Base de dados : LILACS
Pesquisa : G05.308.300 [Categoria DeCS]
Referências encontradas : 48 [refinar]
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Id: lil-788958
Autor: Niu, Haiying; Yu, Hui; Hu, Tangping; Tian, Gailin; Zhang, Lixia; Guo, Xiang; Hu, Hai; Wang, Zhanli.
Título: The prevalence of aminoglycoside-modifying enzyme and virulence genes among enterococci with high-level aminoglycoside resistance in Inner Mongolia, China
Fonte: Braz. j. microbiol;47(3):691-696, July-Sept. 2016. tab.
Idioma: en.
Projeto: Natural Science Foundation of China; . Natural Science Foundation of Inner Mongolia Autonomous Region of China; . Science Studies Program in Universities of the Inner Mongolia Autonomous Region, China.
Resumo: ABSTRACT This study highlights the prevalence of aminoglycoside-modifying enzyme genes and virulence determinants among clinical enterococci with high-level aminoglycoside resistance in Inner Mongolia, China. Screening for high-level aminoglycoside resistance against 117 enterococcal clinical isolates was performed using the agar-screening method. Out of the 117 enterococcal isolates, 46 were selected for further detection and determination of the distribution of aminoglycoside-modifying enzyme-encoding genes and virulence determinants using polymerase chain reaction -based methods. Enterococcus faecium and Enterococcus faecalis were identified as the species of greatest clinical importance. The aac(6')-Ie-aph(2")-Ia and ant(6')-Ia genes were found to be the most common aminoglycoside-modifying enzyme genes among high-level gentamicin resistance and high-level streptomycin resistance isolates, respectively. Moreover, gelE was the most common virulence gene among high-level aminoglycoside resistance isolates. Compared to Enterococcus faecium, Enterococcus faecalis harbored multiple virulence determinants. The results further indicated no correlation between aminoglycoside-modifying enzyme gene profiles and the distribution of virulence genes among the enterococcal isolates with high-level gentamicin resistance or high-level streptomycin resistance evaluated in our study.
Descritores: Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Enterococcus/efeitos dos fármacos
Enterococcus/fisiologia
Farmacorresistência Bacteriana
Aminoglicosídeos/metabolismo
Aminoglicosídeos/farmacologia
-Virulência/genética
Testes de Sensibilidade Microbiana
China/epidemiologia
Prevalência
Infecções por Bactérias Gram-Positivas/microbiologia
Infecções por Bactérias Gram-Positivas/epidemiologia
Enterococcus/metabolismo
Genes Bacterianos
Antibacterianos/metabolismo
Limites: Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: lil-780834
Autor: Cordeiro, Melina Aparecida; Werle, Catierine Hirsch; Milanez, Guilherme Paier; Yano, Tomomasa.
Título: Curli fimbria: an Escherichia coli adhesin associated with human cystitis
Fonte: Braz. j. microbiol;47(2):414-416, Apr.-June 2016. graf.
Idioma: en.
Resumo: Abstract Escherichia coli is the major causative agent of human cystitis. In this study, a preliminary molecular analysis carried out by PCR (polymerase chain reaction) demonstrated that 100% of 31 E. coli strains isolated from patients with recurrent UTIs (urinary tract infections) showed the presence of the curli fimbria gene (csgA). Curli fimbria is known to be associated with bacterial biofilm formation but not with the adhesion of human cystitis-associated E. coli. Therefore, this work aimed to study how curli fimbria is associated with uropathogenic E. coli (UPEC) as an adhesion factor. For this purpose, the csgA gene was deleted from strain UPEC-4, which carries three adhesion factor genes (csgA, fimH and ompA). The wild-type UPEC-4 strain and its mutant (ΔcsgA) were analyzed for their adhesion ability over HTB-9 (human bladder carcinoma), Vero (kidney cells of African green monkey) and HUVEC (human umbilical vein) cells in the presence of α-D-mannose. All the wild-type UPEC strains tested (100%) were able to adhere to all three cell types, while the UPEC-4 ΔcsgA mutant lost its adherence to HTB-9 but continued to adhere to the HUVEC and Vero cells. The results suggest that curli fimbria has an important role in the adhesion processes associated with human UPEC-induced cystitis.
Descritores: Adesinas de Escherichia coli/metabolismo
Cistite/microbiologia
Proteínas de Escherichia coli/metabolismo
Infecções por Escherichia coli/microbiologia
Escherichia coli Uropatogênica/metabolismo
-Aderência Bacteriana
Regulação Bacteriana da Expressão Gênica
Deleção de Sequência
Adesinas de Escherichia coli/genética
Proteínas de Escherichia coli/genética
Escherichia coli Uropatogênica/genética
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-889210
Autor: Jung, Youn Hong; Lee, Yoo Kyung; Lee, Hong Kum; Lee, Kyunghee; Im, Hana.
Título: CspB of an arctic bacterium, Polaribacter irgensii KOPRI 22228, confers extraordinary freeze-tolerance
Fonte: Braz. j. microbiol;49(1):97-103, Jan.-Mar. 2018. graf.
Idioma: en.
Projeto: Korean Government.
Resumo: ABSTRACT Freezing temperatures are a major challenge for life at the poles. Decreased membrane fluidity, uninvited secondary structure formation in nucleic acids, and protein cold-denaturation all occur at cold temperatures. Organisms adapted to polar regions possess distinct mechanisms that enable them to survive in extremely cold environments. Among the cold-induced proteins, cold shock protein (Csp) family proteins are the most prominent. A gene coding for a Csp-family protein, cspB, was cloned from an arctic bacterium, Polaribacter irgensii KOPRI 22228, and overexpression of cspB greatly increased the freeze-survival rates of Escherichia coli hosts, to a greater level than any previously reported Csp. It also suppressed the cold-sensitivity of an E. coli csp-quadruple deletion strain, BX04. Sequence analysis showed that this protein consists of a unique domain at its N-terminal end and a well conserved cold shock domain at its C-terminal end. The most common mechanism of Csp function in cold adaption is melting of the secondary structures in RNA and DNA molecules, thus facilitating transcription and translation at low temperatures. P. irgensii CspB bound to oligo(dT)-cellulose resins, suggesting single-stranded nucleic acid-binding activity. The unprecedented level of freeze-tolerance conferred by P. irgensii CspB suggests a crucial role for this protein in survival in polar environments.
Descritores: Proteínas de Bactérias/metabolismo
Flavobacteriaceae/fisiologia
Proteínas e Peptídeos de Choque Frio/metabolismo
-Regiões Árticas
Proteínas de Bactérias/genética
Regulação Bacteriana da Expressão Gênica
Temperatura Baixa
Ecossistema
Flavobacteriaceae/isolamento & purificação
Flavobacteriaceae/genética
Proteínas e Peptídeos de Choque Frio/genética
Responsável: BR1.1 - BIREME


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Id: biblio-889226
Autor: Thomas, Lebin; Ram, Hari; Singh, Ved Pal.
Título: Inducible cellulase production from an organic solvent tolerant Bacillus sp. SV1 and evolutionary divergence of endoglucanase in different species of the genus Bacillus
Fonte: Braz. j. microbiol;49(2):429-442, Apr.-June 2018. tab, graf.
Idioma: en.
Resumo: Abstract Bacteria are important sources of cellulases with various industrial and biotechnological applications. In view of this, a non-hemolytic bacterial strain, tolerant to various environmental pollutants (heavy metals and organic solvents), showing high cellulolytic index (7.89) was isolated from cattle shed soil and identified as Bacillus sp. SV1 (99.27% pairwise similarity with Bacillus korlensis). Extracellular cellulases showed the presence of endoglucanase, total cellulase and β-glucosidase activities. Cellulase production was induced in presence of cellulose (3.3 times CMCase, 2.9 times FPase and 2.1 times β-glucosidase), and enhanced (115.1% CMCase) by low-cost corn steep solids. An in silico investigation of endoglucanase (EC 3.2.1.4) protein sequences of three Bacillus spp. as query, revealed their similarities with members of nine bacterial phyla and to Eukaryota (represented by Arthropoda and Nematoda), and also highlighted of a convergent and divergent evolution from other enzymes of different substrate [(1,3)-linked beta-d-glucans, xylan and chitosan] specificities. Characteristic conserved signature indels were observed among members of Actinobacteria (7 aa insert) and Firmicutes (9 aa insert) that served as a potential tool in support of their relatedness in phylogenetic trees.
Descritores: Bacillus/enzimologia
Celulase/genética
Celulase/metabolismo
Evolução Molecular
-Bacillus/crescimento & desenvolvimento
Bacillus/isolamento & purificação
Celulose/metabolismo
Biologia Computacional
Fezes/microbiologia
Regulação Bacteriana da Expressão Gênica
Regulação Enzimológica da Expressão Gênica
Mutação INDEL
Análise de Sequência de DNA
Homologia de Sequência
Especificidade por Substrato
Zea mays/metabolismo
Limites: Animais
Bovinos
Responsável: BR1.1 - BIREME


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Id: biblio-889189
Autor: Silva, Clara Maria Guimarães; Silva, Déborah Nascimento dos Santos; Costa, Scarlathe Bezerra da; Almeida, Juliana Soares de Sá; Boente, Renata Ferreira; Teixeira, Felipe Lopes; Domingues, Regina Maria Cavalcanti Pilotto; Lobo, Leandro Araujo.
Título: Inactivation of MarR gene homologs increases susceptibility to antimicrobials in Bacteroides fragilis
Fonte: Braz. j. microbiol;49(1):200-206, Jan.-Mar. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Bacteroides fragilis is the strict anaerobic bacteria most commonly found in human infections, and has a high mortality rate. Among other virulence factors, the remarkable ability to acquire resistance to a variety of antimicrobial agents and to tolerate nanomolar concentrations of oxygen explains in part their success in causing infection and colonizing the mucosa. Much attention has been given to genes related to multiple drug resistance derived from plasmids, integrons or transposon, but such genes are also detected in chromosomal systems, like the mar (multiple antibiotic resistance) locus, that confer resistance to a range of drugs. Regulators like MarR, that control expression of the locus mar, also regulate resistance to organic solvents, disinfectants and oxygen reactive species are important players in these events. Strains derived from the parental strain 638R, with mutations in the genes hereby known as marRI (BF638R_3159) and marRII (BF638R_3706) were constructed by gene disruption using a suicide plasmid. Phenotypic response of the mutant strains to hydrogen peroxide, cell survival assay against exposure to oxygen, biofilm formation, resistance to bile salts and resistance to antibiotics was evaluated. The results showed that the mutant strains exhibit statistically significant differences in their response to oxygen stress, but no changes were observed in survival when exposed to bile salts. Biofilm formation was not affected by either gene disruption. Both mutant strains however, became more sensitive to multiple antimicrobial drugs tested. This indicates that as observed in other bacterial species, MarR are an important resistance mechanism in B. fragilis.
Descritores: Antibacterianos/farmacologia
Proteínas de Bactérias/genética
Bacteroides fragilis/efeitos dos fármacos
Bacteroides fragilis/genética
Infecções por Bacteroides/microbiologia
Proteínas Repressoras/genética
-Proteínas de Bactérias/metabolismo
Bacteroides fragilis/isolamento & purificação
Bacteroides fragilis/metabolismo
Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Inativação Gênica
Testes de Sensibilidade Microbiana
Proteínas Repressoras/metabolismo
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-775125
Autor: Khezri, Maryam; Jouzani, Gholamreza Salehi; Ahmadzadeh, Masoud.
Título: Fusarium culmorum affects expression of biofilm formation key genes in Bacillus subtilis
Fonte: Braz. j. microbiol;47(1):47-54, Jan.-Mar. 2016. graf.
Idioma: en.
Projeto: Agricultural Research, Education and Extension Organization.
Resumo: Abstract It is known that there is correlation between biofilm formation and antagonistic activities of Bacillus subtilis strains; but, the mechanism of this correlation is not clear. So, the effect of the plant pathogen (Fusarium culmorum) on the biofilm formation in a B. subtilis strain with high antagonistic and biofilm formation activities was studied. The expression of sinR and tasA genes involved in the biofilm formation was studied in both single culture of bacterium (B) and co-culture with F. culmorum (FB) using real-time PCR. The results revealed that the expression of the sinR gene in both B and FB conditions was continuously decreased during the biofilm formation period and, after 24 h (B4 and FB4), it reached 1% and 0.3% at the planktonic phase (B1), respectively, whereas the expression of the tasA was continuously increased and was 5.27 and 30 times more than that at the planktonic phase (B1) after 24 h, respectively. So, the expression reduction rate for sinR (3 times) and the expression increasing rate for tasA (6 times) were significantly higher in FB conditions than the B ones. The relative expression of sinR in FB1 (planktonic phase), FB2 (8 h), FB3(12 h), and FB4 (24 h) times was 0.65, 0.44, 0.35, and 0.29, whereas the tasA gene expression was 2.98, 3.44, 4.37, and 5.63-fold of the one at coordinate time points in B conditions, respectively. The significant expression reduction of sinR and increase of tasA confirmed that the presence of pathogen could stimulate biofilm formation in the antagonistic bacterium.
Descritores: Bacillus subtilis/fisiologia
Biofilmes/crescimento & desenvolvimento
Fusarium/fisiologia
Regulação Bacteriana da Expressão Gênica
Interações Microbianas
-Perfilação da Expressão Gênica
Genes Bacterianos
Reação em Cadeia da Polimerase em Tempo Real
Responsável: BR1.1 - BIREME


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Id: lil-769825
Autor: Cavalcanti, Felipe Lira de Sá; Mirones, Cristina Rodríguez; Paucar, Elena Román; Montes, Laura Álvarez; Leal-Balbino, Tereza Cristina; Morais, Marcia Maria Camargo de; Martínez-Martínez, Luis; Ocampo-Sosa, Alain Antonio.
Título: Mutational and acquired carbapenem resistance mechanisms in multidrug resistant Pseudomonas aeruginosa clinical isolates from Recife, Brazil
Fonte: Mem. Inst. Oswaldo Cruz;110(8):1003-1009, Dec. 2015. tab, graf.
Idioma: en.
Projeto: REIPI; . SNS Miguel Servet.
Resumo: An investigation was carried out into the genetic mechanisms responsible for multidrug resistance in nine carbapenem-resistant Pseudomonas aeruginosaisolates from different hospitals in Recife, Brazil. Susceptibility to antimicrobial agents was determined by broth microdilution. Polymerase chain reaction (PCR) was employed to detect the presence of genes encoding β-lactamases, aminoglycoside-modifying enzymes (AMEs), 16S rRNA methylases, integron-related genes and OprD. Expression of genes coding for efflux pumps and AmpC cephalosporinase were assessed by quantitative PCR. The outer membrane proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The blaSPM-1, blaKPC-2 and blaGES-1 genes were detected in P. aeruginosaisolates in addition to different AME genes. The loss of OprD in nine isolates was mainly due to frameshift mutations, premature stop codons and point mutations. An association of loss of OprD with the overexpression of MexAB-OprM and MexXY-OprM was observed in most isolates. Hyper-production of AmpC was also observed in three isolates. Clonal relationship of the isolates was determined by repetitive element palindromic-PCR and multilocus sequence typing. Our results show that the loss of OprD along with overexpression of efflux pumps and β-lactamase production were responsible for the multidrug resistance in the isolates analysed.
Descritores: Carbapenêmicos/metabolismo
Farmacorresistência Bacteriana Múltipla/genética
Mutação
Pseudomonas aeruginosa/efeitos dos fármacos
Pseudomonas aeruginosa/genética
Resistência beta-Lactâmica/genética
beta-Lactamases/metabolismo
-Aminoglicosídeos/metabolismo
Anfotericina B/análogos & derivados
Anfotericina B/metabolismo
Antifúngicos/metabolismo
Brasil
Cefalosporinase/classificação
Cefalosporinase/metabolismo
Códon sem Sentido/metabolismo
Ativação Enzimática/genética
Mutação da Fase de Leitura/genética
Regulação Bacteriana da Expressão Gênica/genética
Proteínas de Membrana Transportadoras/metabolismo
Metiltransferases/metabolismo
Nucleotidiltransferases/metabolismo
Mutação Puntual/genética
Porinas/metabolismo
Pseudomonas aeruginosa/enzimologia
Pseudomonas aeruginosa/isolamento & purificação
Sequências Repetitivas de Ácido Nucleico
beta-Lactamases/genética
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-756633
Autor: Costa, Suelen Bozzi.
Título: Efeitos genotóxicos e indução do SOS em mutantes derivados de Escherichia coli K-12 durante o processo de interação com superfícies bióticas e abióticas / Genotoxic and SOS induction in mutants derived from Escherichia coli K-12 during the process of interaction with biotic and abiotic surfaces.
Fonte: Rio de Janeiro; s.n; 2012. 89 f p.
Idioma: pt.
Tese: Apresentada a Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas para obtenção do grau de Doutor.
Resumo: A célula epitelial é o primeiro contato entre os micro-organismos e o hospedeiro. Essa interação pode levar a produção de diversas citocinas, quimiocinas, moléculas inflamatórias e também estimular a geração de espécies reativas de oxigênio (ERO). Neste trabalho avaliamos se a interação com as células HEp-2 poderia ser genotóxica para os mutantes derivados de Escherichia coli K-12 deficientes em algumas enzimas que fazem parte do sistema de reparo por excisão de base (BER). Além disto, avaliamos a expressão do sistema SOS, que é induzido pela presença de danos no genoma bacteriano. Os resultados obtidos mostraram a presença de filamentos, na interação com células HEp-2, principalmente, no mutante xthA (BW9091) e no triplo mutante xthA nfo nth (BW535). Quando a interação foi quantificada na ausência da D-manose, observamos um aumento das bactérias aderidas. Além disto, a quantidade e o tamanho dos filamentos também aumentaram, mostrando que as adesinas manose-sensíveis estavam envolvidas na filamentação bacteriana. Para comprovar se o aumento da filamentação observada neste ensaio foram uma consequência da indução do sistema SOS, desencadeada pela interação com as células HEp-2, quantificamos a expressão do SOS, na presença e na ausência da D-manose. De fato, observamos que a indução do SOS na ausência da D-manose foi maior, quando comparada, com o ensaio realizado na presença de D-manose. Além disto, observamos que a ausência de xthA foi importante para o aumento da filamentação observada na ausência de D-manose. Diante destes resultados, verificamos se a resposta de filamentação ocorreria quando as bactérias interagiam com uma superfície abiótica como o vidro. Observamos também inúmeros filamentos nos mutantes BER, BW9091 e BW535, quando comparados a cepa selvagem AB1157. Essa filamentação foi associada à indução do SOS, em resposta a interação das bactérias com o vidro...

The epithelial cell is the first contact between microorganisms and host. This interaction results in production of several cytokines, chemokines, and inflammatory molecules by epithelial cells and also stimulate the generation of reactive oxygen species (ROS). In the present study, we have evaluated whether the interaction to HEp-2 cells causes genotoxicity to mutants derived from Escherichia coli K-12 deficient in some enzymes that are part of the system of base excision repair (BER). Moreover, we measured the expression of SOS system, which is induced by the presence of damage to the bacterial genome. Our results showed mainly presence of filamentous bacterial growth in xthA mutant (BW9091) and triple xthA nfo nth mutant (BW535) when submitted to HEp-2 cells interaction assays. When experiments were performed in the absence of mannose, data showed enhanced interaction of viable bacteria to HEp-2 cells for all strains tested. Furthermore, the removal of D-mannose resulted in an increase in both number and size of bacterial filamentous forms, indicating the involvement of mannose-sensitive adhesins in the filamentation of these strains. In order to verify whether the increased filamentation growth in this assay was a consequence of SOS induction, triggered by interaction to HEp-2 cells, we measured expression of SOS in the presence and absence of D-mannose. Indeed, we observed higher expression of SOS response in the absence of mannose than in experiments performed in the presence of D-mannose. Moreover, we observed that the absence of xthA was important to filamentation increasing in absence of D-mannose. Based on these results, we verified if interaction to abiotic surfaces, like glass, could lead to filamentation of these strains. We also observed numerous filaments in BER mutants, BW9091 and BW535, when compared to wild-type strain AB1157. The filamentation observed was a consequence of SOS induction, triggered by attachment to the glass surface...
Descritores: Escherichia coli/isolamento & purificação
Genotoxicidade
Resposta SOS (Genética)
-Biofilmes
Reparo do DNA
Células Epiteliais
Escherichia coli/crescimento & desenvolvimento
Escherichia coli/genética
Escherichia coli/metabolismo
Regulação Bacteriana da Expressão Gênica
Mutagênese/genética
Limites: Seres Humanos
Responsável: BR1365.1 - Biblioteca Biomédica A - CB/A


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Id: lil-753056
Autor: Aquino, B; Stefanello, AA; Oliveira, MAS; Pedrosa, FO; Souza, EM; Monteiro, RA; Chubatsu, LS.
Título: Effect of point mutations on Herbaspirillum seropedicae NifA activity
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;48(8):683-690, 08/2015. tab, graf.
Idioma: en.
Resumo: NifA is the transcriptional activator of the nif genes in Proteobacteria. It is usually regulated by nitrogen and oxygen, allowing biological nitrogen fixation to occur under appropriate conditions. NifA proteins have a typical three-domain structure, including a regulatory N-terminal GAF domain, which is involved in control by fixed nitrogen and not strictly required for activity, a catalytic AAA+ central domain, which catalyzes open complex formation, and a C-terminal domain involved in DNA-binding. In Herbaspirillum seropedicae, a β-proteobacterium capable of colonizing Graminae of agricultural importance, NifA regulation by ammonium involves its N-terminal GAF domain and the signal transduction protein GlnK. When the GAF domain is removed, the protein can still activate nif genes transcription; however, ammonium regulation is lost. In this work, we generated eight constructs resulting in point mutations in H. seropedicae NifA and analyzed their effect on nifH transcription in Escherichia coli and H. seropedicae. Mutations K22V, T160E, M161V, L172R, and A215D resulted in inactive proteins. Mutations Q216I and S220I produced partially active proteins with activity control similar to wild-type NifA. However, mutation G25E, located in the GAF domain, resulted in an active protein that did not require GlnK for activity and was partially sensitive to ammonium. This suggested that G25E may affect the negative interaction between the N-terminal GAF domain and the catalytic central domain under high ammonium concentrations, thus rendering the protein constitutively active, or that G25E could lead to a conformational change comparable with that when GlnK interacts with the GAF domain.
Descritores: Proteínas de Bactérias/genética
Escherichia coli/genética
Herbaspirillum/genética
Fatores de Transcrição/genética
-Proteínas de Bactérias/química
Escherichia coli/metabolismo
Regulação Bacteriana da Expressão Gênica
Herbaspirillum/metabolismo
Fixação de Nitrogênio/genética
Mutação Puntual
Domínios e Motivos de Interação entre Proteínas
Fatores de Transcrição/química
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-749716
Autor: Park, Soon-Nang; Ahn, Sug-Joon; Kook, Joong-Ki.
Título: Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159
Fonte: Braz. j. microbiol;46(2):613-617, Apr-Jun/2015. tab, graf.
Idioma: en.
Projeto: Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea.
Resumo: In this study, we revealed that OA and UA significantly inhibited the expression of most genes related to peptidoglycan biosynthesis in S. mutans UA159. To the best of our knowledge, this is the first report to introduce the antimicrobial mechanism of OA and UA against S. mutans.
Descritores: Antibacterianos/farmacologia
Vias Biossintéticas/efeitos dos fármacos
Vias Biossintéticas/genética
Ácido Oleanólico/farmacologia
Peptidoglicano/biossíntese
Streptococcus mutans/efeitos dos fármacos
Triterpenos/farmacologia
-Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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