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Pesquisa : G06.320.676 [Categoria DeCS]
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Id: biblio-936996
Autor: São Paulo (Cidade). Secretaria da Saúde. Coordenação de Vigilância em Saúde. Gerência do Centro de Controle e Prevenção de Doenças.
Título: Instituição e suspensão das práticas de precauções de contato contra a transmissão cruzada de microrganismos multi-resistentes.
Fonte: São Paulo; São Paulo (Cidade). Secretaria da Saúde. Coordenação de Vigilância em Saúde. Gerência do Centro de Controle e Prevenção de Doenças; Ago. 2008. 01 p.
Idioma: pt.
Descritores: Agentes de Controle de Microrganismos
Organismos Livres de Patógenos Específicos
-Glicopeptídeos
Glicopeptídeos/imunologia
Limites: Seres Humanos
Responsável: BR58.1 - Biblioteca
BR58.1


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Id: lil-715302
Autor: González Navarro, Bárbara O; Forte Miranda, Cándida; Rojas&dagger, Ramón Alonso; Alfonso Montero, Antonio; Francis Turner, Liliana; Arteaga Pérez, María Elena; Riera Ojeda, Layna.
Título: Primera incursión en la obtención de curieles libre de patógenos específicos en Cuba / First foray into the production of specific pathogen-free guinea pigs in Cuba
Fonte: Rev. colomb. biotecnol;16(1):93-98, ene.-jun. 2014. ilus, tab.
Idioma: es.
Resumo: Resultados confiables y económicos solo son obtenidos cuando los animales de experimentación son aislados de factores ambientales y biológicos, implantándose en el biomodelo una microbiota normal, lejos de la presencia de microorganismos patógenos. El objetivo de la investigación fue obtener curieles libre de patógenos específicos por cesárea aséptica, mantenidos en aisladores y alimentados con dietas estériles. Se realizaron 26 histerectomías. Los animales fueron alimentados con una fórmula modificada (L-477) en forma de papilla hasta los 21 días y permanentemente después la C-484 sólida y granulada, esterilizadas a 121oC/20 minutos o a 1,5Mrad. Además fueron suplementados con vitamina C y B1. El forraje o heno fue consumido a partir de la primera generación. La microbiota gastrointestinal se administró por vía oral en 0,5 ml de una dilución de 10-6/g de contenido de la porción final del íleon, ciego y principio del colon de curieles, a las 24 y 48 horas del nacimiento. Se utilizó para el monitoreo microbiológico caldo Tioglicolato, caldo Triptona Soya y caldo Saboraud incubados aeróbicamente a temperatura de 55, 37 y 25oC respectivamente. Se obtuvieron 51 neonatos. La mortalidad más alta se registró entre los primeros 10 días de edad (58,8%). Se lograron 12 animales (3 machos y 9 hembras), 6 de las hembras se reprodujeron aproximadamente a los 9 meses de edad, lográndose 11 crías por parto normal. La metodología aplicada permitió obtener curieles libres de Salmonella sp, Pasteurella sp, Streptococcus del tipo A y C, Bordetella bronchiseptica, Toxoplasma gondii, Virus Sendai y parásitos internos y externos.

Confidence and economics results are only obtained when the animals are isolated of the environmental and biological factors, that could interfere the course of from investigation and when is being established in them, a normal microflora balanced far from the presence of pathogen microorganisms. They were accomplished 26 histerectomies. The animals were fed with a modified formula of L-477 in the form of porridge until 21 days of age and permanently after with the C-484 solid and granulated, sterilized at 121oC/20 minutes or 1,5Mrad. The forage or hay was consumed by the first generation since the 6 months of age. The gastrointestinal flora was administered by oral route with 0,5 ml of a dilution of 10-6/g of the contents of the ileum final portion, cecum and first part of the colon of conventionalized Dunkin Hartley guinea pigs, at 24 and 48 hours born. It was used for microbiological bacteria monitoring Thioglycolate broth, Tryptic Soy broth and Sabouraud broth incubated aerobically at temperatures of 55, 37 and 25oC respectively. There were obtained 51 newborns. The highest mortality was registered during the first 10 days of age (58,8%). There were archieved 12 animals: 9 female and 3 males. 6 of the female were reproduced approximately at 9 months of age and were archieved 11 normal delivery sucklings. There were obtained guinea pigs free of the followings specific pathogens: Salmonella sp., Pasteurella sp., Streptococcus of the group A y C. Bordetella bronchiseptica, Toxoplasma gondii, Sendai Virus, beside internal and external parasites.
Descritores: Dietoterapia
Histerectomia
Elementos Isolantes
Organismos Livres de Patógenos Específicos
-Dieta
Interações Hospedeiro-Patógeno
Responsável: CO326 - Departamento de Biología


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Id: lil-712403
Autor: Sabogal, Angélica María; Arango, César Augusto; Cardona, Gloria Patricia; Céspedes, Ángel Enrique.
Título: Atorvastatin protects GABAergic and dopaminergic neurons in the nigrostriatal system in an experimental rat model of transient focal cerebral ischemia / La atorvastatina protege las neuronas gabérgicas y dopaminérgicas del sistema nigroestriatal en un modelo experimental de isquemia cerebral focal transitoria en ratas
Fonte: Biomédica (Bogotá);34(2):207-217, abr.-jun. 2014. ilus, graf.
Idioma: en.
Resumo: Introduction: Cerebral ischemia is the third leading cause of death and the primary cause of permanent disability worldwide. Atorvastatin is a promising drug with neuroprotective effects that may be useful for the treatment of stroke. However, the effects of atorvastatin on specific neuronal populations within the nigrostriatal system following cerebral ischemia are unknown. Objective: To evaluate the effects of atorvastatin on dopaminergic and GABAergic neuronal populations in exofocal brain regions in a model of transient occlusion of the middle cerebral artery. Materials and methods: Twenty-eight male eight-week-old Wistar rats were used in this study. Both sham and ischemic rats were treated with atorvastatin (10 mg/kg) or carboxymethylcellulose (placebo) by gavage at 6, 24, 48 and 72 hours post-reperfusion. We analyzed the immunoreactivity of glutamic acid decarboxylase and tyrosine hydroxylase in the globus pallidus, caudate putamen and substantia nigra. Results: We observed neurological damage and cell loss in the caudate putamen following ischemia. We also found an increase in tyrosine hydroxylase immunoreactivity in the medial globus pallidus and substantia nigra reticulata, as well as a decrease in glutamic acid decarboxylase immunoreactivity in the lateral globus pallidus in ischemic animals treated with a placebo. However, atorvastatin treatment was able to reverse these effects, significantly decreasing tyrosine hydroxylase levels in the medial globus pallidus and substantia nigra reticulata and significantly increasing glutamic acid decarboxylase levels in the lateral globus pallidus. Conclusion: Our data suggest that post-ischemia treatment with atorvastatin can have neuro-protective effects in exofocal regions far from the ischemic core by modulating the GABAergic and dopaminergic neuronal populations in the nigrostriatal system, which could be useful for preventing neurological disorders.

Introducción. La isquemia cerebral es la tercera causa de muerte y la primera de discapacidad permanente en el mundo. La atorvastatina es un fármaco neuroprotector prometedor para el tratamiento de la apoplejía; sin embargo, su acción sobre las poblaciones neuronales del sistema nigroestriatal después de la isquemia aún se desconoce. Objetivo. Evaluar el efecto de la atorvastatina sobre poblaciones gabérgicas y dopaminérgicas en regiones exofocales en un modelo de oclusión transitoria de la arteria cerebral media. Materiales y métodos. Se utilizaron 28 ratas Wistar macho de ocho semanas de edad. Los ejemplares con isquemia simulada y los ejemplares sometidos a isquemia fueron tratados con atorvastatina (10 mg/kg) y carboximetilcelulosa (placebo) administrados por medio de sonda a las 6, 24, 48 y 72 horas después de la reperfusión. Se analizó la inmunorreacción de la descarboxilasa del ácido glutámico y de la tirosina hidroxilasa en el globo pálido, el putamen caudado y la sustancia negra. Resultados. Los datos confirmaron el daño neurológico y la pérdida celular en el putamen caudado. Se incrementó la inmunorreacción de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata , disminuyendo la inmunorreacción de la descarboxilasa del ácido glutámico en el globo pálido lateral de los animales isquémicos tratados con placebo; sin embargo, el tratamiento con atorvastatina pudo revertirla, lo que logró una disminución significativa de la tirosina hidroxilasa en el globo pálido medial y la sustancia negra pars reticulata y aumentando los niveles de descarboxilasa del ácido glutámico en el globo pálido lateral. Conclusión. Nuestros datos sugieren que la atorvastatina en el tratamiento posterior a la isquemia ejerce neuroprotección en las zonas exofocales, modulando las poblaciones neuronales gabérgicas y dopaminérgicas del sistema nigroestriatal, lo que podría prevenir trastornos neurológicos.
Descritores: Corpo Estriado/efeitos dos fármacos
Neurônios Dopaminérgicos/efeitos dos fármacos
Neurônios GABAérgicos/efeitos dos fármacos
Ácidos Heptanoicos/uso terapêutico
Infarto da Artéria Cerebral Média/tratamento farmacológico
Ataque Isquêmico Transitório/tratamento farmacológico
Fármacos Neuroprotetores/uso terapêutico
Pirróis/uso terapêutico
Substância Negra/efeitos dos fármacos
-Comportamento Animal
Corpo Estriado/irrigação sanguínea
Corpo Estriado/patologia
Avaliação Pré-Clínica de Medicamentos
Neurônios Dopaminérgicos/enzimologia
Neurônios Dopaminérgicos/patologia
Indução Enzimática/efeitos dos fármacos
Neurônios GABAérgicos/enzimologia
Neurônios GABAérgicos/patologia
Glutamato Descarboxilase/biossíntese
Glutamato Descarboxilase/genética
Ácidos Heptanoicos/farmacologia
Infarto da Artéria Cerebral Média/patologia
Ataque Isquêmico Transitório/patologia
Transtornos dos Movimentos/etiologia
Transtornos dos Movimentos/prevenção & controle
Proteínas do Tecido Nervoso/biossíntese
Proteínas do Tecido Nervoso/genética
Fármacos Neuroprotetores/farmacologia
Pirróis/farmacologia
Ratos Wistar
Recuperação de Função Fisiológica
Organismos Livres de Patógenos Específicos
Transtornos das Sensações/etiologia
Transtornos das Sensações/prevenção & controle
Substância Negra/irrigação sanguínea
Substância Negra/patologia
/biossíntese
TYROSINE ABATTOIRS-MONOOXYGENASE/biossíntese
/genética
TYROSINE ABATTOIRS-MONOOXYGENASE/genética
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CO332 - Facultad de Medicina


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Id: lil-699777
Autor: Zhao, Z.G.; Zhang, L.L.; Niu, C.Y.; Zhang, J..
Título: Exogenous normal lymph reduces liver injury induced by lipopolysaccharides in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(2):128-134, 2/2014. graf.
Idioma: en.
Projeto: Education Department in Hebei Province; . Education Department in Hebei Province; . Foundation of Hundred Innovative Talents in Universities of Hebei Province; . Foundation of Hundred Innovative Talents in Universities of Hebei Province.
Resumo: The liver is one of the target organs damaged by septic shock, wherein the spread of endotoxins begins. This study aimed to investigate the effects of exogenous normal lymph (ENL) on lipopolysaccharide (LPS)-induced liver injury in rats. Male Wistar rats were randomly divided into sham, LPS, and LPS+ENL groups. LPS (15 mg/kg) was administered intravenously via the left jugular vein to the LPS and LPS+ENL groups. At 15 min after the LPS injection, saline or ENL without cell components (5 mL/kg) was administered to the LPS and LPS+ENL groups, respectively, at a rate of 0.5 mL/min. Hepatocellular injury indices and hepatic histomorphology, as well as levels of P-selectin, intercellular adhesion molecule 1 (ICAM-1), myeloperoxidase (MPO), and Na+-K+-ATPase, were assessed in hepatic tissues. Liver tissue damage occurred after LPS injection. All levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in plasma as well as the wet/dry weight ratio of hepatic tissue in plasma increased. Similarly, P-selectin, ICAM-1, and MPO levels in hepatic tissues were elevated, whereas Na+-K+-ATPase activity in hepatocytes decreased. ENL treatment lessened hepatic tissue damage and decreased levels of AST, ALT, ICAM-1, and MPO. Meanwhile, the treatment increased the activity of Na+-K+-ATPase. These results indicated that ENL could alleviate LPS-induced liver injury, thereby suggesting an alternative therapeutic strategy for the treatment of liver injury accompanied by severe infection or sepsis.
Descritores: Doença Hepática Induzida por Substâncias e Drogas/terapia
Linfa
-Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Modelos Animais de Doenças
Doença Hepática Induzida por Substâncias e Drogas/patologia
Molécula 1 de Adesão Intercelular/metabolismo
Lipopolissacarídeos
Ratos Wistar
Organismos Livres de Patógenos Específicos
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-657615
Autor: Zanetti, Flavia; Rudak, Liliana; Micucci, Matías; Conte Grand, Daniela; Luque, Andrea; Russo, Susana; Taboga, Oscar; Pérez, Oscar; Calamante, Gabriela.
Título: Obtención y evaluación preliminar de un virus canarypox recombinante como candidato a vacuna antirrábica / Development and preliminary assessment of a recombinant canarypox virus as an antirabic vaccine candidate
Fonte: Rev. argent. microbiol;44(2):75-84, jun. 2012. ilus, graf, tab.
Idioma: es.
Resumo: En la Argentina, la rabia está circunscripta a algunas provincias del norte. La disponibilidad de nuevas vacunas que eliminen la manipulación del virus rábico y que permitan el control de la enfermedad es de importancia estratégica nacional y regional. Las vacunas basadas en poxvirus recombinantes se han utilizado con éxito como vacunas antirrábicas a nivel mundial. SI bien estos sistemas no están disponibles comercialmente, la plataforma de obtención de virus canarypox (CNPV) recombinantes ya ha sido implementada en nuestro laboratorio. El objetivo de este trabajo fue obtener y evaluar un candidato a vacuna antirrábica basado en CNPV recombinantes que expresan la glicoproteína G (RG) del virus rábico (RV). Se construyó un virus recombinante que expresa la secuencia codificante de RG (CNPV-RG). La inoculación de ratones con este virus indujo altos títulos de anticuerpos seroneutralizantes de RV (3,58 y 9,76 Ul/ml después de una o dos inmunizaciones, respectivamente) y protegió al 78 % de los animales desafiados intracerebralmente con RV. Además, se determinó que el CNPV-RG posee una potencia relativa de 3,5 Ul/ml. Los resultados obtenidos constituyen la primera etapa en la evaluación del CNPV-RG como candidato a vacuna antirrábica. Se requerirán nuevos ensayos para confirmar su utilidad en especies de interés veterinario.

In Argentina, rabies is limited to some northern provinces. Availability of new vaccines abolishing the handling of the rabies virus and allowing disease control has regional and national strategic importance. Vaccines based on recombinant poxviruses have been successfully used as antirabic vaccines worldwide. Although these systems are not commercially available, the platform to obtain recombinant canarypox viruses (CNPV) has been previously set up in our laboratory. The aim of this work was the development and evaluation of an antirabic vaccine candidate based on recombinant CNPV expressing the rabies virus (RV) glycoprotein G (RG). A recombinant virus (CNPV-RG) expressing the RG coding sequence was designed. Inoculation of mice with this virus induced high RV seroneutralizing antibodies (3.58 and 9.76 lU/ml after 1 or 2 immunizations, respectively) and protected 78% of intracerebrally RV-challenged animals. In addition, it was determined that CNPV-RG has a relative potency of 3.5 lU/ml. The obtained results constituted the first stage of CNPV-RG evaluation as antirabic vaccine candidate. Further assays will be necessary to confirm its utility in species of veterinary Interest.
Descritores: Antígenos Virais/imunologia
Vírus da Varíola dos Canários/imunologia
Glicoproteínas/imunologia
Vacinas Antirrábicas
Proteínas do Envelope Viral/imunologia
-Anticorpos Antivirais/biossíntese
Anticorpos Antivirais/imunologia
Antígenos Virais/genética
Cercopithecus aethiops
Vírus da Varíola dos Canários/genética
Vírus da Varíola dos Canários/crescimento & desenvolvimento
Vírus da Varíola dos Canários/isolamento & purificação
Linhagem Celular/virologia
Fibroblastos/virologia
Glicoproteínas/genética
Rim
Mesocricetus
Fragmentos de Peptídeos/genética
Fragmentos de Peptídeos/imunologia
Vacinas Antirrábicas/imunologia
Raiva/prevenção & controle
Organismos Livres de Patógenos Específicos
Cultura de Vírus
Vacinas Sintéticas/imunologia
Células Vero/virologia
Proteínas do Envelope Viral/genética
Limites: Animais
Embrião de Galinha
Cricetinae
Camundongos
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Id: lil-607049
Autor: São Paulo (Cidade). Secretaria da Saúde. Coordenação de Vigilância em Saúde. Gerência do Centro de Controle e Prevenção de Doenças.
Título: Instituição e suspensão das práticas de precauções de contato contra a transmissão cruzada de microrganismos multi-resistentes / Suspension of the institution and practices of contact precautions against cross transmission of multidrug-resistant microorganisms.
Fonte: São Paulo; São Paulo (Cidade). Secretaria da Saúde. Coordenação de Vigilância em Saúde. Gerência do Centro de Controle e Prevenção de Doenças; ago. 2008. 01 p.
Idioma: pt.
Descritores: Agentes de Controle de Microrganismos
Organismos Livres de Patógenos Específicos
-Glicopeptídeos
Glicopeptídeos/imunologia
Limites: Seres Humanos
Responsável: BR58.1 - Biblioteca
BR58.1


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Id: lil-591921
Autor: Milosevic, Snezana; Subotic, Angelina; Bulajic, Aleksandra; Djekic, Ivana; Jevremovic, Sladjana; Vucurovic, Ana; Krstic, Branka.
Título: Elimination of TSWV from impatiens hawkerii Bull. and regeneration of virus-free plant
Fonte: Electron. j. biotechnol;14(1):3-4, Jan. 2011. ilus, tab.
Idioma: en.
Projeto: Serbian Ministry of Science and Technological Development.
Resumo: The possibility for obtaining virus free plants from Impatiens hawkerii Bull. shoots infected with Tomato spotted wilt virus (TSWV) through meristem-tip culture was examined. TSWV presence in I. hawkerii plants was detected by DAS-ELISA and RT-PCR and identification of the virus was confirmed by sequencing one of the chosen isolate (GenBank Accesion CQ132190). Meristem-tip explants (0.3-1.5 mm) from virus-infected shoots are cultured on MS media supplemented with different concentrations of the cytokinins, CPPU or TDZ (0.01-1.0 uM), respectively. Using this system, a large number of in vitro shoots could be produced from a single explant. Also, cytokinins showed a stimulatory effect on the length, fresh and dry weights of the newly formed shoots. Plant pigments content in I. hawkerii shoots increased significantly in the presence of cytokinins. Rooting of shoots was spontaneous on the same media. Rooted plantlets were transferred to soil where 97 percent successfully acclimatized. By DAS-ELISA and RT-PCR, 80 percent of the in vitro plantlets were shown to be a virus-free. Considering these, the present protocol seems to be an efficient method for in vitro generation of virus-free I. hawkerii plantlets by meristem tip cultures.
Descritores: Organismos Livres de Patógenos Específicos/fisiologia
Tospovirus/fisiologia
-Meristema/fisiologia
Preparações de Plantas
Responsável: CL1.1 - Biblioteca Central


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Id: lil-464311
Autor: Fonseca, D. M; Bonato, V. L. D; Silva, C. L; Sartori, A.
Título: Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;40(11):1495-1504, Nov. 2007. graf.
Idioma: en.
Resumo: We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular route, this vaccine elicited a predominant Th1 response that was consistent with its protective efficacy against tuberculosis. It has been suggested that the immune response to Hsp60/65 may be the link between exposure to microorganisms and increased cardiovascular risk. Additionally, the high cholesterol levels found in atherosclerosis could modulate host immunity. In this context, we evaluated if an atherogenic diet could modulate the immune response induced by the DNA-HSP65 vaccine. C57BL/6 mice (4-6 animals per group) were initially submitted to a protocol of atherosclerosis induction and then immunized by the intramuscular or intradermal route with 4 doses of 100 mug DNA-HSP65. On day 150 (15 days after the last immunization), the animals were sacrificed and antibodies and cytokines were determined. Vaccination by the intramuscular route induced high levels of anti-Hsp65 IgG2a antibodies, but not anti-Hsp65 IgG1 antibodies and a significant production of IL-6, IFN-g and IL-10, but not IL-5, indicating a Th1 profile. Immunization by the intradermal route triggered a mixed pattern (Th1/Th2) characterized by synthesis of anti-Hsp65 IgG2a and IgG1 antibodies and production of high levels of IL-5, IL-6, IL-10, and IFN-g. These results indicate that experimentally induced atherosclerosis did not affect the ability of DNA-HSP65 to induce a predominant Th1 response that is potentially protective against tuberculosis.
Descritores: Aterosclerose/imunologia
Proteínas de Bactérias/imunologia
Chaperoninas/imunologia
Células Th1/imunologia
Vacinas contra a Tuberculose/imunologia
Vacinas de DNA/imunologia
-Autoanticorpos/sangue
Autoanticorpos/imunologia
Proteínas de Bactérias/administração & dosagem
Chaperoninas/administração & dosagem
Citocinas/sangue
Citocinas/imunologia
Dieta Aterogênica
Injeções Intradérmicas
Injeções Intramusculares
Imunoglobulina G/sangue
Imunoglobulina G/imunologia
MICE, INBRED CABDOMENABDOMINAL INJURIESBL
Organismos Livres de Patógenos Específicos
Vacinas contra a Tuberculose/administração & dosagem
Tuberculose/imunologia
Tuberculose/prevenção & controle
Vacinas de DNA/administração & dosagem
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-357114
Autor: Díaz-Corrales, F. J; Colasante, C; Contreras, Q; Puig, M; Serrano, J. A; Hernández, L; Beaman, B. L.
Título: Nocardia otitidiscaviarum (GAM-5) induces parkinsonian-like alterations in mouse
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;37(4):539-548, Apr. 2004. ilus, tab, graf.
Idioma: en.
Projeto: University of Los Andes. CDCHT.
Resumo: Parkinson's disease, a major neurodegenerative disorder in humans whose etiology is unknown, may be associated with some environmental factors. Nocardia otitidiscaviarum (GAM-5) isolated from a patient with an actinomycetoma produced signs similar to Parkinson's disease following iv injection into NMRI mice. NMRI mice were infected intravenously with a non-lethal dose of 5 x 10(6) colony forming units of N. otitidiscaviarum (GAM-5). Fourteen days after bacterial infection, most of the 60 mice injected exhibited parkinsonian features characterized by vertical head tremor, akinesia/bradykinesia, flexed posture and postural instability. There was a peak of nocardial growth in the brain during the first 24 h followed by a decrease, so that by 14 days nocardiae could no longer be cultured. At 24 h after infection, Gram staining showed nocardiae in neurons in the substantia nigra and occasionally in the brain parenchyma in the frontal and parietal cortex. At 21 days post-infection, tyrosine hydroxylase immunolabeling showed a 58 percent reduction of tyrosine hydroxylase in the substantia nigra, and a 35 percent reduction of tyrosine hydroxylase in the ventral tegmental region. Dopamine levels were reduced from 110 ± 32.5 to 58 ± 16.5 ng/mg protein (47.2 percent reduction) in brain from infected mice exhibiting impaired movements, whereas serotonin levels were unchanged (191 ± 44 protein in control and 175 ± 39 ng/mg protein in injected mice). At later times, intraneuronal inclusion bodies were observed in the substantia nigra. Our observations emphasize the need for further studies of the potential association between Parkinson's disease or parkinsonism-like disease and exposure to various nocardial species.
Descritores: Encéfalo
Nocardia
Nocardiose
Doença de Parkinson
-Encéfalo
Imuno-Histoquímica
Nocardiose
Doença de Parkinson
Organismos Livres de Patógenos Específicos
Substância Negra
Tirosina 3-Mono-Oxigenase
Limites: Seres Humanos
Animais
Feminino
Camundongos
Responsável: BR1.1 - BIREME


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Id: lil-344565
Autor: Fernández, Heriberto; Rodríguez, Roxana; Barudi, Carmen; Lobos, Marta.
Título: A case of acute diarrhea due to the emerging pathogen Campylobacter jejuni subsp. doylei in Southern Chile
Fonte: Braz. j. microbiol;34(1):52-54, Jan.-Apr. 2003.
Idioma: en.
Resumo: The first documented case of acute diarrhea due to C. jejuni subsp. doylei in Chile is reported. The clinical findings, the absence of other enteropathogens, virus or parasites and the fact that C. jejuni subsp. doylei was the only bacteria isolated support the assumption that it was the etiological agent of this diarrheal case.
Descritores: Campylobacter jejuni
Diarreia Infantil
Técnicas In Vitro
Organismos Livres de Patógenos Específicos
-Enterite
Virulência
Limites: Seres Humanos
Criança
Tipo de Publ: Artigo Histórico
Ensaio Clínico
Revisão de Integridade Científica
Responsável: BR32.1 - Serviço de Biblioteca e Informação Biomédica



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