Base de dados : LILACS
Pesquisa : G06.225.383 [Categoria DeCS]
Referências encontradas : 93 [refinar]
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Id: biblio-886765
Autor: PINTO, MARIA E A; ARAÚJO, STHÉFANE G; MORAIS, MARCELA I; SÁ, NÍVEA P; LIMA, CAROLINE M; ROSA, CARLOS A; SIQUEIRA, EZEQUIAS P; JOHANN, SUSANA; LIMA, LUCIANA A R S.
Título: Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils
Fonte: An. acad. bras. ciênc;89(3):1671-1681, July-Sept. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.
Descritores: Paracoccidioides/efeitos dos fármacos
Picratos/farmacologia
Soja/química
Compostos de Bifenilo/farmacologia
Óleos Vegetais/farmacologia
Zea mays/química
Helianthus/química
Antifúngicos/farmacologia
-Picratos/isolamento & purificação
Compostos de Bifenilo/isolamento & purificação
Óleos Vegetais/química
Testes de Sensibilidade Microbiana
Farmacorresistência Fúngica
Dose Letal Mediana
Cromatografia Gasosa-Espectrometria de Massas
Antifúngicos/isolamento & purificação
Responsável: BR1.1 - BIREME


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Id: biblio-1098449
Autor: Spanamberg, Andréia; Ravazzolo, Ana Paula; Denardi, Laura B; Hartz, Sydney A; Santurio, Janio M; Driemeier, David; Ferreiro, Laerte.
Título: Antifungal susceptibility profile of Aspergillus fumigatus isolates from avian lungs / Perfil de suscetibilidade antifúngica de isolados de Aspergillus fumigatus provenientes de pulmões de aves
Fonte: Pesqui. vet. bras = Braz. j. vet. res;40(2):102-106, Feb. 2020. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Susceptibility testing is essential to inform the correct management of Aspergillus infections. In this study we present antifungal susceptibility profile of A. fumigatus isolates recovered from lungs of birds with and without aspergillosis. Fifty three isolates were tested for their antifungal susceptibility to voriconazole (VRC), itraconazole (ITZ), amphotericin (AMB) and caspofungin (CSP) using the M38-A2 broth microdilution reference method. Five isolates were resistant to more than one antifungal drug (CSP + AMB, VRC + ITZ and AMB + ITZ). Fifteen (28%) isolates with susceptible increased exposure (I) to ITZ were sensible to VRC. Resistance to AMB (>2µg/mL) was observed in only four isolates. Eleven (21%) A. fumigatus present resistance to ITZ (13%) and VRC (8%). Fungal isolation from respiratory samples has been regarded as being of limited usefulness in the ante mortem diagnosis of aspergillosis in birds. However, the results suggest that the detection and antifungal susceptibility profile may be helpful for monitoring of therapy for avian species and where antifungal resistance might be emerging and what conditions are associated to the event.(AU)

Os testes de suscetibilidade são essenciais para informar o correto manejo das infecções por Aspergillus. Neste estudo apresentamos o perfil antifúngico de isolados de A. fumigatus provenientes de pulmões de aves com e sem aspergilose. Cinqüenta e três isolados foram testados quanto à susceptibilidade antifúngica ao voriconazol (VRC), itraconazol (ITZ), anfotericina B (AMB) e caspofungina (CSP) pelo método de referência de microdiluição do caldo M38-A2. Cinco isolados foram resistentes a mais de um antifúngico (CSP + AMB, VRC + ITZ e AMB + ITZ). Quinze (28%) isolados suscetíveis - com exposição aumentada (I) ao ITZ foram sensíveis ao VRC. A resistência ao AMB (>2µg/mL) foi observada em apenas quatro isolados. Onze (21%) A. fumigatus apresentaram resistência a ITZ (13%) e VRC (8%). O isolamento de fungos de amostras respiratórias tem sido considerado de utilidade limitada no diagnóstico ante mortem de aspergilose em aves. No entanto, os resultados sugerem que a detecção e o perfil de suscetibilidade a antifúngicos podem ser úteis para o monitoramento da terapia de espécies aviárias, assim como a emergência da resistência antifúngica e quais condições podem estar associadas ao evento.(AU)
Descritores: Doenças das Aves Domésticas
Aspergilose/tratamento farmacológico
Aspergilose/veterinária
Aspergillus fumigatus/isolamento & purificação
Aspergillus fumigatus/efeitos dos fármacos
Galinhas
Farmacorresistência Fúngica/efeitos dos fármacos
Antifúngicos/uso terapêutico
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-407438
Autor: Mendes, Rinaldo Poncio; Ribeiro, Mariceli Araujo.
Título: Drogas antifúngicas / Antifungal agents
Fonte: In: Cimerman, Sérgio; Cimerman, Benjamim. Condutas em infectologia. São Paulo, Atheneu, 2004. p.420-436, ilus, tab.
Idioma: pt.
Descritores: Anfotericina B
Antifúngicos/uso terapêutico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
Farmacorresistência Fúngica
Responsável: BR31.1 - SIDC - Serviço de Informação e Documentação Científica
BR31.1; WC100, C49c, 2004


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Id: biblio-1097201
Autor: Izoton, Carlos Felipe Gomes; Israel, Mônica Simões.
Título: Eficácia antimicrobiana da terapia fotodinâmica no tratamento da candidíase oral em pessoas vivendo com HIV/Aids / Antimicrobial efficacy of photodynamic therapy on the treatment of oral candidiasis in people living with HIV/Aids / Eficacia antimicrobiana de la terapia fotodinámica en el tratamiento de la candidiasis bucal en personas viviendo con VIH/Sida
Fonte: Rev. Pesqui. (Univ. Fed. Estado Rio J., Online);12:505-509, jan.-dez. 2020. tab.
Idioma: en; pt.
Resumo: Objetivo: avaliar a eficácia antimicrobiana da terapia fotodinâmica no tratamento da candidíase oral em pessoas vivendo com HIV/aids. Método: estudo experimental, qualitativo e descritivo com 18 pessoas vivendo com HIV/aids que manifestavam a candidíase oral, maiores de 18 anos, que estavam em tratamento no Hospital Universitário Gaffrée e Guinle. Este grupo subdividiu-se em um grupo controle, composto por sete pessoas, que recebeu tratamento com a terapia fotodinâmica e antifúngicos, e um grupo experimental, com 11, que recebeu apenas a terapia fotodinâmica. A evolução do tratamento de cada participante foi acompanhada por registros fotográficos em duas consultas, inicial e final. Esta pesquisa foi aprovada pelo Comitê de Ética em Pesquisa do hospital, parecer número 2.431.107. Resultados: a maioria dos participantes apresentou melhora clínica, ainda que discreta, e em apenas um houve piora clínica. Conclusão: a terapia fotodinâmica antimicrobiana pode ser eficaz no tratamento da candidíase oral em pessoas vivendo com HIV/Aids

Objective: evaluate the antimicrobial efficacy of photodynamic therapy in the treatment of oral candidiasis in people living with HIV/ aids. Method: experimental, qualitative and descriptive study with 18 people living with HIV/aids who presented oral candidiasis, over 18 years of age, who were being treated at the Gaffrée and Guinle University Hospital. This group was subdivided into a control group, composed of seven people, who received treatment with photodynamic and antifungal therapy, and an experimental group, with 11, who received only the photodynamic therapy. The evolution of the treatment of each participant was followed by photographic registers in two appointments, initial and final. This research was approved by the Research Ethics Committee from the hospital, dictum number 2.431.107. Results: most of the participants showed clinical improvement, albeit discrete, and in only one there was clinical worsening. Conclusion: antimicrobial photodynamic therapy may be effective in the treatment of oral candidiasis in people living with HIV/Aids

Objetivo: evaluar la eficacia antimicrobiana de la terapia fotodinámica en el tratamiento de la candidiasis bucal en personas que viven con VIH/sida. Método: estudio experimental, cualitativo y descriptivo con 18 personas viviendo con VIH/sida que manifestaban la candidiasis bucal, mayores de 18 años, que estaban en tratamiento en el Hospital Universitario Gaffrée y Guinle. Este grupo se subdividió en grupo control, compuesto por siete personas, que recibió tratamiento con la terapia fotodinámica y antifúngicos, y un grupo experimental, con 11, que recibió sólo la terapia fotodinámica. La evolución del tratamiento de cada participante fue acompañada por registros fotográficos en dos consultas, inicial y final. La investigación fue aprobada por el Comité de Ética en Investigación del lugar, dictamen número 2.431.107. Resultados: la mayoría de los participantes presentó mejoría clínica, aunque discreta, y en apenas uno hubo empeoramiento clínico. Conclusión: la terapia fotodinámica antimicrobiana puede ser eficaz en el tratamiento de la candidiasis bucal en personas que viven con el VIH/Sida
Descritores: Fotoquimioterapia/estatística & dados numéricos
Candidíase Bucal/terapia
Infecções Oportunistas Relacionadas com a AIDS/terapia
-Fotoquimioterapia/métodos
Candidíase Bucal/epidemiologia
Síndrome de Imunodeficiência Adquirida/terapia
HIV
Farmacorresistência Fúngica
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Estudo de Validação
Responsável: BR1208.1 - BSEN - Biblioteca Setorial de Enfermagem e Nutrição


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Id: biblio-1087506
Autor: Becker, Leticia Barrey; Lana, Daiane Flores Dalla; Mezzari, Adelina.
Título: Candida blankii: um patógeno emergente de difícil diagnóstico e tratamento clínico / Candida blankii: an emerging pathogen difficult to diagnose and to treat clinically
Fonte: Clin. biomed. res;39(4):341-345, 2019.
Idioma: pt.
Resumo: O gênero Candida possui várias espécies conhecidas e que podem tornar-se patogênicas em determinadas situações. Candida blankii é uma espécie emergente que, na última década, foi identificada como um agente de doenças sistêmicas. Ainda não existe um protocolo de tratamento específico, apesar de que n os poucos casos registrados na literatura a terapia adotada foi efetiva. O objetivo deste estudo foi realizar uma revisão bibliográfica para coletar informações relevantes sobre este patógeno como um possível agente etiológico em infecções sistêmicas, bem como sua epidemiologia e os aspectos de sua patogenicidade. (AU)

The genus Candida has several known species and may become pathogenic in certain situations. Candida blankii is an emerging species that in the past decade has been identified as an agent of systemic diseases. There is no specific treatment protocol yet, although in the few cases reported in the literature the therapy adopted was effective. The objective of this study was to conduct a literature review to collect relevant information about this pathogen as a possible etiological agent in systemic infections, as well as its epidemiology and aspects of pathogenicity. (AU)
Descritores: Candida/classificação
Candida/efeitos dos fármacos
Candida/patogenicidade
-Doenças Transmissíveis Emergentes/genética
Farmacorresistência Fúngica/genética
Suscetibilidade a Doenças/epidemiologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR18.1 - Biblioteca FAMED/HCPA


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Id: biblio-1038269
Autor: Fay, Vanessa da Silva; Rodrigues, Diana Mara Garcia; Gonçalves, Stela Maris Bottin; Gregianini, Tatiana Schaffer; Bonamigo, Renan Rangel.
Título: Drug susceptibility in emerging fungal infections: tests with fluconazole, itraconazole, and amphotericin B
Fonte: An. bras. dermatol;93(3):462-464, May-June 2018. tab.
Idioma: en.
Resumo: Abstract: The number of new cases of emerging fungal infections has increased considerably in recent years, mainly due to the large number of immunocompromised individuals. The objective of this study was to evaluate the susceptibility of emerging fungi to fluconazole, itraconazole and amphotericin B by disk diffusion method. In 2015, 82 emerging fungi were evaluated in IPB-LACEN/RS and 13 (15.8%) were resistant: 10/52 were from superficial mycoses and 3/30 from systemic mycoses. The data from the study point to the need for permanent vigilance regarding the careful evaluation in the prescription and clinical and laboratory follow-up of patients affected by fungal infections.
Descritores: Farmacorresistência Fúngica
Fungos/efeitos dos fármacos
Antifúngicos/uso terapêutico
-Testes de Sensibilidade Microbiana
Fluconazol/uso terapêutico
Infecções por HIV/complicações
Anfotericina B/uso terapêutico
Itraconazol/uso terapêutico
Fungos/isolamento & purificação
Micoses/microbiologia
Micoses/tratamento farmacológico
Antifúngicos/farmacologia
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-828190
Autor: Ribas e Ribas, Aícha Daniela; Spolti, Pierri; Del Ponte, Emerson Medeiros; Donato, Katarzyna Zawada; Schrekker, Henri; Fuentefria, Alexandre Meneghello.
Título: Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review
Fonte: Braz. j. microbiol;47(4):793-799, Oct.-Dec. 2016. tab.
Idioma: en.
Resumo: Abstract Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments.
Descritores: Triazóis/envenenamento
Ecossistema
Farmacorresistência Fúngica
Agricultura
Fungos/efeitos dos fármacos
Antifúngicos/farmacologia
-Doenças das Plantas/microbiologia
Triazóis/uso terapêutico
Fungos/fisiologia
Fungicidas Industriais
Micoses/microbiologia
Micoses/tratamento farmacológico
Antifúngicos/uso terapêutico
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-828210
Autor: Waller, Stefanie Bressan; Madrid, Isabel Martins; Ferraz, Vanny; Picoli, Tony; Cleff, Marlete Brum; de Faria, Renata Osório; Meireles, Mário Carlos Araújo; de Mello, João Roberto Braga.
Título: Cytotoxicity and anti-Sporothrix brasiliensis activity of the Origanum majorana Linn. oil
Fonte: Braz. j. microbiol;47(4):896-901, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract The study aimed to evaluate the anti-Sporothrix sp. activity of the essential oil of Origanum majorana Linn. (marjoram), its chemical analysis, and its cytotoxic activity. A total of 18 fungal isolates of Sporothrix brasiliensis (n: 17) from humans, dogs and cats, and a standard strain of Sporothrix schenckii (n: 1) were tested using the broth microdilution technique (Clinical and Laboratory Standard Institute - CLSI M27-A3) and the results were expressed in minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC). The MIC50 and MIC90 of itraconazole against S. brasiliensis were 2 µg/mL and 8 µg/mL, respectively, and the MFC50 and MFC90 were 2 µg/mL and >16 µg/mL, respectively, with three S. brasiliensis isolates resistant to antifungal. S. schenckii was sensitive at MIC of 1 µg/mL and MFC of 8 µg/mL. For the oil of O. majorana L., all isolates were susceptible to MIC of ≤2.25-9 mg/mL and MFC of ≤2.25-18 mg/mL. The MIC50 and MIC90 were ≤2.25 mg/mL and 4.5 mg/mL, respectively, and the MFC50/90 values were twice more than the MIC. Twenty-two compounds were identified by gas chromatography with a flame ionization detector (CG-FID) and 1,8-cineole and 4-terpineol were the majority. Through the colorimetric (MTT) assay, the toxicity was observed in 70-80% of VERO cells between 0.078 and 5 mg/mL. For the first time, the study demonstrated the satisfactory in vitro anti-Sporothrix sp. activity of marjoram oil and further studies are needed to ensure its safe and effective use.
Descritores: Sporothrix/efeitos dos fármacos
Óleos Voláteis/farmacologia
Antifúngicos/farmacologia
-Esporotricose/microbiologia
Sporothrix/isolamento & purificação
Células Vero
Óleos Voláteis/química
Testes de Sensibilidade Microbiana
Zoonoses/microbiologia
Sobrevivência Celular/efeitos dos fármacos
Chlorocebus aethiops
Farmacorresistência Fúngica
Antifúngicos/química
Limites: Animais
Responsável: BR1.1 - BIREME


  9 / 93 LILACS  
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Id: lil-780823
Autor: Savastano, Catarina; Silva, Elisa de Oliveira; Gonçalves, Lindyanne Lemos; Nery, Jéssica Maria; Silva, Naiara Chaves; Dias, Amanda Latercia Tranches.
Título: Candida glabrata among Candida spp. from environmental health practitioners of a Brazilian Hospital
Fonte: Braz. j. microbiol;47(2):367-372, Apr.-June 2016. tab.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de Minas Gerais.
Resumo: Abstract The incidence of the species Candida albicans and non-albicans Candida was evaluated in a Brazilian Tertiary Hospital from the environment and health practitioners. In a 12-month period we had a total positivity of 19.65% of Candida spp. The most recurring non-albicans Candida species was C. glabrata (37.62%), generally considered a species of low virulence, but with a higher mortality rate than C. albicans. Subsequently, C. parapsilosis (25.74%) and C. tropicalis (16.86%) were the second and third most commonly isolated species. Considering the total samples collected from the emergency room and from the inpatient and the pediatric sector, 19.10% were positive for Candida spp., with the predominance of non-albicans Candida species (89.42%). The high percentage of positivity occurred in the hands (24.32%) and the lab coats (21.88%) of the health care assistants. No sample of C. albicans presented a profile of resistance to the drugs. All the non-albicans Candida species presented a decreased susceptibility to miconazole and itraconazole, but they were susceptible to nystatin. Most of the isolates were susceptible to fluconazole and amphotericin B. As expected, a high resistance rate was observed in C. glabrata and C. krusei, which are intrinsically less susceptible to this antifungal agent. The contamination of environmental surfaces by Candida spp. through hand touching may facilitate the occurrence of Candida infections predominantly in immunocompromised patients. In addition to that, the antifungal agents used should be carefully evaluated considering local epidemiologic trends in Candida spp. infections, so that therapeutic choices may be better guided.
Descritores: Candida/isolamento & purificação
Candidíase/microbiologia
Testes de Sensibilidade Microbiana
Infecção Hospitalar/microbiologia
Pessoal de Saúde/estatística & dados numéricos
Candida glabrata/isolamento & purificação
Equipamentos e Provisões Hospitalares/microbiologia
-Atenção Terciária à Saúde/estatística & dados numéricos
Brasil/epidemiologia
Candida/classificação
Candida/efeitos dos fármacos
Candida/genética
Candidíase/epidemiologia
Infecção Hospitalar/epidemiologia
Farmacorresistência Fúngica
Candida glabrata/classificação
Candida glabrata/efeitos dos fármacos
Candida glabrata/genética
Hospitais
Hospitais/estatística & dados numéricos
Antifúngicos/farmacologia
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


  10 / 93 LILACS  
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Vicente, Vânia Aparecida
Carvalho, Newton Sérgio de
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Id: lil-780822
Autor: Fornari, Gheniffer; Vicente, Vania Aparecida; Gomes, Renata Rodrigues; Muro, Marisol Dominguez; Pinheiro, Rosangela Lameira; Ferrari, Carolina; Herkert, Patricia Fernanda; Takimura, Marcos; Carvalho, Newton Sérgio de; Queiroz-Telles, Flavio.
Título: Susceptibility and molecular characterization of Candida species from patients with vulvovaginitis
Fonte: Braz. j. microbiol;47(2):373-380, Apr.-June 2016. tab, graf.
Idioma: en.
Resumo: Abstract Vulvovaginal candidiasis affects women of reproductive age, which represents approximately 15–25% of vaginitis cases. The present study aimed to isolate and characterize yeast from the patients irrespective of the presentation of clinical symptoms. The isolates were subjected to in vitro susceptibility profile and characterization by molecular markers, which intended to assess the distribution of species. A total of 40 isolates were obtained and identified through the CHROMagar, API20aux and by ITS and D1/D2 regions sequencing of DNAr gene. Candida albicans strains were genotyped by the ABC system and the isolates were divided into two genotypic groups. The identity of the C. albicans, C. glabrata, C. guilliermondii, C. kefyr and Saccharomyces cerevisiae isolates was confirmed by the multilocus analysis. The strains of Candida, isolated from patients with complications, were found to be resistant to nystatin but sensitive to fluconazole, amphotericin B and ketoconazole, as observed by in vitro sensitivity profile. The isolates from asymptomatic patients, i.e., the colonized group, showed a dose-dependent sensitivity to the anti-fungal agents, fluconazole and amphotericin B. However, the isolates of C. albicans that belong to distinct genotypic groups showed the same in vitro susceptibility profile.
Descritores: Candida/efeitos dos fármacos
Candidíase Vulvovaginal/microbiologia
Antifúngicos/farmacologia
-Pacientes/estatística & dados numéricos
Candida/isolamento & purificação
Candida/classificação
Candida/genética
Testes de Sensibilidade Microbiana
Fluconazol/farmacologia
Farmacorresistência Fúngica
Limites: Humanos
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME



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