sin hiposialia. No se encontraron diferencias estadísticamente significativas en relación a pH, concentración de proteínas y uso de medicamentos, variables que no influirían en el padecimiento de xerostomía, independiente de la existencia de hiposialia. Sujetos con xerostomía e hiposialia presentan mayor frecuencia de Artritis Reumatoide y Síndrome de Sjögren.

ABSTRACT: Xerostomia or mouth feeling is a condition that severely affects the quality of life of thosewho suffer from it. Although it is related to the reduction of salivary flow (hyposalivation),there is contradictory evidence and it is suggested to evaluate qualitative salivarycharacteristics and systemic state of those affected in order to understand its etiology and improve associated terapies. The objective of this study was to compare saliva, pH and protein concentration and systemic status among xerostomic subjects with and without hyposialia. Were measured PH and protein concentration and were recorded systemic antecedents and drug use in 27 xerostomic individuals, who were divided into hyposalic and nonhyposalic individuals. The mentioned variables were compared using non-parametric Mann-Whitney test and Chi-Square test. Statistically significant differences were accepted with alpha error equal to or less than 0.05%. Xerostomic subjects with hyposialia presented higher prevalence of Rheumatoid Arthritis and Sjögren's Syndrome compared to xerostomics without hyposialia. No statistically significant differences were found in relation to pH, protein concentration and drug use, variables that would not influence xerostomia, independent of hyposialia. Subjects with xerostomia with hyposialia present a higher frequency of Rheumatoid Arthritis and Sjögren's Syndrome.
Descritores: Xerostomia/fisiopatologia
-Saliva/química
Proteínas e Peptídeos Salivares/análise
Salivação/fisiologia
Taxa Secretória
Síndrome de Sjogren/fisiopatologia
Distribuição de Qui-Quadrado
Estudos Transversais
Estatísticas não Paramétricas
Concentração de Íons de Hidrogênio
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: CL58.1 - Biblioteca


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Id: biblio-839536
Autor: ANTONIAZZI, Raquel Pippi; SARI, Amanda Rodrigues; CASARIN, Maísa; MORAES, Cristina Machado Bragança de; FELDENS, Carlos Alberto.
Título: Association between crack cocaine use and reduced salivary flow
Fonte: Braz. oral res. (Online);31:e42, 2017. tab, graf.
Idioma: en.
Projeto: State of Rio Grande do Sul Research Foundation.
Resumo: Abstract Crack cocaine use appears to have an impact on oral conditions. However, changes in the salivary flow among crack users have not been fully clarified. The aim of this study was to compare stimulated salivary flow and the occurrence of hyposalivation between crack users and non-users. A cross-sectional study was conducted involving 40 crack users and 40 controls matched for sex, age, and smoking habits. Interviews were conducted to acquire data on the perception of dry mouth (xerostomia) and drug use. Stimulated salivary flow was determined using the spitting method. A significant reduction in stimulated salivary flow was found among crack users in comparison to non-users (1.02 vs. 1.59 ml/min). A total of 42.5% and 15% of crack users had very low and low stimulated salivary flow, respectively. Moreover, 65% of users reported xerostomia in comparison to 37.5% non-users (p < 0.012). No significant association was found between xerostomia and hyposalivation (p = 0.384). A multivariate analysis revealed that individuals older than 26 years of age, those with a low household income, and crack users (prevalence ratio: 2.59) had a significant association with the occurrence of hyposalivation. A significant association was found between the use of crack and reduced salivary flow. The use of crack was associated with the occurrence of hyposalivation in the multivariate analysis.
Descritores: Salivação/efeitos dos fármacos
Xerostomia/induzido quimicamente
Cocaína Crack/efeitos adversos
Transtornos Relacionados ao Uso de Cocaína/fisiopatologia
-Salivação/fisiologia
Taxa Secretória/efeitos dos fármacos
Estudos de Casos e Controles
Índice CPO
Estudos Transversais
Análise Multivariada
Inquéritos e Questionários
Estatísticas não Paramétricas
Uso de Tabaco/efeitos adversos
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-839531
Autor: AMBRÓSIO, Lucas Macedo Batitucci; ROVAI, Emanuel da Silva; FRANÇA, Bruno Nunes de; BALZARINI, Danilo Andrés; ABREU, Ieda Santos; LOPES, Sheyla Batista Bologna; NUNES, Thaís Borguezan; LOURENÇO, Silvia Vanessa; PASOTO, Sandra Gofinet; SARAIVA, Luciana; HOLZHAUSEN, Marinella.
Título: Effects of periodontal treatment on primary sjogren's syndrome symptoms
Fonte: Braz. oral res. (Online);31:e8, 2017. tab, graf.
Idioma: en.
Projeto: São Paulo Research Foundation; . São Paulo Research Foundation; . São Paulo Research Foundation; . São Paulo Research Foundation.
Resumo: Abstract The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren’s Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1β, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients.
Descritores: Síndrome de Sjogren/complicações
Periodontite Crônica/etiologia
Periodontite Crônica/terapia
-Saliva/química
Salivação/fisiologia
Taxa Secretória
Fatores de Tempo
Ensaio de Imunoadsorção Enzimática
Síndrome de Sjogren/fisiopatologia
Estudos de Casos e Controles
Reação em Cadeia da Polimerase
Estudos Prospectivos
Estudos Longitudinais
Líquido do Sulco Gengival
Interleucinas/análise
Resultado do Tratamento
Periodontite Crônica/fisiopatologia
Periodontite Crônica/microbiologia
Carga Bacteriana
Limites: Humanos
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-839497
Autor: NIKLANDER, Sven; VEAS, Laura; BARRERA, Cristina; FUENTES, Flavio; CHIAPPINI, Giuliana; MARSHALL, Maureen.
Título: Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life
Fonte: Braz. oral res. (Online);31:e14, 2017. tab.
Idioma: en.
Projeto: Universidad Andrés Bello.
Resumo: Abstract To determine xerostomia-related frequency, factors, salivary flow rates and Oral Health-Related Quality of Life (OHRQoL) of patients attending the Universidad Andrés Bello Dental School Clinic, in the city of Viña del Mar, Chile. The study involved 566 patients assessed with xerostomia, based on a single standardized questionnaire. The severity and impact of xerostomia on OHRQoL was assessed using a visual analogue scale (VAS) and the short version of the Oral Health Impact Profile Questionnaire (OHIP-14sp), respectively. Stimulated and non-stimulated salivary flow rates were obtained from a sample of patients. Xerostomia was reported in 61 patients (10.8%), comprising 50 women (83.3%) and 11 men (16.7%) (p < 0.013). The prevalence was 13% among the women and 6.1% among the men. Gender, age and medication were found to be independent risk factors for the development of xerostomia. Hyposalivation was found in 10 of the 35 patients with xerostomia (28.6%) and in 2 patients without it (p < 0.011). Patients with xerostomia had a reduced OHRQoL, compared with patients without xerostomia, as shown by the total OHIP-14sp score (p < 0.001). Xerostomia was a common, potentially debilitating condition with a major impact on the OHRQoL of a patient population attending a university-based dental clinic. Hyposalivation was present in almost 30% of the patients who complained of xerostomia. It is important that general dentists be aware of this condition, so that they can provide patients with a good diagnosis, treatment and follow-up.
Descritores: Qualidade de Vida
Xerostomia/fisiopatologia
Xerostomia/epidemiologia
Saúde Bucal/estatística & dados numéricos
-Saliva/metabolismo
Glândulas Salivares/fisiopatologia
Salivação/fisiologia
Taxa Secretória
Estudos de Casos e Controles
Chile/epidemiologia
Prevalência
Fatores de Risco
Distribuição por Sexo
Distribuição por Idade
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-893654
Autor: Bozejac, Branislava Velicki; Stojšin, Ivana; Ðuric, Mirna; Zvezdin, Biljana; Brkanić, Tatjana; Budišin, Evica; Vukoje, Karolina; Sečen, Nevena.
Título: Impact of inhalation therapy on the incidence of carious lesions in patients with asthma and COPD
Fonte: J. appl. oral sci;25(5):506-514, Sept.-Oct. 2017. tab.
Idioma: en.
Resumo: Abstract Objective: The aim of this study was to investigate the incidence of carious lesions, the amount of salivary flow rate and pH value in patients with asthma and chronic obstructive pulmonary diseases (COPD), using inhalation therapy. The obtained results were compared with the results of adult healthy subjects, forming a control group. Material and Methods: The study included 80 participants aging between 18 and 65 years. The experimental group (EG) was comprised of 40 participants, previously diagnosed with asthma or COPD undergoing inhalation therapy for more than five years. The control group (CG), comprised of 40 participants, mirrored the same age and gender status of the EG. Dental status was determined by decayed, missing, and filled teeth (DMFT index). Quantity and pH value of saliva were determined in the laboratory. Results: In the EG, the mean value of the salivary flow rate and pH value were statistically significantly lower than in the CG (p<0.001). Patients in the EG had a higher value of DMFT index when compared with the CG, although the difference was not statistically significant (p=0.199). Mean number of decayed teeth, as well as missing teeth, in the EG was statistically significantly higher than in the CG (p<0.001). Mean number of filled teeth in the EG was statistically significantly lower than in the CG (p<0.001). Conclusion: It was found that patients undergoing inhalation therapy face increasing risk of dental caries due to the lower salivary flow rate and pH value along with the inhalation therapy. They should receive intensive preventive care, including oral hygiene instruction and dietary advice.
Descritores: Asma/terapia
Cárie Dentária/etiologia
Doença Pulmonar Obstrutiva Crônica/terapia
Terapia Respiratória/efeitos adversos
Saliva/química
-Estudos de Casos e Controles
Estudos Transversais
Índice CPO
Concentração de Íons de Hidrogênio
Higiene Bucal
Valores de Referência
Fatores de Risco
Salivação
Saliva/metabolismo
Taxa Secretória
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-752435
Autor: ACQUIER, Andrea Beatriz; PITA, Alejandra Karina De Couto; BUSCH, Lucila; SÁNCHEZ, Gabriel Antonio.
Título: Comparison of salivary levels of mucin and amylase and their relation with clinical parameters obtained from patients with aggressive and chronic periodontal disease
Fonte: J. appl. oral sci;23(3):288-294, May-Jun/2015. tab, graf.
Idioma: en.
Projeto: UBACYT.
Resumo: Objective Salivary mucin and amylase levels are increased in patients with chronic periodontitis (CP). Due to the fact that aggressive periodontitis (AgP) not only differs from chronic periodontitis in terms of its clinical manifestation, the aim of this study was to compare salivary mucin and amylase levels and their relation to the clinical parameters of patients with aggressive periodontitis with that of patients with chronic periodontitis. Material and Methods Eighty subjects were divided into two groups: 20 patients with AgP and their 20 matched controls and 20 patients with CP and their 20 matched controls, based on clinical attachment loss (CAL), probing pocket depth (PPD) and bleeding on probing (BOP). Whole unstimulated saliva was obtained and mucin, amylase and protein were determined by colorimetric methods. Pearson's correlation analysis was used to determine the relationship between salivary mucin, amylase and protein levels and the clinical parameters. Results Salivary mucin, amylase and protein levels were increased in patients with AgP and CP but there were no differences between them or between control groups. Pearson's correlation analysis, determined in the entire subjects studied, showed a positive and significant correlation of mucin, amylase and proteins with CAL and PPD and a negative correlation with the flow rate. When Pearson's correlation analysis was carried out in each group separately, Fisher's z transformation showed no significant difference between both groups. Conclusion Comparison of the salivary levels of mucin, amylase and protein and their relationship with clinical parameters of AgP patients with that of CP patients revealed no differences between both groups. .
Descritores: Periodontite Agressiva/metabolismo
Amilases/análise
Periodontite Crônica/metabolismo
Mucinas/análise
Saliva/química
-Análise de Variância
Estudos de Casos e Controles
Perda da Inserção Periodontal
Índice Periodontal
Valores de Referência
Salivação
Taxa Secretória
Estatísticas não Paramétricas
Limites: Adolescente
Adulto
Feminino
Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Luciano, Eliete
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Id: lil-733855
Autor: Cambri, Lucieli Teresa; Vital, Thays Martins; Teixeira, Camila Vieira Ligo; Jambassi Filho, José Claúdio; Dalia, Rodrigo Augusto; Luciano, Eliete.
Título: Perfil lipídico de ratos com hipertireoidismo induzido: efeitos do exercício físico agudo / Lipid profile of rats with induced hyperthyroidism: effects of acute exercise
Fonte: Rev. bras. ciênc. mov;21(3):13-20, 2013.
Idioma: pt.
Resumo: Este estudo teve como objetivo analisar o perfil lipídico de ratos Wistar com hipertireoidismo induzido em repouso e após exercício físico agudo. Foram utilizados 28 ratos machos Wistar, divididos em hipertireoidismo (H; induzido com tiroxina) e controle (C). Metade dos animais de cada grupo foi sacrificada em repouso. A outra metade foi submetida, imediatamente antes do sacrifício, à sessão única de exercício de natação, por 20 minutos (carga de 5% em relação ao peso corporal). Para as comparações entre os grupos utilizou-se Teste T de Student's e ANOVA Two-Way, seguida de post-hoc de Newman-Keuls. O grupo H apresentou menor peso do tecido adiposo nas regiões mesentérica, retroperitoneal e subcutânea, comparado com o grupo C, o que reflete a perda de peso corporal neste grupo. Menores valores de colesterol total, LDL e HDL, na condição em repouso, foram observados no grupo H. Após o exercício agudo houve um incremento estatisticamente significativo de glicose em ambos os grupos, bem como, redução dos níveis de triglicerídeos no grupo C (p<0,05). As concentrações de lipídios totais nocoração foram menores em repouso para o grupo H quando comparado com o grupo C. Após sessão aguda de exercício físico essas concentrações se elevaram no grupo H (p<0,05). A droga utilizada induziu características de hipertireoidismo, associadas ao perfil lipídico, em ratos Wistar. O exercício físico agudo não alterou o perfil lipídico dos animais com hipertireoidismo experimental, exceto os lipídios totais do coração. A partir dos achados do presente estudo, trabalhos futuros poderão utilizar intensidade de exercício físico similar (5% do peso corporal) e analisar outros parâmetros metabólicos relacionados a essa patologia em ratos.

The aim of this study was to analyze the lipid profile of rats Wistar with hyperthyroidism at rest and after an acute exercise session. Twenty-eight male Wistar rats were divided into hyperthyroidism (H; induced with tiroxin), and control (C). Half of the animals of each group were sacrificed at rest. The other half was submitted, immediately before the sacrifice, to an a session of swimming exercise for 20 minutes. For the comparisons among the groups Student's t test and ANOVA Two-way test were used, following by post-hoc of Newman-Keuls. The H group presented lower adipose tissue weight of the mesenteric, retroperitoneal and subcutaneous areas compared with the group C, which reflects the loss of corporal weight observed in this group. Lower values of the total cholesterol, LDL and HDL were observed in the H group at rest condition. After exercise there was a glucose increment in both groups, and reduction of the triglycerides levels in the C group (p<0.05). The concentrations of total lipids in the heart were lower at rest for the H group compared with the C group. After the acute session of physical exercise those concentrations enhanced in the H group (p<0.05). The drug used was efficient in inducing characteristics of hyperthyroidism, associated to the lipid profile, in Wistar rats and that the acute session of exercise did not changed the lipid profile of the animals with experimental hyperthyroidism. This is important, because future studies may use similar intensity of physical exercise (5% body weight) and analyze other metabolic parameters associated with this pathology in rats.
Descritores: Exercício Físico
Hipertireoidismo
Transtornos do Metabolismo dos Lipídeos
Ratos Wistar
-Taxa Secretória
Limites: Animais
Ratos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1552.1 - Biblioteca Central


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Id: lil-696561
Autor: Larrucea V., Carlos; Henríquez O., Erika; Inostroza T., Monserrat; Campos M., Laura; Peña G., Carolina; Larrucea S., Carlo; Arenas S., Miguel; Larrucea S., Karina.
Título: Efecto inmediato de infusiones de consumo habitual en las propiedades salivales / Immediate effect of commonly consumed infusions in the salivary properties
Fonte: Int. j. odontostomatol. (Print);7(3):343-349, Dec. 2013. ilus.
Idioma: es.
Resumo: Gran cantidad de población consume cotidianamente infusiones, como el Té, Manzanilla y Yerba Mate. Diferentes estudios han determinado sus efectos benéficos en los seres humanos, razón por la cual, para este estudio se han seleccionado aquellas infusiones de uso habitual con el fin de caracterizar sus efectos inmediatos sobre las propiedades de la saliva. Con grupos de 37 sujetos sanos, entre 18-23 años, de bajo riesgo cariogénico se obtuvieron 3 muestras de saliva no estimulada: Basal; Post-ingesta de Agua Destilada (Placebo) y Post-ingesta Infusión (Té Negro, Té Verde, Mate, Manzanilla y Manzanilla con Endulzante), respectivamente. Todas las pruebas fueron realizadas bajo condiciones estándar. Se determinó el flujo salival (ml/min), pH mediante pH-metro (PL-600, GOnDO Electronics Co, TW) y capacidad buffer mediante método de Ericsson. Todos los datos se procesaron mediante la prueba ANOVA con el programa Origin 6.0. El promedio de Flujo Salival Basal (0,51 ml/min) tiende a aumentar destacando el efecto de la Manzanilla con Endulzante (0,63 ml/min); el pH basal (7,25) se mantuvo relativamente constante, y la Capacidad Buffer (4,38) también tiende a aumentar destacando la Manzanilla (5,01). El efecto de algunas infusiones es positivo sobre las propiedades salivales, destacando la Infusión de Manzanilla, Manzanilla con Endulzante y Yerba Mate las cuales aumentan significativamente el flujo y la capacidad buffer salival, lo cual sugiere un efecto benéfico en la prevención de caries.

A great number of the population consumes daily a variety of infusions such as Tea, Chamomile and Mate Herb. Different studies have determined their favorable effects in human beings, for this reason those infusions habitually used have been selected for this study, in order to characterize their immediate effects on the saliva properties. We studied groups of 37 healthy subjects, between 18-23 years of age, with low caries risk, and obtained 3 samples of non-stimulated saliva: Basal; Post-ingestion of Distilled Water (Placebo); Post-ingestion of Infusion (Black Tea, Green Tea, Mate Herb, Chamomile and Chamomile with Sucralose). All the tests were realized under standard conditions. We measured, salivary flow (ml/min); pH with pH-meter (PL-600, GOnDO Electronics Co, TW) and buffer capacity with Ericsson's method. All the information was processed with Anova Test in Origin 6.0. Our results showed the average of Salivary Basal Flow (0.51 ml/min) tends to increase standing out the effect of Chamomile with Sucralose (0.63 ml/min), the basal pH (7.25) was maintained relatively constant, and finally the Buffer Capacity (4.38) also tends to increase, emphasizing Chamomile (5.01). The effect of some infusions is positive on the salivary properties, emphasizing the Infusion of Chamomile, Chamomile with Sucralose and Mate Herb, which increase significantly the flow and the salivary buffer capacity. This suggests a favorable effect in the prevention of caries.
Descritores: Bebidas
Salivação
-Análise de Variância
Tampões (Química)
Camomila
Cárie Dentária/prevenção & controle
Concentração de Íons de Hidrogênio
Ilex paraguariensis
Taxa Secretória
Chá
Limites: Humanos
Masculino
Adolescente
Adulto
Feminino
Adulto Jovem
Responsável: CL1.1 - Biblioteca Central


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Id: lil-694355
Autor: Owu, DU; Nwokocha, CR; Obembe, AO; Essien, AD; Ikpi, DE; Osim, EE.
Título: Effect of Gongronema latifolium ethanol leaf extract on gastric acid secretion and cytoprotection in streptozotocin-induced diabetic rats / Efecto del extracto de etanol de las hojas de Gongronema latifolium sobre la secreción del ácido gástrico y la citoprotección en ratas con diabetes inducida por estreptozotocina
Fonte: West Indian med. j;61(9):853-860, Dec. 2012. ilus, tab.
Idioma: en.
Resumo: OBJECTIVES: Gongronema latifolium leaves have been used in folklore medicine to manage diabetes mellitus and alleviate dyspepsia. This study aimed to provide a pharmacological basis to the medicinal use of Gongronema latifolium as an antidiabetic and antiulcerogenic agent in diabetes mellitus. METHODS: Ethanol extract from the leaf (200 mg/kg bodyweight) of Gongronema latifolium was administered to both streptozotocin-induced diabetic and control groups orally for 14 days. Gastric acid secretion was measured and ulcer was induced using ethanol and fourhour pyloric ligation. RESULTS: The mean bodyweight was significantly lower (p < 0.01), while the mean weight of the stomach, liver and small intestine to bodyweight ratio was increased significantly (p < 0.05) in the two diabetic groups compared to control. Extract significantly (p < 0.01) reduced the blood glucose level similar to the nondiabetic control. Basal and stimulated acid secretion in diabetic control rats was significantly (p < 0.01) decreased when compared to control. Extract administration increased the stimulated gastric acid secretion to a level significantly (p < 0.05) higher than control while reduction in gastric secretion by ranitidine was similar compared with control. Gongronema latifolium treatment significantly (p < 0.05) reduced ulcer scores in both ulcer models and increased mucus weight in the diabetic group. CONCLUSION: These results suggest that Gongronema latifolium antiulcerative activity is due to its prevention of chemicalinduced stomach injury.

OBJETIVOS: Las hojas de la gongronema latifolium han sido usadas en la medicina tradicional para tratar la diabetes mellitus y aliviar la dispepsia. Este estudio estuvo dirigido a proporcionar una base farmacológica al uso medicinal de la gongronema latifolium como agente antidiabético y antiulcerogénico en la diabetes mellitus. MÉTODOS: El extracto de etanol de la hoja (200 mg/kg peso corporal) de la Gongronema latifolium se administró oralmente durante 14 días a grupos con diabetes inducida por estreptozotocina, y grupos de control. La secreción ácida gástrica fue moderada y la úlcera fue inducida usando etanol, y ligazón pilórica de cuatro horas. RESULTADOS: El peso corporal promedio fue significativamente más bajo (p < 0.01), mientras que el peso promedio del estómago, el hígado y el intestino delgado con respecto a la proporción del peso corporal aumentó significativamente (p < 0.05) en los dos grupos diabéticos comparados con los controles. El extracto redujo significativamente (p < 0.01) el nivel de glucosa de la sangre, de manera similar al control no diabético. La secreción ácida basal y estimulada en las ratas diabéticas control disminuyó significativamente (p < 0.01) en comparación con el control. La administración del extracto aumentó la secreción ácida gástrica estimulada a un nivel significativamente (p < 0.05) superior al control, en tanto que la reducción de secreción gástrica mediante ranitidina fue similar comparada con el control. El tratamiento con Gongronema latifolium redujo significativamente (p < 0.05) las puntuaciones de las úlceras, tanto en los modelos de la úlcera como en el peso de mucosidad aumentado en el grupo diabético. CONCLUSIÓN: Estos resultados sugieren que la actividad antiulcerosa de la Gongronema latifolium se debe a que previene las lesiones de estómago inducidas por medios químicos.
Descritores: Apocynaceae
Antiulcerosos/farmacologia
Glicemia/metabolismo
Citoproteção/efeitos dos fármacos
Dispepsia/fisiopatologia
Ácido Gástrico
Hipoglicemiantes/farmacologia
Medicina Tradicional
Fitoterapia
Extratos Vegetais/farmacologia
-Diabetes Mellitus Experimental/fisiopatologia
Mucosa Gástrica/efeitos dos fármacos
Folhas de Planta
Ratos Wistar
Ranitidina/farmacologia
Taxa Secretória/efeitos dos fármacos
Úlcera Gástrica/fisiopatologia
Úlcera Gástrica/prevenção & controle
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR21.1 - Biblioteca J Baeta Vianna- Campus Saúde UFMG



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