Base de dados : LILACS
Pesquisa : G07.203.100 [Categoria DeCS]
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Id: biblio-893794
Autor: Geraldini, Simone; Cruz, Igor de Freitas; Romero, Alexandre; Fonseca, Fernando Luiz Affonso; Campos, Michelle Parreira de.
Título: Isotonic sports drink promotes rehydration and decreases proteinuria following karate training / Suplemento hidroeletrolítico favorece reidratação e diminui proteinúria pós-treino em atletas karate
Fonte: J. bras. nefrol;39(4):362-369, Oct.-Dec. 2017. tab.
Idioma: en.
Resumo: Abstract Introduction: Adequate hydration status in the sport is essential for good health, yet the relationship between hydration, proteinuria and sports is little studied. Objective: To analyze the influence of an isotonic sports drink as rehydration strategy on the hydration status and proteinuria after karate training. Methods: Ten athletes participated in this study. In the first session of standard training, called observation training session (STO), the athletes hydrated themselves according to their habits, and in the second session of standard training, called nutritional intervention training session (STIN), an ideal practice of hydration protocol was followed, using an isotonic sports drink as a rehydration liquid during the training. The hydration status was verified by monitoring the body weight before and after training, the urine specific gravity pre-and post-training and the urine volume post-training. To observe the influence of practice of hydration on the renal function post exercise proteinuria was measured. Results: We observed a statistically significant difference in urine density between the samples pre- and post-exercise only on STIN (p = 0.047). When we compare the sessions, there was a lower variation in body weight (p = 0.011) and higher urinary volume (p < 0.001), on nutritional intervention training. In STO, there was a higher percentage of athletes who showed proteinuria (70%) compared to the STIN (50%) in the urine sample after training. Conclusion: The use of isotonic sports drink as practice of hydration by karate athletes promoted rehydration during one session of training and reduce post-training proteinuria.

Resumo Introdução: Um adequado estado de hidratação durante a atividade esportiva é essencial para a manutenção da boa saúde, porém a relação entre hidratação, proteinúria e esportes é pouco estudada. Objetivo: analisar a influência de suplemento hidroeletrolítico (bebida esportiva isotônica) como estratégia de reidratação sobre o estado de hidratação e proteinúria após treino de Karate. Métodos: Dez atletas participaram deste estudo. Na primeira sessão de treino padronizado, denominada sessão de treino de observação (STO), os atletas se reidrataram segundo seus hábitos; na segunda sessão de treino padronizado, denominada sessão de treino de intervenção nutricional (STIN), foi seguido um protocolo ideal de prática de hidratação, utilizando-se de suplemento hidroeletrolítico como líquido reidratante durante o treino. O estado de hidratação foi verificado pelo monitoramento do peso corporal antes e após o treino, pela gravidade específica da urina pré e pós-treino e pelo volume urinário pós-treino. De forma a observar a influência da prática de hidratação sobre a função renal, a proteinúria pós-exercício foi medida. Resultados: Observou-se uma diferença estatisticamente significativa na densidade urinária entre as amostras coletadas pré e pós-exercício apenas na STIN (p = 0,047). Quando comparados entre sessões, houve menor variação ponderal (p = 0,011) e maior volume urinário (p < 0,001) no treino com intervenção nutricional. Na STO, houve um percentual mais elevado de atletas que apresentaram proteinúria (70%) em comparação a STIN (50%) na amostra de urina coletada após o treino. Conclusão: O uso de suplemento hidroeletrolitico como prática de hidratação por atletas de karate favoreceu a reidratação durante uma sessão de treino e reduziu a proteinúria pós-treino.
Descritores: Proteinúria/prevenção & controle
Bebidas
Artes Marciais/fisiologia
Fenômenos Fisiológicos da Nutrição Esportiva/fisiologia
Hidratação
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-1095236
Autor: Faraoni, Juliana Jendiroba; Quero, Isabela Barbosa; Schiavuzzo, Lívia Semedo; Palma-Dibb, Regina Guenka.
Título: Color stability of nanohybrid composite resins in drinks
Fonte: Braz. j. oral sci;18:e191601, jan.-dez. 2019. tab.
Idioma: en.
Resumo: Aim: The objective of this study was to evaluate the effects of solutions on the color stability of nanohybrid composite resins. Methods: The experimental sample consisted of 90 composite specimens (Beautifil II; Z350XT; Premisa), divided into three subgroups (n=10) according to the solutions (matte tea; lemon flavor isotonic drink; artificial saliva). The specimens were immersed in the solutions (5 mL/specimen) while stirring for 5 minutes, four times a day, with 1-hour intervals, repeated for 15 days. The color of the specimens was analyzed before (baseline) and after the 15th day of cycling using the CIELAB system. Data were analyzed using the two-way analysis of variance (ANOVA) and Tukey's test (α=5%). Results: Different behaviors were observed among resins. Beautifil II presented the highest color change (∆E=4.18) and less color stability, statistically different from the others (p<.05). The solutions also presented different behaviors. The lemon flavor isotonic drink (∆E=3.95) promoted the highest color change, statistically different from saliva (∆E=2.75; p<.05). The interaction between Beautifil II and isotonic drink became even more evident and significant (p<.05). Conclusion: The isotonic drink is the solution that most affected the resins, and Beautifil II presents the worst color stability
Descritores: Bebidas
Cor
Resinas Compostas
Nanocompostos
Responsável: BR218.1 - Biblioteca Carlos Henrique Robertson Liberalli


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Mondelli, Rafael Francisco Lia
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Id: biblio-1095176
Autor: Santin, Daniella Cristo; Naufel, Fabiana Scarparo; Mondelli, Rafael Francisco Lia; Piccolotto, Adriano; Schmitt, Vera Lúcia.
Título: Effect of sports drinks on the surface properties of composite resins after prolonged exposure - in vitro study
Fonte: Braz. j. oral sci;18:e191651, jan.-dez. 2019. ilus.
Idioma: en.
Resumo: Aim: Using dietary supplements may affect the properties of composite resins due to their acidic pH. The present in vitro study aimed to assess the surface roughness and color stability of two composite resins - nanohybrid (Empress Direct) and nanoparticulate (Filtek Z350) - after prolonged exposure to dietary supplements. Methods: We produced 30 specimens from each composite (8x2-mm discs) and divided them into six groups (n=10). After the initial measurement of the surface properties (roughness and color), we exposed the specimens to a degradation process in Maltodextrin and Whey Protein for 22.5 and 7.5 days, respectively, using deionized water as the control solution. At the end of 22.5 days, we reassessed the specimens. After verifying data normality with the Kolmogorov-Smirnov test, we performed ANOVA followed by Tukey's test at 5%. Results: We found significant differences for materials immersed in the Whey Protein solution (p<0.05). The roughness of Empress Direct was higher (0.45+0.07) than Filtek Z350 (0.22+0.05). The composites tested also showed color change (ΔE>3.3) after the immersion period (p<0.001). In Maltodextrin, the Empress Direct group presented (4.52+1.23) and Filtek Z350 (4.04+0.66), while after immersion in Whey Protein, they showed (5.34+1.68) and (4.26+1.02), respectively. Conclusion: Sports drinks changed the surface roughness and color stability of the composite resins studied. The Filtek Z350 group showed lower color variation than the Empress Direct composite in both solutions evaluated
Descritores: Propriedades de Superfície
Bebidas
Resinas Compostas
Suplementos Nutricionais
Responsável: BR218.1 - Biblioteca Carlos Henrique Robertson Liberalli


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Lamounier, Joel Alves
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Id: biblio-902890
Autor: Café, Ana Carolina Corrêa; Lopes, Carlos Alexandre de Oliveira; Novais, Rommel Larcher Rachid; Bila, Wendell Costa; Silva, Daniely Karoline da; Romano, Márcia Christina Caetano; Lamounier, Joel Alves.
Título: Consumo de bebidas açucaradas, leite e sua associação com o índice de massa corporal na adolescência: uma revisão sistemática / Intake of sugar-sweetened beverages, milk and its association with body mass index in adolescence: a systematic review
Fonte: Rev. paul. pediatr;36(1):91-99, jan.-mar. 2018. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: Sistematizar as referências da literatura relacionadas à associação entre consumo de bebidas açucaradas não alcoólicas, leite e índice de massa corporal (IMC) em adolescentes. Fontes de dados: Realizou-se a pesquisa dos artigos nos portais PubMed (US National Library of Medicine National Institutes of Health) e BVS (Biblioteca Virtual em Saúde). Os descritores foram: adolescente, adulto jovem, bebidas, ingestão de líquidos, obesidade, sobrepeso, IMC e estado nutricional. Utilizaram-se os filtros: idade entre 10 e 19 anos e artigos em português e inglês, publicados entre 2011 e 2015. Síntese dos dados: Trinta estudos foram selecionados (22 transversais, 4 coortes, 1 ensaio clínico aleatório, 1 caso-controle e 1 quase experimental). Dos 20 estudos que abordaram bebidas açucaradas em geral, 55% encontraram associação entre consumo e aumento do IMC. Em relação aos estudos sobre a ingestão de refrigerantes, todos apresentaram associação entre consumo e aumento do IMC. Dos estudos sobre leite, somente um demonstrou associação entre consumo e aumento do IMC. Três artigos mostraram proteção entre consumo de leite e aumento do IMC, e três trabalhos não encontraram associação de seu consumo com aumento do IMC. Dezenove estudos possuíam amostras representativas e outros 20 declararam ter amostras aleatórias. Dos artigos com questionários, 84% eram validados. Conclusões: Verifica-se que não há consenso na literatura pesquisada sobre a associação entre consumo de bebidas açucaradas não alcoólicas, leite e IMC de adolescentes.

ABSTRACT Objective: To systematize literature references addressing the association of sugar-sweetened beverage (SSB) and milk intake with body mass index (BMI) in adolescents. Data source: A search was carried out in PubMed (US National Library of Medicine National Institutes of Health) and BVS (Virtual Library in Health). The descriptors used were: adolescents, young adult, beverages, drinking, obesity, overweight, BMI, and nutritional status. The following filters were applied: age ranging from 10 to 19 years, studies published in Portuguese or English language between 2011-2015. Data synthesis: Thirty studies were selected (22 cross-sectional studies, 4 cohort studies, 1 randomized clinical trial, 1 case-control study, and 1 quasi-experimental study). There was association between the intake of these beverages and increase in BMI in 55% of all 20 studies that dealt with sugary drinks. When it came to soft drinks, 100% of studies reported association with increase in BMI. As to milk intake, only one article showed association with increased BMI. Three articles reported milk as a protection factor against increase in BMI; three studies found no association between this intake and BMI. Nineteen studies had representative samples and 20 surveys reported random samples. Among papers using questionnaires, 84% had been validated. Conclusions: There is no consensus in the literature about the association between SSB or milk intake and BMI in adolescents.
Descritores: Edulcorantes/administração & dosagem
Bebidas
Índice de Massa Corporal
Leite
Dieta
Limites: Humanos
Animais
Adolescente
Tipo de Publ: Revisão
Revisão Sistemática
Responsável: BR1.1 - BIREME


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Venancio, Sonia Isoyama
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Id: biblio-957377
Autor: Passanha, Adriana; Benício, Maria Helena D'Aquino; Venâncio, Sonia Isoyama.
Título: Influência do aleitamento materno sobre o consumo de bebidas ou alimentos adoçados / Influence of breastfeeding on consumption of sweetened beverages or foods
Fonte: Rev. Paul. Pediatr. (Ed. Port., Online);36(2):148-154, abr.-jun. 2018. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: Verificar se o aleitamento materno associa-se a menores prevalências de consumo de bebidas ou alimentos adoçados entre lactentes. Métodos: Trata-se de um estudo transversal realizado com dados da Pesquisa de Prevalência de Aleitamento Materno em Municípios Brasileiros de 2008. Foi estudada uma amostra representativa de 14.326 lactentes, de 6 a 11,9 meses, residentes em 75 municípios do estado de São Paulo. Avaliou-se a influência do aleitamento materno sobre o consumo de bebidas ou alimentos adoçados mediante regressão de Poisson multinível. Permaneceram como variáveis de ajuste aquelas que apresentaram p<0,20 na análise bruta. Resultados: A maioria dos lactentes encontrava-se em aleitamento materno (56,1%), e 53,3% consumiram bebidas ou alimentos adoçados. O consumo de tais bebidas ou alimentos foi menos prevalente entre os lactentes amamentados, após ajustes pelas variáveis de confusão (RP 0,87; IC95% 0,83-0,91). Conclusões: A presença do aleitamento materno associou-se a menores prevalências de consumo de bebidas ou alimentos adoçados. Assim, pode-se esperar, como efeito adicional das ações de promoção ao aleitamento materno, que haja diminuição do consumo de bebidas ou alimentos adoçados entre lactentes.

ABSTRACT Objective: To verify whether breastfeeding is associated with lower prevalence of consumption of sweetened beverages or foods in infants. Methods: This is a cross-sectional study with data collected from the Survey on Prevalence of Breastfeeding conducted in Brazilian municipalities in 2008. A representative sample of 14,326 infants aged 6 to 11.9 months of age, residents of 75 municipalities in the State of São Paulo, Southeastern Brazil, was studied. The influence of breastfeeding on the consumption of sweetened beverages or food products was analyzed by multilevel Poisson regression. Variables with p<0.20 in the crude analysis were included in the multilevel analysis. Results: Most infants were on breastfeeding (56.1%). The prevalence of sweetened drinks or foods consumption was 53.3%. The consumption of sweetened products was shown to be less prevalent among breastfed infants after adjustment for confounding factors (PR 0.87; 95%CI 0.83-0.91). Conclusions: Breastfeeding was associated with lower consumption of sweetened beverages or foods. As an additional effect of actions aimed at promoting breastfeeding, a decrease in intake of sweetened products is expected among infants.
Descritores: Edulcorantes
Bebidas
Aleitamento Materno/estatística & dados numéricos
Dieta
Alimentos
-Estudos Transversais
Limites: Humanos
Masculino
Feminino
Lactente
Responsável: BR1.1 - BIREME


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Id: biblio-977089
Autor: Pellanda, Lúcia Campos; Passanha, Adriana.
Título: Aleitamento materno e consumo de alimentos adoçados / Breatfeeding and consumption of sweetened foods
Fonte: Rev. Paul. Pediatr. (Ed. Port., Online);36(4):524-525, out.-dez. 2018.
Idioma: pt.
Descritores: Bebidas
Aleitamento Materno
-Dieta
Limites: Humanos
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-950008
Autor: Garavaglia, María B; Rodríguez García, Vanesa; Zapata, María E; Rovirosa, Alicia; González, Verónica; Flax Marcó, Florencia; Carmuega, Esteban.
Título: Edulcorantes no nutritivos: consumo de los niños y adolescentes, y alimentos que los aportan / Non-nutritive sweeteners: children and adolescent consumption and food sources
Fonte: Arch. argent. pediatr;116(3):186-191, jun. 2018. tab.
Idioma: en; es.
Resumo: La disponibilidad de alimentos y bebidas con edulcorantes no nutritivos (ENN) aumentó en años recientes. Objetivos: Estimar el consumo de ENN en niños y adolescentes de la Ciudad de Buenos Aires, la prevalencia de ingesta superior a la admisible y los principales alimentos y bebidas aportadores. Material y Métodos: Estudio descriptivo de información recolectada en la Primera Encuesta Alimentaria y Nutricional de la ciudad de Buenos Aires realizada en 2011 que incluyó 2664 niños y adolescentes de 2 a 18 años. El consumo se evaluó mediante recordatorio de 24 horas. El contenido de ENN en alimentos y bebidas se obtuvo del rotulado nutricional. Se calculó la ingesta total de cada ENN y la adecuación a la ingesta diaria admisible (IDA) establecida por FAO/OMS. Resultados: El 44% de los preescolares, 53% de escolares y 51% de los adolescentes consumieron alimentos con ENN. Ningún niño presentó un consumo superior a la IDA de aspartamo, acesulfame-K y sucralosa. El 0,3% de los preescolares superó la IDA de sacarina, el 1% de preescolares, 0,9% de escolares y el 0,1% de los adolescentes superaron la IDA de ciclamato, debido al consumo de jugos concentrados para diluir. Las bebidas aportaron el 67% del ciclamato, el 91% del acesulfame-K y el 96% del aspartamo. Los edulcorantes de mesa aportaron el 30% del ciclamato y el 32% de la sacarina. Conclusión: El consumo de alimentos con ENN es usual en la población infanto juvenil, principalmente a partir de bebidas. Menos del 1% de los niños supera la IDA de ciclamato y sacarina.

The availability of food and beverages with non-nutritive sweeteners (NNSs) has increased in recent years. Objectives: To estimate NNSs consumption among children and adolescents in the Autonomous City of Buenos Aires, the prevalence of a daily intake higher than acceptable, and the main food and beverages contributing to it. Material and methods: Descriptive study about the information collected in the First Food and Nutritional/Nutrition Survey of Buenos Aires City, which was conducted in 2011 and included 2664 children and adolescents aged 2-18 years. Consumption was assessed by means of a 24-hour recall. NNSs content in food and beverages was obtained from nutrition facts labels. The total dietary intake for each NNSs and the adequacy to the acceptable daily intake (ADI) established by the Food and Agriculture Organization of the United Nations (FAO)/World Health Organization (WHO). Results: Forty four percent of preschoolers, 53% of school children, and 51% of adolescents have had food with NNSs. No child was exposed to a consumption of aspartame, acesulfameK, and sucralose higher than the ADI. Saccharin consumption was higher than the ADI in 0.3% of preschoolers while cyclamate consumption was higher than the ADI in 0.9% of school children and 0.1% of adolescents, due to the consumption of concentrated juice, to be diluted with water. Beverages provided 67% of cyclamate, 91% of acesulfameK, and 96% of aspartame. Table-top sweeteners provided 30% of cyclamate and 32% of saccharin. Conclusion: Consumption of food and beverages with NNSs is usual among children and adolescents, mainly from beverages. Less than 1% of children are exposed to a consumption of cyclamate and saccharin higher than the ADI.
Descritores: Bebidas/estatística & dados numéricos
Dieta/estatística & dados numéricos
Alimentos/estatística & dados numéricos
-Epidemiologia Descritiva
Estudos Transversais
Nível de Efeito Adverso não Observado
Adoçantes não Calóricos/administração & dosagem
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-838316
Autor: Rovirosa, Alicia; Zapata, María E; Gómez, Paula; Gotthelf, Susana; Ferrante, Daniel.
Título: Alimentos y bebidas publicitados en canales infantiles de Argentina: frecuencia, duración y calidad nutricional / Food and beverage advertising on children's TV channels in Argentina: Frequency, duration, and nutritional quality
Fonte: Arch. argent. pediatr;115(1):28-34, feb. 2017. graf, tab.
Idioma: en; es.
Resumo: El marketing de alimentos y bebidas ha sido identificado como uno de los determinantes del consumo de alimentos y bebidas poco saludables en la población infantil. Objetivo. Conocer la frecuencia y duración de publicidades de alimentos y bebidas en programación televisiva infantil y la calidad nutricional de los alimentos y bebidas publicitados. Métodos. Estudio descriptivo transversal. Se realizaron grabaciones en dos períodos, durante la semana y el fin de semana, de canales de cable infantiles y de la programación infantil de los canales de aire. Se registró el tipo, la cantidad y el tiempo de las publicidades emitidas. Se analizó la calidad nutricional de los alimentos y bebidas publicitados. Resultados. Se analizaron 402,3 horas de programación infantil. Se registraron 3711 avisos publicitarios. El 20,9% de las publicidades correspondieron a alimentos y bebidas, en promedio 1,9 ± 1,0 avisos por hora, equivalente a 0,68 ± 0,36 min/hora. Los lácteos, golosinas y productos de las cadenas de comidas rápidas fueron los alimentos con mayor presencia. Solo una tercera parte de los alimentos y bebidas publicitados (35,8%) fueron categorizados como saludables según el sistema de perfiles nutricionales. De acuerdo con el sistema de perfilado del semáforo nutricional, la mitad eran altos en azúcares; una cuarta parte, altos en grasas saturadas y, aproximadamente, 15% eran altos en sodio o grasas. Conclusión. La publicidad de alimentos y bebidas ocupó una quinta parte del tiempo de publicidad televisiva. Los grupos de alimentos más publicitados fueron los lácteos seguidos por dulces y golosinas, productos de las cadenas de comidas rápidas y bebidas. Dos terceras partes de los alimentos y bebidas publicitados se consideraron poco saludables.

Food and beverage marketing has been identified as one of the determinants of unhealthy food and beverage consumption in the child population. Objective. To determine the frequency and duration of food and beverage advertising in children's programming and the nutritional quality of advertised food and beverages. Methods. Descriptive, cross-sectional study. Children's cable and broadcast channel programming was recorded in two periods: over the week and on the weekend. The type, quantity, and duration of commercials were recorded. The nutritional quality of advertised food and beverages was analyzed. Results. A total of 402.3 hours of children's programming were recorded. In total, 3711 commercials were identified. Among these, 20.9% corresponded to food and beverages, i.e., an average of 1.9 ± 1.0 commercials per hour or equivalent to 0.68 ± 0.36 min/hour. Dairy products, candies, and fast-food meals were the most advertised food products. Only a third of advertised food and beverages (35.8%) were categorized as healthy as per the nutrient profiling system. Based on the traffic light labeling system, 50% of advertised food and beverages were high in sugar, 25% were high in saturated fat, and approximately 15% were high in sodium or fat. Conclusion. Food and beverage advertising accounted for 20% of television advertising time. The most advertised products were dairy products, followed by candies and sweet snacks, fast-food meals, and beverages. Two-thirds of advertised food and beverages were considered unhealthy.
Descritores: Televisão
Bebidas
Publicidade/estatística & dados numéricos
Alimentos
Valor Nutritivo
-Argentina
Fatores de Tempo
Estudos Transversais
Limites: Humanos
Criança
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-623978
Autor: Laranja, Sandra M. R; Bergamaschi, Cassia M; Schor, Nestor.
Título: Evaluation of acute administration of natural products with potential diuretic effects, in humans
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):237-240, 1991. ilus, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: In order to evaluate the potential diuretic effect of two natural products, Elephantopus scaber and Alpinia speciosa, a trial administration was carried out in ten healthy volunteers and the effects compared to the those of a placebo. The substances were given on different days, with a seven day interval between doses. The amount of substance administered to the subjects was five times the usual dose i.e. 7.5 g/100 ml and 0.8 g/100 ml respectively. The following parameters parameteres were measured: urinary and plasma sodium, potassium, uric acid, calcium, phosphate, urea, creatinine. The subjects were also examined clinically and total urinary volume was assessed. The only significant finding (p < 0.05) was a slight diuresis with Alpinia speciosa, which also lowered the diastolic (p < 0.05) and systolic (p < 0.01) blood pressures. No effect on electrolytes or renal function parameters was observed, and this probably excludes any renal tubular or glomerular effect from these substances. .
Descritores: Urina/química
Pressão Sanguínea/efeitos dos fármacos
Diuréticos/administração & dosagem
Diuréticos/farmacologia
Eletrólitos/sangue
Natriurese/efeitos dos fármacos
-Bebidas
Brasil
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Responsável: BR1.1 - BIREME


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Amaral, Jose Luiz Gomes do
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Id: biblio-951914
Autor: Pires, Júlia Movilla; Mendes, Fúlvio Rieli; Pires, Ana Paula Salum; Yonamine, Maurício; Amaral, José Luiz Gomes do; Carlini, Elisaldo Araújo.
Título: Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol
Fonte: Braz. J. Pharm. Sci. (Online);54(1):e17174, 2018. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: ABSTRACT Ayahuasca is a beverage with psychoactive properties used in religious and ceremonial rituals by some religious groups. The main active components of ayahuasca are dimethyltryptamine and the harmala alkaloids with ß-carboline structure acting as monoamine oxidase A inhibitors. This combination produces a pronounced activation of serotonergic pathways and presents potential interaction with other psychotropics. The objective of this study was to investigate the possible interactions between ayahuasca and agents employed in general anesthesia. The pharmacological interactions between ayahuasca and morphine or propofol were evaluated in mice using doses of 12, 120 and 1200 mg/kg (0.1 to 10 times the average dose consumed by humans in religious rituals). Ayahuasca alone showed an antinociceptive effect in the writhing and formalin tests, and intensified the analgesic effect of morphine in the hot plate test. Concerning the pharmacological interactions between ayahuasca and propofol, the results were opposite; ayahuasca intensified the depressant effect of propofol in the rotarod test, but decreased the sleeping time induced by propofol. These set of results showed the occurrence of some interactions between ayahuasca and the drugs morphine and propofol, possibly by both pharmacokinetics and pharmacodynamics mechanisms
Descritores: Interações Medicamentosas
Avaliação Pré-Clínica de Medicamentos
Morfina/análise
-Bebidas/efeitos adversos
Propofol/análise
Banisteriopsis/efeitos adversos
Psychotria/efeitos adversos
Analgésicos/efeitos adversos
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME



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