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Marcos, Elaine Valim Camarinha
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Id: lil-452620
Autor: Souza, Fabiana Covolo de; Marcos, Elaine Valim Camarinha; Ura, Somei; Opromolla, Paula Araújo; Nogueira, Maria Esther Salles.
Título: Estudo comparativo entre reação de Mitsuda e antígenos leucocitários humanos em pacientes hansenianos / Comparative study between the Mitsuda test and the human leukocyte antigens in leprosy patients
Fonte: Rev. Soc. Bras. Med. Trop;40(2):188-191, mar.-abr. 2007. tab.
Idioma: pt.
Resumo: Neste estudo, propomos comparar o teste cutâneo de Mitsuda e os alelos HLA-DR2/HLA-DR3 e HLA-DQ1 relacionados com as formas clínicas da hanseníase em 176 pacientes (50 TT, 50 LL e 76 B). Os resultados obtidos não revelaram associação entre reação de Mitsuda e os alelos HLA nas formas clínicas isoladas; no entanto, quando analisados de acordo com a resposta ao teste de Mitsuda, associação significativa foi encontrada entre os pacientes Mitsuda negativos e HLA-DQ1 (p=0,002). Não foi observada associação entre reação de Mitsuda positiva e alelos HLA-DR2/DR3. Concluímos que existe importante participação do alelo HLA-DQ1 na ausência de resposta ao teste de Mitsuda. Sugerimos estudos mais específicos para este alelo.

In this study, we aimed to compare the Mitsuda skin test with the alleles HLA-DR2/HLA-DR3 and HLA-DQ1, in relation to the clinical forms of leprosy in 176 patients (50 TT, 50 LL and 76 B). The results obtained did not reveal any association between the Mitsuda reaction and the HLA alleles in the clinical forms isolated. However, when analyzed according to Mitsuda test response, a significant association was found between patients with negative Mitsuda reaction and HLA-DQ1 (p=0.002). No association was observed between positive Mitsuda reaction and the HLA-DR2/DR3 alleles. We concluded that the allele HLA-DQ1 has an important participation when there is no response to the Mitsuda test. We suggest that more specific studies should be developed on this allele.
Descritores: Antígenos HLA-D/imunologia
Hanseníase/imunologia
Testes Cutâneos/métodos
-Alelos
Antígenos HLA-D/genética
Antígenos HLA-DQ/genética
Antígenos HLA-DQ/imunologia
/genética
HLA-DRTEMEFOS ANTIGEN/genética
/imunologia
HLA-DRTEMEFOS ANTIGEN/imunologia
/genética
HLA-DRABATTOIRS ANTIGEN/genética
/imunologia
HLA-DRABATTOIRS ANTIGEN/imunologia
Fenótipo
Reação em Cadeia da Polimerase
Limites: Humanos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-844184
Autor: Azeredo, Lucas A de; De Nardi, Tatiana; Levandowski, Mateus L; Tractenberg, Saulo G; Kommers-Molina, Julia; Wieck, Andrea; Irigaray, Tatiana Q; Silva Filho, Irênio G da; Grassi-Oliveira, Rodrigo.
Título: The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
Fonte: Rev. bras. psiquiatr;39(2):90-94, Apr.-June 2017. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.
Descritores: Valina/genética
Fator Neurotrófico Derivado do Encéfalo/genética
Polimorfismo de Nucleotídeo Único
Transtornos da Memória/genética
Metionina/genética
-Análise e Desempenho de Tarefas
Escalas de Wechsler
Análise Multivariada
Fatores de Risco
Fatores Etários
Estatísticas não Paramétricas
Predisposição Genética para Doença
Alelos
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-844186
Autor: Oliveira, Fabricio F de; Chen, Elizabeth S; Smith, Marilia C; Bertolucci, Paulo H.
Título: Associations of Cerebrovascular Metabolism Genotypes With Neuropsychiatric Symptoms and Age at Onset of Alzheimer's Disease Dementia
Fonte: Rev. bras. psiquiatr;39(2):95-103, Apr.-June 2017. tab.
Idioma: en.
Projeto: CAPES; . FAPESP.
Resumo: Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer’s disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. Results: Considering 201 patients, only APOE-ɛ4 carriers had earlier dementia onset in multiple correlations, as well as less apathy, more delusions, and more aberrant motor behavior. Both ACE polymorphisms were associated with less intense frontally mediated behaviors. Regarding LDLR variants, carriers of the A allele of rs11669576 had less anxiety and more aberrant motor behavior, whereas carriers of the A allele of rs5930 had less delusions, less anxiety, more apathy, and more irritability. CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. Conclusion: Though only APOE haplotypes affected AD onset, cerebrovascular metabolism genotypes were associated with differences in several neuropsychiatric manifestations of AD.
Descritores: Transtornos Cerebrovasculares/genética
Transtornos Cerebrovasculares/metabolismo
Doença de Alzheimer/genética
Doença de Alzheimer/metabolismo
Genótipo
-Apolipoproteínas E/genética
Modelos Lineares
Transtornos Cerebrovasculares/fisiopatologia
Estudos Transversais
Idade de Início
Dosagem de Genes
Alelos
Proteínas de Transferência de Ésteres de Colesterol/genética
Estudos de Associação Genética
Doença de Alzheimer/fisiopatologia
Transtornos de Início Tardio
Receptores X do Fígado/genética
Lipoproteínas LDL/genética
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Andrade, Luís Eduardo Coelho
Silva, Neusa Pereira da
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Id: biblio-830074
Autor: Grecco, Marcelle; Santos, Viviane Cardoso dos; Pereira, Kaline Medeiros Costa; Andrade, Luís Eduardo Coelho; Silva, Neusa Pereira da.
Título: Fc gamma receptor IIIa polymorphism is not associated with susceptibility to systemic lupus erythematosus in Brazilian patients / Polimorfismo do receptor Fc gama IIIa não está associado à susceptibilidade ao lúpus eritematoso sistêmico em pacientes brasileiros
Fonte: Rev. bras. reumatol;56(6):515-520, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo; . Brazilian Council for Research and Development.
Resumo: ABSTRACT We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease.

RESUMO Avaliou-se a possível associação entre o polimorfismo FCGR3A V/F (158) e a suscetibilidade e o fenótipo clínico do lúpus eritematoso sistêmico (LES) em 305 pacientes com LES admitidos sequencialmente e 300 controles saudáveis da Região Sudeste do Brasil por reação em cadeia da polimerase alelo-específica. Os resultados do presente estudo mostraram não haver associação entre os alelos FCGR3A 158 V/F e a suscetibilidade ao LES nessa série de pacientes, ainda que o genótipo heterozigoto tenha sido fortemente associado à doença.
Descritores: Polimorfismo Genético
Receptores de IgG/genética
Lúpus Eritematoso Sistêmico/genética
-Brasil
Predisposição Genética para Doença
Alelos
Genótipo
Lúpus Eritematoso Sistêmico/imunologia
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-899478
Autor: Öksuz, Mustafa Ferhat; Karkucak, Mutlu; Görukmez, Orhan; Ocakoğlu, Gökhan; Yıldız, Abdulmecit; Ture, Mehmet; Yakut, Tahsin; Dilek, Kamil.
Título: Investigation of MEFV gene polymorphisms (G138G and A165A) in adult patients with familial Mediterranean fever / Investigação de polimorfismos no gene MEFV (G138G e A165A) em pacientes adultos com febre mediterrânica familiar
Fonte: Rev. bras. reumatol;57(6):501-506, Nov.-Dec. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Aim: Various mutations have been identified in the Mediterranean fever (MEFV) gene which is reported to be responsible from Familial Mediterranean fever (FMF). In our study, we aimed to determine the frequency of the MEFV mutations in our region and to investigate the impact of G138G (rs224224, c.414A>G) and A165A (rs224223, c.495C>A) gene polymorphisms on the clinical findings of the disease. Methods: One hundred and sixteen patients diagnosed with FMF and 95 control subjects were included in this study. We used the DNA sequence analysis method to identify the most prevailing 10 mutations located in exon 2 and 10 of MEFV gene. Results: As a result of the MEFV mutation analysis, the most common mutation was the M694V mutation allele with a frequency rate of 41.8%. When the patients group and control group were compared in terms of frequency of both polymorphic alleles (G polymorphic allele, observed in G138G and the A polymorphic allele, observed in A165A), the variation was observed to be statistically significant (p < 0.001). It was found that the MEFV mutation types have no relation with clinical findings and amyloidosis (p > 0.05). Conclusions: To our knowledge, our study is the first study in the Southern Marmara region that reports the frequency of MEFV mutations. Our findings imply that the polymorphisms of G138G and A165A may have an impact on progress of the disease. We think that more studies, having higher number of cases and investigating the polymorphisms of MEFV gene, are needed.

Resumo Objetivo: Identificaram-se mutações no gene da febre mediterrânica (MEFV) relatadas como responsáveis pela febre mediterrânica familiar (FMF). Este estudo teve como objetivo determinar a frequência de mutações no MEFV na região sul do mar de Mármara e investigar o impacto dos polimorfismos genéticos G138G (rs224224, c.414A > G) e A165A (rs224223, c.495C > A) nos achados clínicos da doença. Métodos: Foram incluídos neste estudo 116 pacientes com diagnóstico de FMF e 95 indivíduos no grupo controle. Usou-se o método de análise da sequência de DNA para identificar as 10 mutações mais prevalentes localizadas nos éxons 2 e 10 do gene MEFV. Resultados: Como resultado da análise da mutação MEFV, a mutação mais comum foi a mutação alélica M694 V, com uma taxa de frequência de 41,8%. Quando os grupos de pacientes e controles foram comparados em termos de frequência de ambos os alelos polimórficos (alelo polimórfico G, observado no G138G e o alelo polimórfico A, observado no A165A), a variação observada foi estatisticamente significativa (p < 0,001). Verificou-se que os tipos de mutação no MEFV não tinham relação com os achados clínicos nem com a amiloidose (p > 0,05). Conclusões: Que se tem conhecimento, este estudo é o primeiro feito na região sul do mar de Mármara que relata a frequência de mutações no MEFV. Os achados indicam que os polimorfismos G138G e A165A podem ter um impacto sobre o progresso da doença. Acredita-se que são necessários mais estudos que abranjam um maior número de casos e investiguem os polimorfismos do gene MEFV.
Descritores: Febre Familiar do Mediterrâneo/genética
Pirina/sangue
Mutação
-Febre Familiar do Mediterrâneo/sangue
Polimorfismo Genético
Turquia
Estudos de Casos e Controles
Reação em Cadeia da Polimerase
Estudos Retrospectivos
Alelos
Frequência do Gene
Pessoa de Meia-Idade
Limites: Humanos
Adulto
Idoso
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Marcos, Elaine Valim Camarinha
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Id: biblio-1011110
Autor: Rogel, Clarissa Schmidt; Souza-Santana, Fabiana Covolo de; Marcos, Elaine Valim Camarinha; Ogawa, Marilia Marufuji; Basso, Geovana; Tomimori, Jane.
Título: HLA alleles in renal transplant recipients with nonmelanoma skin cancer in southeastern Brazil
Fonte: An. bras. dermatol;94(3):287-292, May-June 2019. tab.
Idioma: en.
Resumo: Abstract: Background: Renal transplant recipients are submitted to immunosuppression to avoid graft rejection, which makes them susceptible to various conditions. Furthermore, these individuals present malignant tumors more frequently than the general population, including nonmelanoma skin cancer. The individual genetic basis that acts in the pathogenesis of cutaneous cancer may present a protection or susceptibility factor for disease development. One of these factors is the HLA complex. Objective: To investigate HLA alleles association to the occurrence of nonmelanoma skin cancer in renal transplant recipients from São Paulo State. Methods: A total of 213 patients (93 renal transplant recipients with nonmelanoma skin cancer and 120 renal transplant recipients without nonmelanoma skin cancer) were evaluated by retrospective and cross-sectional study. Epidemiological, clinical and HLA typing data were found in databases. HLA class I (A, B) and class II (DR) alleles were compared to establish their association with nonmelanoma skin cancer. Results: Comparing renal transplant recipients with and without nonmelanoma skin cancer, the HLA-B*13 allele was associated with higher risk of developing nonmelanoma skin cancer while B*45 and B*50 alleles were associated with protection. Study limitations: The HLA A, B and DR alleles identification for the kidney transplantation routine is done by low and medium resolution techniques that do not allow discrimination of specific alleles. Conclusion: The involvement of HLA alleles in nonmelanoma skin cancer in renal transplant recipients was confirmed in this study. Renal transplant recipients with HLA-B*13 showed higher risk for developing a skin cancer (OR= 7.29) and should be monitored for a long period of time after transplantation.
Descritores: Neoplasias Cutâneas/genética
Transplante de Rim/efeitos adversos
Antígenos HLA/genética
-Neoplasias Cutâneas/etiologia
Neoplasias Cutâneas/epidemiologia
Brasil/epidemiologia
Antígenos HLA-A/genética
Antígenos HLA-B/genética
Antígenos HLA-DR/genética
Estudos de Casos e Controles
Estudos Transversais
Estudos Retrospectivos
Predisposição Genética para Doença/genética
Alelos
Transplantados
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1001146
Autor: Ermis, Esra; Celik, Sevim Karakas; Solak, Nilgun; Genc, Gunes Cakmak; Dursun, Ahmet.
Título: The role of GNLY gene polymorphisms in psoriasis pathogenesis
Fonte: An. bras. dermatol;94(2):198-203, Mar.-Apr. 2019. tab, graf.
Idioma: en.
Projeto: Unit of Scientific Research Projects of Bulent Ecevit University.
Resumo: Abstract BACKGROUND: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with keratinocyte hyperproliferation. Granulysin (GNLY) is a cytolytic antimicrobial peptide (AMP) that is secreted together with granzyme and perforin from the granules of human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It has been immunohistochemically proven that the expression of granulysin is increased in lesions of psoriasis. OBJECTIVE: This study aimed to investigate the relationship between psoriasis disease and granulysin gene polymorphisms. METHODS: GNLY rs7908 and rs10180391 polymorphisms were studied by PCR-RFLP in 100 psoriasis patients under treatment in the Dermatology Polyclinic of Bulent Ecevit University. In addition, 100 healthy individuals with similar age and sex distribution were used as a control group. RESULTS: In the control group, GNLY rs7908 CC genotype was significantly higher than in psoriasis patients (P= 0.031; OR= 0.305; Cl= 0.305 (0.121 - 0.773). In our study, the genotype distributions in patients and control groups were GNLY rs7908 (SNP) GG (51%, 37%), GC (41%, 44%), CC (8%, 19%); GNLY rs10180391 (SNP) from the CC (41%, 44%), CT (42%, % 41), TT (17%, 15%). STUDY LIMITATIONS: The study only included Turkish patients. CONCLUSION: Our findings showed that GNLY rs7908 CC genotype and C allele had a protective effect against psoriasis and decreased the disease severity (according to PASI score), whereas rs10180391 SNP did not show any effective role in psoriasis pathogenesis.
Descritores: Polimorfismo Genético/genética
Psoríase/genética
Antígenos de Diferenciação de Linfócitos T/genética
-Psoríase/etiologia
Índice de Gravidade de Doença
Estudos de Casos e Controles
Expressão Gênica
Substâncias Protetoras
Alelos
Genótipo
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-1038308
Autor: Ataei, Mitra; Behfarjam, Farinaz; Jadali, Zohreh.
Título: TIM-3 genetic variants and risk of Behçet disease in the Iranian population
Fonte: An. bras. dermatol;94(4):429-433, July-Aug. 2019. tab.
Idioma: en.
Resumo: Abstract: Background: Behçet disease is a prototypical systemic autoimmune disease, caused by a complex interplay between environmental and genetic factors. The transmembrane immunoglobulin and mucin domain-3 (TIM-3) is a distinct member of the TIM family that is preferentially expressed on Th1 cells and plays a role in Th1-mediated autoimmune or inflammatory diseases, such as Behçet disease. Objective: The aim of this study was to test the potential association between TIM-3 gene polymorphisms and Behçet disease. Methods: Two single-nucleotide polymorphisms of TIM-3 (rs9313439 and rs10515746) were genotyped in 212 patients with Behçet disease and 200 healthy controls. Typing of the polymorphisms was performed using multiplex PCR amplification. Results: There were no significant differences in allele and genotype frequencies between the Behçet disease patients and controls who were successfully genotyped. Similar results were also found after stratification by gender, age, or clinical features. Study limitations: Lack of studies on various racial or ethnic groups and small sample size. Conclusion: This study failed to demonstrate any association between the tested TIM-3 polymorphisms and Behçet disease.
Descritores: Síndrome de Behçet/genética
Polimorfismo de Nucleotídeo Único
Receptor Celular 2 do Vírus da Hepatite A/genética
-Estudos de Casos e Controles
Modelos Logísticos
Fatores de Risco
Medição de Risco
Alelos
Estudos de Associação Genética
Reação em Cadeia da Polimerase Multiplex
Frequência do Gene
Irã (Geográfico)
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-839379
Autor: Liu, Tianxiang; Li, Huiru; Ding, Yatong; Qi, Yuancheng; Gao, Yuqian; Song, Andong; Shen, Jinwen; Qiu, Liyou.
Título: Genome-wide gene expression patterns in dikaryon of the basidiomycete fungus Pleurotus ostreatus
Fonte: Braz. j. microbiol;48(2):380-390, April.-June 2017. tab, graf.
Idioma: en.
Projeto: Natural Science Foundation of Henan Province; . Innovative Research Team.
Resumo: Abstract Dikarya is a subkingdom of fungi that includes Ascomycota and Basidiomycota. The gene expression patterns of dikaryon are poorly understood. In this study, we bred a dikaryon DK13 × 3 by mating monokaryons MK13 and MK3, which were from the basidiospores of Pleurotus ostreatus TD300. Using RNA-Seq, we obtained the transcriptomes of the three strains. We found that the total transcript numbers in the transcriptomes of the three strains were all more than ten thousand, and the expression profile in DK13 × 3 was more similar to MK13 than MK3. However, the genes involved in macromolecule utilization, cellular material synthesis, stress-resistance and signal transduction were much more up-regulated in the dikaryon than its constituent monokaryons. All possible modes of differential gene expression, when compared to constituent monokaryons, including the presence/absence variation, and additivity/nonadditivity gene expression in the dikaryon may contribute to heterosis. By sequencing the urease gene poure sequences and mRNA sequences, we identified the monoallelic expression of the poure gene in the dikaryon, and its transcript was from the parental monokaryon MK13. Furthermore, we discovered RNA editing in the poure gene mRNA of the three strains. These results suggest that the gene expression patterns in dikaryons should be similar to that of diploids during vegetative growth.
Descritores: Pleurotus/genética
Perfilação da Expressão Gênica
-Alelos
Genes Fúngicos
Responsável: BR1.1 - BIREME


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Id: biblio-1049760
Autor: Al-Mukhtar, Sadiq; Raouf, Hyam; Zalzala, Haider Hashim; Mahdi, Batool Mutar; Alí Abid, Laheeb; Nehad, Zena.
Título: Relation between osteoarthritis and HLA-A in Iraqui patients
Fonte: Prensa méd. argent;104(5):261-264, jul2018.
Idioma: en.
Resumo: Relación entre osteoartritis y HLA - A en pacientes iraquíes. (HLA: acrónimo inglés de antcígenos leucocitarios humanos - Human Leucocyte Antigens). La osteoartritis e la afección más común que involucra el aparato osteo-articular. Representa a un grupo heterogéneo de condiciones resultante de cambios comunes histopatológicos y radiológicos. Existen múltiples factores de riesgo para la osteoartritis: edad, obesidad, y el antígeno genético. El leococitario humano (HLA) como parte del sistema inmune, teniendo un rol en el proceso nosológico. Diversos estudios han determinado la diferente asociación entre la clase HLA - I y la II. El objetivo de esta investigación fue el de determinar la eventualidad de una relación entre el HLA-I y el II en la osteocondritis. Los resultados obtenidos se discuten en el artículo.

Background: Osteoarthritis (OA) is the most common type of joint disease. It represents a heterogeneous group of conditions resulting in common histopathologic and radiologic changes. There are multiples risk factors for osteoarthritis includes the following: Age, Obesity and Genetics. Human leukocyte antigen (HLA) as part of immune system has a role in the disease process. Many reported studies have pointted to different HLA classs I and II association. Aim: To investigate whether there is an association between HLA class II and OA. Patients and methods: A cross sectional comparatives study including patient with primary osteoarthritis attending the department of orthopedic in Al-Kindy teaching hospital Baghdad, Iraq between September 2016-September 2017. Patient's selection was done by the orthopaedics. The HLA-A tuping was performed in HLA research unit at Al-Kindy College of Medicine using PCR-SSO according to the manufacturer instruction using both Amplification and Hybridization kit by Automated method using Autolipa - 48Innogenities-Belgium. The results ewre interepted using LIRAS version 5.0 software innogenetics - Belgium, odds ratio were used to test signifcant differences. Results: Thirty five Iraqi Arab Muslims patients with primary osteoarthritis. The control group was comprised from 75 healtht unrelated sex and age matched volunteers among the staff of Al-Kindey college of medicine that didn't have a history of osteoarthritis. There was an increased frequencies of HLA-A*0101,0202,6802 in patients with osteoarthritis compared with healthy controls (P value=0.001,<0.001,<0.001 respectively)
Descritores: Osteoartrite/diagnóstico
Osteocondrite/patologia
Reação em Cadeia da Polimerase
Fatores de Risco
Alelos
Antígenos HLA/imunologia
Limites: Humanos
Responsável: AR392.1 - Biblioteca



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