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Id: biblio-1138564
Autor: Quino, Willi; Hurtado, Carmen V; Meza, Ana María; Zamudio, María Luz; Gavilan, Ronnie G.
Título: Patrones de resistencia a los antimicrobianos en serovares de Salmonella enterica en Perú, 2012-2015 / Patterns of resistance to antimicrobials in serovars of Salmonella enterica in Peru, 2012-2015
Fonte: Rev. chil. infectol;37(4):395-401, ago. 2020. tab, graf.
Idioma: es.
Resumo: Resumen Introducción: La salmonelosis es una zoonosis universal, causante de frecuentes brotes de enfermedades transmitidas por alimentos; Salmonella enterica es la especie con la mayor prevalencia, describiéndose un aumento progresivo de su resistencia a antimicrobianos. Objetivo: Determinar la frecuencia de serotipos y los patrones de resistencia antimicrobiana en aislados de S. enterica remitidos al Instituto Nacional de Salud, Lima, Perú. Materiales y Métodos: Se realizó un estudio descriptivo, transversal. Se incluyeron en el estudio todas las cepas remitidas como parte de la vigilancia nacional basada en laboratorio entre los años 2012 y 2015. Las cepas fueron confirmadas mediante pruebas convencionales y serotipificadas por el esquema de Kauffmann-White; la susceptibilidad antimicrobiana y la confirmación del fenotipo BLEE se realizó según el método de Kirby-Bauer y método de Jarlier. Resultados: Un total de 540 cepas de S. enterica fueron incluidos en el estudio, de las que 96% (520/540) correspondió a cepas de origen humano y 4% (20/540) de origen no humano (aves, alimentos y ambiental). En muestras humanas, el serovar más frecuente fue S. Infantis (57%), seguido de S. Enteritidis (27%) y S. Typhimurium (6%). Se encontró una alta resistencia a nitrofurantoína (74%), ácido nalidíxico (64%), ciprofloxacina (63%), tetraciclina (63%), ampicilina (56%), cotrimoxazol (56%), cefotaxima (53%) y cloranfenicol (50%). En muestras no humanas, el serotipo más frecuente fue S. Infantis (45%), seguido de S. Typhimurium (40%) y S. Enteritidis (10%). encontrándose una alta resistencia a ciprofloxacina (45%), cotrimoxazol (40%), y tetraciclina (40%). El 65% del total de las cepas presentó resistencia a más de dos antimicrobianos, 43,3% fueron productoras de BLEE y 99% de éstas presentaron resistencia a entre seis y ocho antimicrobianos. Conclusiones: Se encontró una alta frecuencia de Salmonella Infantis productoras de BLEE, con multi-resistencia a los antimicrobianos en los aislados de muestras humanas y no humanas recibidas en el Instituto Nacional de Salud.

Abstract Background: Salmonellosis is a universal zoonosis, causing frequent outbreaks of foodborne illness; Salmonella enterica is the species with the highest prevalence, a progressive increase in its resistance to antimicrobials is described. Aim: To determine the frequency of serovars and antimicrobial resistance patterns in S. enterica isolates submitted to the National Institute of Health, Lima, Peru. Methods: This is a cross-sectional study. All strains referred as part of national laboratory-based surveillance between 2012 and 2015 were included in the study. Strains were confirmed by conventional tests and serotyped by the Kauffmann-White scheme; antimicrobial susceptibility and confirmation of the BLEE phenotype was performed according to the method of Kirby-Bauer and Jarlier's method. Results: A total of 540 strains of S. enterica were included in the study, where 96% (520/540) corresponded to human strains and 4% (20/540) to non-human strains (birds, food and environmental). In human samples, the most frequent serovar was S. Infantis (57%), followed by S. Enteritidis (27%) and S. Typhimurium (6%). High resistance to nitrofurantoin (74%), nalidixic acid (64%), ciprofloxacin (63%), tetracycline (63%), ampicillin (56%), sulfamethoxazole-trimethoprim (56%), cefotaxime (53%) and chloramphenicol (50%) was detected. In non-human samples, the most frequent serotype was S. Infantis (45%), followed by S. Typhimurium (40%) and S. Enteritidis (10%); a high resistance to nalidixic acid (55%), ciprofloxacin (45%), sulfamethoxazole-trimethoprim (40%), nitrofurantoin (40%), tetracycline (40%) was found. 65% of all strains had resistance to more than two antibiotics, 43,3% were ESBL producers and 99% of these had resistance between six and eight antibiotics. Conclusions: We found a high frequency of S. Infantis producing ESBL with multi-resistance to the antimicrobials in human and nonhuman samples received by the National Institute of Health.
Descritores: Salmonella enterica/efeitos dos fármacos
-Peru/epidemiologia
Testes de Sensibilidade Microbiana
Estudos Transversais
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Sorogrupo
Antibacterianos/farmacologia
Responsável: CL1.1 - Biblioteca Central


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Id: lil-709042
Autor: Arroyave, Yeni; Agudelo, Hanier; Rojas, Alexei.
Título: Caracterización de un brote de infección o colonización por Acinetobacter baumannii, en el Hospital Universitario San José, ESE, Popayán, Colombia / Characterization of an Acinectobacter baumannii infection outbreak at San José University Hospital, Popayán, Colombia
Fonte: Rev. colomb. cir;29(1):42-49, ene.-mar. 2014. graf, tab.
Idioma: es.
Resumo: Objetivo. Caracterizar un brote de infección o colonización por Acinetobacter baumannii. Materiales y métodos. Se llevó a cabo un estudio de 37 pacientes con diagnóstico de infección o colonización por A. baumannii hecho por cultivo positivo para dicho germen, entre enero de 2009 y diciembre de 2010. Los pacientes fueron caracterizados sociodemográfica y clínicamente. Se describió la frecuencia de potenciales factores de riesgo para infección o colonización por A. baumannii. Resultados. El 86 % de los pacientes presentó algún tipo de farmacorresistencia múltiple, siendo la más común la extendida a los carbapenems. Los potenciales factores de riesgo para infección o colonización más frecuentemente encontrados, fueron procedimientos invasivos (100 %), hospitalización en la unidad de cuidados intensivos (89,2 %), estancia hospitalaria prolongada (75,6 %), infección previa por otro microorganismo (51,4 %) y desnutrición (40,5 %). En cuanto a los potenciales factores de riesgo para desenlace fatal, se encontraron choque séptico (72,2 %), aislamientos con farmacorresistencia múltiple (86 %) y más de un aislamiento de A. baumannii. Conclusiones. Los principales hallazgos de este trabajo fueron la presencia de farmacorresistencia múltiple y de potenciales factores de riesgo para infección o colonización por A. baumannii en la población estudiada. La mortalidad fue de 48,4 %, principalmente por choque séptico (72,2 %), similar a lo descrito por otros autores. Las estrategias de reforzamiento de la limpieza y desinfección, especialmente la higiene de manos, han demostrado ser medidas efectivas para la prevención y el control de brotes por A. baumannii, por lo cual se recomienda la implementación y el estricto cumplimiento de dichas estrategias en el medio hospitalario.

Materials and methods: This is a case series of 37 patients with the diagnosis of infection/colonization by Acinetobacter baumannii by positive culture for this organism that occurred between January 2009 and December 2010. Patients were characterized clinically, socially and demographically. The frequency and potential risk factors for infection/colonization by Acinetobacter baumannii are described. Results: 86% of patients had some type of multidrug resistance, the most common being resistant to carbapenems. Potential risk factors most frequently found were: invasive procedures (100%), ICU stay (89.2%), prolonged hospital stay (75.6%), previous infection with another microorganism (51.4%), and malnutrition (40.5%). As for potential risk factors for fatal outcome we found: septic shock (72.2%), multidrug isolates (86%), and more than one isolate of Acinetobacter baumannii. Conclusions and recommendations: The main findings of this study were the presence of multidrug resistance and potential risk factors for infection/colonization by Acinetobacter baumannii in the study population. Mortality rate was 48.4%, due mainly to septic shock (72.2%), similar to that described by other authors. Strategies to reinforce the cleaning and disinfection, especially hand hygiene measures, have proven effective for the prevention and control of outbreaks by Acinetobacter baumannii; therefore, the implementation and strict compliance of these strategies are recommended in the hospital setting.
Descritores: Farmacorresistência Bacteriana Múltipla
Acinetobacter baumannii
-Infecções por Acinetobacter
Surtos de Doenças
Resistência a Múltiplos Medicamentos
Bactérias Aeróbias Gram-Negativas
Responsável: CO113


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Id: biblio-991369
Autor: Aravena, Carmen; Valencia, Bárbara; Villegas, Andrea; Ortega, Mauricio; Fernández R, Alda; Araya R, Pamela; Saavedra, Aníbal; Del Campo, Rosa.
Título: Caracterización de cepas clínicas y ambientales de Salmonella enterica subsp. enterica serovar Heidelberg aisladas en Chile / Characterization of Salmonella Heidelberg strains isolated in Chile
Fonte: Rev. méd. Chile;147(1):24-33, 2019. tab.
Idioma: es.
Projeto: Dirección de Investigación Universidad de Valparaíso.
Resumo: Background: Salmonella Heidelberg (S. Heidelberg) causes gastroenteritis and sometimes bacteremia and endocarditis. In other countries, this serovar has multidrug resistance including extended-spectrum β-lactamases (ESBLs) and AmpC (β-lactamases (AmpC), associated with the blaCMY-2 gene. In Chile, an outbreak by S. Heidelberg occurred in 2011, the phenotypic and genetic characteristics of Chilean strains are unknown. Aim: To determine the antimicrobial susceptibility, presence of plasmids and virulence factor genes in S. Heidelberg strains isolated in Chile over the period 2006-2011. Material and Methods: In sixty-one S. Heidelberg clinical and environmental strains collected by the Public Health Institute in Chile during 2006-2011, antimicrobial susceptibility, plasmids and virulence factor genes (invA, sifA, pefA, agfA, lpfA and, stkD) were studied. Results: S. Heidelberg had a high susceptibility to sulfamethoxazole-trimethoprim, gentamicin, ceftriaxone, ceftiofur, chloramphenicol, amoxicillin-clavulanic acid and ampicillin. However, 52% had decreased susceptibility to ciprofloxacin and 33% resistance to tetracycline. ESBLs were detected in three strains isolated from blood cultures, environment and human feces. The latter strain was positive for AmpC and blaCMY-2 gene. Fifty three of 61 strains showed one to seven plasmids of 0.8 to approximately 30 kb. Most plasmids were small with sizes between 0.8 and 2 kb. All isolates were positive for all genes except pefA. Conclusions: S. Heidelberg isolated from Chilean samples was susceptible to first-line antimicrobials, except tetracycline and ciprofloxacin. The emergence of strains with ESBLs and AmpC should be a warning. The strains were homogeneous for virulence genes, but heterogeneous in their plasmids.
Descritores: Plasmídeos/isolamento & purificação
Salmonella/isolamento & purificação
Salmonella/efeitos dos fármacos
Antibacterianos/farmacologia
-Valores de Referência
Salmonella/genética
Salmonella/patogenicidade
Fatores de Tempo
Virulência
DNA Bacteriano
Testes de Sensibilidade Microbiana
Chile
Eletroforese em Gel de Campo Pulsado
Farmacorresistência Bacteriana Múltipla
Microbiologia Ambiental
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1171772
Autor: Guerrero Elba; Lemus Dihadenys; Yzquierdo Sergio; Vílchez Glenda; Muñoz Mariana; Montoro Ernesto; Takiff Howard.
Título: Association between embB mutations and ethambutol resistance in Mycobacterium tuberculosis isolates from Cuba and the Dominican Republic: reproducible patterns and problems / Association between embB mutations and ethambutol resistance in Mycobacterium tuberculosis isolates from Cuba and the Dominican Republic: reproducible patterns and problems.
Fonte: Rev. argent. microbiol;45(1):21-6, mar. 2013.
Idioma: es.
Resumo: The relation of ethambutol resistance to embB mutations remains unclear, and there are no reports on ethambutol resistance from the caribbean. We examined the sequence of embB in 57 distinct Multi-Drug Resistant (MDR) and non-MDR strains of Mycobacterium tuberculosis, mostly from Cuba and the Dominican Republic. embB306 codon mutations were found exclusively in MDR-TB, but in both ethambutol sensitive and resistant strains. Valine substitutions predominated in ethambutol resistant strains, while isoleucine replacements were more common in sensitive strains. Three ethambutol resistant MDR strains without embB306 substitutions had replacements in embB406 or embB497, but these were also found in ethambutol sensitive MDR strains. The results confirm previous findings that amino acid substitutions in EmbB306, EmbB406 and EmbB497 are found only in MDR-TB strains but in both phenotypically resistant and sensitive strains. One ethambutol resistant non-MDR strain did not have any embB mutation suggesting that other undefined mutations can also confer ethambutol resistance.
Descritores: Antituberculosos/farmacologia
Etambutol/farmacologia
Mycobacterium tuberculosis/genética
Pentosiltransferases/genética
Resistência Microbiana a Medicamentos/genética
Tuberculose Resistente a Múltiplos Medicamentos/microbiologia
-Análise Mutacional de DNA
Cuba/epidemiologia
Códon/genética
DNA Bacteriano/genética
Farmacorresistência Bacteriana Múltipla/genética
Humanos
Mutação
Mycobacterium tuberculosis/efeitos dos fármacos
Pentosiltransferases/fisiologia
Relação Dose-Resposta a Droga
Reprodutibilidade dos Testes
República Dominicana/epidemiologia
Sensibilidade e Especificidade
Substituição de Aminoácidos
Testes de Sensibilidade Microbiana
Tuberculose Resistente a Múltiplos Medicamentos/epidemiologia
Tipo de Publ: Estudo Comparativo
Artigo de Revista
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Responsável: AR5.1 - Centro de Gestión del Conocimiento y las Comunicaciónes


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Id: biblio-1171769
Autor: Busquets Natalia P; Baroni María R; Ochoteco María C; Zurbriggen María L; Virgolini Stella; Meneghetti Fernando G.
Título: Aislamientos bacterianos de muestras respiratorias de pacientes pediátricos con fibrosis quística y su distribución por edades / [Bacterial isolates from respiratory samples of pediatric patients with cystic fibrosis and their distribution by ages].
Fonte: Rev. argent. microbiol;45(1):44-9, mar. 2013.
Idioma: es.
Resumo: The bacterial isolates from respiratory samples of 50 pediatric patients with cystic fibrosis, their distribution by ages and antimicrobial resistance pattern as well as the intermittence of isolations and coinfections, were investigated. Staphylococcus aureus was isolated in 72

of patients, followed by Pseudomonas aeruginosa (58

), and the Burkholderia cepacia complex (12

). The frequency of resistance of P. aeruginosa isolates to ß-lactam antibiotics was low (13.8

). Fifty percent of S. aureus isolates was methicillin-resistant, and 57.1

of H. influenza was ampicillin resistant due to ß-lactamase production. In children under 4 years-old, S. aureus was predominant, followed by P. aeruginosa and H. influenzae. This order of predominance was observed in all the groups studied, except in that of children between 10 and 14 years-old. Stenotrophomonas maltophilia and Achromobacter xylosoxidans isolates were intermittent and accompanied by other microorganisms. Finally, we observed a great variety of bacterial species, which imposes stringent performance requirements for microbiological studies in all respiratory samples of these patients.
Descritores: Bactérias Gram-Negativas/isolamento & purificação
Fibrose Cística/complicações
Infecções Respiratórias/microbiologia
Sistema Respiratório/microbiologia
Staphylococcus aureus/isolamento & purificação
-Adolescente
Bactérias Gram-Negativas/efeitos dos fármacos
Coinfecção/epidemiologia
Coinfecção/microbiologia
Criança
Escarro/microbiologia
Especificidade da Espécie
Estudos Retrospectivos
Faringe/microbiologia
Farmacorresistência Bacteriana Múltipla
Fatores Etários
Feminino
Fibrose Cística/microbiologia
Humanos
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/etiologia
Infecções Estafilocócicas/microbiologia
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/etiologia
Infecções por Bactérias Gram-Negativas/epidemiologia
Infecções por Bactérias Gram-Negativas/etiologia
Infecções por Bactérias Gram-Negativas/microbiologia
Lactente
Masculino
Nasofaringe/microbiologia
Pré-Escolar
Tipo de Publ: Resumo em Inglês
Artigo de Revista
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Responsável: AR5.1 - Centro de Gestión del Conocimiento y las Comunicaciónes


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Id: biblio-1171768
Autor: Manias Valeria; Nagel Alicia; Mollerach Analía; Mendosa María A; Freyre Hugo; Gómez Abel; Ferrara Elisa; Vay Carlos; de Los A Méndez Emilce.
Título: Endocarditis por Brucella canis: primer caso documentado en un paciente adulto en Argentina / [Brucella canis endocarditis: first documented case in Argentina].
Fonte: Rev. argent. microbiol;45(1):50-3, mar. 2013.
Idioma: es.
Resumo: We herein present the case of an adult male patient who consulted for lower extremity edema, a 2- month history of fever and oppressive chest pain radiating to the left arm. He referred neither contact with breeding animals nor consumption of unpasteurized dairy products. A diagnosis of endocarditis was confirmed by cardiac studies. Since the empirical treatment with cephalotin, ampicillin and gentamicin failed, the patient underwent aortic valve replacement. A total of four blood cultures were positive with a gram-negative rod. Bacterial identification was performed using the API 20 NE technique (bioMÞrieux), the Phoenix automated method (BD) and conventional biochemical tests which were unable to classify the isolate as to genus and species. The strain was sent to the INEI-ANLIS "Dr. Carlos G. Malbrán" where it was identified as Brucella canis. The antimicrobial treatment was switched to doxycycline, rifampicin and trimethoprim-sulfamethoxazole with good evolution of the patient. The clinical significance of this case report lies in the possible failure of the empiric antibiotic therapy administered for endocarditis, since B. canis did not respond to the conventional antimicrobial treatment for this pathology.
Descritores: Brucella canis/isolamento & purificação
Brucelose/microbiologia
Endocardite Bacteriana/microbiologia
-Adulto
Argentina/epidemiologia
Bacteriemia/microbiologia
Brucella canis/efeitos dos fármacos
Brucelose/cirurgia
Brucelose/epidemiologia
Brucelose/tratamento farmacológico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
Dor no Peito/etiologia
Doxiciclina/uso terapêutico
Edema/etiologia
Endocardite Bacteriana/cirurgia
Endocardite Bacteriana/epidemiologia
Endocardite Bacteriana/tratamento farmacológico
Farmacorresistência Bacteriana Múltipla
Febre/etiologia
Humanos
Implante de Prótese de Valva Cardíaca
Masculino
Rifampina/uso terapêutico
Terapia Combinada
Técnicas de Tipagem Bacteriana
Valva Aórtica/cirurgia
Valva Aórtica/microbiologia
Tipo de Publ: Relatos de Casos
Resumo em Inglês
Artigo de Revista
Responsável: AR5.1 - Centro de Gestión del Conocimiento y las Comunicaciónes


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Id: lil-780813
Autor: Café Oliveira, Luita Nice; Muniz-Sobrinho, Jairo da Silva; Viana-Magno, Luiz Alexandre; Oliveira Melo, Sônia Cristina; Macho, Antonio; Rios-Santos, Fabrício.
Título: Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes
Fonte: Braz. j. infect. dis;20(2):166-172, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Multidrug-resistant tuberculosis (MDRTB) is a serious world health problem that limits public actions to control tuberculosis, because the most used anti-tuberculosis first-line drugs fail to stop mycobacterium spread. Consequently, a quick detection through molecular diagnosis is essential to reduce morbidity and medical costs. Despite the availability of several molecular-based commercial-kits to diagnose multidrug-resistant tuberculosis, their diagnostic value might diverge worldwide since Mycobacterium tuberculosis genetic variability differs according to geographic location. Here, we studied the predictive value of four common mycobacterial mutations in strains isolated from endemic areas of Brazil. Mutations were found at the frequency of 41.9% for katG, 25.6% for inhA, and 69.8% for rpoB genes in multidrug-resistant strains. Multimarker analysis revealed that combination of only two mutations (“katG/S315T + rpoB/S531L”) was a better surrogate of multidrug-resistant tuberculosis than single-marker analysis (86% sensitivity vs. 62.8%). Prediction of multidrug-resistant tuberculosis was not improved by adding a third or fourth mutation in the model. Therefore, rather than using diagnostic kits detecting several mutations, we propose a simple dual-marker panel to detect multidrug-resistant tuberculosis, with 86% sensitivity and 100% specificity. In conclusion, this approach (previous genetic study + analysis of only prevalent markers) would considerably decrease the processing costs while retaining diagnostic accuracy.
Descritores: Proteínas de Bactérias/genética
RNA Polimerases Dirigidas por DNA/genética
Catalase/genética
Farmacorresistência Bacteriana Múltipla/genética
Isoniazida/farmacologia
Antituberculosos/farmacologia
-Rifampina/farmacologia
DNA Bacteriano
Testes de Sensibilidade Microbiana
Marcadores Genéticos
Reação em Cadeia da Polimerase
Valor Preditivo dos Testes
Sensibilidade e Especificidade
Tuberculose Resistente a Múltiplos Medicamentos/microbiologia
Genótipo
Mutação/genética
Mycobacterium tuberculosis/efeitos dos fármacos
Mycobacterium tuberculosis/genética
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Estudo de Validação
Responsável: BR1.1 - BIREME


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Id: lil-789481
Autor: Pereira, Jussyêgles Niedja da Paz; Rabelo, Marcelle Aquino; Lima, Jailton Lobo da Costa; Neto, Armando Monteiro Bezerra; Lopes, Ana Catarina de Souza; Maciel, Maria Amélia Vieira.
Título: Phenotypic and molecular characterization of resistance to macrolides, lincosamides and type B streptogramin of clinical isolates of Staphylococcus spp. of a university hospital in Recife, Pernambuco, Brazil
Fonte: Braz. j. infect. dis;20(3):276-281, May.-June 2016. tab, graf.
Idioma: en.
Resumo: Abstract Introduction There is a mechanism of macrolide resistance in Staphylococcus spp. which also affects the lincosamides and type B streptogramins characterizing the so-called MLSB resistance, whose expression can be constitutive (cMLSB) or inducible (iMLSB) and is encoded mainly by ermA and ermC genes. The cMLSB resistance is easily detected by susceptibility testing used in the laboratory routine, but iMLSB resistance is not. Therapy with clindamycin in cases of infection with isolated iMLSB resistance may fail. Objective To characterize the phenotypic (occurrence of cMLSB and iMLSB phenotypes) and molecular (occurrence of ermA and ermC genes) profiles of MLSB resistance of clinical isolates of susceptible and methicillin-resistant Staphylococcus aureus and CNS (coagulase-negative Staphylococcus) from patients of a university hospital, in Pernambuco. Methods The antimicrobial susceptibility of 103 isolates was determined by the disk diffusion technique in Mueller–Hinton agar followed by oxacillin screening. The iMLSB phenotype was detected by D test. Isolates with cMLSB and iMLSB phenotypes were subjected to polymerase chain reaction (PCR) for the detection of ermA and ermC genes. Results The cMLSB and iMLSB phenotypes were respectively identified in 39 (37.9%) and five (4.9%) isolates. The iMLSB phenotype was found only in four (10.8%) methicillin-susceptible S. aureus and one (4.5%) methicillin-resistant S. aureus. In the 44 isolates subjected to PCR, four (9.1%) only ermA gene was detected, a lower frequency when compared to only ermC 17 (38.6%) gene and to one (2.3%) isolate presenting both genes. Conclusion In the Staphylococcus spp. analyzed, the ermC gene was found more often than the ermA, although the iMLSB phenotype had been less frequent than the cMLSB. It was important to perform the D test for its detection to guide therapeutic approaches.
Descritores: Staphylococcus/efeitos dos fármacos
Staphylococcus/genética
Macrolídeos/farmacologia
Estreptogramina B/farmacologia
Farmacorresistência Bacteriana Múltipla/genética
Lincosamidas/farmacologia
-Fenótipo
Brasil
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Genes Bacterianos/genética
Hospitais Universitários
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-828144
Autor: Souza-Oliveira, Ana Carolina; Cunha, Thúlio Marquez; Passos, Liliane Barbosa da Silva; Lopes, Gustavo Camargo; Gomes, Fabiola Alves; Röder, Denise Von Dolinger de Brito.
Título: Ventilator-associated pneumonia: the influence of bacterial resistance, prescription errors, and de-escalation of antimicrobial therapy on mortality rates
Fonte: Braz. j. infect. dis;20(5):437-443, Sept.-Oct. 2016. tab.
Idioma: en.
Resumo: Abstract Ventilator-associated pneumonia is the most prevalent nosocomial infection in intensive care units and is associated with high mortality rates (14–70%). Aim This study evaluated factors influencing mortality of patients with Ventilator-associated pneumonia (VAP), including bacterial resistance, prescription errors, and de-escalation of antibiotic therapy. Methods This retrospective study included 120 cases of Ventilator-associated pneumonia admitted to the adult adult intensive care unit of the Federal University of Uberlândia. The chi-square test was used to compare qualitative variables. Student's t-test was used for quantitative variables and multiple logistic regression analysis to identify independent predictors of mortality. Findings De-escalation of antibiotic therapy and resistant bacteria did not influence mortality. Mortality was 4 times and 3 times higher, respectively, in patients who received an inappropriate antibiotic loading dose and in patients whose antibiotic dose was not adjusted for renal function. Multiple logistic regression analysis revealed the incorrect adjustment for renal function was the only independent factor associated with increased mortality. Conclusion Prescription errors influenced mortality of patients with Ventilator-associated pneumonia, underscoring the challenge of proper Ventilator-associated pneumonia treatment, which requires continuous reevaluation to ensure that clinical response to therapy meets expectations.
Descritores: Prescrições de Medicamentos
Farmacorresistência Bacteriana Múltipla
Pneumonia Associada à Ventilação Mecânica/etiologia
Pneumonia Associada à Ventilação Mecânica/mortalidade
Erros de Medicação/efeitos adversos
Antibacterianos/uso terapêutico
-Brasil
Distribuição de Qui-Quadrado
Modelos Logísticos
Registros Médicos
Estudos Retrospectivos
Fatores de Risco
Mortalidade Hospitalar
Relação Dose-Resposta a Droga
Pneumonia Associada à Ventilação Mecânica/tratamento farmacológico
Unidades de Terapia Intensiva
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-828146
Autor: Gavriliu, Liana-Catalina; Popescu, Gabriel-Adrian; Popescu, Cristina.
Título: Antimicrobial resistance of Pseudomonas aeruginosa in a Romanian hospital at the dawn of multidrug resistance
Fonte: Braz. j. infect. dis;20(5):509-510, Sept.-Oct. 2016. tab.
Idioma: en.
Projeto: EUFISCDI.
Descritores: Pseudomonas aeruginosa/efeitos dos fármacos
Farmacorresistência Bacteriana Múltipla
Antibacterianos/farmacologia
-Pseudomonas aeruginosa/isolamento & purificação
Infecções por Pseudomonas/tratamento farmacológico
Valores de Referência
Romênia
Hospitais
Limites: Humanos
Tipo de Publ: Carta
Responsável: BR1.1 - BIREME



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