Base de dados : LILACS
Pesquisa : G04.144.220.220.687.444 [Categoria DeCS]
Referências encontradas : 2 [refinar]
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Texto completo SciELO Saúde Pública
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Id: lil-744843
Autor: Bastos, Francisco I..
Título: Skill and art in an intolerant world: a brief commentary on the article by Paiva et al. / Engenho e arte em um mundo intolerante: breves comentários ao texto de Paiva et al. / Ingenio y arte en un mundo intolerante: breves comentarios al texto de Paiva et al.
Fonte: Cad. saúde pública = Rep. public health;31(3):1-2, 03/2015.
Idioma: en.
Descritores: Oócitos/citologia
Oócitos/fisiologia
Oogênese/fisiologia
Ovário/embriologia
/genética
TUMOR SUPPRESSOR PROTEIN PDIPETALONEMA INFECTIONS/genética
-Animais Recém-Nascidos
Apoptose/fisiologia
Fragmentação do DNA
Regulação da Expressão Gênica no Desenvolvimento
Marcação In Situ das Extremidades Cortadas
Camundongos Endogâmicos CBA
Camundongos Knockout
Prófase Meiótica I/fisiologia
MICE, INBRED CABDOMENABDOMINAL INJURIESBL
Proteínas Nucleares/metabolismo
Ovário/citologia
Ovário/fisiologia
Poli(ADP-Ribose) Polimerases/metabolismo
Limites: Animais
Feminino
Masculino
Camundongos
Gravidez
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-571988
Autor: Berríos, Soledad; Manterola, Marcia; Prieto, Zulita; López-Fenner, Julio; Page, Jesús; Fernández-Donoso, Raúl.
Título: Model of chromosome associations in Mus domesticus spermatocytes
Fonte: Biol. Res;43(3):275-285, 2010. ilus, graf, tab.
Idioma: en.
Projeto: FONDECYT; . Agencia Española de Cooperación Internacional para el Desarrollo (Spain).
Resumo: Understanding the spatial organization of the chromosomes in meiotic nuclei is crucial to our knowledge of the genome's functional regulation, stability and evolution. This study examined the nuclear architecture of Mus domesticus 2n=40 pachytene spermatocytes, analyzing the associations among autosomal bivalents via their Centromere Telomere Complexes (CTC). The study developed a nuclear model in which each CTC was represented as a 3D computer object. The probability of a given combination of associations among CTC was estimated by simulating a random distribution of 19 indistinguishable CTC over n indistinguishable "cells" on the nuclear envelope. The estimated association frequencies resulting from this numerical approach were similar to those obtained by quantifying actual associations in pachytene spermatocyte spreads. The nuclear localization and associations of CTC through the meiotic prophase in well-preserved nuclei were also analyzed. We concluded that throughout the meiotic prophase: 1) the CTC of autosomal bivalents are not randomly distributed in the nuclear space; 2) the CTC associate amongst themselves, probably at random, over a small surface of the nuclear envelope, at the beginning of the meiotic prophase; 3) the initial aggregation of centromere regions occurring in lepto-zygotene likely resolves into several smaller aggregates according to patterns of preferential partitioning; 4) these smaller aggregates spread over the inner face of the nuclear envelope, remaining stable until advanced stages of the meiotic prophase or even until the first meiotic division.
Descritores: Núcleo Celular/ultraestrutura
Cromossomos de Mamíferos/ultraestrutura
Espermatócitos/ultraestrutura
-Centrômero/ultraestrutura
Modelos Biológicos
Prófase Meiótica I/fisiologia
Membrana Nuclear/ultraestrutura
Telômero/ultraestrutura
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central



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