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Pesquisa : G07.690.773.968.477 [Categoria DeCS]
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Id: lil-783795
Autor: Gandini, Marco; Cerri, Simona; Pregel, Paola; Giusto, Gessica; Vercelli, Cristina; Iussich, Selina; Tursi, Massimiliano; Farca, Anna Maria.
Título: Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats
Fonte: Acta cir. bras;31(5):333-337, May 2016. graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on intestinal ischemic and reperfusion injury METHODS: Superior mesenteric artery was isolated and clamped in 36 adult male Sprague Dawley rats. After 60 minutes, clamp was removed and a group received intraperitoneally UNITO solution (PTX 25mg/kg + lidocaine 5mg/kg + MB 2mg/kg), while the other group was treated with warm 0.9% NaCl solution. Rats were euthanized 45 min after drug administration. Lung and bowel were collected for histological evaluation (using Park's score) and determination of myeloperoxidase (MPO) and malondialdehyde (MDA) levels. RESULTS: Control samples showed lymphoplasmocytic infiltrate and crypt necrosis of villi. MPO and MDA measurements shown no differences between treated and control groups. CONCLUSION: The combination of lidocaine, methylene blue and pentoxyphylline administered intraperitoneally at the studied dose, did not decreased histological lesion scores and biochemical markers levels in intestinal ischemia/reperfusion injury.
Descritores: Pentoxifilina/uso terapêutico
Traumatismo por Reperfusão/tratamento farmacológico
Intestinos/irrigação sanguínea
Lidocaína/uso terapêutico
Azul de Metileno/uso terapêutico
Anti-Inflamatórios/uso terapêutico
-Pentoxifilina/administração & dosagem
Distribuição Aleatória
Peroxidase/metabolismo
Modelos Animais
Combinação de Medicamentos
Sinergismo Farmacológico
Inflamação/prevenção & controle
Inflamação/tratamento farmacológico
Infusões Parenterais
Intestinos/enzimologia
Lidocaína/administração & dosagem
Pulmão/irrigação sanguínea
Pulmão/metabolismo
Malondialdeído/metabolismo
Azul de Metileno/administração & dosagem
Anti-Inflamatórios/administração & dosagem
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  2 / 184 LILACS  
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Id: biblio-837677
Autor: Li, Weiming; Xu, Pengyuan; Cen, Yunyun; Sun, Dali; Yang, Ting; Xu, Qingwen; Li, Shumin; Li, Yijun; Ding, Bo.
Título: Impacts of albumin synergized with hydroxyethyl starch on early microvascular albumin leakage after major abdominal surgery in rabbits
Fonte: Acta cir. bras;32(2):108-115, Feb. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the impacts of albumin synergized with hydroxyethyl starch (HES) on early microvascular albumin leakage after major abdominal surgery in rabbits. Methods: Forty male Japanese rabbits were randomly divided into four groups: the control group, the saline group, the albumin group, and the Syn group (hydroxyethyl starch+albumin). The latter three groups were performed gastrectomy plus resection of pancreatic body and tail and splenectomy. The serum albumin concentration was detected before and 48h after surgery, and the conditions of mesenteric microvascular leakage in these 4 groups were observed under microscope 48 h after surgery to calculate the leakage rate. Results: Compared with the saline group, the albumin group and the Syn group exhibited significantly increased serum albumin concentrations 48h after surgery (P<0.05). The albumin leakage rate was the most obvious in the albumin group, followed by the saline group, while that in the Syn group was the minimal, and there existed significant differences among these groups (P<0.05) . Conclusion: Simple administration of albumin in the early stage after major abdominal surgery could increase the albumin leakage, while the synergization of albumin and hydroxyethyl starch could reduce the albumin leakage.
Descritores: Albumina Sérica/administração & dosagem
Albumina Sérica/análise
Permeabilidade Capilar/fisiologia
Derivados de Hidroxietil Amido/administração & dosagem
-Albumina Sérica/metabolismo
Cloreto de Sódio
Distribuição Aleatória
Deslocamentos de Líquidos Corporais/fisiologia
Modelos Animais
Sinergismo Farmacológico
Abdome/cirurgia
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


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Lambertucci, J. R
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Id: lil-623562
Autor: Lambertucci, J. R.
Título: A new approach to the treatment of acute schistosomiasis
Fonte: Mem. Inst. Oswaldo Cruz;84(supl.1):23-30, 1989. tab.
Idioma: en.
Conferência: Apresentado em: Simpósio Internacional de Esquistossomose, 2, Apresentado em: Reunião Nacional de Esquistossomose2, Belo Horizonte, 22-27 out. 1989.
Descritores: Oxamniquine/uso terapêutico
Praziquantel/uso terapêutico
Esquistossomose mansoni/tratamento farmacológico
Quimioterapia Combinada
-Sinergismo Farmacológico
Camundongos Endogâmicos CBA
Limites: Animais
Cobaias
Camundongos
Responsável: BR1.1 - BIREME


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Id: biblio-894905
Autor: Aguilera, Elena; Varela, Javier; Serna, Elva; Torres, Susana; Yaluff, Gloria; Bilbao, Ninfa Vera de; Cerecetto, Hugo; Alvarez, Guzmán; González, Mercedes.
Título: Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment
Fonte: Mem. Inst. Oswaldo Cruz;113(3):153-160, Mar. 2018. graf.
Idioma: en.
Projeto: CSIC; . Agencia Nacional de Investigación e Innovación.
Resumo: BACKGROUND The current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations. OBJECTIVES Study the anti-Trypanosoma cruzi activity of associations of benznidazole (Bnz) with three new synthetic T. cruzi-triosephosphate isomerase inhibitors, 2, 3, and 4, in order to potentiate their actions. METHODS The in vitro effect of the drug combinations were determined constructing the corresponding isobolograms. In vivo activities were assessed using an acute murine model of Chagas disease evaluating parasitaemias, mortalities and IgG anti-T. cruzi antibodies. FINDINGS The effect of Bnz combined with each of these compounds, on the growth of epimastigotes, indicated an additive action or a synergic action, when combining it with 2 or 3, respectively, and an antagonic action when combining it with 4. In vivo studies, for the two chosen combinations, 2 or 3 plus one fifth equivalent of Bnz, showed that Bnz can also potentiate the in vivo therapeutic effects. For both combinations a decrease in the number of trypomastigote and lower levels of anti-T. cruzi IgG-antibodies were detected, as well clear protection against death. MAIN CONCLUSIONS These results suggest the studied combinations could be used in the treatment of Chagas disease.
Descritores: Triose-Fosfato Isomerase/química
Trypanosoma cruzi/efeitos dos fármacos
Trypanosoma cruzi/imunologia
Nitroimidazóis/farmacologia
-Anticorpos Antiprotozoários
Sinergismo Farmacológico
Quimioterapia Combinada
Responsável: BR1.1 - BIREME


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Id: biblio-889040
Autor: Ao, Man; Xiao, Xu; Ao, Yazhou.
Título: Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(3):e6650, 2018. graf.
Idioma: en.
Projeto: The Research and Development Project of Science and Technology.
Resumo: In the present study, we successfully developed a docetaxel (DTX) and thalidomide (TDD) co-delivery system based on low density lipoprotein (LDL) modified silica nanoparticles (LDL/SLN/DTX/TDD). By employing the tumor homing property of LDL and the drug-loading capability of silica nanoparticles, the prepared LDL/SLN/DTX/TDD was expected to locate and specifically deliver the loaded drugs (DTX and TDD) to achieve effective chemotherapy of liver cancer. In vitro analysis revealed that nano-sized LDL/SLN/DTX/TDD with decent drug loading capabilities was able to increase the delivery efficiency by targeting the low density lipoprotein receptors, which were overexpressed on HepG2 human hepatocellular liver carcinoma cell line, which exerted better cytotoxicity than unmodified silica nanoparticles and free drugs. In vivo imaging and anti-cancer assays also confirmed the preferable tumor-homing and synergetic anti-cancer effects of LDL/SLN/DTX/TDD.
Descritores: Talidomida/administração & dosagem
Dióxido de Silício/administração & dosagem
Taxoides/administração & dosagem
Lipoproteínas LDL/sangue
Neoplasias Hepáticas Experimentais/tratamento farmacológico
Antineoplásicos/administração & dosagem
-Talidomida/uso terapêutico
Fatores de Tempo
Taxoides/uso terapêutico
Sinergismo Farmacológico
Nanopartículas
Células Hep G2
Neoplasias Hepáticas Experimentais/sangue
Antineoplásicos/uso terapêutico
Limites: Seres Humanos
Animais
Masculino
Camundongos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-1007944
Autor: García, Javier; Alvarenga, Nelson.
Título: Actividad sinérgica in vitro de los alcaloides Crotsparina y Esparsiflorina aislados de Croton bomplandianum frente a Pseudomonas aeruginosa / In vitro synergic activity of the alkaloids Crotsparine and Sparsiflorine, isolated from Croton bomplandianum, against Pseudomonas aeruginosa
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);17(1):47-53, abr. 2019. ilus, tab.
Idioma: es.
Resumo: Se evaluó la actividad sinérgica de los alcaloides crotsparina y esparsiflorina, aislados de Croton bomplandianum Baill. con los antibacterianos gentamicina y ciprofloxacina frente a Pseudomonas aeruginosa, microorganismo frecuentemente responsable de infecciones intrahospitalarias. Se empleó el método del "tablero de damas". Se encontraron combinaciones que presentaban efecto sinérgico, logrando la reducción de 87,5% de la CMI de gentamicina, mientras que para ciprofloxacina se logró una reducción del 25,0%. Esto abre interesantes perspectivas sobre el uso combinado de productos naturales puros y fármacos en uso clínico para el tratamiento de infecciones producidas por este microrganismo(AU)
Descritores: Pseudomonas aeruginosa/efeitos dos fármacos
Gentamicinas/farmacologia
Ciprofloxacino/farmacologia
Croton
Alcaloides/farmacologia
Antibacterianos/farmacologia
-Gentamicinas/isolamento & purificação
Sinergismo Farmacológico
Alcaloides/química
Responsável: PY3.1 - Biblioteca


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Id: biblio-973106
Autor: Varas, Pablo Agustín; Costa, Sebastián Ignacio; Kohen, Sergio Gustavo; Baistrocchi, Roberto.
Título: Manejo farmacológico del dolor en la odontología actual / Pharmacological management of pain in today´s dentistry
Fonte: Rev. Asoc. Odontol. Argent;105(3):116-122, sept. 2017. tab, graf.
Idioma: es.
Resumo: Una de las principales preocupaciones de los pacientes que van a ser sometidos a un procedimiento odontológico es el dolor que dicho procedimiento pueda ocasionar. Por lotanto, lograr un control eficaz y seguro de ese dolor es una parte esencial de la práctica odontológica diaria. Los fármacos de primera elección para el tratamiento del dolor y el edemason, sin lugar a dudas, los antiinflamatorios no esteroideos(AINEs). Principios activos como el ibuprofeno (y sus congéneres) o sus derivados permiten controlar simultáneamente el dolor y el edema posquirúrgicos de una forma eficaz y segura. En muchas ocasiones, el AINE prescrito para mantener al paciente asintomático o con síntomas tolerables es suficiente. Sin embargo, cuando esto no ocurre, debemos recurrir a otrosfármacos, o realizar asociaciones con fármacos que complementen el efecto analgésico y trabajen logrando un sinergismo de potenciación que incremente el efecto buscado y disminuya los efectos adversos de cada una de las sustancias por separado, utilizando menores dosis. Un ejemplo comprobado de esas asociaciones es la de ibuprofeno con paracetamol. En el presente artículo se sugieren diversas estrategias pre- y posoperatorias para el manejo del dolor de origen inflamatorio, y un protocolo para su tratamiento.
Descritores: Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/farmacocinética
Anti-Inflamatórios não Esteroides/uso terapêutico
Dor Pós-Operatória/tratamento farmacológico
-Ibuprofeno/farmacologia
Acetaminofen/farmacologia
Combinação de Medicamentos
Sinergismo Farmacológico
Formas de Dosagem
Analgésicos/farmacologia
Analgésicos/farmacocinética
Analgésicos/uso terapêutico
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: AR29.1 - Biblioteca


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Id: biblio-914261
Autor: Silva, Ingrid Carla Guedes da; Santos, Hellen Bandeira de Pontes; Cavalcanti, Yuri Wanderley; Nonaka, Cassiano Francisco Weege; Sousa, Simone Alves de; Castro, Ricardo Dias de.
Título: Antifungal Activity of Eugenol and its Association with Nystatin on Candida albicans
Fonte: Pesqui. bras. odontopediatria clín. integr;17(1):e3235, 13/01/2017. tab.
Idioma: en.
Resumo: Objective: To evaluate the anti-Candida effect of eugenol and its antimicrobial interaction with nystatin. Material and Methods: The antimicrobial potential was assessed by microdilution technique (M27A3 reference method), by determining the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) against C. albicans (ATCC 90028). The possible action of eugenol on the fungal cell wall was evaluated with the assistance of the osmotic protector sorbitol (0.8 M). The antimicrobial interaction with nystatin was assessed through the checkerboard method. All tests were performed in triplicate. Results: All groups showed reductions in PI and GBI values and improvements in oral health knowledge, but IG1 and IG2 showed statistically significant differences in these variables compared to CG. Conclusion: The eugenol has antifungal activity against C. albicans and its mechanism of action is probably not related to damage to the fungal cell wall. Association between eugenol and nystatin was not found to be an advantageous possibility for growth inhibition of C. albican.
Descritores: Antibacterianos
Candida albicans
Sinergismo Farmacológico
Eugenol
-Brasil
Técnicas In Vitro
Tipo de Publ: Estudo Comparativo
Estudos de Avaliação
Responsável: BR1822.9 - Associação de Apoio à Pesquisa em Saúde Bucal


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Id: biblio-907474
Autor: Da Silva, Karla Monik A; Chaves, Thiago P; Santos, Ravely L; Brandao, Deysiane O; Fernandes, Felipe Hugo A; Ramos Júnior, Fernando José de L; Dos Santos, Vanda L; Felismino, Delcio de C; Medeiros, Ana Cláudia D.
Título: Modulation of the erythromycin resistance in Staphylococcus aureus by ethanolic extracts of Ximenia americana L and Schinopsis brasiliensis Engl / Modulación de la resistencia a la eritromicina en Staphylococcus aureus por extractos etanólicos de Ximeniaamericana L y Schinopsis brasiliensis Engl
Fonte: Bol. latinoam. Caribe plantas med. aromát;14(2):92-98, Mar. 2015. tab.
Idioma: en.
Resumo: It was evaluated the in vitro efficacy of ethanolic extract of leaves and bark of Ximenia americana L and Schinopsis brasiliensis Engl. alone and in association with erythromycin as modulators of microbial resistance against six clinical isolates of Staphylococcus aureus resistant to erythromycin (SA1-SA6) and S. aureus ATCC 25923 by the microdilution method. The extracts were also subjected to bioassay with Artemia salina. The ethanolic extract of barks of X. americana showed a synergistic effect with erythromycin against SA01, SA03 and SA04. The leaf extract of S. brasiliensis exerted synergistic effect against SA03 and the bark extract showed against SA01 and S03. The results suggest that extracts from S.brasiliensis and X. americana have potential as modulator agents of bacterial resistance, which could be used as adjuvants in the treatment of infections by S. aureus resistant to erythromycin, with previous studies of toxicity.

Se evaluó la eficacia in vitro de los extractos etanólicos de hojas y corteza de Ximenia americana L y Schinopsis brasiliensis Engl solos y en asociación con eritromicina como moduladores de la resistencia microbiana frente a seis aislados clínicos de Staphylococcus aureus resistentes a Eritromicina (SA1-SA6) y S. aureus ATCC 25923, por el método de microdilución. Además se determinó la actividad tóxica de los extractos contra Artemia salina. Solo el extracto etanólico de la corteza de X. americana mostró un efecto sinérgico con la eritromicina frente a SA01, SA03 y SA04. El extracto de las hojas de S. brasiliensis ejerció efecto sinérgico contra SA03 y el extracto de corteza, contra SA01 y S03. Los resultados sugieren que S. brasiliensis y X. americana tienen potencial como agentes moduladores de la resistencia bacteriana, que podrían ser utilizados como adyuvantes en el tratamiento de infecciones por S. aureus resistentes a eritromicina, con estudios previos de toxicidad.
Descritores: Anacardiaceae/química
Farmacorresistência Bacteriana
Olacaceae/química
Extratos Vegetais/farmacologia
Staphylococcus aureus
-Sinergismo Farmacológico
Eritromicina
Etanol/farmacologia
Testes de Sensibilidade Microbiana
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-889247
Autor: Guerra, Felipe QS; Araújo, Rodrigo SA; Sousa, Janiere P; Silva, Viviane A; Pereira, Fillipe O; Mendonça-Junior, Francisco JB; Barbosa-Filho, José M; Pereira, Julio Abrantes; Lima, Edeltrudes O.
Título: A new coumarin derivative, 4-acetatecoumarin, with antifungal activity and association study against Aspergillus spp
Fonte: Braz. j. microbiol;49(2):407-413, Apr.-June 2018. tab, graf.
Idioma: en.
Resumo: Abstract Fungal infections have become a concern for health professionals, and the emergence of resistant strains has been reported for all known classes of antifungal drugs. Among the fungi causing disease, we highlight those that belong to the genus Aspergillus. For these reasons, the search for new antifungals is important. This study examines the effects of a coumarin derivative, 4-acetatecoumarin (Cou-UMB16) both alone and together with antifungal drugs, and its mode of action against Aspergillus spp. Cou-UMB16 was tested to evaluate its effects on mycelia growth, and germination of Aspergillus spp. fungal conidia. We investigated its possible action on cell walls, on the cell membrane, and also the capacity of this coumarin derivative to enhance the activity of antifungal drugs. Our results suggest that Cou-UMB16 inhibits Aspergillus spp. virulence factors (mycelia growth and germination of conidia) and affects the structure of the fungal cell wall. When applying Cou-UMB16 in combination with azoles, both synergistic and additive effects were observed. This study concludes that Cou-UMB16 inhibits mycelial growth and spore germination, and that the activity is due to its action on the fungal cell wall, and that Cou-UMB16 could act as an antifungal modifier.
Descritores: Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Aspergillus/efeitos dos fármacos
Cumarínicos/isolamento & purificação
Cumarínicos/farmacologia
Sinergismo Farmacológico
-Aspergillus/crescimento & desenvolvimento
Azóis/farmacologia
Membrana Celular/efeitos dos fármacos
Parede Celular/efeitos dos fármacos
Hifas/efeitos dos fármacos
Hifas/crescimento & desenvolvimento
Esporos Fúngicos/efeitos dos fármacos
Esporos Fúngicos/crescimento & desenvolvimento
Responsável: BR1.1 - BIREME



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