Base de dados : LILACS
Pesquisa : G07.345.500 [Categoria DeCS]
Referências encontradas : 141 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 15 ir para página                         

  1 / 141 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-888075
Autor: Rodrigues, L. S; Alves Filho, D. C; Brondani, I. L; Silva, V. S; Paula, P. C; Adams, S. M; Martini, P. M; Martini, A. P. M.
Título: Variáveis morfogênicas e estruturais de sorgo forrageiro implantado com diferentes arranjos populacionais sob pastoreio contínuo / Morphogenetic and structural variables of sorghum implanted with different population arrangements under continuous grazing
Fonte: Arq. bras. med. vet. zootec. (Online);70(1):287-296, Jan.-Feb. 2018. tab.
Idioma: pt.
Resumo: O objetivo do estudo foi avaliar os efeitos da utilização de diferentes arranjos populacionais na implantação de sorgo forrageiro nas características morfogênicas e estruturais do pasto. Os tratamentos foram 22 ou 44cm entrelinhas e 12 ou 24kg de sementes ha-1. O método de pastoreio foi contínuo. Foram utilizadas 36 novilhas, com idade e peso corporal médios de 15 meses de 262kg. As variáveis morfogênicas não foram influenciadas significativamente (P>0,05) pelos arranjos populacionais e pelos períodos de avaliação, sendo obtidos taxa de alongamento e senescência foliar de 1,43 e 1,11cm dia-1afilho-1, respectivamente, taxa de aparecimento foliar e intervalo de surgimento de folhas de 0,28 folhas dia-1afilho-1 e 3,81 dias, filocrono e duração de vida foliar de 72,99 e 351,68 graus dia, nessa ordem. As características estruturais do pasto foram influenciadas pelos períodos de avaliação. Do primeiro para o terceiro período de avaliação, foi verificada uma redução de 65,53% no número de folhas em alongamento e de 47,79% no número de folhas vivas.(AU)

The objective of the study was to evaluate the effects of using different population arrangements in the implementation of sorghum in the morphogenetic and structural characteristics of the pasture. The treatments were 22 or 44cm between rows and 12 or 24kg ha-1 of seed. The grazing method was continuous. The sample consisted of 36 heifers with an average age of 15 months and average body weight of 262kg. Morphogenic variables were not significantly influenced (P>0.05) by population arrangements and evaluation periods, elongation rate and leaf senescence of 1.43 and 1.11cm afilho-1 day-1 being obtained, respectively, and leaf appearance rate of leaf appearance leaves the range of 0.28 day-1 and 1afilho 3.81 days, phyllochron and leaf duration of life of 72.99 and 351.68 degree day, in that order. The structural characteristics of the pasture were influenced by evaluation periods. From the first to the third evaluation period, a reduction of 65.53% in the number of leaves in stretching and 47.79% in the number of living leaves was verified.(AU)
Descritores: Pastagens/análise
Sorghum/anatomia & histologia
Morfogênese
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  2 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1011538
Autor: Biology DepartmentCarvalho, Paula Pinheiro de; Biology DepartmentAntoniazzi, Camila Aparecida; Biology DepartmentFaria, Rodrigo Brito de; Biology DepartmentCarvalho, Ilio Fealho de; Rocha, Diego Ismael; Biology DepartmentSilva, Maurecilne Lemes da.
Título: In Vitro Organogenesis from Root Explants of Passiflora miniata Mast, an Amazonian Species with Ornamental Potential
Fonte: Braz. arch. biol. technol;62:e19170803, 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT The present study reports a shoot organogenesis-based system for in vitro regeneration of Passiflora miniata, an Amazonia passion fruit species. Root segments were cultured in Murashige and Skoog (MS) medium supplemented with different concentrations (range 2-9 µM) of 6-benzyladenine (BA); thidiazuron (TDZ) or kinetin (KIN). Plant growth regulators were not added to the control treatment. Root explants have showed a high regenerative potential. After 30 days of in vitro culture, the root explants showed several shoots formed direct and indirectly. TDZ provided the best response in the differentiation adventitious shoots, mainly in the presence of 6.8 µM. The cytokinins BA and KIN responded producing a reduced number of shoots. After 120 days, rooted regenerated plants were transferred to a greenhouse for acclimatization. This regeneration system opens new perspectives for micropropagation and conservation of this wild Amazonic passion fruit species.
Descritores: Morfogênese
-Técnicas In Vitro
Passiflora
Organogênese Vegetal
Responsável: BR1.1 - BIREME


  3 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Id: biblio-844991
Autor: Falcón Cama, Viviana; Acosta-Rivero, Nelson; González Pozos, Sirenia; Dueñas-Carrera, Santiago; Acosta Medina, Emilio; Kourí Flores, Juan.
Título: Ultrastructural remodelling of e ndoplasmic reticulum-derived membranes and hepatitis C virus morphogenesis in human liver samples / Modificación ultraestructural de las membranas derivadas del retículo endoplasmático y morfogénesis del virus de la hepatitis C en muestras de hígado humano
Fonte: Rev. cuba. med. trop;68(3):191-202, sep.-dic. 2016. ilus.
Idioma: en.
Descritores: Hepacivirus
Retículo Endoplasmático
Morfogênese
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


  4 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-990030
Autor: Pellón, Mario; Conei, Daniel; Saint-Pierre, Gustavo; Smok, Carolina; Donoso, Viviana; del-Sol, Mariano; Rojas, Mariana.
Título: Desarrollo embriofetal del iris: inmunotinción del morfógeno Shh / Embryo-fetal development of iris: immunohistochemestry of morphogen Shh
Fonte: Int. j. morphol;37(1):221-226, 2019. tab, graf.
Idioma: es.
Resumo: RESUMEN: Para que se desarrolle el iris, se requiere una especificación de la capa periférica de la copa óptica a un destino no neuronal y además la migración de células mesenquimales perioculares. Nuestro objetivo fue reconocer los cambios histológicos de los derivados periféricos de la copa óptica y mesénquima periocular, como también reconocer la presencia del morfógeno Sonic hedgehog (Shh) en las capas que constituyen el esbozo de iris. Se utilizaron 15 ratones hembras (Mus musculus) adultas jóvenes gestantes. Se realizó eutanasia con tiopental sódico. Los embriones y fetos de 12, 14,5 y 17 días post-coital (dpc) fueron procesados con técnica histológica e inmunohistoquímica con anticuerpo anti-Shh (scbt, H-160, conejo) con dilución 1:100 en PBS. A los 12 dpc, se observa una cópa óptica que presenta capas retinianas interna y externa, y el iris no se observa. Entre el cristalino y el ectodermo superficial se identifican 4 capas de células mesenquimales. A los 14,5 dpc, el iris contiene dos capas epiteliales (interna y externa) que se continúan con las capas neural y pigmentaria de la retina. Se observan 8 capas de células mesenquimales. A los 17 dpc, la capa epitelial interna del iris presenta un segmento más elongado con inmunotinción positiva a Shh y otra parte que constituye un epitelio de células cilíndricas simples negativas a este anticuerpo. La capa epitelial externa presenta el mismo epitelio inmunonegativo. Las capas de la retina también son positivas, como también la periferia del cristalino. No esta formado el iris ni tampoco el cuerpo ciliar. La inmunopositividad en el cristalino, en el primer segmento de la capa interna del esbozo del iris y en la capa ganglionar retinal a los 17 dpc, se relaciona con la diferenciación tardía del iris y con los ojos cerrados de las crías al nacimiento.

SUMMARY: In order for the iris to develop, a specification of the peripheral layer of the optic cup to a non-neuronal target is required, as well as the migration of periocular mesenchymal cells. Our aim was to recognize the histological changes of peripheral derivatives of the optic cup and periocular mesenchyme, as well as recognize the presence of the morphogen Sonic hedgehog (Shh) in the layers constituting the outline of the iris. 15 female mice (Mus musculus) pregnant young adults were used. Euthanasia was performed with sodium thiopental. Embryos and fetuses of 12, 14.5 and 17 days post-coital (dpc) were processed with histological and immunohistochemical technique with anti-Shh antibody (scbt, H 160, rabbit) with dilution 1:100 in PBS. At 12 dpc, an optic cup showing internal and external retinal layers is observed, and the iris is not observed. Between the lens and the superficial ectoderm, 4 layers of mesenchymal cells are identified. At 14.5 dpc, the iris contains two epithelial layers (internal and external) that are continued with the neural and pigmentary layers of the retina. 8 layers of mesenchymal cells are observed. At 17 dpc, the inner epithelial layer of the iris presents a more elongated segment with positive immunostaining to Shh and another part that constitutes an epithelium of simple cylindrical cells negative to this antibody. The outer epithelial layer presents the same immunonegative epithelium. The layers of the retina are also positive, as well as the periphery of the lens. The iris is not formed nor is the ciliary body.The immunopositivity in the lens, in the first segment of the inner layer of the iris outline and in the retinal ganglion layer at 17 dpc, is related to the late differentiation of the iris and the closed eyes of the offspring at birth.
Descritores: Iris/embriologia
Olho/embriologia
Proteínas Hedgehog
-Iris/anatomia & histologia
Olho/anatomia & histologia
Morfogênese
Limites: Animais
Feminino
Camundongos
Responsável: CL1.1 - Biblioteca Central


  5 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Texto completo
Id: biblio-1093610
Autor: Taboada Lugo, Noel.
Título: La vía de señalización Notch en el origen de algunas malformaciones congénitas / The Notch Signaling Pathway at the Origin of Some Congenital Malformations
Fonte: Rev. cuba. obstet. ginecol;44(3):1-17, jul.-set. 2018.
Idioma: es.
Resumo: La vía de señalización Notch desempeña un papel clave para regular el destino celular, crecimiento, proliferación y la muerte celular programada durante el desarrollo de organismos eucariotas. Esta vía está relacionada con una enorme diversidad de procesos del desarrollo y su disfunción está implicada en el origen de muchas malformaciones congénitas. Se realizó una revisión bibliográfica con el objetivo de actualizar la información sobre la vía de señalización Notch y su relación con el origen de diferentes malformaciones congénitas sensibles a la deficiencia materna de ácido fólico y otros micronutrientes. La literatura médica publicada en idiomas español e inglés se recopiló a través de buscadores como PubMed, Medline, Scielo, Lilacs y la biblioteca Cochrane en enero de 2018 usando palabras clave apropiadas. El conocimiento de esta vía de señalización podría ayudar a comprender mejor algunos aspectos de la morfogénesis, ya que, al actuar como un controlador maestro del destino celular, la proliferación, diferenciación y muerte celular programada, ofrece puntos específicos y susceptibles de intervención que posibilitan la prevención de determinadas malformaciones congénitas en el hombre(AU)

Notch signaling pathway plays a key role to regulate cell grow, fates, proliferation and programmed cell death in development of eukaryotic organisms. This pathway is related with an enormous diversity of developmental processes and its dysfunction is implicated in the origin of many congenital malformations. A review was performed to provide updated information on Notch signaling pathway involved in the origin of some congenital malformations related with maternal deficiency of folic acid and other micronutrients. Published medical literature in Spanish and English languages was retrieved from PubMed, Medline, Scielo, Lilacs and the Cochrane Library in January 2018, using appropriate key words. Knowledge about this signaling pathway could help to better understand some topics of morphogenesis, since by acting as a master controller of cell fate, proliferation, differentiation and programmed cell death, it offers susceptible and specific points which make possible to prevent some human congenital malformations(AU)
Descritores: Receptores Notch/análise
Receptores Notch/genética
Receptores Notch/uso terapêutico
Morfogênese/genética
-Anormalidades Congênitas/genética
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CU1.1 - Biblioteca Médica Nacional


  6 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-1011433
Autor: Isah, Tasiu.
Título: De novo in vitro shoot morphogenesis from shoot tip-induced callus cultures of Gymnema sylvestre (Retz.) R. Br. ex Sm
Fonte: Biol. Res;52:3, 2019. tab, graf.
Idioma: en.
Resumo: BACKGROUND: Gymnema sylvestre is a medicinal woody perennial vine known for its sweetening properties and antidiabetic therapeutic uses in the modern and traditional medicines. Its over-exploitation for the therapeutic uses and to meet the demand of pharmaceutical industry in raw materials supply for the production of anti-diabetic drugs has led to considerable decline in its natural population. RESULTS: An efficient system of shoot bud sprouting from nodal segment explants and indirect plant regeneration from apical meristem-induced callus cultures of G. sylvestre have been developed on Murashige and Skoog (MS) medium amended with concentrations of cytokinins. Of the three growth regulators tested, N6-benzylaminopurine (BAP) was the most efficient and 2.0 mg L-1 gave the best shoot formation efficiency. This was followed by thidiazuron (TDZ) and kinetin (Kin) but, most of the TDZ-induced micro shoots showed stunted growth. Multiple shoot formation was observed on medium amended with BAP or TDZ at higher concentrations. The produced micro shoots were rooted on half strength MS medium amended with auxins and rooted plantlets acclimatized with 87% survival of the regenerates. CONCLUSIONS: The developed regeneration system can be exploited for genetic transformation studies, particularly when aimed at producing its high yielding cell lines for the anti-diabetic phytochemicals. It also offers opportunities for exploring the expression of totipotency in the anti-diabetic perennial vine.
Descritores: Reguladores de Crescimento de Plantas/farmacologia
Regeneração/efeitos dos fármacos
Brotos de Planta/crescimento & desenvolvimento
Gymnema sylvestre/crescimento & desenvolvimento
Morfogênese/efeitos dos fármacos
-Compostos de Fenilureia/farmacologia
Purinas/farmacologia
Tiadiazóis/farmacologia
Compostos de Benzil/farmacologia
Brotos de Planta/efeitos dos fármacos
Gymnema sylvestre/efeitos dos fármacos
Cinetina/farmacologia
Responsável: CL1.1 - Biblioteca Central


  7 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Id: biblio-1124629
Autor: Taboada Lugo, Noel.
Título: Avances en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas. Parte 2 y última: Cardiopatías congénitas / Advances in the knowledge of the molecular and cellular bases of congenital heart diseases. Second of two parts: Congenital heart defects
Fonte: CorSalud;11(4):307-316, oct.-dic. 2019. tab.
Idioma: es.
Resumo: RESUMEN Las cardiopatías congénitas son los defectos congénitos más frecuentes en los seres humanos. Se realizó una revisión de la literatura médica con el objetivo de identificar los avances más recientes en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas. La información obtenida se dividió en dos partes: en la primera se dirigió la atención a los genes y a la morfogénesis cardíaca, y esta segunda parte la complementa, haciendo hincapié en las cardiopatías congénitas propiamente dichas.

ABSTRACT Congenital heart defect is the most common birth defect in humans. We conducted a review of the medical literature with the aim of identifying the most recent advances in the knowledge of its molecular and cellular bases. The information obtained was divided into two parts: the first one emphasized on genes and cardiac morphogenesis, and this second part complements the previous one, with special focus on congenital heart defects.
Descritores: Fatores de Transcrição
Transdução de Sinais
Metilação de DNA
Cardiopatias Congênitas
Morfogênese
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


  8 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Id: biblio-1124636
Autor: Góngora Gómez, Onelis; Gómez Vázquez, Yadnil E; Bauta Milord, Rosalí.
Título: Cardiopatías congénitas en los principales síndromes causados por aneuploidías / Congenital heart disease in the main aneuploidy syndromes
Fonte: CorSalud;11(4):353-354, oct.-dic. 2019.
Idioma: es.
Descritores: Cardiopatias Congênitas
Aneuploidia
Morfogênese
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


  9 / 141 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Maltz, Marisa
Texto completo
Id: biblio-1101256
Autor: EV, Laís Daniela; DAMÉ-TEIXEIRA, Nailê; DO, Thuy; MALTZ, Marisa; PAROLO, Clarissa Cavalcanti Fatturi.
Título: The role of Candida albicans in root caries biofilms: an RNA-seq analysis
Fonte: J. appl. oral sci;28:e20190578, 2020. tab, graf.
Idioma: en.
Projeto: Brazilian National Counsel of Technological and Scientific Development; . Coordination for the Improvement of Higher Level Education; . Rio Grande do Sul State Foundation for Research Support; . Leeds Teaching Hospitals Charitable Foundation; . Dunhill Medical Trust.
Resumo: Abstract Objective This study sought to analyze the gene expression of Candida albicans in sound root surface and root caries lesions, exploring its role in root caries pathogenesis. Methodology The differential gene expression of C. albicans and the specific genes related to cariogenic traits were studied in association with samples of biofilm collected from exposed sound root surface (SRS, n=10) and from biofilm and carious dentin of active root carious lesions (RC, n=9). The total microbial RNA was extracted, and the cDNA libraries were prepared and sequenced on the Illumina Hi-Seq2500. Unique reads were mapped to 163 oral microbial reference genomes including two chromosomes of C. albicans SC5314 (14,217 genes). The putative presence of C. albicans was estimated (sum of reads/total number of genes≥1) in each sample. Count data were normalized (using the DESeq method package) to analyze differential gene expression (using the DESeq2R package) applying the Benjamini-Hochberg correction (FDR<0.05). Results Two genes (CaO19.610, FDR=0.009; CaO19.2506, FDR=0.018) were up-regulated on SRS, and their functions are related to biofilm formation. Seven genes ( UTP20 , FDR=0.018; ITR1 , FDR=0.036; DHN6 , FDR=0.046; CaO19.7197 , FDR=0.046; CaO19.7838 , FDR=0.046; STT4 , FDR=0.046; GUT1 , FDR=0.046) were up-regulated on RC and their functions are related to metabolic activity, sugar transport, stress tolerance, invasion and pH regulation. The use of alternative carbon sources, including lactate, and the ability to form hypha may be a unique trait of C. albicans influencing biofilm virulence. Conclusions C. albicans is metabolically active in SRS and RC biofilm, with different roles in health and disease.
Descritores: Raiz Dentária/microbiologia
Candida albicans/genética
DNA Fúngico/genética
Cárie Radicular/microbiologia
Biofilmes/crescimento & desenvolvimento
-Candida albicans/isolamento & purificação
Candida albicans/crescimento & desenvolvimento
Expressão Gênica
Regulação Fúngica da Expressão Gênica
Regulação para Cima
Análise de Sequência de RNA
Transcriptoma
Morfogênese
Limites: Humanos
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta


  10 / 141 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Id: biblio-1089742
Autor: Taboada Lugo, Noel.
Título: Avances en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas. Parte 1 de 2: Morfogénesis cardíaca / Advances in the knowledge of the molecular and cellular bases of congenital heart diseases. Part 1 of 2: Cardiac morphogenesis
Fonte: CorSalud;11(3):233-240, jul.-set. 2019. tab.
Idioma: es.
Resumo: RESUMEN Las cardiopatías congénitas son los defectos congénitos más frecuentes en humanos. Muchos estudios indican que el desarrollo cardíaco está estrechamente regulado por diferentes vías de señalización celular y eventos morfológicos, genéticamente controlados. La identificación de nuevos genes que intervienen en el proceso de cardiogénesis es de gran utilidad para conocer los mecanismos moleculares y celulares por el que se genera el amplio espectro fenotípico de las cardiopatías congénitas. Se realizó una revisión bibliográfica, con el objetivo de identificar los avances más recientes en el conocimiento de las bases moleculares y celulares de las cardiopatías congénitas; lo que permite una clasificación más efectiva de estos defectos congénitos y una futura optimización del tratamiento individualizado para cada paciente, además de ofrecer posibles puntos específicos y susceptibles de intervención que posibilitarían la prevención de algunos de los defectos congénitos más frecuentes en los seres humanos.

ABSTARACT Congenital heart diseases are the most common congenital defect in humans. Many studies indicate that the cardiac development is tightly regulated by different cell signaling pathways and genetically controlled morphological events. The identification of new genes involved in the cardiogenesis process is very useful in order to know the molecular and cellular mechanisms by which the broad phenotypic spectrum of congenital heart disease is generated. An updated bibliographic review was carried out, with the aim of identifying the most recent advances in the knowledge of the molecular and cellular bases of congenital heart disease. This knowledge allows a more effective classification of these congenital defects and a future optimization of the individualized treatment for each patient, in addition to offering possible specific and susceptible points of intervention that would allow the prevention of some of these more frequent congenital defects in humans.
Descritores: Cardiopatias Congênitas
-Fatores de Transcrição
Transdução de Sinais
Metilação de DNA
Morfogênese
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara



página 1 de 15 ir para página                         
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde