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Pesquisa : G04.144.220.220.781 [Categoria DeCS]
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Id: biblio-1283594
Autor: Cheng, Gong; Abbas Raza, Sayed Haidar; Khan, Rajwali; Wang, Hong; Shater, Abdullah F; Mohammedsaleh, Zuhair M; Wang, Li; Tian, Yuan; Long, Feng; Zan, Linsen.
Título: C/EBPb converts bovine fibroblasts to adipocytes without hormone cocktail induction
Fonte: Electron. j. biotechnol;52:67-75, July. 2021. tab, graf, ilus.
Idioma: en.
Projeto: Key R&D Program of Shaanxi Province; . National Key R&D Program of China; . National Natural Science Foundation; . of China.
Resumo: BACKGROUND: Adipogenesis and fibrogenesis can be considered as a competitive process in muscle, which may affect the intramuscular fat deposition. The CCAAT/enhancer-binding protein beta (C/EBPb) plays an important role in adipogenesis, which is well-characterized in mice, but little known in bovine so far. RESULTS: In this study, real-time qPCR revealed that the level of C/EBPb was increased during the developmental stages of bovine and adipogenesis process of preadipocytes. Overexpression of C/EBPb promoted bovine fibroblast proliferation through mitotic clonal expansion (MCE), a necessary process for initiating adipogenesis, by significantly downregulating levels of p21 and p27 (p < 0.01). Also, the PPARc expression was inhibited during the MCE stage (p < 0.01). 31.28% of transfected fibroblasts adopted lipid-laden adipocyte morphology after 8 d. Real-time qPCR showed that C/EBPb activated the transcription of early stage adipogenesis markers C/EBPa and PPARc. Expression of ACCa, FASN, FABP4 and LPL was also significantly upregulated, while the expression of LEPR was weakened. CONCLUSIONS: It was concluded C/EBPb can convert bovine fibroblasts into adipocytes without hormone induction by initiating the MCE process and promoting adipogenic genes expression, which may provide new insights into the potential functions of C/EBPb in regulating intramuscular fat deposition in beef cattle.
Descritores: Bovinos/metabolismo
Adipócitos/metabolismo
Proteína beta Intensificadora de Ligação a CCAAT/metabolismo
Fibroblastos/metabolismo
-Tecido Adiposo/metabolismo
Células Clonais
Proliferação de Células
Adipogenia
Reação em Cadeia da Polimerase em Tempo Real
Mitose
Músculos
Responsável: CL1.1 - Biblioteca Central


  2 / 105 LILACS  
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Id: biblio-974953
Autor: Paier, Carlos Roberto Koscky; Maranhão, Sarah Sant'Anna; Carneiro, Teiliane Rodrigues; Lima, Lídia Moreira; Rocha, Danilo Damasceno; Santos, Renan da Silva; Farias, Kaio Moraes de; Moraes-Filho, Manoel Odorico de; Pessoa, Claudia.
Título: Natural products as new antimitotic compounds for anticancer drug development
Fonte: Clinics;73(supl.1):e813s, 2018. tab, graf.
Idioma: en.
Resumo: Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. These antitumor compounds are referred to as antimitotics. Vinca alkaloids and taxanes are natural products that target microtubules and inhibit mitosis, and their derivatives are among the most commonly used drugs in cancer therapy worldwide. However, severe adverse effects such as neuropathies are frequently observed during treatment with microtubule-targeting agents. Many efforts have been directed at developing improved antimitotics with increased specificity and decreased likelihood of inducing side effects. These new drugs generally target specific components of mitotic regulation that are mainly or exclusively expressed during cell division, such as kinases, motor proteins and multiprotein complexes. Such small molecules are now in preclinical studies and clinical trials, and many are products or derivatives from natural sources. In this review, we focused on the most promising targets for the development of antimitotics and discussed the advantages and disadvantages of these targets. We also highlighted the novel natural antimitotic agents under investigation by our research group, including combretastatins, withanolides and pterocarpans, which show the potential to circumvent the main issues in antimitotic therapy.
Descritores: Produtos Biológicos/química
Antimitóticos/química
Desenvolvimento de Medicamentos/métodos
Antineoplásicos/química
-Produtos Biológicos/farmacologia
Antimitóticos/farmacologia
Mitose/efeitos dos fármacos
Neoplasias/patologia
Neoplasias/tratamento farmacológico
Antineoplásicos/farmacologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-950766
Autor: Doan, Chung Chinh; Le, Long Thanh; Hoang, Son Nghia; Do, Si Minh; Van Le, Dong.
Título: Simultaneous silencing of VEGF and KSP by siRNA cocktail inhibits proliferation and induces apoptosis of hepatocellular carcinoma Hep3B cells
Fonte: Biol. Res;47:1-15, 2014. ilus, graf, tab.
Idioma: en.
Resumo: BACKGROUND: Vascular endothelial growth factor (VEGF) is involved in the growth of new blood vessels that feed tumors and kinesin spindle protein (KSP) plays a critical role in mitosis involving in cell proliferation. Simultaneous silencing of VEGF and KSP, an attractive and viable approach in cancer, leads on restricting cancer progression. The purpose of this study is to examine the therapeutic potential of dual gene targeted siRNA cocktail on human hepatocellular carcinoma Hep3B cells. RESULTS: The predesigned siRNAs could inhibit VEGF and KSP at mRNA level. siRNA cocktail showed a further downregulation on KSP mRNA and protein levels compared to KSP-siRNA or VEGF-siRNA, but not on VEGF expression. It also exhibited greater suppression on cell proliferation as well as cell migration or invasion capabilities and induction of apoptosis in Hep3B cells than single siRNA simultaneously. This could be explained by the significant downregulation of Cyclin D1, Bcl-2 and Survivin. However, no sigificant difference in the mRNA and protein levels of ANG2, involving inhibition of angiogenesis was found in HUVECs cultured with supernatant of Hep3B cells treated with siRNA cocktail, compared to that of VEGF-siRNA. CONCLUSION: Silencing of VEGF and KSP plays a key role in inhibiting cell proliferation, migration, invasion and inducing apoptosis of Hep3B cells. Simultaneous silencing of VEGF and KSP using siRNA cocktail yields promising results for eradicating hepatocellular carcinoma cells, a new direction for liver cancer treatment.
Descritores: Cinesina/genética
Apoptose/genética
Inativação Gênica
RNA Interferente Pequeno/genética
Fator A de Crescimento do Endotélio Vascular/genética
Proliferação de Células/genética
-Sais de Tetrazólio
Transfecção
Inibidores de Cisteína Proteinase/metabolismo
Regulação para Baixo
Movimento Celular
Western Blotting
Cinesina/metabolismo
Anexina A5
Genes bcl-2
Ciclina D1/metabolismo
Proteínas de Transporte Vesicular/metabolismo
Linhagem Celular Tumoral
Fator A de Crescimento do Endotélio Vascular/metabolismo
Proteínas Inibidoras de Apoptose/metabolismo
Células Endoteliais da Veia Umbilical Humana/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Citometria de Fluxo
Survivina
Mitose/genética
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950791
Autor: Shen, Wenlong; Wang, Dong; Ye, Bingyu; Shi, Minglei; Zhang, Yan; Zhao, Zhihu.
Título: A possible role of Drosophila CTCF in mitotic bookmarking and maintaining chromatin domains during the cell cycle
Fonte: Biol. Res;48:1-8, 2015. graf.
Idioma: en.
Projeto: National Basic Research Program of China; . National Natural Science Foundation of China; . National Key Technology R& D Program of China.
Resumo: BACKGROUND: The CCCTC-binding factor (CTCF) is a highly conserved insulator protein that plays various roles in many cellular processes. CTCF is one of the main architecture proteins in higher eukaryotes, and in combination with other architecture proteins and regulators, also shapes the three-dimensional organization of a genome. Experiments show CTCF partially remains associated with chromatin during mitosis. However, the role of CTCF in the maintenance and propagation of genome architectures throughout the cell cycle remains elusive. RESULTS: We performed a comprehensive bioinformatics analysis on public datasets of Drosophila CTCF (dCTCF). We characterized dCTCF-binding sites according to their occupancy status during the cell cycle, and identified three classes: interphase-mitosis-common (IM), interphase-only (IO) and mitosis-only (MO) sites. Integrated function analysis showed dCTCF-binding sites of different classes might be involved in different biological processes, and IM sites were more conserved and more intensely bound. dCTCF-binding sites of the same class preferentially localized closer to each other, and were highly enriched at chromatin syntenic and topologically associating domains boundaries. CONCLUSIONS: Our results revealed different functions of dCTCF during the cell cycle and suggested that dCTCF might contribute to the establishment of the three-dimensional architecture of the Drosophila genome by maintaining local chromatin compartments throughout the whole cell cycle.
Descritores: Proteínas Repressoras/fisiologia
Cromatina/fisiologia
Proteínas de Drosophila/fisiologia
Drosophila melanogaster/química
Genoma de Inseto/genética
Mitose/fisiologia
-Sítios de Ligação
Sequência de Bases
Ciclo Celular/fisiologia
Sequência Conservada
Biologia Computacional
Sintenia
Montagem e Desmontagem da Cromatina/fisiologia
Anotação de Sequência Molecular
Conjuntos de Dados como Assunto
Fator de Ligação a CCCTC
Interfase/fisiologia
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1242070
Autor: Sampaio, Mario; Assis, F; Barros, Regina M.
Título: Estudo preliminar do cariotipo do dasypus novemcinctus l. da Região Amazonica do Brasil (area de Belem) / Preliminary study of karyotype of the Dasypus novemcinctus L of the Amazon region of Brazil.
Fonte: Belem; s.n; s.d. 2 p.
Idioma: pt.
Descritores: Aberrações Cromossômicas
Meiose/fisiologia
Meiose/genética
Mitose/fisiologia
Mitose/genética
Tipo de Publ: Relatos de Casos
Artigo Histórico
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "BR191.1", "_a": "01643/s"}]


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Id: biblio-1156184
Autor: Silva, Christine Maria Muniz; Fontenele, João Paulo Uchoa; Lopes, Jailson Rodrigues; de Brito, Gabriella Cristina Coelho; Teixeira, Manuel Joaquim Diógenes; Rocha, Francisco Airton Castro.
Título: Neurothekeoma in the Axilla Causing Persistent Shoulder Pain: Case Report / Neurotecoma na axila causando dor persistente no ombro: Relato de caso
Fonte: Rev. bras. ortop;55(6):804-807, Nov.-Dec. 2020. graf.
Idioma: en.
Resumo: Abstract Neurothekeomas, also known as neural sheath myxomas, are rare benign tumors of the neural sheath affecting most commonly the head, arms and shoulder of women in their 2nd and 3rd decades of life. Due to the low prevalence and undefined clinical picture, they are hardly considered in the initial differential diagnosis of skin tumors. We report the case of a 24 year-old woman who was seen in 2016 reporting > 1 year of moderate pain and limited mobility of her left shoulder. Clinical evaluation revealed restricted mobility of the affected shoulder and nuclear magnetic resonance imaging showed a T2-weighted contrast-enhanced multilobular mass in the quadrilateral area apparently invading the adjacent humeral cortical region. Histopathology of a needle sample material revealed loose fibroconnective tissue with no signs of invasion, mitosis or atypical figures. Successful surgical excision was performed and the diagnosis of neurothekeoma was confirmed after detailed histopathology, including immunohistochemistry. The patient was asymptomatic at 18 months of follow-up, with full recovery of shoulder movement and no signs of relapse.

Resumo Neurotecomas, também conhecidos como mixomas da bainha neural, são tumores benignos raros da bainha neural afetando mais comumente a cabeça, braços e ombros de mulheres entre 20 e 40 anos de idade. Devido à baixa prevalência e quadro clínico mal definido, essas lesões são raramente consideradas no diagnóstico diferencial de tumores cutâneos. Relatamos o caso de uma mulher de 24 anos de idade que procurou atendimento em 2016 relatando dor moderada por mais de um ano e limitação dos movimentos do ombro esquerdo. Ao exame, foi constatada restrição da mobilidade dessa articulação e uma ressonância magnética revelou imagem multilobular com aumento de sinal em T2 na região quadrilateral, aparentando invasão da região cortical do úmero subjacente. A histopatologia de uma biópsia incisional mostrou lesão composta por tecido conjuntivo frouxo, sem sinais de invasão, figuras de mitose ou atipias. Foi realizada excisão completa da lesão e o diagnóstico de neurotecoma foi confirmado após análise histopatológica que incluiu painel imunohistoquímico. À revisão de 18 meses, a paciente estava assintomática com recuperação completa do movimento e sem evidência de recidiva da lesão.
Descritores: Braço
Recidiva
Neoplasias Cutâneas
Axila
Biópsia
Espectroscopia de Ressonância Magnética
Neurotecoma
Tecido Conjuntivo
Dor de Ombro
Diagnóstico Diferencial
Cabeça
Articulações
Mitose
Mixoma
Neoplasias
Limites: Humanos
Feminino
Adulto
Responsável: BR26.1 - Biblioteca Central


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Id: biblio-886681
Autor: WANDSCHEER, ALANA C D; MARCHESAN, ENIO; TEDESCO, SOLANGE B; FRESCURA, VIVIANE DAL-SOUTO; SOARES, CAMILLE F; LONDERO, GUILHERME P; TELÓ, GUSTAVO M; HANSEL, DÂMARIS S S.
Título: Cytogenotoxicity of rice crop water after application of the tricyclazole fungicide
Fonte: An. acad. bras. ciênc;89(2):1251-1258, Apr.-June 2017. tab, graf.
Idioma: en.
Projeto: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Resumo: ABSTRACT Tricyclazole is currently one of the fungicides recommended for the treatment of diseases in irrigated rice. However, there is relatively little information on its cytotoxic and genotoxic potential. The objective of this study was to evaluate the cytotoxicity and genotoxicity of rice crop water after apllication of the tricyclazole fungicide through the Allium cepa L. test. The rice crop water samplings were collected before and 1, 15 and 30 days after application of the fungicide in rice plant shoots. The Allium cepa roots were placed in contact with the rice crop water to check for possible chromosomal abnormalities and mitotic index of the bioindicators meristematic cells. The data obtained by the Allium cepa test indicates that the application of the tricyclazole fungicide leads to an increase in the genotoxic activity in the rice crop water, through the appearance of chromosomal abnormalities, without, however, causing significant effects on the mitotic index. The major chromosomal alterations observed were anaphasic and telophasic bridges and laggard chromosomes.
Descritores: Oryza/efeitos dos fármacos
Cebolas/efeitos dos fármacos
Fungicidas Industriais
-Oryza/genética
Poluentes Químicos da Água/toxicidade
Dano ao DNA
Aberrações Cromossômicas/induzido quimicamente
Produtos Agrícolas
Produtos Agrícolas/genética
Irrigação Agrícola
Mitose/efeitos dos fármacos
Índice Mitótico
Testes de Mutagenicidade/métodos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-839151
Autor: Nunes, R D M; Sales, I M S; Silva, S I O; Sousa, J M C; Peron, A P.
Título: Antiproliferative and genotoxic effects of nature identical and artificial synthetic food additives of aroma and flavor / Efeito antiproliferativo e genotóxico de aditivos alimentares de aroma e sabor sintéticos, dos tipos idêntico ao natural e artificial
Fonte: Braz. j. biol;77(1):150-154, Jan-Mar. 2017. tab.
Idioma: en.
Resumo: Abstract This study aimed to analyze the antiproliferative and genotoxic potential of synthetic food flavorings, nature identical passion fruit and artificial vanilla. This assessment used root meristem cells of Allium cepa L., in exposure times of 24 and 48 hours and using doses of 0.2; 0.4 and 0.6 mL. Roots were fixed in Carnoy’s solution, hydrolyzed in hydrochloric acid, stained with acetic orcein and analyzed with optical microscope at 400× magnification, 5,000 cells for each treatment. For data analysis, it was used Chi-square test at 5%. Doses of 0.2 mL at ET 48 h; 0.4 and 0.6 mL at ET 24 and 48 h of passion fruit flavor, and the three doses of the vanilla flavor at ET 24 and 48 h significantly reduced the cell division rate in the meristems of roots, proving to be cytotoxic. Doses of 0.2; 0.4 and 0.6 mL of the passion fruit additive, and the three doses of vanilla tested, in the two exposure times, induced mitotic spindle changes and micronuclei formation in the cells of the test organism used, proving to be genotoxic. Therefore, under the studied conditions, flavoring solutions of vanilla and passion fruit, marketed nationally and internationally, significantly altered the functioning of the cell cycle in root meristem cells of A. cepa.

Resumo Neste trabalho teve-se por objetivo analisar o potencial antiproliferativo e genotóxico de aromatizantes alimentares sintéticos, idêntico ao natural de Maracujá, e artificial de Baunilha. Esta avaliação foi realizada por meio das células meristemáticas de raízes de Allium cepa L., nos tempos de exposição de 24 e 48 horas e nas doses de 0,2; 0,4 e 0,6 ml. As raízes foram fixadas em solução de Carnoy, hidrolisadas em ácido clorídrico e coradas com orceína acética. Analisou-se, em microscópio óptico em aumento de 400×, 5.000 células por grupo tratamento, e utilizou-se o teste estatístico Qui-quadrado a 5% para análise dos dados. Verificou-se que as doses de 0,2 ml, no TE 48 h; 0,4 e 0,6 ml, nos TE 24 e 48 h, do aromatizante de Maracujá, e as três doses analisadas, nos TE 24 e 48 h, do aditivo de Baunilha reduziram significativamente o índice de divisão celular dos meristemas de raízes, mostrando-se citotóxicas. As doses 0,2; 0,4 e 0,6 ml do aditivo de Maracujá, e a de 0,6 ml do aromatizante de Baunilha, nos dois tempos de exposição considerados, induziram alterações de fuso mitótico e micronúcleos as células do organismo de prova utilizado, mostrando-se genotóxicas. Portanto, nas condições analisadas, as soluções aromatizantes de Baunilha e Maracujá, comercializadas nacional e internacionalmente, alteraram significativamente o funcionamento do ciclo celular das células meristemáticas de raízes de A. cepa.
Descritores: Dano ao DNA
Meristema/efeitos dos fármacos
Micronúcleos com Defeito Cromossômico
Aditivos Alimentares/toxicidade
-Núcleo Celular
Raízes de Plantas/efeitos dos fármacos
Cebolas/efeitos dos fármacos
Mitose
Responsável: BR1.1 - BIREME


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Id: biblio-956577
Autor: Ferreira, Tácito; Santos, Ivan Dunshee de Abranches Oliveira; Oliveira, Andrea Fernandes; Ferreira, Lydia Masako.
Título: Estudo retrospectivo dos pacientes portadores de melanoma cutâneo atendidos na Universidade Federal de São Paulo / Retrospective study of patients with cutaneous melanoma treated at the Federal University of São Paulo
Fonte: Rev. Col. Bras. Cir;45(4):e1715, 2018. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: avaliar as características dos pacientes portadores de melanoma cutâneo atendidos no Hospital São Paulo - UNIFESP. Métodos: estudo retrospectivo de 184 casos de melanoma cutâneo. Foram analisadas as informações sobre sexo, idade, características do tumor, características histológicas e estadiamento. Resultados: a média de idade ao diagnóstico foi de 58,7 anos, com distribuição etária homogênea entre os sexos e predominância em indivíduos brancos (70,6%). Observou-se acometimento predominante de tronco, em homens (36,7%), e de membros inferiores, em mulheres (42%). A exposição solar, com queimaduras, foi mais comum entre homens (31,2%) do que entre mulheres (23,5%). Houve aumento de aproximadamente três vezes no acometimento linfonodal quando o índice mitótico subia de zero (11,9%) para uma ou mais mitoses por campo (36,2%), e aumento progressivo do acometimento linfonodal e de desfechos ruins quanto maior a espessura de Breslow: 10,2% quando menor do que 1mm e 59,2% quando maior do que 4mm. Conclusão: as características dos pacientes portadores de melanoma cutâneo atendidos no Hospital São Paulo são semelhantes às encontradas na literatura.

ABSTRACT Objective: to evaluate the characteristics of the patients with cutaneous melanoma treated at the São Paulo Hospital - UNIFESP. Methods: we conducted a retrospective study of 184 cases of cutaneous melanoma. We analyzed information on gender, age, tumor characteristics, histological characteristics and staging. Results: mean age at diagnosis was 58.7 years, with homogeneous age distribution between genders and predominance in white individuals (70.6%). There was a predominance of trunk involvement in men (36.7%) and lower limbs in women (42%). Sun exposure, with sunburns, was more common among males (31.2%) than among females (23.5%). There was an approximately three-fold increase in lymph node involvement when the mitotic index rose from zero (11.9%) to one or more mitosis per field (36.2%). In addition, the greater the Breslow thickness, the greater the lymph node involvement and poor the outcomes: 10.2% when less than 1mm and 59.2% when greater than 4mm. Conclusion: the characteristics of patients with cutaneous melanoma treated at Hospital São Paulo are similar to those found in the literature.
Descritores: Neoplasias Cutâneas/epidemiologia
Melanoma/epidemiologia
-Queimadura Solar
Brasil/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Distribuição por Sexo
Distribuição por Idade
Linfonodos
Pessoa de Meia-Idade
Mitose
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-949344
Autor: Barros, Pedro Paulo; Gonçalves, Gisele Mara Silva; Silva, Gustavo Henrique da; Bastos, Maria Clara Villaça Dias; Ramos, Loren Nogaroto; Fernandes, Marilia Marinello.
Título: Capsiate treatment in liver surgeries may compromise its recovery
Fonte: Acta cir. bras;33(5):439-445, May 2018. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH. Results: Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations. Conclusion: Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery.
Descritores: Capsaicina/análogos & derivados
Hepatectomia
Fígado/enzimologia
-Aspartato Aminotransferases/metabolismo
Capsaicina/farmacologia
Ratos Wistar
Apoptose/efeitos dos fármacos
Alanina Transaminase/metabolismo
Fosfatase Alcalina/metabolismo
Fígado/efeitos dos fármacos
Fígado/patologia
Regeneração Hepática/efeitos dos fármacos
Mitose/efeitos dos fármacos
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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