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Id: biblio-2393 LILACS-Express
Autor: Drumond, Denise(aut); Gollner, Ângela Maria(aut); Cupolilo, Sônia Maria(aut); Santos Júnior, João Lúcio(aut).
Título: Citologia cervical e o teste para HPV
Fonte: HU rev;31(3):49-53, set.-dez.2005.
Idioma: pt.
Resumo: O câncer de colo de útero constitui grave problema de saúde pública no Brasil, apesar de ser um tipo de câncer evitável e curável quando diagnosticado precocemente. A colpocitologia constitui método de diagnóstico há cerca de 50 anos. Recentemente desenvolvida, a citologia em meio líquido apresenta algumas vantagens, porém ainda é um método mais caro que a citologia convencional. A captura híbrida II é método de identificação do HPV, com relação custo-benefício ainda muito discutida no Brasil.
-Papillomaviridae
Neoplasias do Colo do Útero
Biologia Celular
Teste de Papanicolaou
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR378.1 - Biblioteca Central


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Id: lil-623745
Autor: Raikhel, Alexander S.
Título: The cell biology of mosquito vitellogenesis
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.3):93-101, 1987. ilus, graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Insect Physiology, Biochemistry and Control, Rio de Janeiro, Nov. 10-13, 1987.
Projeto: National Institutes of Health.
Resumo: Insect vitellogenesis involves coordinated activities of the fat body and oocytes. We have studied these activities at the cellular level in the mosquito. During each vitellogenic cycle, the fat body undergoes three successive stages: 1) proliferation of biosynthetic organelles, 2) vitellogenin synthesis, 3) termination of vitellogenin synthesis and degradation of biosynthetic organelles by lysosomes. Analysis with monoclonal antibodies and radiolabelling demonstrated that the mosquito yolk protein consists of two subunits (200-kDa and 65-kDa). Both subunits are glycosylated, their carbohydrate moieties are composed of high-mannose oligosaccharides. The yolk protein subunits are derived from a single 220 kDa precursor detected by an in vitro translation. Oocytes become competent to internalize proteins as a result of juvenile hormone-mediated biogenesis of endocytotic organelles. The yolk protein is then accumulated by receptor-mediated endocytosis. A pathway of the yold protein and factors determining its routing in the oocyte have been studied.
Descritores: Vitelogênese
Controle de Mosquitos/organização & administração
Biologia Celular/organização & administração
-Culicidae
Responsável: BR1.1 - BIREME


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Id: lil-623759
Autor: Savino, Wilson; Dardenne, Mireille.
Título: Cell biology of thymic hormone secretion
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.2):15-21, 1987. ilus, graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Immunomodulators: Biology and Therapeutic Applications, Rio de Janeiro, Apr. 26-30, 1987.
Descritores: Hormônios do Timo/análise
Hormônios do Timo/sangue
-Hormônios do Timo/uso terapêutico
Biologia Celular
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-966974
Autor: Alvarenga, Paula Batista de; Oliveira, Danilo; Santos, Thaisa Reis; Rezende, Soraia Rage; Ramos, Oglênia Pereira; Troncha, Paula Mara Ribeiro; Medeiros, Alessandra Aparecida; Noleto, Pablo Gomes; Headley, Selwyn Arlington; Santos, Ricarda Maria dos; Saut, João Paulo Elsen.
Título: Prevalence of inflamatory processes in the reproductive tracts of crossbred dairy cows / Prevalência de processos inflamatórios no sistema reprodutivo de vacas leiteiras mestiças
Fonte: Biosci. j. (Online);34(3):703-708, mai/jun. 2018. tab, ilus.
Idioma: en.
Resumo: This study evaluated the prevalence of cervicitis and endometritis and their interrelations in crossbred dairy cows that were more than 60 days in milk (DIM), and the efficiency of the cytology technique (cytobrush) and histology as diagnostic methods for these diseases. The reproductive tracts (n=149) derived from cows were collected from a slaughterhouse and grossly evaluated to determine uterine involution and the phase of the estrous cycle. Subsequently, cervical and uterine cytological evaluations were done to characterize the inflammatory response as cervicitis (with a neutrophilic count greater than 5%) or endometritis (with more than 6% neutrophils). Additionally, randomly obtained samples from the cervix and uterus were collected for histological evaluation. Cytological evaluation revealed that the frequency of cervicitis was 6% (9/149), and endometritis was diagnosed in 8.1% (12/149) of the samples; both inflammatory reactions were diagnosed 2.1% (3/149) in three of these. Histological evaluation revealed that of the cows diagnosed with cervicitis by cytology, 66.6% (6/9) had no inflammatory reaction in the cervical mucosa, and 33.3% (3/9) had mild inflammation in this region. Histological evaluation of the uterine horn revealed that of the 12 cows diagnosed with endometritis by cytology, 50% (6/12) of these had a histological diagnosis of mild and moderate inflammatory responses, 8.3% (1/12) of these demonstrated a severe inflammatory response, while no inflammatory reaction was identified in 41.7% (5/12) of the endometrial biopsies evaluated. In conclusion, the endometrial and cervical inflammatory response diagnosed by the cytobrush technique persisted in 12.1% of the cows. Comparatively, the frequency of the inflammatory responses at the cervix and uterus was reduced by histological analysis relative to cytological evaluation with the cytobrush technique.

O objetivo deste estudo foi determinar a prevalência de cervicite e endometrite citológicas e suas inter-relações em vacas leiteiras mestiças com mais de 60 dias pós-parto (DPP), bem como avaliar as técnicas de citologia (cytobrush) e histologia como métodos diagnósticos para estas doenças. Foram utilizados 149 tratos reprodutivos de vacas com mais de 60 DPP de abatedouro e avaliados macroscopicamente para determinar a involução uterina e a fase do ciclo estral. Posteriormente, realizou-se citologia cervical e uterina para o diagnóstico de inflamação utilizando como ponto de corte, contagem de polimorfonucleares (PMN) superior a 5% e 6%, respectivamente, para cervicite e endometrite citológica. Também foram coletadas amostras de cérvix e útero para histologia. Do total de vacas, identificaram-se 6% (9/149) com cervicite e 8,1% (12/149) com endometrite citológica, sendo três destes animais (2,1%) com ambas as inflamações. Histologicamente, dos animais com cervicite citológica, 66,6% (6/9) não apresentaram infiltrado inflamatório na mucosa cervical e 33,3% (3/9) apresentaram inflamação leve. A histologia uterina mostrou que de 12 vacas com endometrite citológica, 50% (6/12) apresentaram infiltrados inflamatórios leves a moderados, 8,3% (1/12) grave e 41,7% (5/12) não tinham Inflamação endometrial. Concluiu-se que a inflamação endometrial e cervical, por meio da técnica de citologia, persistiu em 12,1% das vacas com mais de 60 DPP. Quando se utiliza a histologia como método de diagnóstico, a detecção de inflamação cervical e uterina é inferior ao detectado pela técnica de citologia por meio do esfregaço endometrial (cytobrush).
Descritores: Bovinos
Doenças dos Bovinos
Cervicite Uterina
Biologia Celular
Endometrite
-Histologia
Responsável: BR396.1 - Biblioteca Central


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Id: biblio-1025368
Autor: Salvarezza, Diágora María Carla; Castellano, Laura; Smit, Rosina; Lespi, Pablo.
Título: Correlación citohistológica de Papanicolaou Clase III (ASCUS) / Cytohistological Correlation of Pap Class III (ASCUS)
Fonte: Rev. Asoc. Med. Bahía Blanca;14(1):27-29, ene.-mar. 2004.
Idioma: es.
Resumo: La anomalía en células epiteliales de significado incierto (ASCUS) abarca aquellas lesiones en células escamosas de origen inflamatorio o displásico, que no están bien definidas (sospechosas). El objetivo de nuestro trabajo fue determinar el porcentaje de citologías diagnosticadas como ASCUS que resultaron en cambios reactivos o lesiones intraepiteliales y evaluar la correlación con los hallazgos citólogicos e histopatológicos de estudios posteriores. Se analizaron 114 citologías cervicales (PAPs) diagnosticadas como ASCUS en el Servicio de Patología del H.I.G."Dr. José Penna". De este grupo sólo 60 pacientes fueron estudiadas con biopsias y citologías posteriores. El 70% (42/60) correspondieron a lesiones reactivas, seguidas en frecuencia por un 30% (18/60) de lesión intraepitelial de alto y bajo grado. Nosotros enfatizamos la importancia del estudio y seguimiento de todas las pacientes con diagnóstico de ASCUS ya que en un 30% de los casos se observó lesión intraepitelial con las consiguientes implicancias clínicas y pronósticas para las pacientes.

Atypical Squamous Cells of Undetermined Significance (ASCUS) comprise those lesions appearing in squamous cells that are not well defined (suspect lesions) of inflammatory or dysplastic origin. The purpose of this work is to determine the percentage of cytologies diagnosed as ASCUS that resulted in reactive changes or intraepithelial lesions and to relate it with cytologic and histopathologic findings in previous studies. 114 cervical cytologies (PAPs) diagnosed as ASCUS at the Pathology Unit of H.I.G. "Dr. José Penna" were assessed. Of this group, only 60 patients were later studied with biopsy and cytology procedures. 70% (42/60) corresponded to reactive lesions, followed in occurrence by 30% (18/60) of high and low degree intraepithelial lesions. We would like to emphasize the importance of the study and follow-up of all patients with ASCUS diagnosis, since we observed intraepithelial lesions in 30% of the cases, with the consequent clinical and prognostic implications for the patients.
Descritores: Células Escamosas Atípicas do Colo do Útero
-Biologia Celular
Teste de Papanicolaou
Limites: Feminino
Tipo de Publ: Relatos de Casos
Responsável: AR393.1 - Centro de Información y Documentación Dr H. Urquiola


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Id: biblio-882852
Autor: Silva, Allan Nogueira da; Pimentel, Kleber; Martins, Maria Tereza Silveira; Silva, Carlos Alberto Lima da; Lopes, Antônio Carlos Vieira; Torrales, Maria Betânia.
Título: Acurácia da citologia vaginal e colposcopia para diagnóstico de neoplasia intraepitelial cervical no CICAN-Bahia / Accuracy of vaginal cytology and colposcopy in the diagnosis of cervical intraepithelial neoplasia in CICAN-Bahia / Precisión de la citología vaginal y colposcopia en el diagnóstico de la neoplasia intraepitelial cervical en CICAN-Bahia
Fonte: Rev. baiana saúde pública;41(2):https://doi.org/10.22278/2318-2660.2017.v41.n2.a2244, abr. 2017.
Idioma: pt.
Resumo: O rastreamento do câncer do colo uterino é realizado por meio da citologia cervical e colposcopia. O objetivo deste estudo foi avaliar a acurácia da citologia cervical e da colposcopia para o diagnóstico de neoplasia intraepitelial cervical no do Centro Estadual de Oncologia. Para tanto, utilizou-se os dados das citologias de 351 pacientes e de 378 colposcopias que também realizaram biópsias de lesões suspeitas. Foram estimadas as medidas de acurácia das citologias e das colposcopias. Os valores da sensibilidade e especificidade para citologia foram de 85,04% (Intervalo de Confiança 95% 80,34 ­ 89,01), 40% (Intervalo de confiança 95% 28,47 ­ 52,41), respectivamente; e, para colposcopia, de 97,73% (Intervalo de confiança 95% 95,37 ­ 99,08) e 15,79% (Intervalo de confiança 95% 8,43 ­ 25,96), respectivamente. O valor da Razão de Probabilidade positiva da citologia foi de 1,42 (Intervalo de confiança 95%, 1,16 ­ 1,72) e da Razão de Probabilidade negativa foi de 0,37 (Intervalo de confiança 95%, 0,25 ­ 0,56). Já para colposcopia, o valor da Razão de Probabilidade positiva foi de 1,16 (Intervalo de confiança 95%, 1,05 ­ 1,28); e, a Razão de Probabilidade negativa de 0,14 (Intervalo de confiança 95%, 0,06 ­ 0,36). Assim, sugere-se que a capacidade da citologia e colposcopia de modificar a probabilidade pós-teste de doença no Centro Estadual de Oncologia é pequena, em virtude do baixo valor das Razões de Probabilidade positiva.

Screening for cervical cancer is performed by cervical cytology and colposcopy. The objective of this study was to evaluate the accuracy of cervical cytology and colposcopy in the diagnosis of cervical intraepithelial neoplasia in State Oncology Center. For that it was used cytology data from 351 patients and colposcopy data from 378 patients, which also performed biopsies of suspicious lesions. The measures of accuracy of cytology and colposcopy were estimated. The values of sensitivity and specificity for cytology were 85.04% (95% confidence interval 80,34 - 89.01), 40% (95% confidence interval 28,47 - 52.41), respectively, and for colposcopy were 97.73% (95% confidence interval 95.37 - 99.08) and 15.79% (95% confidence interval, 8.43 - 25,96), respectively. The positive likelihood ratio value of cytology was 1.42 (95% CI, 1.16 to 1.72) and negative Likelihood ratio was 0.37 (95% confidence interval, 0.25 to 0.56). As for colposcopy, the positive likelihood ratio value was 1.16 (95% confidence interval, 1.05 to 1.28) and the negative likelihood ratio, 0.14 (95% confidence interval, 0.06 to 0.36). Thus it is suggested that the capacity of these tests to modify the post-test probability of disease in State Oncology Center is small because of the low value of positive likelihood ratio.

La detección de cáncer de cuello uterino es realizada por medio de citología cervical y por colposcopia. El objetivo de este estudio fue evaluar la precisión de la citología cervical y de la colposcopia en el diagnóstico de la neoplasia intraepitelial cervical in el Centro Estadual de Oncología. Para ello, utilizaronse los datos de citología de 351 pacientes y de 378 colposcopias que también realizaron biopsias de lesiones sospechosas. Fueron estimadas las medidas de precisión de las citologías y de las colposcopias. Los valores de sensibilidad y especificidad para la citología fueron 85,04% (Intervalo de confianza 95%: 80,34 - 89,01), 40% (Intervalo de confianza 95%: 28,47 - 52,41), respectivamente, y, para la colposcopia, de 97,73% (Intervalo de confianza 95% 95,37 - 99,08) y 15,79% (Intervalo de confianza 95%: 8,43 - 25,96), respectivamente. El valor de Razón de probabilidad positivo de la citología fue 1,42 (Intervalo de confianza 95%, 1,16-1,72) y de Razón de Probabilidad negativo fue 0,37 (Intervalo de confianza 95%: 0,25 a 0,56). En cuanto a la colposcopia, el valor de Razón de Probabilidad positivo fue 1,16 (Intervalo de confianza 95%, desde 1,05 hasta 1,28) y de Razón de Probabilidad negativa, 0,14 (Intervalo de confianza 95%, 0,06 hasta 0,36). Así, sugierese que la capacidad de la citología y colposcopia de modificar la probabilidad post test en el Centro Estadual de Oncología es pequeña, debido al bajo valor de las razones de probabilidad positiva.
Descritores: Carcinoma in Situ
Neoplasias do Colo do Útero
Colposcopia
Biologia Celular
Teste de Papanicolaou
Limites: Seres Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


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Id: biblio-1022084
Autor: Ribas, José Antônio; Carvalho, Eulógio Queiroz; Stussi, Jussara Pedroso.
Título: Endometrite fúngica em éguas: diagnóstico e implicações clínico-patológicas / Fungal endometritis in mares: diagnosis and clinicopathological aspects
Fonte: Rev. bras. ciênc. vet;21(4):204-212, out.-dez.2014. il..
Idioma: pt.
Resumo: Este estudo objetivou estabelecer a etiologia e achados clínico-patológicos das endometrites fúngicas. Para tal, realizou-se anamnese, exame ginecológico, cultura, citologia e biópsia endometriais em 85 éguas em idade reprodutiva e que não pariam havia um ano ou mais. Das 85 éguas, 24 (28%) apresentaram exames compatíveis com endometrite infecciosa. Destas, em 20% (5/24), confirmou-se endometrite com envolvimento fúngico. Os fungos isolados foram: Candida guilliermondii, C. tropicalis, C. pseudotropicalis associadas ao Bacillus sp. em uma égua; C. albicans em duas fêmeas (uma associada a Escherichia coli); um caso de Trichosporon penicillatum e um de T. capitatum. Todos animais diagnosticados com endometrite fúngica apresentaram inflamações endometriais moderadas, nos exames de citologia e no histopatológico, sendo estes achados compatíveis com o histórico e o exame reprodutivo destes animais. Destacou-se a presença constante de linfócitos e plasmócitos nos dois exames, assim como das lesões degenerativas no endométrio através da biópsia endometrial. Em 80% (4/5) constataram-se estruturas fúngicas na citologia endometrial, porém no exame histopatológico, não foi possível detectar tais estruturas. Após o estudo pode-se afirmar que a metodologia utilizada foi eficiente para diagnosticar a endometrite fúngica, com destaque para o exame de citologia endometrial, e que este tipo de endometrite teve caráter crônico em todos os animais.

The aim of the present study was to determine the causes and clinical findings of endometritis. The history, reproductive examination and endometrials culture, uterine cytology and biopsy from 85 mares in reproductive age that did not foal a year or more were performed. Twenty four (28%) out of 85 mares had signals compatible with infectious endometritis. From those, 20% (5/24) had fungal involvement, and the agents were: Candida guilliermondii, C. tropicalis, C. pseudotropicalis, in association to Bacillus sp. in one mare; two mares had C. albicans, and one of them associated with Escherichia coli; a case of Trichosporon penicillatum and another of T. capitatum. All animals with fungal endometritis presented moderate endometrial inflammation, at cytology and uterine biopsy, which was compatible with the animal's history and reproductive exam. The endometrial cytology and biopsy revealed numerous lymphocytes and plasmocytes as well as the degenerative lesions in the endometrial biopsy. Fungal structures were presented at the endometrial cytology smears in 80% (4/5) of the mares, however those structures were not detected in the biopsy. In conclusion, the methodology used was efficient to diagnose fungal endometritis, with standing for the examination of endometrial cytology, and the fungal endometritis had chronic character in all animals.
Descritores: Útero
Doença
Biologia Celular
Endometrite
Cavalos
-Biópsia
Limites: Animais
Responsável: BR409.1 - Biblioteca


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Id: lil-623874
Autor: Galvão, Archibaldo Bello; Guitton, Neide.
Título: Noções de estrutura e biologia dos ácaros / Concepts about the structure and the biology of Acari
Fonte: Mem. Inst. Oswaldo Cruz;84(supl.4):223-239, 1989. ilus.
Idioma: pt.
Resumo: Characterization of sub-classe Acari of importance in Agronomy, Veterinary and Medical Parasitology, based on morphology, behavior and environment of allergenic and parasitc species. Keys for the identification of the six families of Psoroptoidea, chiefly of Pyroglyphidae, starting from which various aspects of the acari of domectic dust and their allergenic behavior are studied.
Descritores: Psoroptidae/parasitologia
Ácaros/classificação
-Agronomia
Biologia Celular
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-1016569
Autor: Zamora-Julca, Roxana Elizabeth; Ybaseta-Medina, Jorge; Palomino-Herencia, Adrián.
Título: Relación entre citología, biopsia y colposcopía en cáncer cérvico uterino / Relationship between cytology, biopsy and colposcopy in cervical cancer
Fonte: Rev. méd. panacea;8(1):31-45, ene.-abr. 2019. ilus, tab, graf, mapas.
Idioma: es.
Resumo: Objetivo: Determinar la relación que existe entre citología, biopsia y colposcopia en cáncer cérvico uterino. Materiales y métodos: : Es un estudio, descriptivo, transversal y retrospectivo..Se realizó una revisión bibliográfica de los artículos publicados en los últimos 5 años, y de otros originales teniendo en cuenta su nivel de evidencia médica I - II. Se utilizaron los buscadores de la biblioteca Cochrane, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central y artículos de la Agencia Internacional del Cáncer de Francia. Se revisaron los siguientes aspectos: Definiciones, epidemiología, etiología, factores de riesgo, citología, colposcopia, histopatología, clasificaciones, estadios clínicos, tratamientos, prevención, promoción de salud y problemas sociales. Resultados: En Europa, se encontró una concordancia insignificante entre citología - colposcopia (k=0,16; IC 95% 0,09-0,22); una concordancia moderada entre colposcopia - biopsia (k=0,57; IC 95% 0,47-0,68); y una concordancia insignificante entre citología - biopsia (k=0,21; IC 95% 0,08-0,34). ; En América Latina; se observó: la citología S: 80% y E: 56.6%; la colposcopia mostró S: 72,7% y E: 71,4%. La colposcopia mostró mayor correlación diagnóstica que la citología cervical en lesiones pre malignas de cáncer cervico uterino. La relación colpo-histológica mostró un 87,5% de coincidencias en las LIE bajo grado y en las LIE de alto grado un 71,4%. Perú 2017, citología mostró una S: 69% y E: 40%; colposcopía S: 86% y E: 44%. La relación citología - colposcopia S: 96% y E: 19%. Existe una asociación estadísticamente significativa de los resultados de la anatomía patológica con los hallazgos colposcópicos y del PAP (P<0.05) .La citología - colposcopia para lesiones precursoras y malignas de cáncer de cuello uterino moderada concordancia (Kappa: 0.4549); débil concordancia entre la citología - histología (Kappa: 0.3889) y buena concordancia entre la colposcopía - histología (Kappa: 0.6191). Trabajos Regionales Los hallazgos anátomo-patológicos fueron: 25,9% carcinomas invasivos y el 74,1% lesiones intraepiteliales de alto de malignidad. Conclusiones: La citología y la colposcopía han demostrado tener una utilidad clínica para la detección precoz de displasia moderada, displasia severa, carcinoma in situ y carcinoma escamoso invasor. Aunque no se obtuvo una adecuada correlación colpo-citológica, la correlación cito-histológica fue muy elevada tanto en las lesiones intraepiteliales de bajo grado como en las de alto grado. (AU)

Objective: To determine the relationship between cytology, biopsy and colposcopy in cervical cancer. Materials and methods: It is a descriptive, transversal and retrospective study. A bibliographic review of the articles published in the last 5 years, and of other originals taking into account their level of medical evidence I - II was made. We used search engines from the Cochrane library, Dynamed, Evidence-Based Medicine Updates, New England Journal of Medicine, J Clinical Oncology, Medscape, PubMed, PubMed Central and articles from the International Cancer Agency of France. The following aspects were reviewed: Definitions, epidemiology, etiology, risk factors, cytology, colposcopy, histopathology, classifications, clinical stages, treatments, prevention, health promotion and social problems Discussion: In Europe, insignificant concordance was found between cytology - colposcopy (k = 0.16, 95% CI 0.09-0.22); a moderate agreement between colposcopy - biopsy (k = 0.57, 95% CI 0.47-0.68); and an insignificant concordance between cytology - biopsy (k = 0.21, 95% CI 0.08-0.34). ; In Latin America; it was observed: cytology S: 80% and E: 56.6%; colposcopy showed S: 72.7% and E: 71.4%. Colposcopy showed a greater diagnostic correlation than cervical cytology in pre malignant lesions of uterine cervical cancer. The colpo-histological relationship showed 87.5% of coincidences in the low-grade IELs and 71.4% in the high-grade IELs. Peru 2017, cytology showed an S: 69% and E: 40%; Colposcopy S: 86% and E: 44%. The relationship cytology - colposcopy S: 96% and E: 19%. There is a statistically significant association of the results of the pathological anatomy with the colposcopic and PAP findings (P <0.05). Cytology - colposcopy for precursor and malignant lesions of moderate cervical cancer concordance (Kappa: 0.4549); weak concordance between cytology - histology (Kappa: 0.3889) and good agreement between colposcopy - histology (Kappa: 0.6191). Regional Workings The anatomopathological findings were: 25.9% invasive carcinomas and 74.1% intraepithelial lesions of high of malignancy. Conclusions:Cytology and colposcopy have been shown to be clinically useful for the early detection of moderate dysplasia, severe dysplasia, carcinoma in situ, and invasive squamous cell carcinoma. Although an adequate colpo-cytological correlation was not obtained, the cyto-histological correlation was very high in both low-grade and high-grade intraepithelial lesions. (AU)
Descritores: Biópsia
Neoplasias do Colo do Útero
Colposcopia
Biologia Celular
-Epidemiologia Descritiva
Estudos Transversais
Estudos Retrospectivos
Limites: Seres Humanos
Feminino
Tipo de Publ: Revisão
Responsável: PE382.9


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Id: lil-741870
Autor: Saad, Sara Teresinha Olalla; Carvalho, Hernandes Faustino.
Título: Motivating medical students to learn basic science concepts using chronic myeloid leukemia as an integration theme
Fonte: Rev. bras. hematol. hemoter;37(1):63-66, Jan-Feb/2015.
Idioma: en.
Resumo: Objective: To report on the use of chronic myeloid leukemia as a theme of basic clinical integration for first year medical students to motivate and enable in-depth understanding of the basic sciences of the future physician. Methods: During the past thirteen years we have reviewed and updated the curriculum of the medical school of the Universidade Estadual de Campinas. The main objective of the new curriculum is to teach the students how to learn to learn. Since then, a case of chronic myeloid leukemia has been introduced to first year medical students and discussed in horizontal integration with all themes taught during a molecular and cell biology course. Cell structure and components, protein, chromosomes, gene organization, proliferation, cell cycle, apoptosis, signaling and so on are all themes approached during this course. At the end of every topic approached, the students prepare in advance the corresponding topic of clinical cases chosen randomly during the class, which are then presented by them. During the final class, a paper regarding mutations in the abl gene that cause resistance to tyrosine kinase inhibitors is discussed. After each class, three tests are solved in an interactive evaluation. Results: The course has been successful since its beginning, 13 years ago. Great motivation of those who participated in the course was observed. There were less than 20% absences in the classes. At least three (and as many as nine) students every year were interested in starting research training in the field of hematology. At the end of each class, an interactive evaluation was performed and more than 70% of the answers were correct in each evaluation. Moreover, for the final evaluation, the students summarized, in a written report, the molecular and therapeutic basis of chronic myeloid leukemia, with scores ranging from 0 to 10. Considering all 13 years, a median of 78% of the class scored above ...
Descritores: Ensino
Leucemia Mielogênica Crônica BCR-ABL Positiva
Educação Superior
Biologia Celular
Motivação
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM



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