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Pesquisa : G07.345.500 [Categoria DeCS]
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Texto completo SciELO Cuba
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Id: biblio-1093610
Autor: Taboada Lugo, Noel.
Título: La vía de señalización Notch en el origen de algunas malformaciones congénitas / The Notch Signaling Pathway at the Origin of Some Congenital Malformations
Fonte: Rev. cuba. obstet. ginecol;44(3):1-17, jul.-set. 2018.
Idioma: es.
Resumo: La vía de señalización Notch desempeña un papel clave para regular el destino celular, crecimiento, proliferación y la muerte celular programada durante el desarrollo de organismos eucariotas. Esta vía está relacionada con una enorme diversidad de procesos del desarrollo y su disfunción está implicada en el origen de muchas malformaciones congénitas. Se realizó una revisión bibliográfica con el objetivo de actualizar la información sobre la vía de señalización Notch y su relación con el origen de diferentes malformaciones congénitas sensibles a la deficiencia materna de ácido fólico y otros micronutrientes. La literatura médica publicada en idiomas español e inglés se recopiló a través de buscadores como PubMed, Medline, Scielo, Lilacs y la biblioteca Cochrane en enero de 2018 usando palabras clave apropiadas. El conocimiento de esta vía de señalización podría ayudar a comprender mejor algunos aspectos de la morfogénesis, ya que, al actuar como un controlador maestro del destino celular, la proliferación, diferenciación y muerte celular programada, ofrece puntos específicos y susceptibles de intervención que posibilitan la prevención de determinadas malformaciones congénitas en el hombre(AU)

Notch signaling pathway plays a key role to regulate cell grow, fates, proliferation and programmed cell death in development of eukaryotic organisms. This pathway is related with an enormous diversity of developmental processes and its dysfunction is implicated in the origin of many congenital malformations. A review was performed to provide updated information on Notch signaling pathway involved in the origin of some congenital malformations related with maternal deficiency of folic acid and other micronutrients. Published medical literature in Spanish and English languages was retrieved from PubMed, Medline, Scielo, Lilacs and the Cochrane Library in January 2018, using appropriate key words. Knowledge about this signaling pathway could help to better understand some topics of morphogenesis, since by acting as a master controller of cell fate, proliferation, differentiation and programmed cell death, it offers susceptible and specific points which make possible to prevent some human congenital malformations(AU)
Descritores: Receptores Notch/análise
Receptores Notch/genética
Receptores Notch/uso terapêutico
Morfogênese/genética
-Anormalidades Congênitas/genética
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CU1.1 - Biblioteca Médica Nacional


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Texto completo SciELO Chile
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Id: biblio-1011433
Autor: Isah, Tasiu.
Título: De novo in vitro shoot morphogenesis from shoot tip-induced callus cultures of Gymnema sylvestre (Retz.) R. Br. ex Sm
Fonte: Biol. Res;52:3, 2019. tab, graf.
Idioma: en.
Resumo: BACKGROUND: Gymnema sylvestre is a medicinal woody perennial vine known for its sweetening properties and antidiabetic therapeutic uses in the modern and traditional medicines. Its over-exploitation for the therapeutic uses and to meet the demand of pharmaceutical industry in raw materials supply for the production of anti-diabetic drugs has led to considerable decline in its natural population. RESULTS: An efficient system of shoot bud sprouting from nodal segment explants and indirect plant regeneration from apical meristem-induced callus cultures of G. sylvestre have been developed on Murashige and Skoog (MS) medium amended with concentrations of cytokinins. Of the three growth regulators tested, N6-benzylaminopurine (BAP) was the most efficient and 2.0 mg L-1 gave the best shoot formation efficiency. This was followed by thidiazuron (TDZ) and kinetin (Kin) but, most of the TDZ-induced micro shoots showed stunted growth. Multiple shoot formation was observed on medium amended with BAP or TDZ at higher concentrations. The produced micro shoots were rooted on half strength MS medium amended with auxins and rooted plantlets acclimatized with 87% survival of the regenerates. CONCLUSIONS: The developed regeneration system can be exploited for genetic transformation studies, particularly when aimed at producing its high yielding cell lines for the anti-diabetic phytochemicals. It also offers opportunities for exploring the expression of totipotency in the anti-diabetic perennial vine.
Descritores: Reguladores de Crescimento de Planta/farmacologia
Regeneração/efeitos dos fármacos
Brotos de Planta/crescimento & desenvolvimento
Gymnema sylvestre/crescimento & desenvolvimento
Morfogênese/efeitos dos fármacos
-Compostos de Fenilureia/farmacologia
Purinas/farmacologia
Tiadiazóis/farmacologia
Compostos de Benzil/farmacologia
Brotos de Planta/efeitos dos fármacos
Gymnema sylvestre/efeitos dos fármacos
Cinetina/farmacologia
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Cuba
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Id: biblio-1124629
Autor: Taboada Lugo, Noel.
Título: Avances en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas. Parte 2 y última: Cardiopatías congénitas / Advances in the knowledge of the molecular and cellular bases of congenital heart diseases. Second of two parts: Congenital heart defects
Fonte: CorSalud;11(4):307-316, oct.-dic. 2019. tab.
Idioma: es.
Resumo: RESUMEN Las cardiopatías congénitas son los defectos congénitos más frecuentes en los seres humanos. Se realizó una revisión de la literatura médica con el objetivo de identificar los avances más recientes en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas. La información obtenida se dividió en dos partes: en la primera se dirigió la atención a los genes y a la morfogénesis cardíaca, y esta segunda parte la complementa, haciendo hincapié en las cardiopatías congénitas propiamente dichas.

ABSTRACT Congenital heart defect is the most common birth defect in humans. We conducted a review of the medical literature with the aim of identifying the most recent advances in the knowledge of its molecular and cellular bases. The information obtained was divided into two parts: the first one emphasized on genes and cardiac morphogenesis, and this second part complements the previous one, with special focus on congenital heart defects.
Descritores: Fatores de Transcrição
Transdução de Sinais
Metilação de DNA
Cardiopatias Congênitas
Morfogênese
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


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Id: biblio-1124636
Autor: Góngora Gómez, Onelis; Gómez Vázquez, Yadnil E; Bauta Milord, Rosalí.
Título: Cardiopatías congénitas en los principales síndromes causados por aneuploidías / Congenital heart disease in the main aneuploidy syndromes
Fonte: CorSalud;11(4):353-354, oct.-dic. 2019.
Idioma: es.
Descritores: Cardiopatias Congênitas
Aneuploidia
Morfogênese
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


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Texto completo SciELO Brasil
Maltz, Marisa
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Id: biblio-1101256
Autor: EV, Laís Daniela; DAMÉ-TEIXEIRA, Nailê; DO, Thuy; MALTZ, Marisa; PAROLO, Clarissa Cavalcanti Fatturi.
Título: The role of Candida albicans in root caries biofilms: an RNA-seq analysis
Fonte: J. appl. oral sci;28:e20190578, 2020. tab, graf.
Idioma: en.
Projeto: Brazilian National Counsel of Technological and Scientific Development; . Coordination for the Improvement of Higher Level Education; . Rio Grande do Sul State Foundation for Research Support; . Leeds Teaching Hospitals Charitable Foundation; . Dunhill Medical Trust.
Resumo: Abstract Objective This study sought to analyze the gene expression of Candida albicans in sound root surface and root caries lesions, exploring its role in root caries pathogenesis. Methodology The differential gene expression of C. albicans and the specific genes related to cariogenic traits were studied in association with samples of biofilm collected from exposed sound root surface (SRS, n=10) and from biofilm and carious dentin of active root carious lesions (RC, n=9). The total microbial RNA was extracted, and the cDNA libraries were prepared and sequenced on the Illumina Hi-Seq2500. Unique reads were mapped to 163 oral microbial reference genomes including two chromosomes of C. albicans SC5314 (14,217 genes). The putative presence of C. albicans was estimated (sum of reads/total number of genes≥1) in each sample. Count data were normalized (using the DESeq method package) to analyze differential gene expression (using the DESeq2R package) applying the Benjamini-Hochberg correction (FDR<0.05). Results Two genes (CaO19.610, FDR=0.009; CaO19.2506, FDR=0.018) were up-regulated on SRS, and their functions are related to biofilm formation. Seven genes ( UTP20 , FDR=0.018; ITR1 , FDR=0.036; DHN6 , FDR=0.046; CaO19.7197 , FDR=0.046; CaO19.7838 , FDR=0.046; STT4 , FDR=0.046; GUT1 , FDR=0.046) were up-regulated on RC and their functions are related to metabolic activity, sugar transport, stress tolerance, invasion and pH regulation. The use of alternative carbon sources, including lactate, and the ability to form hypha may be a unique trait of C. albicans influencing biofilm virulence. Conclusions C. albicans is metabolically active in SRS and RC biofilm, with different roles in health and disease.
Descritores: Raiz Dentária/microbiologia
Candida albicans/genética
DNA Fúngico/genética
Cárie Radicular/microbiologia
Biofilmes/crescimento & desenvolvimento
-Candida albicans/isolamento & purificação
Candida albicans/crescimento & desenvolvimento
Expressão Gênica
Regulação Fúngica da Expressão Gênica
Regulação para Cima
Análise de Sequência de RNA
Transcriptoma
Morfogênese
Limites: Humanos
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta


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Id: biblio-1089742
Autor: Taboada Lugo, Noel.
Título: Avances en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas. Parte 1 de 2: Morfogénesis cardíaca / Advances in the knowledge of the molecular and cellular bases of congenital heart diseases. Part 1 of 2: Cardiac morphogenesis
Fonte: CorSalud;11(3):233-240, jul.-set. 2019. tab.
Idioma: es.
Resumo: RESUMEN Las cardiopatías congénitas son los defectos congénitos más frecuentes en humanos. Muchos estudios indican que el desarrollo cardíaco está estrechamente regulado por diferentes vías de señalización celular y eventos morfológicos, genéticamente controlados. La identificación de nuevos genes que intervienen en el proceso de cardiogénesis es de gran utilidad para conocer los mecanismos moleculares y celulares por el que se genera el amplio espectro fenotípico de las cardiopatías congénitas. Se realizó una revisión bibliográfica, con el objetivo de identificar los avances más recientes en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas; lo que permite una clasificación más efectiva de estos defectos congénitos y una futura optimización del tratamiento individualizado para cada paciente, además de ofrecer posibles puntos específicos y susceptibles de intervención que posibilitarían la prevención de algunos de los defectos congénitos más frecuentes en los seres humanos.

ABSTARACT Congenital heart diseases are the most common congenital defect in humans. Many studies indicate that the cardiac development is tightly regulated by different cell signaling pathways and genetically controlled morphological events. The identification of new genes involved in the cardiogenesis process is very useful in order to know the molecular and cellular mechanisms by which the broad phenotypic spectrum of congenital heart disease is generated. An updated bibliographic review was carried out, with the aim of identifying the most recent advances in the knowledge of the molecular and cellular bases of congenital heart disease. This knowledge allows a more effective classification of these congenital defects and a future optimization of the individualized treatment for each patient, in addition to offering possible specific and susceptible points of intervention that would allow the prevention of some of these more frequent congenital defects in humans.
Descritores: Cardiopatias Congênitas
-Fatores de Transcrição
Transdução de Sinais
Metilação de DNA
Morfogênese
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


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Ramalho, Lizete Toledo de Oliveira
Id: lil-197365
Autor: Galassi, Marlei Aparecida Seccani; Pinto, Lourdes Aparecida Martins dos Santos; Bollini, Paulo Domingos André; Ramalho, Lizete Toledo de Oliveira; Hétem, Sebastiäo.
Título: Estudo histológico do desenvolvimento dos dentes humanos / Contribution to the study of human tooth development: histologic study
Fonte: Rev. Assoc. Paul. Cir. Dent;51(1):58-65, jan.-fev. 1997. ilus.
Idioma: pt.
Resumo: Os autores apresentam um estudo histológico do desenvolvimento dental associado a algumas observaçöes macroscópicas e radiográficas de gêmeas natimortas com 5 meses de vida intra-uterina. Apesar das diferenças de peso e volume corporal e do fato de os germes dentais näo terem sido identificados radiograficamente, a análise histológica demonstrou estrutura mineralizada de esmalte e dentina nos incisivos mediais decíduos superiores e inferiores, nos incisivos laterais decíduos inferiores e na cúspide dos primeiros molares decíduos superiores, sem diferenças entre ambas as gêmeas
Descritores: Germe de Dente/crescimento & desenvolvimento
Germe de Dente/embriologia
-Esmalte Dentário/crescimento & desenvolvimento
Esmalte Dentário/embriologia
Morte Fetal
Dente Decíduo/crescimento & desenvolvimento
Dente Decíduo/embriologia
Gêmeos Monozigóticos
Morfogênese
Limites: Humanos
Gravidez
Feminino
Responsável: BR97.1 - Serviço de Documentação Odontológica


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Texto completo SciELO Brasil
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Id: biblio-990194
Autor: Siliprandi, Carolina C; Tuset, Víctor M; Lombarte, Antoni; Farré, Marc; Rossi-Wongtschowski, Carmen L. D. B.
Título: Optimal fishing samplers to reveal the morphological structure of a fish assemblage in a subtropical tidal flat
Fonte: Neotrop. ichthyol;17(1):e170168, 2019. tab, graf.
Idioma: en.
Projeto: Fundação de Apoio à Pesquisa do Estado de São Paulo.
Resumo: Morphological characters of species are essential for assessing the functional structure of a fish assemblage, since differences between them, for example in body shape, are related to many functional and ecological traits (e.g., swimming, search for food, striking and capturing prey, evading predators, spawning). Globally, tidal flats are relevant to fish assemblages by offering feeding, refuge, and reproduction grounds. To analyze the morphofunctional structure of the fish assemblage from a tidal flat on the Brazilian coast, we conducted standardized sampling using nine different fishing gears. The geometric morphometric method was applied to describe the fish shapes and verify the morphological structure of the assemblage. Here, we present the influence/susceptibility of each gear type on the morphological diversity of the fish assemblage. The results indicated that beach seine, otter trawl, marginal encircling gillnet, and fish traps, together, were the most effective gears to represent the maximum morphological variability of fish inhabiting that tidal flat. Moreover, the assemblage showed high morphological redundancy considered as a resistance of the ecosystem for avoiding functional diversity loss, emphasizing the importance of complementary gear use when determining fish assemblages in a conservation context.(AU)

Os caracteres morfológicos das espécies são essenciais para avaliar a estrutura funcional de uma assembleia de peixes, uma vez que as diferenças entre elas são indicativas de distintas características ecológicas. De forma geral, as planícies de maré são importantes para assembleias de peixes por oferecerem áreas para alimentação, refúgio e reprodução. Para analisar a estrutura morfofuncional da assembleia de peixes de uma planície de maré na costa brasileira, realizamos amostragens utilizando nove diferentes artes de pesca. Para descrever as formas dos peixes e verificar a diversidade morfológica da assembleia foi aplicado o método de morfometria geométrica. Aqui, apresentamos a influência/suscetibilidade de cada arte de pesca na composição morfológica da assembleia de peixes, uma vez que a forma do corpo está relacionada a diversos aspectos funcionais e ecológicos (como por exemplo nadar, procurar ativamente por comida, atacar e capturar presas, evadir de predadores, se reproduzir). Os resultados indicaram que o arrasto de praia, o arrasto de fundo, a rede de emalhar marginal e as armadilhas, em conjunto, foram os apetrechos mais efetivos para representar a máxima diversidade morfológica dos peixes que habitam esta planície de maré. Além disso, a assembleia apresentou elevada redundância morfológica, fato que indica resistência deste ecossistema para evitar a perda de diversidade funcional.(AU)
Descritores: Peixes/anatomia & histologia
Morfogênese
-Indústria Pesqueira
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-998038
Autor: Slynko, Yuliia; Sokolova, Iryna; Gubina-Vakulik, Halyna; Potapchyk, Anatoly; Korneyko, Iryna.
Título: Peculiarities of Morphology of Large Salivary Glands in Experimental Animals Under Different Conditions of Motor Activity of Their Mothers During Pregnancy
Fonte: Pesqui. bras. odontopediatria clín. integr;19(1):4402, 01 Fevereiro 2019. ilus.
Idioma: en.
Resumo: Objective: To evaluate of the microstructure of the salivary glands of experimental animals born from of females rats, who were subjected to different modes of motor activity during the pregnancy: limited and compensated by regular moderate training. Material and Methods: The sample was composed 84 three-month-old descendants of Wistar rats which were divided into three groups: G1 (n = 27): posterity of female rats, who during gestation were in standard conditions; G2 (n = 25): posterity of female rats, who during pregnancy were in hypokinesia conditions; G3 (n = 32): which stayed in conditions of hypokinesia, but had running load in running wheel regularly 5 times a week. Results: In adult descendants of G2, morphological structure of the submandibular salivary glands was characterized by decrease size and number of glandular cells; reduction of their cytoplasm; increase in heterochromatin amount and decrease in the intensity of fuchsinophilia. Microstructure of the submandibular salivary glands of the offspring of G3 indicates positive effect of regular short-term physical activity on the morphofunctional state of the specified glands. An increased number of tissue basophils in their stroma is also in favor of greater functional activity of salivary glands. Conclusion: This study indicates deceleration of the metabolic processes in salivary glands of animals under the influence of hypokinesia of their mothers during pregnancy. It was also confirmed that regular physical activity completely eliminates the negative effect of mothers' hypokinesia on morphology the salivary glands of the descendant.
Descritores: Glândulas Salivares
Glândula Submandibular
Achados Morfológicos e Microscópicos
Morfogênese
Atividade Motora
-Ucrânia
Gravidez
Ratos Wistar
Hipocinesia
Experimentação Animal
Limites: Animais
Gravidez
Ratos
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-965882
Autor: Hundertmarck, Anelise Pereira; Rocha, Marta Gomes da; Pötter, Luciana; Salvador, Paulo Roberto; Bergoli, Tuani Lopes; Moura, Érica Dambros de; Nunes, Pedro Arthur de Albuquerque; Sichonany, Maria José de Oliveira.
Título: Biomass flow and defoliation pattern in alexandergrass fertilized with nitrogen / Fluxos de biomassa e padrões de desfolhação em papuã fertilizado com nitrogênio
Fonte: Biosci. j. (Online);33(1):143-152, jan./feb. 2017. tab.
Idioma: en.
Resumo: The determination of biomass flows can assist on improving pasture fertilization techniques, contributing to identify the best management methods and, in relation the use of fertilizers. Nitrogen deficiency in pastures can reduce forage production. On the other hand, there is an environmental concern on nitrogen (N) losses when this nutrient is used in excess and this concern guides the search for new grazing systems that optimize its use. Leaf biomass flow, intensity and frequency of defoliation were evaluated in Alexandergrass (Urochloa plantaginea (Link) Hitch) fertilized with Zero, 100, 200 or 300 kg/ha nitrogen (N) as urea. The grazing method was put and take stocking in order to keep the forage mass at 3,000 kg/ha DM. The experimental animals were Angus heifers with an initial age of 15 months and body weight of 241.5±5 kg. The experimental design was completely randomized following a repeated measure arrangement, with four treatments and variable number of experimental units. The highest growth of leaf blades was achieved with 100 kg/ha N. Senescence and intake flows and defoliation intensity were similar among the N levels used. The frequency of return to the same tiller (days) was influenced by N levels and evaluation periods. Our findings recommend the use of 100 kg/ha N in Alexandergrass pasture.

A determinação dos fluxos de biomassa pode auxiliar no aperfeiçoamento das técnicas de adubação de pastagens, pois contribui para a identificação das melhores formas de manejo, que incluem o uso de fertilizantes. A deficiência de N em pastagens pode reduzir a produção de forragem. Por outro lado, existe uma preocupação ambiental relativa às perdas de nitrogênio (N) quando esse nutriente é utilizado em excesso e essa preocupação direciona a pesquisa para novos sistemas de pastejo que otimizem o uso deste nutriente. Os fluxos de biomassa foliar, a intensidade e frequência de desfolha foram avaliados quando o papuã (Urochloa plantaginea (Link) Hitch) foi adubado com Zero, 100, 200 ou 300 kg/ha de nitrogênio (N), na forma de ureia. O método de pastejo foi contínuo com número variável de animais para manter a massa de forragem em 3000 kg/ha de MS. Os animais experimentais foram bezerras Angus com idade e peso corporal médio inicial de 15 meses e 241,5±5 kg, respectivamente. O delineamento experimental foi inteiramente casualizado, com medidas repetidas no tempo, com quatro tratamentos e número variável de unidades experimentais. O uso de 100 kg/ha de N proporcionou maior fluxo de crescimento de lâminas foliares. Os fluxos de senescência e de consumo e a intensidade de desfolha foram similares nos níveis de N utilizados. A frequência de retorno dos animais ao mesmo perfilho (dias) foi influenciado pelos níveis de N e períodos de avaliação. É recomendada a utilização de 100 kg/ha de N em pastagem de papuã.
Descritores: Ureia
Pastagens
Biomassa
Morfogênese
Nitrogênio
Responsável: BR396.1 - Biblioteca Central



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