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Pesquisa : G06.225.383 [Categoria DeCS]
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Id: biblio-1038269
Autor: Fay, Vanessa da Silva; Rodrigues, Diana Mara Garcia; Gonçalves, Stela Maris Bottin; Gregianini, Tatiana Schaffer; Bonamigo, Renan Rangel.
Título: Drug susceptibility in emerging fungal infections: tests with fluconazole, itraconazole, and amphotericin B
Fonte: An. bras. dermatol;93(3):462-464, May-June 2018. tab.
Idioma: en.
Resumo: Abstract: The number of new cases of emerging fungal infections has increased considerably in recent years, mainly due to the large number of immunocompromised individuals. The objective of this study was to evaluate the susceptibility of emerging fungi to fluconazole, itraconazole and amphotericin B by disk diffusion method. In 2015, 82 emerging fungi were evaluated in IPB-LACEN/RS and 13 (15.8%) were resistant: 10/52 were from superficial mycoses and 3/30 from systemic mycoses. The data from the study point to the need for permanent vigilance regarding the careful evaluation in the prescription and clinical and laboratory follow-up of patients affected by fungal infections.
Descritores: Farmacorresistência Fúngica
Fungos/efeitos dos fármacos
Antifúngicos/uso terapêutico
-Testes de Sensibilidade Microbiana
Fluconazol/uso terapêutico
Infecções por HIV/complicações
Anfotericina B/uso terapêutico
Itraconazol/uso terapêutico
Fungos/isolamento & purificação
Micoses/microbiologia
Micoses/tratamento farmacológico
Antifúngicos/farmacologia
Limites: Seres Humanos
Masculino
Feminino
Adulto
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-828190
Autor: Ribas e Ribas, Aícha Daniela; Spolti, Pierri; Del Ponte, Emerson Medeiros; Donato, Katarzyna Zawada; Schrekker, Henri; Fuentefria, Alexandre Meneghello.
Título: Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review
Fonte: Braz. j. microbiol;47(4):793-799, Oct.-Dec. 2016. tab.
Idioma: en.
Resumo: Abstract Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments.
Descritores: Triazóis/envenenamento
Ecossistema
Farmacorresistência Fúngica
Agricultura
Fungos/efeitos dos fármacos
Antifúngicos/farmacologia
-Doenças das Plantas/microbiologia
Triazóis/uso terapêutico
Fungos/fisiologia
Fungicidas Industriais
Micoses/microbiologia
Micoses/tratamento farmacológico
Antifúngicos/uso terapêutico
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-828210
Autor: Waller, Stefanie Bressan; Madrid, Isabel Martins; Ferraz, Vanny; Picoli, Tony; Cleff, Marlete Brum; de Faria, Renata Osório; Meireles, Mário Carlos Araújo; de Mello, João Roberto Braga.
Título: Cytotoxicity and anti-Sporothrix brasiliensis activity of the Origanum majorana Linn. oil
Fonte: Braz. j. microbiol;47(4):896-901, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract The study aimed to evaluate the anti-Sporothrix sp. activity of the essential oil of Origanum majorana Linn. (marjoram), its chemical analysis, and its cytotoxic activity. A total of 18 fungal isolates of Sporothrix brasiliensis (n: 17) from humans, dogs and cats, and a standard strain of Sporothrix schenckii (n: 1) were tested using the broth microdilution technique (Clinical and Laboratory Standard Institute - CLSI M27-A3) and the results were expressed in minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC). The MIC50 and MIC90 of itraconazole against S. brasiliensis were 2 µg/mL and 8 µg/mL, respectively, and the MFC50 and MFC90 were 2 µg/mL and >16 µg/mL, respectively, with three S. brasiliensis isolates resistant to antifungal. S. schenckii was sensitive at MIC of 1 µg/mL and MFC of 8 µg/mL. For the oil of O. majorana L., all isolates were susceptible to MIC of ≤2.25-9 mg/mL and MFC of ≤2.25-18 mg/mL. The MIC50 and MIC90 were ≤2.25 mg/mL and 4.5 mg/mL, respectively, and the MFC50/90 values were twice more than the MIC. Twenty-two compounds were identified by gas chromatography with a flame ionization detector (CG-FID) and 1,8-cineole and 4-terpineol were the majority. Through the colorimetric (MTT) assay, the toxicity was observed in 70-80% of VERO cells between 0.078 and 5 mg/mL. For the first time, the study demonstrated the satisfactory in vitro anti-Sporothrix sp. activity of marjoram oil and further studies are needed to ensure its safe and effective use.
Descritores: Sporothrix/efeitos dos fármacos
Óleos Voláteis/farmacologia
Antifúngicos/farmacologia
-Esporotricose/microbiologia
Sporothrix/isolamento & purificação
Células Vero
Óleos Voláteis/química
Testes de Sensibilidade Microbiana
Zoonoses/microbiologia
Sobrevivência Celular/efeitos dos fármacos
Cercopithecus aethiops
Farmacorresistência Fúngica
Antifúngicos/química
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-780823
Autor: Savastano, Catarina; Silva, Elisa de Oliveira; Gonçalves, Lindyanne Lemos; Nery, Jéssica Maria; Silva, Naiara Chaves; Dias, Amanda Latercia Tranches.
Título: Candida glabrata among Candida spp. from environmental health practitioners of a Brazilian Hospital
Fonte: Braz. j. microbiol;47(2):367-372, Apr.-June 2016. tab.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de Minas Gerais.
Resumo: Abstract The incidence of the species Candida albicans and non-albicans Candida was evaluated in a Brazilian Tertiary Hospital from the environment and health practitioners. In a 12-month period we had a total positivity of 19.65% of Candida spp. The most recurring non-albicans Candida species was C. glabrata (37.62%), generally considered a species of low virulence, but with a higher mortality rate than C. albicans. Subsequently, C. parapsilosis (25.74%) and C. tropicalis (16.86%) were the second and third most commonly isolated species. Considering the total samples collected from the emergency room and from the inpatient and the pediatric sector, 19.10% were positive for Candida spp., with the predominance of non-albicans Candida species (89.42%). The high percentage of positivity occurred in the hands (24.32%) and the lab coats (21.88%) of the health care assistants. No sample of C. albicans presented a profile of resistance to the drugs. All the non-albicans Candida species presented a decreased susceptibility to miconazole and itraconazole, but they were susceptible to nystatin. Most of the isolates were susceptible to fluconazole and amphotericin B. As expected, a high resistance rate was observed in C. glabrata and C. krusei, which are intrinsically less susceptible to this antifungal agent. The contamination of environmental surfaces by Candida spp. through hand touching may facilitate the occurrence of Candida infections predominantly in immunocompromised patients. In addition to that, the antifungal agents used should be carefully evaluated considering local epidemiologic trends in Candida spp. infections, so that therapeutic choices may be better guided.
Descritores: Candida/isolamento & purificação
Candidíase/microbiologia
Testes de Sensibilidade Microbiana
Infecção Hospitalar/microbiologia
Pessoal de Saúde/estatística & dados numéricos
Candida glabrata/isolamento & purificação
Equipamentos e Provisões Hospitalares/microbiologia
-Atenção Terciária à Saúde/estatística & dados numéricos
Brasil/epidemiologia
Candida/classificação
Candida/efeitos dos fármacos
Candida/genética
Candidíase/epidemiologia
Infecção Hospitalar/epidemiologia
Farmacorresistência Fúngica
Candida glabrata/classificação
Candida glabrata/efeitos dos fármacos
Candida glabrata/genética
Hospitais
Hospitais/estatística & dados numéricos
Antifúngicos/farmacologia
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Vicente, Vânia Aparecida
Carvalho, Newton Sérgio de
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Id: lil-780822
Autor: Fornari, Gheniffer; Vicente, Vania Aparecida; Gomes, Renata Rodrigues; Muro, Marisol Dominguez; Pinheiro, Rosangela Lameira; Ferrari, Carolina; Herkert, Patricia Fernanda; Takimura, Marcos; Carvalho, Newton Sérgio de; Queiroz-Telles, Flavio.
Título: Susceptibility and molecular characterization of Candida species from patients with vulvovaginitis
Fonte: Braz. j. microbiol;47(2):373-380, Apr.-June 2016. tab, graf.
Idioma: en.
Resumo: Abstract Vulvovaginal candidiasis affects women of reproductive age, which represents approximately 15–25% of vaginitis cases. The present study aimed to isolate and characterize yeast from the patients irrespective of the presentation of clinical symptoms. The isolates were subjected to in vitro susceptibility profile and characterization by molecular markers, which intended to assess the distribution of species. A total of 40 isolates were obtained and identified through the CHROMagar, API20aux and by ITS and D1/D2 regions sequencing of DNAr gene. Candida albicans strains were genotyped by the ABC system and the isolates were divided into two genotypic groups. The identity of the C. albicans, C. glabrata, C. guilliermondii, C. kefyr and Saccharomyces cerevisiae isolates was confirmed by the multilocus analysis. The strains of Candida, isolated from patients with complications, were found to be resistant to nystatin but sensitive to fluconazole, amphotericin B and ketoconazole, as observed by in vitro sensitivity profile. The isolates from asymptomatic patients, i.e., the colonized group, showed a dose-dependent sensitivity to the anti-fungal agents, fluconazole and amphotericin B. However, the isolates of C. albicans that belong to distinct genotypic groups showed the same in vitro susceptibility profile.
Descritores: Candida/efeitos dos fármacos
Candidíase Vulvovaginal/microbiologia
Antifúngicos/farmacologia
-Pacientes/estatística & dados numéricos
Candida/isolamento & purificação
Candida/classificação
Candida/genética
Testes de Sensibilidade Microbiana
Fluconazol/farmacologia
Farmacorresistência Fúngica
Limites: Seres Humanos
Feminino
Adolescente
Adulto
Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-975604
Autor: Ali, Khaled; Hamed, Mahmood A; Hassan, Hameda; Esmail, Amira; Sheneef, Abeer.
Título: Identification of Fungal Pathogens in Otomycosis and Their Drug Sensitivity: Our Experience
Fonte: Int. arch. otorhinolaryngol. (Impr.);22(4):400-403, Oct.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract Introduction Otomycosis is a common problem in otolaryngology practice. However, we usually encounter some difficulties in its treatment because many patients show resistance to antifungal agents, and present high recurrence rate. Objectives To determine the fungal pathogens that cause otomycosis as well as their susceptibility to the commonly used antifungal agents. Additionally, to discover the main reasons for antifungal resistance. Methods We conducted an experimental descriptive study on 122 patients clinically diagnosed with otomycosis from April 2016 to April 2017. Aural discharge specimens were collected for direct microscopic examination and fungal culture. In vitro antifungal susceptibility testing was performed against the commonly used antifungal drugs. We tested the isolated fungi for their enzymatic activity. Results Positive fungal infection was found in 102 samples. The most common fungal pathogens were Aspergillus and Candida species, with Aspergillus niger being the predominant isolate (51%). The antifungal susceptibility testing showed that mold isolates had the highest sensitivity to voriconazole (93.48%), while the highest resistance was to fluconazole (100%). For yeast, the highest sensitivity was to nystatin (88.24%), followed by amphotericin B (82.35%), and the highest resistance was to terbinafine (100%), followed by Itraconazole (94.12%). Filamentous fungi expressed a high enzymatic ability, making them more virulent. Conclusion The Aspergillus and Candida species are the most common fungal isolates in otomycosis. Voriconazole and Nystatin are the medications of choice for the treatment of otomycosis in our community. The high virulence of fungal pathogens is owed to their high enzymatic activity. Empirical use of antifungals should be discouraged.
Descritores: Farmacorresistência Fúngica
Otomicose/microbiologia
Fungos/isolamento & purificação
Antifúngicos/farmacologia
-Aspergillus/isolamento & purificação
Aspergillus niger/isolamento & purificação
Leveduras/isolamento & purificação
Candida/isolamento & purificação
Testes de Sensibilidade Microbiana
Anfotericina B/farmacologia
Epidemiologia Descritiva
Epidemiologia Experimental
Itraconazol/farmacologia
Voriconazol/farmacologia
/farmacologia
AMERICAN HEART ASSOCIATION9TEMEFOS/farmacologia
Limites: Seres Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-839344
Autor: Brandolt, Tchana Martinez; Klafke, Gabriel Baracy; Gonçalves, Carla Vitola; Bitencourt, Laura Riffel; Martinez, Ana Maria Barral de; Mendes, Josiara Furtado; Meireles, Mário Carlos Araújo; Xavier, Melissa Orzechowski.
Título: Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates
Fonte: Braz. j. microbiol;48(1):145-150, Jan.-Mar. 2017. tab.
Idioma: en.
Resumo: Abstract Vulvovaginal candidiasis (VVC) is an infection of the genital mucosa caused by different species of the genus Candida. Considering the lack of data on this topic in the south of Brazil, this study aimed to assess the prevalence of Candida spp. in the cervical-vaginal mucosa of patients treated at a university hospital in southern Rio Grande do Sul, as well as the etiology and the susceptibility of the isolates against fluconazole, itraconazole, miconazole and nystatin. Samples were collected at the gynecology clinic of the Federal Hospital of the University of Rio Grande, and the isolates were identified using phenotypic and biochemical tests. The susceptibility analysis was performed according to the CLSI M27-A2 protocol. Of the 263 patients included, Candida spp. was isolated in 27%, corresponding to a prevalence of approximately 15% for both VVC and colonization. More than 60% of the isolates were identified as Candida albicans; C. non-albicans was isolated at a rate of 8.6% in symptomatic patients and 14.3% in asymptomatic patients. The prevalence of resistance against fluconazole and itraconazole was 42% and 48%, respectively; the minimal inhibitory concentration of miconazole ranged from 0.031 to 8 µg/mL, and that of nystatin ranged from 2 to >16 µg/mL. The high rate of resistance to triazoles observed in our study suggests the necessity of the association of laboratory exams to clinical diagnosis to minimize the practice of empirical treatments that can contribute to the development of resistance in the isolates.
Descritores: Candida/efeitos dos fármacos
Candidíase Vulvovaginal/microbiologia
Candidíase Vulvovaginal/epidemiologia
-Brasil/epidemiologia
Candida/isolamento & purificação
Candida/classificação
Testes de Sensibilidade Microbiana
Infecções por HIV
Prevalência
Farmacorresistência Fúngica
Antifúngicos/farmacologia
Limites: Seres Humanos
Feminino
Gravidez
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1026420
Autor: Carnovale, S.
Título: Candida auris: un patógeno emergente y multiresistente / Candida auris: An emerging multiresistant pathogen
Fonte: Med. infant;26(3):326-326, sept. 2019.
Idioma: es.
Descritores: Candida/isolamento & purificação
Candida/efeitos dos fármacos
Farmacorresistência Fúngica
/uso terapêutico
FRUCTOSEDIPHOSPHATESABDOMEN/uso terapêutico
-Isolamento de Pacientes
Limites: Seres Humanos
Responsável: AR305.1 - SID - Servicio de Información y Documentación


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Mello, J. R. B
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Id: biblio-1011330
Autor: Peter, C. M; Waller, S. B; Picoli, T; Osório, L. G; Zani, J. L; Meireles, M. C. A; Faria, R. O; Mello, J. R. B; Hubner, S. O; Lima, M; Fischer, G.
Título: Chemical and cytotoxic analyses of three varieties of Brazilian propolis (green propolis, jataí propolis and brown propolis) and its anti-Sporothrix brasiliensis in vitro activity / [Análises químicas e citotóxicas de três variedades de própolis brasileiras (própolis verde, própolis jataí e própolis marrom) e sua atividade in vitro anti-Sporothrix brasiliensis]
Fonte: Arq. bras. med. vet. zootec. (Online);71(3):819-827, May-June 2019. tab, graf.
Idioma: en.
Resumo: In this study, we described the antifungal activity of three Brazilian propolis extracts: brown, green and from jataí bees against Sporothrix brasiliensis. The extracts were obtained from ethanolic extraction and their chemical composition was determined by high-performance liquid chromatography coupled to mass spectrometry. The cellular toxicity was measured in MDBK (Madin-Darby Bovine Kidney) cells and quantified by the MTT assay (3- (4,5 dimethylthiazol-2yl -2,5-diphenyl-2H bromine tetrazolato). For antifungal activity, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined by broth microdilution. The results showed that cell toxicity was not observed at lower concentrations (0.097 to 0.39μg/ml) for all extracts in comparison to cell control. Among the chemical compounds identified, caffeic acid, p-coumaric acid, chlorogenic acid, ferulic acid and rutin were quantified. In antifungal activity, green and jataí did not exhibit activity against the isolates (MIC and MFC greater than 0.78mg/ml). However, all isolates of S. brasiliensis were sensitive to brown propolis (MIC of 0.09 to 0.78mg/ml), including the standard strain (P<0.001). Among the Brazilian propolis studied, the brown propolis showed activity against the S. brasiliensis isolates and more studies should be undertaken in order to evaluate its promising use in the treatment of sporotrichosis.(AU)

Neste estudo, descreveu-se a atividade antifúngica de três extratos de própolis brasileiras: marrom, verde e de abelhas jataí (Tetragonisca angustula), contra Sporothrix brasiliensis. Os extratos foram obtidos de extração etanólica, e a sua composição química foi determinada por cromatografia líquida de alta eficiência, acoplada à espectrometria de massa. A toxicidade celular foi medida em células MDBK (Madin-Darby Bovine Kidney), avaliada por observação microscópica e quantificada pelo ensaio MTT (3- (4,5-dimetiltiazol-2-ilo -2,5-difenil-2H bromo tetrazolato). Para a atividade antifúngica, determinou-se a concentração inibitória mínima (CIM) e a concentração fungicida mínima (CFM) por meio de microdiluição em caldo. Os resultados mostraram que a toxicidade celular não foi observada em concentrações menores (0,097 a 0,39μg/ml). Entre os compostos químicos identificados, foram quantificados o ácido cafeico, ácido p-cumárico, ácido clorogênico, ácido ferúlico e a rutina. Na atividade antifúngica, as própolis verde e jataí não apresentaram atividade contra os isolados (CIM e CFM maior que 0,78mg/ml), porém todos os isolados de S. brasiliensis foram sensíveis à própolis marrom (CIM de 0,09 a 0,78mg/ml), incluindo a cepa padrão (P<0,001). Entre as própolis brasileiras estudadas, a marrom mostrou atividade contra S. brasiliensis, e mais estudos devem ser realizados para avaliar seu uso promissor no tratamento da esporotricose.(AU)
Descritores: Própole/análise
Própole/uso terapêutico
Sporothrix/isolamento & purificação
-Itraconazol/uso terapêutico
Farmacorresistência Fúngica
Apiterapia/veterinária
Antifúngicos/análise
Limites: Seres Humanos
Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-995036
Autor: Barahona-Correa, Julian Esteban; Calvo-Valderrama, María Gabriela; Romero-Alvernia, Diana Marcela; Angulo-Mora, Juliana; Alarcón-Figueroa, Luisa Fernanda; Rodríguez-Malagón, María Nelcy; Garzón-Herazo, Javier Ricardo.
Título: Epidemiology of Candidemia at a University Hospital in Colombia, 2008-2014 / Epidemiología de los casos de candidemia en un hospital universitario en Colombia, 2008-2014
Fonte: Univ. med;60(1), 2019. tab.
Idioma: en.
Resumo: Introducción: Candida spp. es una levadura comensal de la microbiota humana. Por características del hospedero, las infecciones del torrente sanguíneo pueden aparecer y causar una gran morbimortalidad. Métodos: Estudio restrospectivo transversal analítico de los cultivos positivos para Candida spp. entre 2008 y 2014 en un hospital universitario en Bogotá, Colombia. Se evaluaron las características clínicas y microbiológicas presentes previo a la toma de la primera muestra de sangre positiva y se determinaron asociaciones con infecciones por especies no C. albicans (NCA). Resultados: Se incluyeron 123 casos de candidemia. C. albicans fue la especie más aislada (42 %). Sin embargo, las especies NCA como grupo fueron observadas más frecuentemente. Más del 70 % de los casos presentaron manejo en la unidad de cuidado intensivo, con una mediana de estancia de 14 días previo a la primera muestra de sangre positiva. Se detectaron numerosas características médicas; sin embargo, ninguna estuvo asociada con candidemia por especies NCA. Se observó resistencia a por lo menos un antifúngico en el 29 % de los casos, aunque en una muestra reducida de pruebas de sensibilidad. Conclusiones: Nuestros resultados sustentan el viraje mundial hacia la candidemia por especies NCA; pero no encontramos asociaciones clínicas en este grupo. Debe dársele prioridad a la identificación de factores de riesgo y a la optimización de los puntajes de predicción, que permitan identificar pacientes en riesgo que se beneficien de terapia preventiva.

Introduction: Candida species are commensal yeasts of the human microbiota. However, due to several host's conditions, bloodstream infections may arise causing high morbimortality. Methods: Retrospective cross-sectional analytical study of positive blood cultures for Candida spp. between 2008'2014 at a university hospital in Bogotá. Colombia. We evaluated clinical and microbiological characteristics prior to the first positive blood sample was obtained and determined associations with non'C. albicans (NCA) species infections. Results: We included 123 candidemia cases. C. albicans was the most frequently isolated species (42%). However; NCA species as a group were observed more often. Over 70% of cases were managed at the ICU, with a median stay of 14 days. Several medical factors were frequently observed, however none appeared to be associated with NCA species candidemia. Resistance to at least one antifungal agent was observed in 29% of cases, although a reduced sample of susceptibility tests was available. Conclusions: Our results support a worldwide shift towards NCA candidemia. However, clinical features were not associated with NCA infections. The identification of risk factors and the improvement of prediction scores must be prioritized, in order to identify' patients at high risk who may benefit of pre-emptive therapy.
Descritores: Candidíase/epidemiologia
Farmacorresistência Fúngica
Candidemia/história
Responsável: CO185.1 - Biblioteca Alfonso Borrero Cabal, S. J.



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