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Monteiro, Talita Antonia Furtado
Vasconcelos, Pedro Fernando da Costa
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Id: biblio-1067134
Autor: Monteiro, Talita Antonia Furtado; Arnaud, Maria Vanda Catão; Barros, Vera Lúcia Sousa; Monteiro, José Luiz Furtado; Vasconcelos, Pedro Fernando da Costa.
Título: Identificação do gene EBER1 e EBNA1 do vírus de Epstein Barr (EBV) em tecidos de pacientes com doença de Hodgkin na região Norte do Brasil / Identification of gene EBER1 and EBNA 1 of Epstein Barr virus (EBV) in tissues of patients with Hodgkin's disease in Northern Brazil
Fonte: Rev. panam. infectol;16(1):17-24, 2014. tab, graf.
Idioma: pt.
Resumo: O vírus de Epstein Barr (EBV) é o agente causador da mononucle¬ose infecciosa e está associado a várias desordens proliferativas malignas tais como: linfoma de Burkitt, linfoma de Hodgkin e lin¬fomas não Hodgkin. Objetivo: detectar o genoma do EBV mediante a identificação dos genes EBER1 e EBNA1 em casos de doença de Hodgkin. Métodos: um total de 65 casos de linfomas diagnosti¬cados no Hospital Ophir Loyola no período de 1996 e 2005 foram analisados no Instituto Evandro Chagas, Ananindeua, Brasil. Todos os espécimes parafinizados foram analisados por hibridização in situ (gene EBER1) e PCR em tempo real (EBNA1). Resultados: do total, 64,6% (42/65) dos pacientes eram do sexo masculino e 35,4% (23/65) do sexo feminino. O EBV foi identificado por HIS nas células Reed Sternberg e variantes em 76,9% (50/65) dos casos com idade média de 28,3 anos (variação 2-84 anos). Os subtipos histológicos de casos EBV-positivos foram os seguintes: esclerose nodular em 50% (25/50), celularidade mista em 28% (14/50), depleção linfocitária em 14% (7/50) e predominância linfocitária em 8% (4/50). O DNA do EBV foi detectado em 53% (26/49) dos casos de doença de Hodgkin com um coeficiente de regressão para a curva padrão de 0,99. Conclusão: este estudo foi a primeira descrição do vírus de Epstein Barr em casos de linfoma de Hodgkin na Amazônia Brasileira, reforçando a hipótese de que o EBV seja um co-fator no processo de transformação neoplásica em conjunto com a predisposição genética e imunidade do paciente

Introduction: EBV is the causative agent of infectious mononucleosis and is associated with several malignant proliferative disorders such as Burkitt's lymphoma, Hodgkin's lymphoma, some B and T cell non-Hodgkin's lymphomas. Objective: The main objective of the study was to determine the prevalence of EBER 1 gene and EBNA1 gene in cases of Hodgkin's disease. Material and Methods: A total of 65 cases of lymphomas diagnosed between 1996 and 2005 were obtained from “Instituto Ofir Loyola” and analyzed at the “Instituto Evandro Chagas” Ananindeua, Brazil. The EBV antigens using EBER 1 probe in situ hybridization (HIS) and real time quantitative PCR. Results: From the total obtained, 64.6% (42/65) were male and 35.4% (23/65) female. EBV was identified in the Reed- Sternberg cells and variants in 76.9% (50/65) of Hodgkin's disease cases, the median age were 28.3 years (range 2-84). The histologic subtypes of EBV-positive cases were as follows: nodular sclerosis in 50% (25/50), mixed cellularity in 28% (14/50), lymphocyte depletion in 14% (7/50) and lymphocyte predominance in 8% (4/50). We detected EBV DNA in 53% (26/49) with a coefficient of regression for the standard curve of a minimum of 0.99. Conclusion: These results were the first demonstration of the role of Epstein Barr virus in cases of Hodgkin diseases in northern Brazil and are consistent with the hypothesis that the presence of EBV during neoplasic transformation could be an additional cofactor acting together with both genetic predisposition and immunity of the patient
Descritores: Doença de Hodgkin/diagnóstico
Doença de Hodgkin/história
Genoma Viral
HERPESVIRUS HUMANO ABBREVIATIONS AS TOPIC
-Hibridização In Situ
Reação em Cadeia da Polimerase em Tempo Real
Limites: Masculino
Feminino
Humanos
Responsável: BR31.1 - SIDC - Serviço de Informação e Documentação Científica


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Texto completo
Id: biblio-974329
Autor: Borges, Iara Apolinário; Assis, Felipe Lopes de; Silva, Ludmila Karen dos Santos; Abrahão, Jônatas.
Título: Rio Negro virophage: Sequencing of the near complete genome and transmission electron microscopy of viral factories and particles
Fonte: Braz. j. microbiol;49(supl.1):260-261, 2018. graf.
Idioma: en.
Resumo: ABSTRACT Rio Negro virophage (RNV) was co-isolated with a strain of mimivirus named sambavirus, from Brazilian Amazon. We report the near complete genome sequence of RNV, the first virophage isolated in Brazil. We also present new microscopical data demonstrating that RNV particles have similar dimensions to that described to sputnik virophages.
Descritores: Togaviridae/genética
Acanthamoeba/virologia
Genoma Viral
Virófagos/genética
-Filogenia
Togaviridae/isolamento & purificação
Togaviridae/ultraestrutura
Brasil
Fases de Leitura Aberta
Microscopia Eletrônica de Transmissão
Virófagos/isolamento & purificação
Virófagos/ultraestrutura
Responsável: BR1.1 - BIREME


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Id: biblio-974285
Autor: Pereira, Joylson de Jesus; Baumworcel, Natasha; Fioretti, Júlia Monassa; Domingues, Cinthya Fonseca; Moraes, Laís Fernandes de; Marinho, Robson dos Santos Souza; Vieira, Maria Clara Rodrigues; Pinto, Ana Maria Viana; de Castro, Tatiana Xavier.
Título: Molecular characterization of feline calicivirus variants from multicat household and public animal shelter in Rio de Janeiro, Brazil
Fonte: Braz. j. microbiol;49(4):777-784, Oct.-Dec. 2018. tab, graf.
Idioma: en.
Projeto: FAPERJ.
Resumo: ABSTRACT The aim of this study was to perform the molecular characterization of conserved and variable regions of feline calicivirus capsid genome in order to investigate the molecular diversity of variants in Brazilian cat population. Twenty-six conjunctival samples from cats living in five public short-term animal shelters and three multicat life-long households were analyzed. Fifteen cats had conjunctivitis, three had oral ulceration, eight had respiratory signs (cough, sneeze and nasal discharge) and nine were asymptomatic. Feline calicivirus were isolated in CRFK cells and characterized by reverse transcription PCR target to both conserved and variable regions of open reading frame 2. The amplicons obtained were sequenced. A phylogenetic analysis along with most of the prototypes available in GenBank database and an amino acid analysis were performed. Phylogenetic analysis based on both conserved and variable region revealed two clusters with an aLTR value of 1.00 and 0.98 respectively and the variants from this study belong to feline calicivirus genogroup I. No association between geographical distribution and/or clinical signs and clustering in phylogenetic tree was observed. The variants circulating in public short-term animal shelter demonstrated a high variability because of the relatively rapid turnover of carrier cats constantly introduced of multiple viruses into this location over time.
Descritores: Doenças do Gato/virologia
Calicivirus Felino/isolamento & purificação
Calicivirus Felino/genética
Infecções por Caliciviridae/veterinária
Animais de Estimação/virologia
-Filogenia
Brasil
Fases de Leitura Aberta
Genoma Viral
Calicivirus Felino/classificação
Infecções por Caliciviridae/virologia
Proteínas do Capsídeo/genética
Limites: Animais
Gatos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: biblio-974345
Autor: Wang, Chuan-Xu; Li, Xin.
Título: JMT-1: a novel, spherical lytic halotolerant phage isolated from Yuncheng saline lake
Fonte: Braz. j. microbiol;49(supl.1):262-268, 2018. graf.
Idioma: en.
Projeto: Key Disciplines Construction Foundation of the \"1331 Project\" of Shanxi Province; . Natural Science Foundation of Shanxi Province; . PhD Start-up Foundation of Yuncheng University.
Resumo: ABSTRACT This work described a novel halotolerant phage, JMT-1, with a spherical morphology. JMT-1, which was isolated from a hypersaline lake, could produce clear plaques on Chromohalobacter sp. LY7-3. The purified virions are spherical, have no visible tail, and are about 30-50 nm in diameter. JMT-1 has a wide host range, and this study showed that the phage can infect at least five halophilic bacteria. The proteins of JMT-1 were analyzed using sodium dodecyl sulfate polyacrylamide gel electrophoresis, and six proteins were detected. Results show that JMT-1 is a bacteriophage with a linear double-stranded DNA. Meanwhile, the genome is approximately 23 kb in length and is sensitive to the restriction endonucleases Bam I, EcoR I, Hind III and Kpa I. JMT-1 has a high titer, approaching 1.5 × 109 pfu/mL after dilution to 10−6 pfu/mL. The phage is also sensitive to chloroform but not to temperature, pH, and lowered salt concentration. JMT-1 is a spherical lytic halotolerant phage with a wide host range and has the tolerance to specific extreme environments. These data could provide references for studying phage resources in extreme environments and would also provide the useful methods for isolation and identification of other valuable phage in the salt lake environment.
Descritores: Bacteriófagos/isolamento & purificação
Vírion/isolamento & purificação
Lagos/virologia
Especificidade de Hospedeiro
-Bactérias/virologia
Bacteriófagos/classificação
Bacteriófagos/fisiologia
Bacteriófagos/genética
Vírion/classificação
Vírion/fisiologia
Cloreto de Sódio/análise
Lagos/análise
China
Genoma Viral
Responsável: BR1.1 - BIREME


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Weiblen, Rudi
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Id: biblio-828184
Autor: Arenhart, Sandra; Silva Junior, José Valter Joaquim; Flores, Eduardo Furtado; Weiblen, Rudi; Gil, Laura Helena Vega Gonzales.
Título: Use of homologous recombination in yeast to create chimeric bovine viral diarrhea virus cDNA clones
Fonte: Braz. j. microbiol;47(4):993-999, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract The open reading frame of a Brazilian bovine viral diarrhea virus (BVDV) strain, IBSP4ncp, was recombined with the untranslated regions of the reference NADL strain by homologous recombination in Saccharomyces cerevisiae, resulting in chimeric full-length cDNA clones of BVDV (chi-NADL/IBSP4ncp#2 and chi-NADL/IBSP4ncp#3). The recombinant clones were successfully recovered, resulting in viable viruses, having the kinetics of replication, focus size, and morphology similar to those of the parental virus, IBSP4ncp. In addition, the chimeric viruses remained stable for at least 10 passages in cell culture, maintaining their replication efficiency unaltered. Nucleotide sequencing revealed a few point mutations; nevertheless, the phenotype of the rescued viruses was nearly identical to that of the parental virus in all experiments. Thus, genetic stability of the chimeric clones and their phenotypic similarity to the parental virus confirm the ability of the yeast-based homologous recombination to maintain characteristics of the parental virus from which the recombinant viruses were derived. The data also support possible use of the yeast system for the manipulation of the BVDV genome.
Descritores: Leveduras/genética
Genoma Viral
DNA Complementar
Vírus da Diarreia Viral Bovina/genética
Recombinação Homóloga
-Replicação Viral
Leveduras/metabolismo
Linhagem Celular
Fases de Leitura Aberta
Análise de Sequência de DNA
Vírus da Diarreia Viral Bovina/fisiologia
Vírus da Diarreia Viral Bovina/ultraestrutura
Limites: Animais
Bovinos
Responsável: BR1.1 - BIREME


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Id: lil-788969
Autor: Cunty, Amandine; Cesbron, Sophie; Briand, Martial; Carrère, Sébastien; Poliakoff, Françoise; Jacques, Marie-Agnès; Manceau, Charles.
Título: Draft genome sequences of five Pseudomonas syringae pv. actinidifoliorum strains isolated in France
Fonte: Braz. j. microbiol;47(3):529-530, July-Sept. 2016. tab.
Idioma: en.
Resumo: ABSTRACT Pseudomonas syringae pv. actinidifoliorum causes necrotic spots on the leaves of Actinidia deliciosa and Actinidia chinensis. P. syringae pv. actinidifoliorum has been detected in New Zealand, Australia, France and Spain. Four lineages were previously identified within the P. syringae pv. actinidifoliorum species group. Here, we report the draft genome sequences of five strains of P. syringae pv. actinidifoliorum representative of lineages 1, 2 and 4, isolated in France. The whole genomes of strains isolated in New Zealand, representative of P. syringae pv. actinidifoliorum lineages 1 and 3, were previously sequenced. The availability of supplementary P. syringae pv. actinidifoliorum genome sequences will be useful for developing molecular tools for pathogen detection and for performing comparative genomic analyses to study the relationship between P. syringae pv. actinidifoliorum and other kiwifruit pathogens, such as P. syringae pv. actinidiae.
Descritores: Genoma Viral
Análise de Sequência de DNA
Pseudomonas syringae/classificação
Pseudomonas syringae/genética
-Doenças das Plantas/microbiologia
Genômica/métodos
Pseudomonas syringae/isolamento & purificação
Sequenciamento de Nucleotídeos em Larga Escala
Responsável: BR1.1 - BIREME


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Id: lil-788968
Autor: Chand, Karam; Biswas, Sanchay Kumar; Sharma, Gaurav; Saxena, Arpit; Tewari, Neha; Mahajan, Sonalika; Pandey, Awadh Bihari.
Título: Full genome sequencing of the bluetongue virus-1 isolate MKD20/08/Ind from goat in India
Fonte: Braz. j. microbiol;47(3):527-528, July-Sept. 2016.
Idioma: en.
Resumo: ABSTRACT This communication reports full genome sequencing of the bluetongue virus-1 (BTV-1) isolate MKD20/08/Ind from goat in northern India. The total BTV-1 genome size was found to be 19,190 bp. A comparison study between the Indian isolate and other global isolates revealed that it belongs to the 'Eastern' BTV topotype. The full genome sequence of BTV-1 will provide vital information on its geographical origin and it will also be proved useful for comparing the Indian isolate with global isolates from other host species.
Descritores: Cabras/virologia
Genoma Viral
Análise de Sequência de DNA
Vírus Bluetongue/genética
-Filogenia
Vírus Bluetongue/isolamento & purificação
Vírus Bluetongue/classificação
Genômica
Sequenciamento de Nucleotídeos em Larga Escala
Sorogrupo
Índia
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-998219
Autor: Bernal Aguirre, Laura Elena; Mongelós-Dacunte, Pamela Esther; Alfonzo Salinas, Tania Mabel; Cardozo, Fátima; Mendoza Torres, Laura Patricia.
Título: Optimización de una técnica de PCR convencional para detección de virus de papiloma humano tipo 16 y 18 / Optimization of a conventional PCR technique for detection of human papillomavirus type 16 and 18
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);16(3):6-12, dic. 2018. tab, ilus.
Idioma: es.
Resumo: El cáncer de cuello uterino es el segundo cáncer femenino más común a nivel mundial. El agente causal es el virus de papiloma humano (VPH). Se han identificado 13 tipos de virus de papiloma humano de alto riesgo oncogénico (VPH-AR), entre los cuales el VPH 16 y VPH 18 son los más frecuentemente detectados en cáncer de cuello uterino, siendo en Paraguay detectados en el 70% de casos de cáncer invasor. Por ello, el objetivo fue estandarizar y determinar el límite de detección de una técnica de PCR convencional para la detección de VPH 16 y 18. Para la detección de ADN de VPH 16 y 18, se observaron mejores resultados con 2mM de MgCl2 y 60°C para la temperatura de alineamiento. El límite de detección para las PCR fue de 14,6x10-11ng/µL para VPH 16 y 21,7x10-12ng/µL para VPH 18. Este trabajo servirá de base a otros estudios de detección e identificación de estos tipos virales por PCR, con miras a identificar un grupo de mujeres positivas para VPH-AR que poseen mayor riesgo de desarrollo de lesión y cáncer de cuello uterino y precisan de un seguimiento más cercano(AU

Cervical cancer is the second most common female cancer worldwide. It is caused by the human papilloma virus (HPV). Thirteen genotypes of high oncogenic risk human papilloma viruses (HPV-HR) have been identified, among which types 16 and 18 are the most frequently detected in cervical cancer. In Paraguay, they are detected in 70% of the invasive cancer cases. Therefore, the objective was to standardize and determine the detection limit of a conventional PCR technique for the detection of HPV 16 and 18. Better results were observed with 2mM MgCl2 and 60°C for the alignment temperature in detection of HPV 16 and 18 DNA. The limit of detection was 14.6x10-11ng/µL for HPV 16 and 21.7x10-12ng/µL for HPV 18. This work will help other studies for the detection and identification of these viral types by PCR in order to identify a group of HPV-HR positive women who have higher risk for the development of lesions and cervical cancer and need a closer follow-up(AU)
Descritores: Neoplasias do Colo do Útero/virologia
Reação em Cadeia da Polimerase/métodos
Infecções por Papillomavirus/virologia
Papillomavirus Humano 16/genética
Papillomavirus Humano 18/genética
-Sequência de Bases
Genoma Viral
Primers do DNA
Eletroforese em Gel de Poliacrilamida
Limite de Detecção
Limites: Humanos
Feminino
Responsável: PY3.1 - Biblioteca


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Id: biblio-1008720
Autor: Cardozo-Segovia, Fátima María; Rojas-Segovia, Alejandra María; Franco, Leticia; Herebia, Lilian; Vallejos, María Asunción; Páez-Acchiardi, Gloria Malvina; Guillén, Yvalena; Mendoza-Torres, Laura Patricia.
Título: Búsqueda de flavivirus en individuos con sospecha clínica de dengue y resultado negativo para el antígeno NS1 en Paraguay / Search of flavivirus in individuals with clinical suspicion of dengue and negative for the NS1 antigen in Paraguay
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);15(1):7-15, abr. 2017. ilus.
Idioma: es.
Resumo: Los flavivirus son responsables de una considerable morbi-mortalidad a nivel mundial. Entre ellos, el virus del dengue (DENV) es causante de graves problemas de salud pública en Paraguay. El objetivo del estudio fue detectar infecciones por flavivirus a través de una reacción de RT-nested PCR genérica para flavivirus en 195 muestras de individuos con sospecha de dengue, negativos por el test inmunocromatográfico (antígeno NS1 ­ DENV), provenientes del área metropolitana de Asunción entre 2011 y 2013. Las muestras positivas para flavivirus fueron sometidas a dos reacciones de RT-nested PCRs específicas para DENV. El límite de detección (LD) para flavivirus fue de 0,2 UFP/reacción. En total 43/195 muestras fueron positivas para flavivirus. De estas, 38/43 (88,4%) correspondieron a DENV (6 DENV-1, 30 DENV-2 y 2 DENV-3). Además, 5/43 casos (11,6%) positivos para flavivirus fueron negativos para DENV por ambas reacciones específicas, pudiendo deberse a infecciones por otros flavivirus. Los resultados sugieren que la utilización de una reacción genérica seguida de otras reacciones específicas para DENV en casos febriles negativos para NS1 por el método inmunocromatográfico permitiría detectar más casos de infecciones por DENV y además, podría contribuir a la identificación de casos debido a infecciones por otros flavivirus.

Flaviviruses are responsible for considerable worldwide morbidity and mortality. Among them, the dengue virus (DENV) causes serious public health problems in Paraguay. The objective of the study was to detect flavivirus infections using a generic RT-nested -PCR in 195 samples of individuals with suspected dengue and negative for the inmunochromatographic test (NS1 antigen ­ DENV), from the metropolitan area of Asuncion between 2011 and 2013. The flavivirus-positive samples were subjected to two reactions of DENV-specific RT-nested PCRs. The detection limit (DL) for flavivirus was 0.2 PFU / reaction. In total, 43/195 samples were positive for flavivirus. Of them, 38/43 (88,4%) corresponded to DENV (6 DENV-1, 30 DENV-2 and 2 DENV-3). In addition, 5/43 cases (11.6%) positive for flavivirus were negative for DENV by both specific reactions, and may be infections caused by other flaviviruses. The results suggest that the use of a generic reaction followed by other DENV specific reactions in febrile negative cases for NS1 by the immunochromatographic method would allow the detection of more cases of DENV infections and could contribute to the identification of cases due to infections by others flaviviruses.
Descritores: Infecções por Flavivirus/diagnóstico
Vírus da Dengue/isolamento & purificação
Flavivirus/isolamento & purificação
-Paraguai
Estudos Transversais
Genoma Viral
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Vírus da Dengue/genética
Vírus da Dengue/imunologia
Febre
Flavivirus/genética
Antígenos Virais/isolamento & purificação
Limites: Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Estudo Observacional
Responsável: PY3.1 - Biblioteca


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Id: biblio-894923
Autor: Freire, Caio César de Melo; Palmisano, Giuseppe; Braconi, Carla T; Cugola, Fernanda R; Russo, Fabiele B; Beltrão-Braga, Patricia CB; Iamarino, Atila; Lima Neto, Daniel Ferreira de; Sall, Amadou Alpha; Rosa-Fernandes, Livia; Larsen, Martin R; Zanotto, Paolo Marinho de Andrade.
Título: NS1 codon usage adaptation to humans in pandemic Zika virus
Fonte: Mem. Inst. Oswaldo Cruz;113(5):e170385, 2018. tab, graf.
Idioma: en.
Projeto: FAPESP; . CNPq; . FAPESP; . FAPESP; . FAPESP; . FAPESP; . FAPESP.
Resumo: BACKGROUND Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome. OBJECTIVES To better understand the recent and rapid expansion of ZIKV, as well as the presentation of novel complications, we compared the genetic differences between the African sylvatic lineage and the Asian epidemic lineage that caused the recent massive outbreaks. FINDINGS The epidemic lineages have significant codon adaptation in NS1 gene to translate these proteins in human and Aedes aegypti mosquito cells compared to the African zoonotic lineage. Accordingly, a Brazilian epidemic isolate (ZBR) produced more NS1 protein than the MR766 African lineage (ZAF) did, as indicated by proteomic data from infections of neuron progenitor cells-derived neurospheres. Although ZBR replicated more efficiently in these cells, the differences observed in the stoichiometry of ZIKV proteins were not exclusively explained by the differences in viral replication between the lineages. MAIN CONCLUSIONS Our findings suggest that natural, silent translational selection in the second half of 20th century could have improved the fitness of Asian ZIKV lineage in human and mosquito cells.
Descritores: Proteínas não Estruturais Virais/genética
Infecção por Zika virus/epidemiologia
Infecção por Zika virus/virologia
-Brasil/epidemiologia
Códon
Genoma Viral
Responsável: BR1.1 - BIREME



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