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Pesquisa : H01.158.273.180 [Categoria DeCS]
Referências encontradas : 237 [refinar]
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Id: biblio-950909
Autor: Wei, Li; He, Fei; Zhang, Wen; Chen, Wenhua; Yu, Bo.
Título: Bioinformatics analysis of microarray data to reveal the pathogenesis of diffuse intrinsic pontine glioma
Fonte: Biol. Res;51:26, 2018. tab, graf.
Idioma: en.
Resumo: BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is the main cause of pediatric brain tumor death. This study was designed to identify key genes associated with DIPG. METHODS: The gene expression profile GSE50021, which consisted of 35 pediatric DIPG samples and 10 normal brain samples, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified by limma package. Functional and pathway enrichment analyses were performed by the DAVID tool. Protein-protein interaction (PPI) network, and transcription factor (TF)-microRNA (miRNA)-target gene network were constructed using Cytoscape. Moreover, the expression levels of several genes were validated in human glioma cell line U251 and normal glia HEB cells through real-time polymerase chain reaction (PCR). RESULTS: A total of 378 DEGs were screened (74 up-regulated and 304 down-regulated genes). In the PPI network, GRM1, HTR2A, GRM7 and GRM2 had higher degrees. Besides, GRM1 and HTR2A were significantly enriched in the neuroactive ligand-receptor interaction pathway, and calcium signaling pathway. In addition, TFAP2C was a significant down-regulated functional gene and hsa-miR-26b-5p had a higher degree in the TF-miRNA-target gene network. PCR analysis revealed that GRM7 and HTR2A were significantly downregulated while TFAP2C was upregulated in U251 cells compared with that in HEB cells (p < 0.001). GRM2 was not detected in cells. CONCLUSIONS: GRM1 and HTR2A might function in DIPG through the neuroactive ligand-receptor interaction pathway and the calcium signaling pathway. Furthermore, the TFAP2C and hsa-miR-26b-5p might play important roles in the development and progression mechanisms of DIPG.
Descritores: Biologia Computacional/métodos
Neoplasias do Tronco Encefálico/genética
MicroRNAs/genética
Glioma/genética
-Regulação para Baixo
Regulação para Cima
Análise em Microsséries/métodos
Reação em Cadeia da Polimerase em Tempo Real
Transcriptoma
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1129074
Autor: Santillán-Garzón, Sonia; Diego Álvarez, Dan; Buades, Celia; Romera-López, Alejandro; Pérez-Cabornero, Lucía; Valero-Hervás, Diana; Catanalpiedra, Diego; Felipe-Ponce, Vanesa; Hernández-Poveda, Gracia; Roca, María José; Casañs, Clara; Fernández-Pedrosa, Victoria; Collado M, Carmen; Arilla C, Ángela; Triviño P, Juan Carlos; Rodríguez C, Óscar; Marco, Guillermo; Gil, Mayte; Miñambres, Rebeca; Ballester, Alida.
Título: Diagnóstico molecular de enfermedades genéticas: del diagnóstico genético al diagnóstico genómico con la secuenciación masiva / Molecular diagnosis of genetic diseases: from genetic to genomic diagnosis using next generation sequencing
Fonte: Rev. Méd. Clín. Condes;26(4):458-469, jul. 2015. ilus, tab, graf.
Idioma: es.
Resumo: En la actualidad se conocen 8.000 enfermedades genéticas monogénicas. La mayoría de ellas son heterogéneas, por lo que el diagnóstico molecular por técnicas convencionales de secuenciación suele ser largo y costoso debido al gran número de genes implicados. El tiempo estimado para el diagnóstico molecular se encuentra entre 1 y 10 años, y este retraso impide que los pacientes reciban medidas terapéuticas y de rehabilitación específicas, que sus familiares entren en programas preventivos y que reciban asesoramiento genético. La secuenciación masiva está cambiando el modelo de diagnóstico molecular de los afectos, sin embargo, los médicos y profesionales de la salud se enfrentan al dilema de la selección del método más eficiente, con el menor coste sanitario y con la mayor precisión de sus resultados. El objetivo de este trabajo es revisar la tecnología de secuenciación masiva y definir las ventajas y los problemas en su utilización.

Currently 8000 monogenic genetic diseases are known. Most of them are heterogeneous, so their molecular diagnosis by conventional sequencing techniques is labour intensive and time consuming due to the large number of genes involved. The estimated time is between 1 and 10 years for molecular diagnosis and this delay prevents patients from receiving therapy and rehabilitation measures, and their families from entering prevention programs and being given genetic counselling. Next generation sequencing (NGS) is changing the model of molecular diagnosis of patients; however, doctors and health professionals are faced with the dilemma of choosing the most efficient method, with lower health care costs and the most accurate results. The aim of this paper is to review the NGS technology and define the advantages and problems in the use of this technology.
Descritores: Doenças Genéticas Inatas/diagnóstico
Doenças Genéticas Inatas/genética
-Biologia Computacional
Genômica
Técnicas de Diagnóstico Molecular
Sequenciamento de Nucleotídeos em Larga Escala
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1100918
Autor: Li, Musheng; Zhao, Junhong; Cao, Meiwan; Liu, Ruitao; Chen, Guanhua; Li, Songyu; Xie, Yuanwen; Xie, Jing; Cheng, Yang; Huang, Ling; Su, Mingmin; Xu, Yuxin; Zheng, Mingyue; Zou, Kejian; Geng, Lanlan; Xu, Wanfu; Gong, Sitang.
Título: Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells
Fonte: Biol. Res;53:12, 2020. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Natural Science Foundation of Guangdong Province; . Medical Science and Technology Foundation of Guangdong; . Guangzhou Municipal Science and Technology Project; . Guangzhou Municipal Health and Family Planning Commission; . Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center; . Guangzhou Women and Children's Medical Center and Sun Yat-Sen University; . Natural Science Foundation of Hainan Province; . Guangzhou Women and Children's Medical Center; . Hainan natural science foundation.
Resumo: BACKGROUND: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. RESULTS: In our study, we used exosomes isolated from human mast cells-1 (HMCs-1) to culture with NCM460, HT-29 or CaCO2 of intestinal epithelial cells (lECs) to investigate the communication between MCs and lECs. We found that MCs-derived exosomes significantly increased intestinal epithelial permeability and destroyed intestinal barrier function, which is attributed to exosome-mediated functional miRNAs were transferred from HMCs-1 into lECs, leading to inhibit tight junction-related proteins expression, including tight junction proteins 1 (TJP1, ZO-1), Occludin (OCLN), Claudin 8 (CLDN8). Microarray and bioinformatic analysis have further revealed that a panel of miRNAs target different tight junction-related proteins. Interestingly, miR-223 is enriched in mast cell-derived exosome, which inhibit CLDN8 expression in IECs, while treatment with miR-223 inhibitor in HT-29 cells significantly reversed the inhibitory effect of HMCs-1-derived exosomes on CLDN 8 expression. Most importantly, enrichment of MCs accumulation in intestinal mucosa of patients with IBD compared with those healthy control. CONCLUSIONS: These results indicated that enrichment of exosomal miR-223 from HMCs-1 inhibited CLDN8 expression, leading to destroy intestinal barrier function. These finding provided a novel insight of MCs as a new target for therapeutic treatment of IBD.
Descritores: MicroRNAs/metabolismo
Células Epiteliais/metabolismo
Mucosa Intestinal/metabolismo
Mastócitos/metabolismo
-Permeabilidade
Doenças Inflamatórias Intestinais/metabolismo
Células Cultivadas
Células CACO-2/citologia
Biologia Computacional
Análise Serial de Tecidos
Exossomos/metabolismo
Claudinas/metabolismo
Ocludina/metabolismo
Proteína da Zônula de Oclusão-1/metabolismo
Limites: Humanos
Animais
Bovinos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1124205
Autor: Wei, Xiyi; Zhang, Yuan; Yang, Zhou; Sha, Yeqin; Pan, Yitong; Chen, Yusheng; Cai, Lei.
Título: Analysis of the role of the interleukins in colon cancer
Fonte: Biol. Res;53:20, 2020. tab, graf.
Idioma: en.
Projeto: Scientific Research Foundation provided by Pudong Hospital affiliated to Fudan University.
Resumo: BACKGROUND: The role of interleukin family in colon cancer remained controversial. The purpose of this study was to investigate the association between interleukin family and colon cancer progression through bioinformatics methods and to validate such association in clinical patients. METHODS: A total of 15 differentially expressed interleukins between the colon cancer tissue and normal colon tissue were evaluated from the Cancer Genome Atlas (TCGA) database with R software and only interleukin-7 (IL-7) was significantly associated with survival. The signaling pathway associated with IL-7 was then investigated using gene enrichment analysis. In addition, subsets of TNM were analyzed in detail and univariate and multivariate COX regression analysis were conducted. Finally, we performed western blotting, immunohistochemistry, cell proliferation and cell apoptosis analysis to examine the expression of IL-7 in patients with intestinal cancer. RESULTS: The study demonstrated that IL-7 could inhibit the progression of colon cancer. In addition, IL-7 was found to be associated with overall survival (OS) and pathological stage. Further analysis of IL-7 expression with clinical data indicated that IL-7 was a key factor in inhibiting colon cancer progression. CONCLUSION: IL-7 was a key factor in inhibiting the progression of colon cancer and was closely related to overall survival.
Descritores: Adenocarcinoma/metabolismo
Interleucina-7/metabolismo
Neoplasias do Colo/metabolismo
-Imuno-Histoquímica
Transdução de Sinais
Western Blotting
Apoptose
Progressão da Doença
Biologia Computacional
Proliferação de Células
Citometria de Fluxo
Estadiamento de Neoplasias
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: CL1.1 - Biblioteca Central


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Id: lil-553372
Autor: Mello, Barbara Pereira de.
Título: Busca de marcadores moleculares tecido-associados em regiões transcritas não caracterizadas do genoma humano / Search for tissue-associated molecular markers in non-characterized transcribed regions of the human genome.
Fonte: São Paulo; s.n; 2009. 87 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Fundação Antônio Prudente para obtenção do grau de Doutor.
Resumo: Com foco na atividade transcricional do genoma humano, foi desenvolvido um trabalho de mestrado, em que construímos um microarranjo de cDNAs composto por sequências ORESTES resultantes do Projeto Genoma do Câncer Humano (FAPESP/LICR - HCGP) que não se alinharam com sequências de cDNA geradas por outros projetos. Este arranjo foi hibridizado contra cDNAs derivados de diferentes tecidos humanos, normais ou tumorais, resultando na identificação de 3.421 regiões transcritas do genoma humano (83,3% da plataforma) não descritas por outros projetos de sequênciamento como transcritos. Acreditando que parte dessas sequências pudessem representar RNAs não codificadores, variantes de splicing ou transcritos antisenso naturais fizemos uma reanálise computacional das sequências avaliadas no trabalho de mestrado e também uma análise de expressão diferencial das mesmas, buscando variações de expressão de transcritos tumor- e/ou tecido-associadas. Identificamos como possíveis ncRNAs 28% das sequências analisadas. Mil e sete sequências foram identificadas como diferencialmente expressas, sendo que 291 representam potenciais ncRNAs. Além disso, três potenciais marcadores tumorais de próstata foram validados por PCR em tempo real. Estudos adicionais de um desses marcadores, PCA3, revelaram um possível papel desse ncRNA na regulação do gene PRUNE2 e a existência de uma retenção intrônica não descrita na sequência de PCA3, aparentemente mais frequente em amostras normais de próstata. Também pudemos contribuir com análises iniciais de um potencial novo marcador de câncer de próstata a ser explorado para a complementação de marcadores já existentes, mas falhos em alguns aspectos. Um artigo referente a parte desse trabalho foi publicado no periódico Nucleic Acids Research (MELLO et al. 2009).

With focus on transcriptional activity of the human genome, we developed a master's work, in which we built a cDNA microarray composed of ORESTES sequences resulting from the Human Cancer Genome Project (FAPESP / LICR - HCGP) that did not align with cDNA sequences generated by other projects. This array was hybridized against cDNAs derived from different normal or tumor tissues, resulting in the identification of 3,421 transcribed regions of the human genome (83.3% of the slide) not described by other sequencing projects as transcripts. Believing that some of these sequences may represent non-coding RNAs, and splicing variants of natural antisense transcripts we did a new computational analysis of the sequences found in the master's work and also an analysis of differential expression of these sequences, seeking changes in expression of tumor- and/or tissue-associated transcripts. We identified as possible ncRNAs 28% of the sequences analyzed. One thousand and seven sequences were identified as differentially expressed, and from these 291 represent potential ncRNAs. In addition, three potential tumor markers for prostate cancer were validated by real-time PCR. Further studies of one of these markers, PCA3, revealed a possible role of this ncRNA in the regulation of PRUNE2 gene and the existence of an intron retention not described within PCA3 sequence, apparently more common in normal samples from prostate. We could also contribute with initial analysis of a potential new marker for prostate cancer to be explored in complementing currently markers not very acurated. An article containing part of this work was published in the journal Nucleic Acids Research (MELLO et al. 2009).
Descritores: Análise de Sequência
Biologia Computacional
Genoma Humano
Biomarcadores Tumorais
Neoplasias da Próstata
Perfilação da Expressão Gênica
-Alinhamento de Sequência
DNA Complementar
Responsável: BR30.1 - Biblioteca
BR30.1


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Id: biblio-1124209
Autor: Jia, Jianlei; Jin, Jipeng; Chen, Qian; Yuan, Zan; Li, Haiqin; Bian, Junhao; Gui, Linsheng.
Título: Eukaryotic expression, Co-IP and MS identify BMPR-1B protein-protein interaction network
Fonte: Biol. Res;53:24, 2020. tab, graf.
Idioma: en.
Resumo: BACKGROUND: BMPR-1B is part of the transforming growth factor ß super family and plays a pivotal role in ewe litter size. Functional loss of exon-8 mutations in the BMPR-1B gene (namely the FecB gene) can increase both the ewe ovulation rate and litter size. RESULTS: This study constructed a eukaryotic expression system, prepared a monoclonal antibody, and characterized BMPR-1B/FecB protein-protein interactions (PPIs). Using Co-immunoprecipitation coupled to mass spectrometry (Co-IP/MS), 23 proteins were identified that specifically interact with FecB in ovary extracts of ewes. Bioinformatics analysis of selected PPIs demonstrated that FecB associated with several other BMPs, primarily via signal transduction in the ovary. FecB and its associated interaction proteins enriched the reproduction process via BMP2 and BMP4 pathways. Signal transduction was identified via Smads proteins and TGF-beta signaling pathway by analyzing the biological processes and pathways. Moreover, other target proteins (GDF5, GDF9, RhoD, and HSP 10) that interact with FecB and that are related to ovulation and litter size in ewes were identified. CONCLUSIONS: In summary, this research identified a novel pathway and insight to explore the PPi network of BMPR-1B.
Descritores: Ovário/metabolismo
Receptores de Proteínas Morfogenéticas Ósseas Tipo I/genética
Eucariotos/genética
Mapas de Interação de Proteínas/genética
-Espectrometria de Massas
Polimorfismo de Fragmento de Restrição
Ovinos
Transdução de Sinais
Reação em Cadeia da Polimerase
Biologia Computacional
Receptores de Proteínas Morfogenéticas Ósseas Tipo I/metabolismo
Eucariotos/metabolismo
Genótipo
Mutação
Limites: Animais
Feminino
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1119013
Autor: Bolivar Parra, Laura; Giraldo Hincapié, Paula Andrea; Montoya Campuzano, Olga Inés.
Título: Antimicrobial activity of a synthetic bacteriocin found in the genome of Lactobacillus casei on the microbiota of Antioquian soft cheese (Quesito Antioqueño) / Actividad antimicrobiana de una bacteriocina sintética proveniente del genoma de Lactobacillus casei sobre la microbiota de Quesito Antioqueño
Fonte: Vitae (Medellín);27(1):1-9, 2020. Ilustraciones.
Idioma: en.
Resumo: Background: Lactic Acid Bacteria (LAB) are of special interest in the food industry due to their ability to produce metabolites. Among them, bacteriocins, which can inhibit the growth of altering microorganisms, and pathogens in a wide variety of foods, are considered safe for human consumption and are used as preservatives. Objectives: Evaluate the effect of a bacteriocin found by in silico methods on the microbiota present in Antioquian soft cheese. Methods: In this research, we design a synthetic bacteriocin, called Bac 22, found in the genome of Lactobacillus casei using the genomic mining methodology and bioinformatics tools. We also conducted a preliminary biological and hemolytic activities studies of the Bac 22 toward the microbiota present in the Antioquian soft cheese (Quesito Antioqueño). Results: The bacteriocin Bac 22 at a concentration of 100 µM presented a hemolytic capacity lower than 1% and reduced the CFU / g of total coliforms significantly when added to Antioquian soft cheese for eight days. Conclusions: The Bac 22 demonstrated a positive potential effect over the shelf life of a dairy product, such as the Antioquian soft cheese.

Antecedentes: Las Bacterias Ácido Lácticas (BAL) son de especial interés para la industria alimentaria por su capacidad de producir metabolitos entre ellos, las bacteriocinas que inhiben el crecimiento de microorganismos alterantes y de patógenos en una amplia variedad de alimentos, se consideran seguras para el consumo humano y son utilizadas como conservantes. Objetivo: Se evaluó el efecto de una bacteriocina encontrada por métodos in silico sobre la microbiota presente en Quesito Antioqueño. Métodos: se evaluó la actividad hemolítica de Bac 22, una bacteriocina sintética encontrada en el genoma de Lactobacillus casei a partir de minería genómica y de herramientas bioinformáticas, y se realizó un estudio preliminar de la actividad biológica de Bac 22 sobre la microbiota presente en el Quesito Antioqueño. Resultados: Bac 22 a una concentración de 100 µM presentó una capacidad hemolítica menor al 1%, y redujo significativamente el número de UFC/g en coliformes totales al adicionarse en el Quesito Antioqueño durante ocho días. Conclusiones: Bac 22 muestra un efecto potencial sobre la vida útil del mismo.
Descritores: Lactobacillus casei
Anti-Infecciosos
-Peptídeos
Bacteriocinas
Queijo
Biologia Computacional
Tipo de Publ: Artigo Clássico
Responsável: CO56.3 - Biblioteca


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Id: biblio-1087161
Autor: Yin, Ronghuan; Wang, Yanru; Wang, Zeying; Zhu, Yubo; Cong, Yuyan; Wang, Wei; Deng, Liang; Liu, Haiying; Guo, Dan; Bai, Wenlin.
Título: Discovery and molecular analysis of conserved circRNAs from cashmere goat reveal their integrated regulatory network and potential roles in secondary hair follicle
Fonte: Electron. j. biotechnol;41:37-47, sept. 2019. tab, graf, ilus.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Key Project Foundation of Educational Department of Liaoning Province, China; . Innovative Talent Support Program Foundation of Universities and Colleges in Liaoning Province, China; . Science and Technology Innovation Talent Support Foundation for Young and Middle-aged People of Shenyang City, China.
Resumo: Background: Circular RNAs, a novel class in the eukaryotic transcriptome, are characterized by the 3' and 5' ends that are covalently joined in a covalently closed loop without free ends. Circular RNAs are considerably stable molecules and act as microRNA sponges with regulatory potential to the protein-coding genes. Results: Eight circular RNAs were found to be significantly upregulated at anagen skin tissue of cashmere goat compared with their counterparts at telogen. Rich and complex regulatory patterns were revealed among the eight upregulated circular RNAs at anagen and related miRNAs with their potential regulatory genes. The potential regulatory genes of eight upregulated circular RNAs at anagen were involved in several pathways related to the main physiological process of hair follicle, such as histone acetylation and axon. For chi_circ_1926, chi_circ_3541, chi_circ_0483, chi_circ_3196, and chi_circ_2092, overall, the relative expression in secondary hair follicle exhibited highly similar trends with their corresponding host genes during the different stages of the hair follicle cycle. However, the expression trends of chi_circ_0100, chi_circ_2829, and chi_circ_1967 were found to diverge from their corresponding host genes during the different stages of the hair follicle cycle. Conclusions: A total of eighteen circular RNAs were identified and characterized from skin tissue of cashmere goat. The eight upregulated circular RNAs at anagen might have significant roles in the secondary hair follicle of cashmere goat. Our results would provide a novel regulatory layer to elucidate the molecular mechanisms underlying the development of secondary hair follicle and the growth of cashmere fiber in cashmere goat.
Descritores: Cabras/genética
Folículo Piloso/crescimento & desenvolvimento
RNA Circular/genética
-Pele
Expressão Gênica
Biologia Computacional
MicroRNAs
Células Eucarióticas
Redes Reguladoras de Genes
Transcriptoma
RNA Circular/metabolismo
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1808
Autor: Emidio, Nayara; Carpanez, Arthur; Quellis, Leonardo; Farani, Priscila; Vasconcelos, Eveline; Faria-Pinto, Priscila.
Título: Proteômica: uma introdução aos métodos e aplicações / Introduction to methods and applications in proteomics
Fonte: HU rev;41(3/4):101-111, dez. 2015.
Idioma: pt.
Resumo: As proteínas desempenham a maior parte das funções fisiológicas das células, constituindo também importantes alvos farmacológicos e biomarcadores de doenças. A pesquisa qualitativa, quantitativa e a elucidação estrutural destas moléculas são fundamentais para a compreensão do funcionamento dos sistemas biológicos, bem como na aplicação destas para o desenvolvimento de novos métodos diagnóstico. O estudo do proteoma nos permite identificar as proteínas que estão sendo expressas em um determinado momento, quantificá-las e observar suas modificações pós-transducionais. Dessa maneira, a análise proteômica fornece informações mais abrangentes e que não podem ser inferidas a partir das informações obtidas através da análise genômica. Este tipo de estudo envolve etapas como: extração e tratamento da amostra, separação das proteínas e/ou peptídeos, espectrometria de massas e análise dos dados usando ferramentas de bioinformática. O presente trabalho faz uma revisão narrativa sobre as principais técnicas aplicadas desde o preparo de amostras até a identificação das proteínas.
Descritores: Espectrometria de Massas
Proteômica
-Peptídeos
Biomarcadores
Proteínas
Biologia Computacional
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Id: biblio-1087514
Autor: Liang, Zhangcheng; Lin, Xiaozi; He, Zhigang; Li, Weixin; Ren, Xiangyun; Lin, Xiaojie.
Título: Dynamic changes of total acid and bacterial communities during the traditional fermentation of Hong Qu glutinous rice wine
Fonte: Electron. j. biotechnol;43:23-31, Jan. 2020. ilus, graf.
Idioma: en.
Projeto: Natural Science Foundation of Fujian Province, China; . Regional Development Project of Fujian Province, China.
Resumo: Background: Hong Qu glutinous rice wine (HQGRW) is brewed under non-aseptic fermentation conditions, so it usually has a relatively high total acid content. The aim of this study was to investigate the dynamics of the bacterial communities and total acid during the fermentation of HQGRW and elucidate the correlation between total acid and bacterial communities. Results: The results showed that the period of rapid acid increase during fermentation occurred at the early stage of fermentation. There was a negative response between total acid increase and the rate of increase in alcohol during the early fermentation stage. Bacterial community analysis using high-throughput sequencing technology was found that the dominant bacterial communities changed during the traditional fermentation of HQGRW. Both principal component analysis (PCA) and hierarchical clustering analysis revealed that there was a great difference between the bacterial communities of Hong Qu starter and those identified during the fermentation process. Furthermore, the key bacteria likely to be associated with total acid were identified by Spearman's correlation analysis. Lactobacillus, unclassified Lactobacillaceae, and Pediococcus were found, which can make significant contributions to the total acid development (| r| N 0.6 with FDR adjusted P b 0.05), establishing that these bacteria can associate closely with the total acid of rice wine. Conclusions: This was the first study to investigate the correlation between bacterial communities and total acid during the fermentation of HQGRW. These findings may be helpful in the development of a set of fermentation techniques for controlling total acid.
Descritores: Bactérias/isolamento & purificação
Vinho/microbiologia
-Pediococcus/isolamento & purificação
Pediococcus/genética
Pediococcus/metabolismo
Fatores de Tempo
Acetobacter/isolamento & purificação
Acetobacter/genética
Acetobacter/metabolismo
Análise por Conglomerados
Análise de Sequência
Biologia Computacional
Análise de Componente Principal
Fermentação
Microbiota
Concentração de Íons de Hidrogênio
Lactobacillus/isolamento & purificação
Lactobacillus/genética
Lactobacillus/metabolismo
Responsável: CL1.1 - Biblioteca Central



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