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Pesquisa : G05.308.203.374.790 [Categoria DeCS]
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Id: biblio-1015986
Autor: Wang, Qingheng; Yang, Chuangye; Hao, Ruijuan; Zheng, Zhe; Jiao, Yu; Du, Xiaodong; Deng, Yuewen; Huang, Ronglian.
Título: Molecular characterization of CHST11 and its potential role in nacre formation in pearl oyster Pinctada fucata martensii
Fonte: Electron. j. biotechnol;28:113-119, July. 2017. tab, ilus, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: Background: C4ST-1 catalyzes the transfer of sulfate groups in the sulfonation of chondroitin during chondroitin sulfate synthesis. Chondroitin sulfate consists of numerous copies of negatively charged sulfonic acid groups that participate in the nucleation process of biomineralization. In the present study, we obtained two CHST11 genes (PmCHST11a and PmCHST11b) which encoded the C4ST-1 and explored the functions of these genes in the synthesis of chondroitin sulfate and in the formation of the nacreous layer of shells. Results: Both PmCHST11a and PmCHST11b had a sulfotransferase-2 domain, a signal peptide and a transmembrane domain. These properties indicated that these genes localize in the Golgi apparatus. Real-time PCR revealed that both PmCHST11a and PmCHST11b were highly expressed in the central zone of the mantle tissue. Inhibiting PmCHST11a and PmCHST11b via RNA interference significantly decreased the expression levels of these genes in the central zone of the mantle tissue and the concentration of chondroitin sulfate in extrapallial fluid. Moreover, shell nacre crystallized irregularly with a rough surface after RNA interference. Conclusions: This study indicated that PmCHST11a and PmCHST11b are involved in the nacre formation of Pinctada fucata martensii through participating in the synthesis of chondroitin sulfate.
Descritores: Sulfotransferases/metabolismo
Pinctada
Nácar/biossíntese
-Proteoglicanas de Sulfatos de Condroitina/biossíntese
Sulfotransferases/genética
Técnicas de Amplificação de Ácido Nucleico/métodos
Interferência de RNA
Reação em Cadeia da Polimerase em Tempo Real
FRONTAL BONEABDOMINAL INJURIES
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1009000
Autor: Liu, Chunming; Yang, Bowen; Ming, Yuetong; Liu, Jianfeng; Cheng, Yunqing.
Título: Construction of an RNAi vector for knockdown of GM-ACS genes in the cotyledonary nodes of soybean
Fonte: Electron. j. biotechnol;26:40-45, Mar. 2017. ilus, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Special Foundation for Young Scientists of Jilin Province, China.
Resumo: Background: Ethylene plays an important role in the regulation of floral organ development in soybean, and 1-aminocyclopropane-1-carboxylate synthase (ACS) is a rate-limiting enzyme for ethylene biosynthesis. However, whether ACS also regulates floral organ differentiation in soybean remains unknown. To address this, we constructed an RNAi vector to inhibit ACS expression in cotyledonary nodes. Linear DNA cassettes of RNAi-ACS obtained by PCR were used to transform soybean cotyledonary nodes. Results: In total, 131 of 139 transiently transformed plants acquired herbicide resistance and displayed GUS activities in the new buds. In comparison to untransformed seedling controls, a greater number of flower buds were differentiated at the cotyledonary node; GM-ACS1 mRNA expression levels and ethylene emission in the transformed buds were reduced. Conclusion: These results indicate that the cotyledonary node transient transformation system may be suitable for stable transformation and that the inhibition of ACS expression may be an effective strategy for promoting floral organ differentiation in soybean.
Descritores: Soja/enzimologia
Soja/genética
Interferência de RNA
Liases/metabolismo
-Soja/crescimento & desenvolvimento
Transformação Genética
Expressão Gênica
Diferenciação Celular
Reação em Cadeia da Polimerase
Regulação da Expressão Gênica de Plantas
Etilenos/biossíntese
Resistência a Herbicidas
Vetores Genéticos
Glucuronidase
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-889146
Autor: Ono, Ekaterina Alexandrovna Durymanova; Taniwaki, Sueli Akemi; Brandão, Paulo.
Título: Short interfering RNAs targeting a vampire-bat related rabies virus phosphoprotein mRNA
Fonte: Braz. j. microbiol;48(3):566-569, July-Sept. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP; . National Counsel of Technological and Scientific Development.
Resumo: Abstract The aim of this study was to assess the in vitro and in vivo effects of short-interfering RNAs (siRNAs) against rabies virus phosphoprotein (P) mRNA in a post-infection treatment for rabies as an extension of a previous report (Braz J Microbiol. 2013 Nov 15;44(3):879-82). To this end, rabies virus strain RABV-4005 (related to the Desmodus rotundus vampire bat) were used to inoculate BHK-21 cells and mice, and the transfection with each of the siRNAs was made with Lipofectamine-2000™. In vitro results showed that siRNA 360 was able to inhibit the replication of strain RABV-4005 with a 1 log decrease in virus titter and 5.16-fold reduction in P mRNA, 24 h post-inoculation when compared to non-treated cells. In vivo, siRNA 360 was able to induce partial protection, but with no significant difference when compared to non-treated mice. These results indicate that, despite the need for improvement for in vivo applications, P mRNA might be a target for an RNAi-based treatment for rabies.
Descritores: Fosfoproteínas/genética
Raiva/veterinária
Vírus da Raiva/genética
Proteínas Virais/genética
Quirópteros/virologia
RNA Interferente Pequeno/genética
Interferência de RNA
-Fosfoproteínas/metabolismo
Raiva/virologia
Vírus da Raiva/fisiologia
Proteínas Virais/metabolismo
Replicação Viral
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
RNA Interferente Pequeno/metabolismo
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-841758
Autor: Ngai, Michelle; McDowell, Mary Ann.
Título: The search for novel insecticide targets in the post-genomics era, with a specific focus on G-protein coupled receptors
Fonte: Mem. Inst. Oswaldo Cruz;112(1):1-7, Jan. 2017. tab.
Idioma: en.
Projeto: Telemedicine and Advanced Technology Research Center.
Resumo: Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resistance fueled the discovery of novel modes of action, and the power of genomics has reinvigorated this search. This review discusses the importance of comparative and functional insect genomics in the identification of potential gene targets for an insecticidal mode of action with low off-target toxicity. Due to the global participation in the sequencing and annotation of insect genomes, the targeting of specific genes with molecular tools like RNAi and CRISPR/Cas9 for genome engineering and consequent functional identification and validation has become more efficient. While there are multiple avenues to explore for insecticidal candidates, this review identifies G-protein coupled receptors as attractive targets, and hones in on the octopamine and dopamine receptors due to their potential.
Descritores: Marcação de Genes/métodos
Receptores Acoplados a Proteínas-G/genética
Receptores Acoplados a Proteínas-G/metabolismo
-Resistência a Inseticidas
Controle de Insetos/métodos
Interferência de RNA
Genoma de Inseto
Inseticidas
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-996534
Autor: Moraes, Luís Bruno da Cruz e Alves de.
Título: Desenvolvimento de xenotransplantes de tumores pancreáticos humanos para varredura genética de alvos moleculares com potencial terapêutico / Establishment of xenografts from human pancreatic tumors for genetic screening of molecular targets with therapeutic potential.
Fonte: São Paulo; s.n; 2018. 174 p. graf, tab, ilus.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Instituto de Química para obtenção do grau de Doutor.
Resumo: O adenocarcinoma ductal pancreático (PDAC, pancreatic ductal adenocarcinoma), o tipo mais prevalente de câncer do pâncreas, é uma neoplasia extremamente agressiva e com elevado índice de letalidade. Há uma necessidade premente de identificação de vulnerabilidades no PDAC que possam ser exploradas como alvos terapêuticos, e a utilização de modelos pré-clínicos que recapitulem a complexidade biológica e heterogeneidade clínica da doença é um aspecto central para a realização dessa tarefa. Os xenotransplantes de tecido tumoral derivado de pacientes (PDX, patient-derived tumor tissue xenografts), realizados em camundongos imunodeficientes, replicam com grande similaridade as principais características do tumor original e, assim, constituem uma ferramenta valiosa para o teste de drogas e estudos funcionais. Neste trabalho, 17 amostras cirúrgicas de PDAC humano foram implantadas subcutaneamente em camundongos nude atímicos. Sete tumores (41%) foram enxertados com sucesso e têm sido mantidos em sucessivas gerações de animais receptores. O exame histológico de seis desses xenoenxertos identificou características morfológicas compatíveis com os padrões reconhecidos no PDAC humano, assim como uma consistente similaridade de seu status de diferenciação histológica em relação aos perfis verificados nos tumoresoriginais. O cultivo in vitro de células derivadas de um dos xenotumores resultou em uma nova linhagem de câncer de pâncreas, com morfologia e cinética de crescimento comparáveis às de outras linhagens celulares de câncer pancreático. O potencial tumorigênico dessa nova linhagem foi validado in vivo, com uma consistente formação de tumores após inoculação em camundongos nude. A fim de aproveitar esse recurso para a investigação de potenciais alvos terapêuticos no PDAC, um rastreamento de vulnerabilidades moleculares foi realizado por meio de silenciamento gênico em larga-escala com RNA de interferência (RNAi). Uma biblioteca lentiviral de 4492 shRNAs (short hairpin RNAs), alvejando cerca de 350 genes envolvidos na regulação epigenética, foi empregada para a triagem de genes de suscetibilidade nas células derivadas de PDX, e em outras cinco linhagens tumorais pancreáticas (AsPC-1, BxPC-3, Capan-1, MIA PaCa-2 e PANC-1). Inicialmente, foi realizada uma série de experimentos preliminares, visando à amplificação e controle de qualidade da biblioteca de silenciamento, à produção de vetores lentivirais e à padronização das condições experimentais para a transdução e seleção das células-alvo. Apenas três das linhagens avaliadas (AsPC-1, MIA PaCa-2 e PANC-1) mostraram-se permissíveis à transdução pelos vetores lentivirais, e foram assim utilizadas no screening de alvos epigenéticos. A análise dos dados obtidos nesse ensaio está em curso e os resultados serão utilizados para a definição de potenciais alvos candidatos. Em conclusão, recursos valiosos para apoiar a pesquisa sobre o câncer de pâncreas foram desenvolvidos. A coleção de PDXs estabelecida, bem como a linhagem celular recém-derivada, constituem uma fonte permanente e estável de células de PDAC para análises moleculares e estudos funcionais que busquem elucidar aspectos da doença ainda pouco compreendidos. Adicionalmente, os reagentes gerados e a expertise adquirida com os ensaiosrealizados com a biblioteca de shRNAs contra alvos epigenéticos serão de grande utilidade em futuras investigações para identificar genes com funções importantes na manutenção do fenótipo tumoral, e consequentemente com potencial para serem explorados terapeuticamente

Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is a highly aggressive and lethal neoplasm. There is a pressing need to identify vulnerabilities in PDAC suited to be exploited as therapeutic targets, and the use of preclinical models recapitulating the biological complexity and clinical heterogeneity of the disease is central to this task. Patient-derived tumor tissue xenografts (PDX), established in immunodeficient mice, replicate with great similarity the main characteristics of the original tumor and thus constitute a valuable tool for drug testing and functional studies. In this work, 17 surgical samples of human PDAC were implanted subcutaneously in athymic nude mice. Seven tumors (41%) were successfully grafted and have been maintained through successive generations of recipient animals. Histological examination of six of these xenografts identified morphological characteristics compatible with the recognized patterns of human PDAC, as well as a consistent similarity of their histological differentiation status in relation to the profiles verified in the original tumors. In vitro culture of cells derived from one of these xenografts resulted in a new pancreatic cancer cell line, with morphology and growth kinetics comparable to those of other pancreatic tumor cells. The tumorigenic potential of this freshly derived cell line was validated in vivo, with a consistent tumor formation following inoculation into nude mice. To take advantage ofthis resource to investigate potential therapeutic targets in PDAC, a screening of molecular vulnerabilities was performed through large-scale gene silencing with RNA interference (RNAi). A lentiviral library containing 4492 short hairpin RNAs (shRNAs), targeting about 350 genes involved in epigenetic regulation, was employed for the search of susceptibility genes in the PDX-derived cells and in other five pancreatic tumor cell lines (AsPC-1, BxPC -3, Capan-1, MIA PaCa-2 and PANC-1). Initially, a series of preliminary experiments were carried out aiming at the amplification and quality control of the silencing library, production of lentiviral vectors and adjustment of the experimental conditions for transduction and selection of the target cells. Only three of the cell lines evaluated (AsPC-1, MIA PaCa-2 and PANC-1) were permissible for transduction by the lentiviral vectors, and were accordingly used in the screening of epigenetic targets. The analysis of data obtained in this trial is ongoing and the results will be used for definition of potential candidate targets. In conclusion, valuable resources to support research on pancreatic cancer have been developed. The established collection of PDXs as well as the newly derived cell line constitutes a permanent and stable source of PDAC cells for molecular analyzes and functional studies seeking to elucidate aspects of this disease that are still poorly understood. Additionally, both the reagents generated and the expertise gained from the RNAi assay against epigenetic targets will have inordinate usefulness in future investigations to identify genes with major functions in maintaining the malignant phenotype, and consequently with the potential to be exploited therapeutically
Descritores: Neoplasias Pancreáticas/fisiopatologia
Linhagem Celular Tumoral/classificação
Xenoenxertos/metabolismo
-Transplante Heterólogo/instrumentação
Biblioteca Gênica
RNA Interferente Pequeno
Interferência de RNA
Epigenômica/normas
Limites: Animais
Feminino
Camundongos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas
BR40.1; T574.88 M827d, M827d. 30100026217-Q


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Id: biblio-889093
Autor: Chen, Changxuan; Wang, Kaizhen; Wang, Qian; Wang, Xin.
Título: LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(6):e7080, 2018. graf.
Idioma: en.
Resumo: Prostate cancer (PCa) is the second leading cause of cancer death in men. Irradiation is one of the available options for treatment of PCa, however, approximately 10-45% of PCa are resistant to irradiation. We aimed to explore the role of long non-coding RNA highly upregulated in liver cancer (HULC) in the sensitivity of PCa cells to irradiation. Survival rate, cell apoptosis, cycle, expressions of related proteins, and caspase-3 activity were assessed to explore the effects of HULC on sensitivity of PCa cells to irradiation. Expression of HULC in DU-145, PC3, LNCaP, and RWPE-1 cells was determined and the influence of HULC on DU-145 cells was explored. Then, PC3 cells aberrantly expressing HULC were implanted into NOD-SCID mice for tumor xenograft study. Changes of autophagy after aberrant expression of HULC in vivo and in vitro were tested. Furthermore, the interacted protein of HULC and involved signaling pathway were investigated. In PC3 and LNCaP cells under irradiation, survival rate and cell cycle were decreased and apoptosis was increased by HULC knockdown. HULC knockdown arrested PC3 cells at G0/G1 phase. DU-145 was sensitive to irradiation, and resistance to irradiation of DU-145 cells was enhanced by HULC overexpression. Moreover, HULC knockdown enhanced the sensitivity of PC3 xenografts to irradiation. HULC knockdown promoted autophagy through interaction with Beclin-1 and inhibition of mTOR, resulting in increased apoptosis. HULC knockdown improved sensitivity of PCa cells to irradiation both in vivo and in vitro. HULC suppressed Beclin-1 phosphorylation, thereby reduced autophagy, involving the mTOR pathway.
Descritores: Autofagia/efeitos da radiação
Neoplasias da Próstata/patologia
Tolerância a Radiação/fisiologia
RNA Longo não Codificante/efeitos da radiação
-Apoptose/efeitos da radiação
Western Blotting
Linhagem Celular Tumoral/efeitos da radiação
Reação em Cadeia da Polimerase em Tempo Real
Interferência de RNA/efeitos da radiação
Transfecção
Limites: Humanos
Masculino
Responsável: BR1.1 - BIREME


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Szwarcwald, Célia Landmann
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Id: lil-776715
Autor: Malta, Deborah Carvalho; Szwarcwald, Celia Landmann.
Título: Pesquisa Nacional de Saúde e a Saúde Pública Brasileira / National Health Survey and Public Health in Brazil
Fonte: Rev. bras. epidemiol;18(supl.2):1-2, Out.-Dez. 2015.
Idioma: en.
Descritores: Begomovirus/genética
Lycopersicon esculentum/virologia
Doenças das Plantas/virologia
Plantas Geneticamente Modificadas/virologia
Interferência de RNA
Vírus Satélites/genética
-Begomovirus/fisiologia
Lycopersicon esculentum/genética
Lycopersicon esculentum/imunologia
Omã
Doenças das Plantas/genética
Doenças das Plantas/imunologia
Doenças das Plantas/prevenção & controle
Plantas Geneticamente Modificadas/genética
Plantas Geneticamente Modificadas/imunologia
RNA de Cadeia Dupla/genética
RNA de Cadeia Dupla/metabolismo
RNA Viral/genética
RNA Viral/metabolismo
Vírus Satélites/fisiologia
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-750470
Autor: Pacheco-Rosas, Daniel; Pomerantz, Alan; Blachman-Braun, Ruben.
Título: Síndrome de Wiskott-Aldrich: Caso clínico / Wiskott-Aldrich syndrome: Case report
Fonte: Arch. argent. pediatr;113(3):e137-e139, jun. 2015.
Idioma: es.
Resumo: El síndrome de Wiskott-Aldrich es una inmunodeficiencia primaria; con una incidencia de 3,5 a 5,2 por cada millón de recién nacidos masculinos. Se caracteriza por tener un patrón de herencia recesiva ligada al cromosoma X. En estos pacientes; se ha descrito la tríada clásica de inmunodeficiencia; microtrombocitopenia y eczema. Presentamos un paciente de 5 años de edad; hispánico; con antecedentes de numerosas infecciones desde el primer año de vida. Actualmente; presenta desnutrición crónica; talla baja secundaria y retraso en el desarrollo del lenguaje. Se diagnosticó una mutación poco frecuente del gen asociado al síndrome de Wiskott-Aldrich.

The Wiskott-Aldrich syndrome is a rare X-linked recessive immunodeficiency, with an estimated incidence of 3.5 to 5.2 cases per million males. It is characterizedby immunodeficiency, microthrombocytopenia and eczema. We present a 5-year-old Hispanic male, with a medical history of numerous infectious diseases, compromised health, chronic malnutrition, language delay and failure to thrive. An infrequent mutation in the Wiskott-Aldrich syndrome gene was found.
Descritores: Proteínas Aviárias/metabolismo
Caderinas/metabolismo
Células-Tronco Neurais/citologia
Células-Tronco Neurais/metabolismo
-Proteínas Aviárias/antagonistas & inibidores
Proteínas Aviárias/genética
Sequência de Bases
Contagem de Células
Caderinas/antagonistas & inibidores
Caderinas/genética
Regulação da Expressão Gênica no Desenvolvimento
Técnicas de Silenciamento de Genes
Tubo Neural/citologia
Tubo Neural/embriologia
Tubo Neural/metabolismo
Análise de Sequência com Séries de Oligonucleotídeos
Fenótipo
Interferência de RNA
RNA Interferente Pequeno/genética
Transdução de Sinais
Limites: Animais
Embrião de Galinha
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: lil-748299
Autor: Xiao, Wen-Jun; Zhu, Yao; Dai, Bo; Zhang, Hai-Liang; Ye, Ding-Wei.
Título: Assessment of survival of patients with metastatic clear cell renal cell carcinoma after radical cytoreductive nephrectomy versus no surgery: a SEER analysis
Fonte: Int. braz. j. urol;41(2):288-295, Mar-Apr/2015. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: Purposes To examine the factors related to the choice of cytoreductive nephrectomy (CN) for patients with metastatic clear cell renal cell carcinoma (mCCRCC), and compare the population-based survival rates of patients treated with or without surgery in the modern targeted therapy era. Materials and Methods From 2006 to 2009, patients with mCCRCC were identified from SEER database. The factors that affected patients to be submitted to CN were examined and propensity scores for each patient were calculated. Then patients were matched based upon propensity scores. Univariable and multivariable cox regression models were used to compare survival rates of patients treated with or without surgery. Finally, sensitivity analysis for the cox model on a hazard ratio scale was performed. Results Age, race, tumor size, T stage and N stage were associated with nephrectomy univariablely. After the match based upon propensity scores, the 1-, 2-, and 3-year cancer-specific survival rate estimates were 45.1%, 27.9%, and 21.7% for the no-surgery group vs 70.6%, 52.2%, and 41.7% for the surgery group, respectively (hazard ratio 0.42, 95%CI: 0.35-0.52, log-rank P<0.001). In multivariable Cox proportional hazard regression model, race, T stage, N stage and median household income were significantly associated with survival. Sensitivity analysis on a hazard ratio scale indicated that the hazard ratio might be above 1.00 only when the unknown factor had an opposite effect on survival which was 3-fold than CN. Conclusion The results of our study showed that CN significantly improves the survival of patients with metastatic CCRCC even in the targeted therapy era. .
Descritores: /genética
BONE MORPHOGENETIC PROTEIN TEMEFOS/genética
Movimento Celular
Proliferação de Células
Carcinoma Pulmonar de Células não Pequenas/genética
Neoplasias Pulmonares/genética
Interferência de RNA
-/metabolismo
BONE MORPHOGENETIC PROTEIN TEMEFOS/metabolismo
Linhagem Celular Tumoral
Carcinoma Pulmonar de Células não Pequenas/metabolismo
Carcinoma Pulmonar de Células não Pequenas/mortalidade
Carcinoma Pulmonar de Células não Pequenas/patologia
Regulação Neoplásica da Expressão Gênica
Estimativa de Kaplan-Meier
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/mortalidade
Neoplasias Pulmonares/patologia
Estadiamento de Neoplasias
Fatores de Risco
RNA Mensageiro/metabolismo
Fatores de Tempo
Transfecção
Limites: Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-747147
Autor: Silva, Daniela da; Lopez, Priscila; Mantovani, Jair Cortez.
Título: Auditory Brainstem Response in Term and Preterm Infants with Neonatal Complications: The Importance of the Sequential Evaluation
Fonte: Int. arch. otorhinolaryngol. (Impr.);19(2):161-165, Apr-Jun/2015. tab.
Idioma: en.
Resumo: Introduction Literature data are not conclusive as to the influence of neonatal complications in the maturational process of the auditory system observed by auditory brainstem response (ABR) in infants at term and preterm. Objectives Check the real influence of the neonatal complications in infants by the sequential auditory evaluation. Methods Historical cohort study in a tertiary referral center. A total of 114 neonates met inclusion criteria: treatment at the Universal Neonatal Hearing Screening Program of the local hospital; at least one risk indicator for hearing loss; presence in both evaluations (the first one after hospital discharge from the neonatal unit and the second one at 6 months old); all latencies in ABR and transient otoacoustic emissions present in both ears. Results The complications that most influenced the ABR findings were Apgar scores less than 6 at 5 minutes, gestational age, intensive care unit stay, peri-intraventricular hemorrhage, and mechanical ventilation. Conclusion Sequential auditory evaluation is necessary in premature and term newborns with risk indicators for hearing loss to correctly identify injuries in the auditory pathway. .
Descritores: Carcinoma in Situ/metabolismo
Carcinoma Ductal Pancreático/metabolismo
Proteínas de Transporte/metabolismo
Proteínas dos Microfilamentos/metabolismo
Neoplasias Pancreáticas/metabolismo
Fatores de Transcrição/metabolismo
-Linhagem Celular Tumoral
Carcinoma in Situ/genética
Carcinoma in Situ/patologia
Carcinoma Ductal Pancreático/genética
Carcinoma Ductal Pancreático/mortalidade
Carcinoma Ductal Pancreático/secundário
Proteínas de Transporte/genética
Modelos Animais de Doenças
Progressão da Doença
Transição Epitelial-Mesenquimal
Camundongos Knockout
Proteínas dos Microfilamentos/deficiência
Proteínas dos Microfilamentos/genética
Invasividade Neoplásica
Recidiva Local de Neoplasia
Estadiamento de Neoplasias
Prognóstico
Neoplasias Pancreáticas/genética
Neoplasias Pancreáticas/mortalidade
Neoplasias Pancreáticas/patologia
Pseudópodes/metabolismo
Interferência de RNA
Análise de Sobrevida
Fatores de Tempo
Transfecção
Fatores de Transcrição/genética
Limites: Animais
Humanos
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde