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Pesquisa : G06.920.925 [Categoria DeCS]
Referências encontradas : 208 [refinar]
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Id: biblio-974292
Autor: Caldas, Lúcio Ayres; Freitas, Tânia Rosária Pereira; Azevedo, Renata Campos; de Souza, Wanderley.
Título: Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
Fonte: Braz. j. microbiol;49(4):785-789, Oct.-Dec. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 µg/mL).
Descritores: Antivirais/farmacologia
Prostaglandinas A/farmacologia
Doença das Mucosas por Vírus da Diarreia Viral Bovina/virologia
Vírus da Diarreia Viral Bovina/efeitos dos fármacos
-Antivirais/análise
Prostaglandinas A/análise
Replicação Viral/efeitos dos fármacos
Doença das Mucosas por Vírus da Diarreia Viral Bovina/tratamento farmacológico
Linhagem Celular
Vírus da Diarreia Viral Bovina/fisiologia
Vírus da Diarreia Viral Bovina/genética
Diarreia
Limites: Animais
Bovinos
Responsável: BR1.1 - BIREME


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Weiblen, Rudi
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Id: biblio-828184
Autor: Arenhart, Sandra; Silva Junior, José Valter Joaquim; Flores, Eduardo Furtado; Weiblen, Rudi; Gil, Laura Helena Vega Gonzales.
Título: Use of homologous recombination in yeast to create chimeric bovine viral diarrhea virus cDNA clones
Fonte: Braz. j. microbiol;47(4):993-999, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract The open reading frame of a Brazilian bovine viral diarrhea virus (BVDV) strain, IBSP4ncp, was recombined with the untranslated regions of the reference NADL strain by homologous recombination in Saccharomyces cerevisiae, resulting in chimeric full-length cDNA clones of BVDV (chi-NADL/IBSP4ncp#2 and chi-NADL/IBSP4ncp#3). The recombinant clones were successfully recovered, resulting in viable viruses, having the kinetics of replication, focus size, and morphology similar to those of the parental virus, IBSP4ncp. In addition, the chimeric viruses remained stable for at least 10 passages in cell culture, maintaining their replication efficiency unaltered. Nucleotide sequencing revealed a few point mutations; nevertheless, the phenotype of the rescued viruses was nearly identical to that of the parental virus in all experiments. Thus, genetic stability of the chimeric clones and their phenotypic similarity to the parental virus confirm the ability of the yeast-based homologous recombination to maintain characteristics of the parental virus from which the recombinant viruses were derived. The data also support possible use of the yeast system for the manipulation of the BVDV genome.
Descritores: Leveduras/genética
Genoma Viral
DNA Complementar
Vírus da Diarreia Viral Bovina/genética
Recombinação Homóloga
-Replicação Viral
Leveduras/metabolismo
Linhagem Celular
Fases de Leitura Aberta
Análise de Sequência de DNA
Vírus da Diarreia Viral Bovina/fisiologia
Vírus da Diarreia Viral Bovina/ultraestrutura
Limites: Animais
Bovinos
Responsável: BR1.1 - BIREME


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Id: biblio-839349
Autor: Martins, Gabrielle R; Marinho, Rebeca C; Bezerra Junior, Rosivaldo Q; Alves, Antoniel de O; Câmara, Lilia M. C; Albuquerque-Pinto, Luiz C; Teixeira, Maria F. da S.
Título: Goat umbilical cord cells are permissive to small ruminant lentivirus infection in vitro
Fonte: Braz. j. microbiol;48(1):125-131, Jan.-Mar. 2017. graf.
Idioma: en.
Projeto: National Council of Scientific and Technological Development.
Resumo: Abstract Small ruminant lentiviruses isolated from peripheral blood leukocytes and target organs can be propagated in vitro in fibroblasts derived from goat synovial membrane cells. These cells are obtained from tissues collected from embryos or fetuses and are necessary for the establishment of the fibroblast primary culture. A new alternative type of host cells, derived from goat umbilical cord, was isolated and characterized phenotypically with its main purpose being to obtain cell monolayers that could be used for the diagnosis and isolation of small ruminant lentiviruses in cell culture. To accomplish this goal, cells were isolated from umbilical cords; characterized phenotypically by flow cytometry analysis; differentiate into osteogenic, chondrogenic and adipogenic lineage; and submitted to viral challenge. The proliferation of goat umbilical cord cells was fast and cell monolayers formed after 15 days. These cells exhibited morphology, immunophenotype, growth characteristics, and lineage differentiation potential similar to mesenchymal stem cells of other origins. The goat umbilical cord derived cells stained positive for vimentin and CD90, but negative for cytokeratin, CD34 and CD105 markers. Syncytia and cell lysis were observed in cell monolayers infected by CAEV-Cork and MVV-K1514, showing that the cells are permissive to small ruminant lentivirus infection in vitro. These data demonstrate the proliferative competence of cells derived from goat umbilical cords and provide a sound basis for future research to standardize this cell lineage.
Descritores: Cordão Umbilical/citologia
Lentivirus/fisiologia
Células-Tronco Mesenquimais/virologia
-Osteogênese
Replicação Viral
Técnicas In Vitro
Cabras
Biomarcadores
Diferenciação Celular
Células Cultivadas
Imunofenotipagem
Técnicas de Cultura de Células
Condrogênese
Efeito Citopatogênico Viral
Adipogenia
Células-Tronco Mesenquimais/citologia
Células-Tronco Mesenquimais/metabolismo
Células-Tronco Mesenquimais/patologia
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-1020077
Autor: Strottmann, Daisy Maria; Zanluca, Camila; Mosimann, Ana Luiza Pamplona; Koishi, Andrea C; Auwerter, Nathalia Cavalheiro; Faoro, Helisson; Cataneo, Allan Henrique Depieri; Kuczera, Diogo; Wowk, Pryscilla Fanini; Bordignon, Juliano; Duarte dos Santos, Claudia Nunes.
Título: Genetic and biological characterisation of Zika virus isolates from different Brazilian regions
Fonte: Mem. Inst. Oswaldo Cruz;114:e190150, 2019. tab, graf.
Idioma: en.
Projeto: FIOCRUZ; . BNDES; . CNPq; . CAPES; . Fundação Araucária; . CNDS; . JB; . CNPq; . DMS; . CZ; . ALPM.
Resumo: BACKGROUND Zika virus (ZIKV) infections reported in recent epidemics have been linked to clinical complications that had never been associated with ZIKV before. Adaptive mutations could have contributed to the successful emergence of ZIKV as a global health threat to a nonimmune population. However, the causal relationships between the ZIKV genetic determinants, the pathogenesis and the rapid spread in Latin America and in the Caribbean remain widely unknown. OBJECTIVES The aim of this study was to characterise three ZIKV isolates obtained from patient samples during the 2015/2016 Brazilian epidemics. METHODS The ZIKV genomes of these strains were completely sequenced and in vitro infection kinetics experiments were carried out in cell lines and human primary cells. FINDINGS Eight nonsynonymous substitutions throughout the viral genome of the three Brazilian isolates were identified. Infection kinetics experiments were carried out with mammalian cell lines A549, Huh7.5, Vero E6 and human monocyte-derived dendritic cells (mdDCs) and insect cells (Aag2, C6/36 and AP61) and suggest that some of these mutations might be associated with distinct viral fitness. The clinical isolates also presented differences in their infectivity rates when compared to the well-established ZIKV strains (MR766 and PE243), especially in their abilities to infect mammalian cells. MAIN CONCLUSIONS Genomic analysis of three recent ZIKV isolates revealed some nonsynonymous substitutions, which could have an impact on the viral fitness in mammalian and insect cells.
Descritores: Aedes/virologia
Zika virus/genética
Infecção por Zika virus/virologia
Camundongos Endogâmicos BALB C
-Filogenia
Cultura de Vírus
Replicação Viral
Células Vero
Brasil
Chlorocebus aethiops
Carga Viral
Limites: Humanos
Animais
Responsável: BR1.1 - BIREME


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Id: biblio-889146
Autor: Ono, Ekaterina Alexandrovna Durymanova; Taniwaki, Sueli Akemi; Brandão, Paulo.
Título: Short interfering RNAs targeting a vampire-bat related rabies virus phosphoprotein mRNA
Fonte: Braz. j. microbiol;48(3):566-569, July-Sept. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP; . National Counsel of Technological and Scientific Development.
Resumo: Abstract The aim of this study was to assess the in vitro and in vivo effects of short-interfering RNAs (siRNAs) against rabies virus phosphoprotein (P) mRNA in a post-infection treatment for rabies as an extension of a previous report (Braz J Microbiol. 2013 Nov 15;44(3):879-82). To this end, rabies virus strain RABV-4005 (related to the Desmodus rotundus vampire bat) were used to inoculate BHK-21 cells and mice, and the transfection with each of the siRNAs was made with Lipofectamine-2000™. In vitro results showed that siRNA 360 was able to inhibit the replication of strain RABV-4005 with a 1 log decrease in virus titter and 5.16-fold reduction in P mRNA, 24 h post-inoculation when compared to non-treated cells. In vivo, siRNA 360 was able to induce partial protection, but with no significant difference when compared to non-treated mice. These results indicate that, despite the need for improvement for in vivo applications, P mRNA might be a target for an RNAi-based treatment for rabies.
Descritores: Fosfoproteínas/genética
Raiva/veterinária
Vírus da Raiva/genética
Proteínas Virais/genética
Quirópteros/virologia
RNA Interferente Pequeno/genética
Interferência de RNA
-Fosfoproteínas/metabolismo
Raiva/virologia
Vírus da Raiva/fisiologia
Proteínas Virais/metabolismo
Replicação Viral
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
RNA Interferente Pequeno/metabolismo
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-889115
Autor: Qiu, Zhenpeng; Zhou, Junxuan; Zhang, Cong; Cheng, Ye; Hu, Junjie; Zheng, Guohua.
Título: Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2. 2. 15 cells by targeting Lin28a/let-7a axis
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(7):e7220, 2018. tab, graf.
Idioma: en.
Projeto: Hubei Provincial Department of Education.
Resumo: An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor. The present study aimed to investigate the antiproliferative and anti-invasive effects of urolithin A in a stable full-length HBV gene integrated cell line HepG2.2.15 using CCK-8 and transwell assays. The RNA and protein expressions of targets were assessed by quantitative PCR and western blot, respectively. Results revealed that urolithin A induced cytotoxicity in HepG2.2.15 cells, which was accompanied by the cleavage of caspase-3 protein and down-regulation of Bcl-2/Bax ratio. Moreover, urolithin A suppressed the protein expressions of Sp-1, Lin28a, and Zcchc11, and elevated the expression of microRNA let-7a. Importantly, urolithin A also regulated the Lin28a/let-7a axis in transient HBx-transfected HCC HepG2 cells. Furthermore, urolithin A decelerated the HepG2.2.15 cell invasion, which was involved in suppressing the let-7a downstream factors HMGA2 and K-ras. These findings indicated that urolithin A exerted the antiproliferative effect by regulating the Lin28a/let-7a axis and may be a potential supplement for HBV-infected HCC therapy.
Descritores: Proteínas de Ligação a RNA/efeitos dos fármacos
Carcinoma Hepatocelular/tratamento farmacológico
Cumarínicos/farmacologia
MicroRNAs/efeitos dos fármacos
Neoplasias Hepáticas/tratamento farmacológico
-Valores de Referência
Sincalida/análise
Fatores de Tempo
Replicação Viral/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Western Blotting
Reprodutibilidade dos Testes
Análise de Variância
Proteínas de Ligação a RNA/análise
Carcinoma Hepatocelular/genética
Carcinoma Hepatocelular/virologia
MicroRNAs/análise
Proliferação de Células/efeitos dos fármacos
Células Hep G2
Reação em Cadeia da Polimerase em Tempo Real
Neoplasias Hepáticas/genética
Neoplasias Hepáticas/virologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-841788
Autor: Castrillón-Betancur, Juan Camilo; Urcuqui-Inchima, Silvio.
Título: Overexpression of miR-484 and miR-744 in Vero cells alters Dengue virus replication
Fonte: Mem. Inst. Oswaldo Cruz;112(4):281-291, Apr. 2017. graf.
Idioma: en.
Projeto: COLCIENCIAS.
Resumo: BACKGROUND Dengue is considered one of the world’s most important mosquito-borne diseases. MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that play an important role in the regulation of gene expression in eukaryotes. Although miRNAs possess antiviral activity against many mammalian-infecting viruses, their involvement in Dengue virus (DENV) replication remains poorly understood. OBJECTIVE To determine the role of miR-484 and miR-744 in DENV infection and to examine whether DENV infection alters the expression of both miRNAs. METHODS We used bioinformatics tools to explore the relationship between DENV and cellular miRNAs. We then overexpressed miR-484 or miR-744 in Vero cells to examine their role in DENV replication using flow cytometry, reverse transcriptase quantitative polymerase chain reaction (RT-qPCR), and western blotting. FINDINGS We found several cellular miRNAs that target a conserved region within the 3′ untranslated region (3′ UTR) of the genome of the four DENV serotypes and found that overexpression of miR-484 or miR-744 inhibits infection by DENV-1 to DENV-4. Furthermore, we observed that DENV RNA might be involved in the downregulation of endogenous miR-484 and miR-744. CONCLUSION Our study identifies miR-484 and miR-744 as two possible restriction host factors against DENV infection. However, further studies are needed to directly verify whether miR-484 and miR-744 both have an anti-DENV effect in vivo.
Descritores: Replicação Viral/fisiologia
Replicação Viral/genética
Chlorocebus aethiops
Regulação da Expressão Gênica/genética
Western Blotting
Reação em Cadeia da Polimerase
Biologia Computacional
Regiões não Traduzidas
Regiões não Traduzidas/fisiologia
Vírus da Dengue/fisiologia
Vírus da Dengue/genética
MicroRNAs/metabolismo
-Citometria de Fluxo
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-1026165
Autor: Palazzi, Eduardo Gimenes; Pituco, Edviges Maristela; Vicente, Elisabete Jose; Hansen, Daiane; Felicio, Joana D'Arc; Lima, Michele dos Santos; Nogueira, Adriana Hellmeister de Campos; De Stephano, Eliane; Okuda, Liria Hiromi; D'Angelo, Magali.
Título: Avaliação do extrato etanólico de casca de Punica granatum (romã) na diminuição da replicação viral do BoHV-1 Colorado em embriões murinos experimentalmente infectados / Evaluation of ethanol extract of Punica granatum (Pomegranate) peel decrease in viral replication of BoHV-1 in Colorado murine embryos experimentally infected
Fonte: Arq. Inst. Biol;82:1-9, 2015. ilus.
Idioma: pt.
Resumo: O objetivo do trabalho foi avaliar a diminuição da replicação viral (BoHV-1 Colorado) em embriões murinos após tratamento do extrato etanólico da casca de Punica granatum (EEPg). Camundongos fêmeas Swiss com idade entre 6 e 8 semanas foram superovuladas com 0,2 mL a 5 UI de hormônios (eCG e hCG), e acasaladas com machos da mesma idade. Após 18 horas, as fêmeas sofreram eutanásia em câmara de CO2 e, através de abertura no peritônio, os zigotos foram coletados e lavados com solução de pronase 0,5%.Os zigotos foram divididos em quatro grupos: G1 (controle), G2 (expostos aos vírus BoHV-1 Colorado a 108 TCID50/mL), G3 (expostos ao EEPg) e G4 (expostos aos vírus e ao EEPg). Os grupos foram mantidos a 37,5ºC em meio TCM199 (100µL) com 10% de soro fetal bovino em estufa a 5% de CO2 e 95% de umidade. Após 24 h, analisamos a taxa de clivagem (teste exato de Fisher; p<0,05), a morfologia (por microscopia óptica), a nested-PCR e a titulação dos embriões em cocultura com células MDBK após mais 72 h do tratamento (teste de Mann-Whitney; p<0,05) e microscopia eletrônica de transmissão (ME). Os embriões murinos tratados com EEPg apresentaram resultados satisfatórios: sem alterações morfológicas, taxa de clivagem semelhante ao controle e, apesar da detecção da presença do vírus pela nested-PCR e ME, houve diminuição do título viral após tratamentos com esse extrato, o que sugere interferência desse tratamento no ciclo viral do BoHV-1 Colorado sem alterar o desenvolvimento dos embriões.(AU)

The aim of this study was to evaluate the reduction of viral replication (Colorado BoHV-1) in murine embryos after the treatment of ethanol extract of Punica granatum peel (PgEE). Swiss female mice aged 6 to 8 weeks were superovulated with 0.2 mL of the 5 UI hormones (eCG and hCG) and mated with males of the same age. After 18 hours, the females were euthanized in a CO2 chamber, and through the opening in the peritoneum, zygotes were collected and washed with 0.5% pronase solution. The zygotes were divided into four groups: G1 (control), G2 (exposed to the virus Colorado BoHV -1 to 108 TCID50/mL), G3 (exposed to PgEE) and G4 (exposed to the virus and to PgEE). The groups were maintained at 37.5ºC in TCM199 (100 mL) with 10% fetal bovine serum in an incubator at 5% CO2 and 95% humidity. After 24 h, we analyzed the cleavage rate (Fisher's exact test; p<0.05), the morphology (by light microscopy), the nested-PCR and the titration of embryos in co-culture with MDBK cells after over 72 h of treatment (Mann-Whitney test; p<0.05) and transmission electron microscopy (TEM). The murine embryos treated with PgEE showed satisfactory results: no morphological changes, cleavage rate similar to controls, despite the detection of the presence of virus by nested PCR and TEM, there was a decrease of the viral titer after the treatment with this extract, which suggests interference of this treatment in the viral cycle BoHV-1 Colorado without altering the embryo development.(AU)
Descritores: Replicação Viral
Lythraceae
Muridae
Noxas
-Embrião de Mamíferos
Responsável: BR1942.1 - NID - Biblioteca - Núcleo de Informação e Documentação


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Borojevic, Radovan
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Id: biblio-945981
Autor: Gamarra, María Liz; Albuquerque, Maria Carolina Maciel; Teodoro, Anderson Junger; Martucci, Renata Brum; Borojevic, Radovan; Câmara, Fernando Portela; Romanos, Maria Teresa Villela; Santos, Norma.
Título: Susceptibility of a continuous murine cell line (GRX) to viral infection / Suscetibilidade de uma linhagem celular murina contínua (GRX) à infecção viral
Fonte: Rev. Pan-Amazônica Saúde (Online);2(2):65-69, 2011. tab, graf, ilus.
Idioma: en.
Resumo: The ability of a murine cell line (GRX) to support viral replication was evaluated. GRX cell cultures were infected with different DNA or RNA viruses. It was observed that the GRX cell line is susceptible to the replication of Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), Mayaro virus (MAY), Sindbis virus (SIN), and West equine encephalitis virus (WEE), and can beused as substrate for viral replication studies. Viral replication induced cytopathic effect (CPE) 24-48 h post-infection. The 2.4 5.4 GRX cells yielded infectious virus titers between 10 TCID (Tissue Culture Infectious Dose50) /25 µL and 10 5.4 and 10 TCID50 /25 µL in the first viral passage. These results demonstrate that GRX cells efficiently sustain viral replication and there fore can be used as a valuable tool in the virology laboratory.

Este estudo avaliou a capacidade de uma linhagem celular murina (GRX) de realizar a replicação viral. Culturas de células GRX foram infectadas com diferentes vírus DNA e RNA. Foi observado que a linhagem celular GRX é suscetível à replicação dos vírus Herpes simplex tipos 1 e 2 (HSV-1 e HSV-2), Mayaro (MAY), Sindbis (SIN) e vírus da encefalite equina do oeste (WEE) e pode ser utilizada como suporte para estudos sobre replicação viral. A replicação viral induziu o efeito 2.4 citopático 24 a 48 h pós-infecção. As células GRX produziram titulações de vírus infecciosos entre 10 TCID50 (dose 50 5.4 infecciosa de cultura de tecido )/25 µL e 10, 5.4 TCID50 /25 µL na primeira passagem viral. Esses resultados demonstram que as células GRX sustentam, de forma eficiente, a replicação viral e, portanto, podem ser utilizadas como uma ferramenta valiosa para estudos laboratoriais sobre virologia.
Descritores: Técnicas de Cultura de Células
Células Estreladas do Fígado
Replicação Viral/fisiologia
Limites: Masculino
Feminino
Humanos
Responsável: BR275.1 - Biblioteca


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Id: biblio-971386
Autor: Gil, Pedro Ignacio.
Título: Participación de las mitocondrias, los endosomas y el citoesqueleto en la replicación del virus pixuna.
Fonte: Córdoba; s.n; 2016. 112 p. ilus, graf.
Idioma: es.
Tese: Apresentada a Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Secretaría de Graduados en Ciencias de la Salud. Doctor en Ciencias de la Salud para obtenção do grau de Doutor.
Resumo: El género Alphavirus es de gran interés epidemiológico ya que sus miembros, incluyendo los virus del "Complejo de Encefalitis Equina Venezolana", pueden provocar importantes enfermedades, tanto en animales domésticos con en el hombre. Durante las últimas décadas se ha registrado un aumento en la incidencia mundial de virus transmitidos por artrópodos (arbovirus), particularmente aquellos transmitidos por mosquitos, como los virus de Encefalitis Equina Venezolana, el Virus Rio Negro, Moyaro, PIXV y Chikunguya, entre otros.

Abstract: The present work is based on the study of the replication mechanisms of Pixuna virus (PIXV), including the participation of the endosomal pathway during viral stripping as well as the mitochondria and cytoskeleton, both microtubules (MTs) and microbilaments (MFLS), in the replication process for the correct location on your replication sites.
Descritores: Infecções por Alphavirus
Vírus da Encefalite Equina Venezuelana/imunologia
Replicação Viral
Encefalite por Arbovirus/imunologia
-Argentina/epidemiologia
Limites: Masculino
Feminino
Humanos
Tipo de Publ: Estudo de Validação
Responsável: AR32.1 - Biblioteca Prof. Dr. J. M. Allende
AR32.1; TCS, G-7 2016



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