Base de dados : LILACS
Pesquisa : H01.158.273.343.335 [Categoria DeCS]
Referências encontradas : 375 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 38 ir para página                         

  1 / 375 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1047452
Autor: Jiang, Liwen; Nie, Hongtao; Li, Chen; Li, Dongdong; Huo, Zhongming; Yan, Xiwu.
Título: The genetic diversity of wild and cultivated Manila clam (Ruditapes philippinarum) revealed by 29 novel microsatellite markers
Fonte: Electron. j. biotechnol;34:17-21, july. 2018. tab.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Modern Agro-industry Technology Research System; . Program for Liaoning Excellent Talents in University; . Cultivation Plan for Youth Agricultural Science and Technology Innovative Talents of Liaoning Province; . Natural Science Foundation of Dalian; . Dalian Youth Science and Technology Star Project Support Program; . Scientific Research project of Liaoning Education Department.
Resumo: Background: Microsatellite loci often used as a genetic tool for estimating genetic diversity population variation in a wide variety of different species. The application of microsatellite markers in genetics and breeding includes investigating the genetic differentiation of wild and cultured populations, assessing and determining the genetic relationship of different populations. The aim of this work is to develop several microsatellite markers via highthroughput sequencing and characterize these markers in commercially important bivalve Ruditapes philippinarum. Results: Among the two populations of R. philippinarum studied, 110 alleles were detected. The number of alleles at the cultured population ranged from 3 to 17 (mean NA = 6.897) and wild population ranged from 2 to 15 (mean NA = 6.793). The observed and expected heterozygosities of cultured population ranged from 0.182 to 0.964, and from 0.286 to 0.900, with an average of 0.647 and 0.692, respectively. The observed and expected heterozygosities of wild population ranged from 0.138 to 1.000, and from 0.439 to 0.906, with an average of 0.674 and 0.693, respectively. The polymorphism information content ranged from 0.341 to 0.910 with an average of 0.687. Sixteen and thirteen microsatellite loci deviated significantly from Hardy­Weinberg equilibrium after correction for multiple tests in cultured and wild population, respectively. Conclusions: Twenty-nine novel microsatellite loci were developed using Illumina paired-end shotgun sequencing and characterized in two population of R. philippinarum.
Descritores: Variação Genética
Bivalves/genética
Repetições de Microssatélites
-Polimorfismo Genético
Aquicultura
Loci Gênicos
Genética Populacional
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


  2 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-1100921
Autor: Verdugo, Ricardo A; Genova, Alex Di; Herrera, Luisa; Moraga, Mauricio; Acuña, Mónica; Berríos, Soledad; Llop, Elena; Valenzuela, Carlos Y; Bustamante, M. Leonor; Digman, Dayhana; Symon, Adriana; Asenjo, Soledad; López, Pamela; Blanco, Alejandro; Suazo, José; Barozet, Emmanuelle; Caba, Fresia; Villalón, Marcelo; Alvarado, Sergio; Cáceres, Dante; Salgado, Katherine; Portales, Pilar; Moreno-Estrada, Andrés; Gignoux, Christopher R; Sandoval, Karla; Bustamante, Carlos D; Eng, Celeste; Huntsman, Scott; Burchard, Esteban G; Loira, Nicolás; Maass, Alejandro; Cifuentes, Lucía.
Título: Development of a small panel of SNPs to infer ancestry in Chileans that distinguishes Aymara and Mapuche components
Fonte: Biol. Res;53:15, 2020. tab, graf.
Idioma: en.
Projeto: FONDEF.
Resumo: BACKGROUND: Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries may be confounded with socio-economic factors due to population stratification. Therefore, ancestry is a potential confounder variable that should be considered in epidemiologic studies and in public health plans. However, there are few studies that have assessed the ancestry of the current admixed Chilean population. This is partly due to the high cost of genome-scale technologies commonly used to estimate ancestry. In this study we have designed a small panel of SNPs to accurately assess ancestry in the largest sampling to date of the Chilean mestizo population (n = 3349) from eight cities. Our panel is also able to distinguish between the two main Amerindian components of Chileans: Aymara from the north and Mapuche from the south. RESULTS: A panel of 150 ancestry-informative markers (AIMs) of SNP type was selected to maximize ancestry informativeness and genome coverage. Of these, 147 were successfully genotyped by KASPar assays in 2843 samples, with an average missing rate of 0.012, and a 0.95 concordance with microarray data. The ancestries estimated with the panel of AIMs had relative high correlations (0.88 for European, 0.91 for Amerindian, 0.70 for Aymara, and 0.68 for Mapuche components) with those obtained with AXIOM LAT1 array. The country's average ancestry was 0.53 ± 0.14 European, 0.04 ± 0.04 African, and 0.42 ± 0.14 Amerindian, disaggregated into 0.18 ± 0.15 Aymara and 0.25 ± 0.13 Mapuche. However, Mapuche ancestry was highest in the south (40.03%) and Aymara in the north (35.61%) as expected from the historical location of these ethnic groups. We make our results available through an online app and demonstrate how it can be used to adjust for ancestry when testing association between incidence of a disease and nongenetic risk factors. CONCLUSIONS: We have conducted the most extensive sampling, across many different cities, of current Chilean population. Ancestry varied significantly by latitude and human development. The panel of AIMs is available to the community for estimating ancestry at low cost in Chileans and other populations with similar ancestry.
Descritores: Grupos Étnicos/genética
Índios Sul-Americanos/genética
Polimorfismo de Nucleotídeo Único/genética
Grupos Populacionais/genética
Genética Populacional/organização & administração
-Saliva
Marcadores Genéticos/genética
Chile
Filogeografia
Técnicas de Genotipagem
Frequência do Gene/genética
Genótipo
Limites: Humanos
Masculino
Feminino
Responsável: CL1.1 - Biblioteca Central


  3 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1154964
Autor: Restrepo-Escobar, Natalia; Yepes-Acevedo, Anny Johanna; Márquez, Edna Judith.
Título: Population genetics of three threatened catfish species in heterogeneous environments of the Cauca River, Colombia
Fonte: Neotrop. ichthyol;19(1):e200040, 2021. tab, graf, mapas.
Idioma: en.
Projeto: Universidad Nacional de Colombia; . Empresas Públicas de Medellín.
Resumo: Neotropical catfishes Ageneiosus pardalis, Pimelodus grosskopfii and Sorubim cuspicaudus are migratory fishes of commercial importance that exhibit decreasing populations due to overfishing and other anthropic interventions. This study used species-specific microsatellite loci to test the hypothesis that threatened fish populations show genetic vulnerability signs and are genetically structured in the middle and lower sections of the Cauca River. The studied species exhibit genetic diversity levels higher than the average values reported for Neotropical Siluriformes; however, they seem to have suffered recent bottlenecks and they present significant endogamy levels that are higher for the critically endangered catfish P. grosskopfii. Furthermore, both Ageneiosus pardalis and S. cuspicaudus are each formed by one genetic group, while Pimelodus grosskopfii comprises two coexisting genetic groups. The information obtained in this study is useful for the decision making in management plans that are appropriate for the sustainability of these three species populations within the proposal for the expansion of the hydroelectric development and other anthropic activities.(AU)

Los bagres Neotropicales Ageneiosus pardalis, Pimelodus grosskopfii y Sorubim cuspicaudus, son peces migratorios de importancia comercial cuyas poblaciones han disminuido debido a la sobrepesca y otras intervenciones antrópicas. En este trabajo, se utilizaron loci microsatélites especie-específicos para contrastar la hipótesis de que las poblaciones de peces amenazadas muestran señales de vulnerabilidad genética y están genéticamente estructuradas en los sectores medio y bajo del río Cauca. Las especies estudiadas exhiben niveles de diversidad genética superiores a los promedios reportados para Siluriformes Neotropicales; sin embargo, parecen haber sufrido cuellos de botella recientes y presentan niveles significativos de endogamia que son más altos para el bagre en peligro crítico, P. grosskopfii. Además, Ageneiosus pardalis y S. cuspicaudus están conformados cada uno por un solo grupo genético, mientras que Pimelodus grosskopfii comprende dos grupos genéticos que coexisten. La información obtenida en este estudio es útil para la toma de decisiones en planes de manejo que sean adecuados para la sostenibilidad de las poblaciones de estas tres especies de bagre dentro de las propuestas para la expansión de desarrollo hidroeléctrico y otras actividades antrópicas.(AU)
Descritores: Peixes-Gato
Meio Ambiente
Genética Populacional
-Variação Genética
Rios
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  4 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1154970
Autor: Joya, Cristhian Danilo; Landínez-García, Ricardo Marcel; Márquez, Edna Judith.
Título: Development of microsatellite loci and population genetics of the catfish Pimelodus yuma (Siluriformes: Pimelodidae)
Fonte: Neotrop. ichthyol;19(1):e200114, 2021. tab, graf, mapas, ilus.
Idioma: en.
Projeto: Empresas Públicas de Medellín and Universidad Nacional de Colombia.
Resumo: Pimelodus yuma (formerly Pimelodus blochii) is a freshwater fish, endemic to the Colombian Magdalena-Cauca and Caribbean basins that experiences habitat disturbances resulting from anthropogenic activities. Due to the lack of information about the population genetics of this species, this study developed 14 species-specific microsatellite loci to assess the genetic diversity and population structure of samples from the lower section of the Cauca River. The studied species showed genetic diversity levels higher than the average values reported for Neotropical Siluriformes and significant inbreeding levels as was described for some congeners. Furthermore, P. yuma comprises two coexisting genetic groups that exhibit gene flow along the lower section of the Cauca River. This information constitutes a baseline for future monitoring of the genetic diversity and population structure in an anthropic influenced sector of the Magdalena-Cauca basin.(AU)

Pimelodus yuma (anteriormente Pimelodus blochii) es un pez dulceacuícola endémico de las cuencas colombianas Magdalena-Cauca y Caribe que experimenta alteraciones del hábitat como resultado de actividades antropogénicas. Debido a la falta de información sobre la genética poblacional de esta especie, este estudio desarrolló 14 loci microsatélites especie-específicos para evaluar la diversidad genética y la estructura poblacional de muestras de la sección baja del río Cauca. La especie estudiada mostró niveles de diversidad genética más altos que los valores promedio reportados para Siluriformes neotropicales y niveles de endogamia significativos como se describió para algunos congéneres. Además, P. yuma comprende dos grupos genéticos coexistentes que exhiben flujo de genes a lo largo de la sección baja del río Cauca. Esta información constituye una línea base para futuros monitoreos de la diversidad genética y la estructura poblacional en un sector de influencia antrópica de la cuenca Magdalena-Cauca.(AU)
Descritores: Variação Genética
Peixes-Gato/genética
Repetições de Microssatélites
Genética Populacional
-Sequenciamento de Nucleotídeos em Larga Escala
Água Doce
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  5 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1154971
Autor: Rangel-Medrano, José David; Márquez, Edna Judith.
Título: Development of microsatellite loci and population genetics in the bumblebee catfish species Pseudopimelodus atricaudus and Pseudopimelodus magnus (Siluriformes: Pseudopimelodidae)
Fonte: Neotrop. ichthyol;19(1):e200053, 2021. tab, graf.
Idioma: en.
Projeto: Universidad Nacional de Colombia; . Empresas Públicas de Medellín.
Resumo: The Neotropical freshwater catfish Pseudopimelodus atricaudus and Pseudopimelodus magnus are two recently discovered species endemic to the Colombian Magdalena-Cauca River basin. In this study, a set of 13 microsatellite loci were developed by using next generation sequence technology to assess the genetic diversity and population structure in P. atricaudus and test for cross-species amplification in P. magnus. Both species exhibited high genetic diversity (P. atricaudus: Na: 9.000 - 9.769 alleles/locus, Ho: 0.760 - 0.804, HE: 0.804 - 0.840; P. magnus: Na: 12.8 - 5.4 alleles/locus, Ho: 0.638 - 0.683, HE: 0.747 - 0.755) compared to the mean levels of genetic diversity reported for Neotropical Siluriformes, and lack of genetic differentiation among sampling sites within the Cauca River (P. atricaudus: F'ST=0.013 - 0.017, P > 0.05, D'est= -0.004 - 0.023, P > 0.05; P. magnus: F'ST= 0.031, P= 0.055; D'est= 0.045, P= 0.058). This work is the first insight on the diversity and the population genetics of species of the family Pseudopimelodidae and provides a framework to further population genetic and conservation analyses needed in this poorly studied family at the microevolutionary level.(AU)

Los bagres neotropicales Pseudopimelodus atricaudus y Pseudopimelodus magnus son dos especies recientemente descubiertas, endémicas de la cuenca Magdalena-Cauca en Colombia. En este estudio, se desarrollaron 13 loci microsatélites usando tecnología de secuenciación de próxima generación para evaluar la diversidad genética y la estructura poblacional de P. atricaudus y evaluar su amplificación cruzada en P. magnus. Ambas especies exhibieron altos valores de diversidad genética (P. atricaudus: Na: 9.000 - 9.769 alelos/locus, HO: 0.760 - 0.804, HE: 0.804 - 0.840; P. magnus: Na: 12.8 - 5.4 alelos/locus, HO: 0.638 - 0.683, HE: 0.747 - 0.755) comparados con los valores promedios de diversidad genética reportados para Siluriformes neotropicales, y ausencia de estructura genética entre los sitios analizados (P. atricaudus: F'ST= 0.013 - 0.017, P > 0.05, D'est= -0.004 - 0.023, P > 0.05; P. magnus: F'ST= 0.031, P= 0.055; D'est= 0.045, P= 0.058). Este trabajo representa la primera aproximación a la diversidad y genética poblacional de especies de la familia Pseudopimelodidae y proporciona un marco de referencia para futuros estudios genético-poblacionales y de conservación, requeridos en esta familia de bagres poco estudiada en el nivel microevolutivo.(AU)
Descritores: Variação Genética
Peixes-Gato/genética
Repetições de Microssatélites
Genética Populacional
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


  6 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1151817
Autor: Carletto-Körber, Fabiana P. M; Vera, Noelia S; Cornejo, Lila Susana; González-Ittig, Raúl E.
Título: Caries and genetic variability of streptococcus mutans / Caries y variabilidad genética de streptococcus mutans
Fonte: J. oral res. (Impresa);(2020,Perspectives in Oral Sciences):39-48, mar. 31, 2020. ilus, graf, tab.
Idioma: en.
Resumo: In the last two decades, the increase in population genetics studies has contributed to elucidating important questions about the evolution of the pathogenesis of bacteria of clinical interest. The objective of this study is to revise and update the knowledge of the last fifteen years regarding the genetic variability of Streptococcus mutans and their association with dental caries. Streptococcus mutans, one of the most widely distributed bacteria in the world, are heavily associated with this condition. This research shows the results of numerous studies carried out in various countries that, using molecular and biochemical methods, revealed associations between different serotypes and caries activity. In addition, it is reported that the population genetics structure of Streptococcus mutans in Argentina is highly recombinant, which reflects the largest waves of human immigration that occurred in the 19th and 20th centuries. On the other hand, demographic analysis suggests that these bacteria experienced a population expansion that coincided with the beginning of agricultural development.

En las últimas dos décadas el incremento de los estudios de genética de poblaciones ha contribuido a dilucidar cuestiones importantes sobre la evolución de la patogénesis de bacterias de interés clínico. El objetivo de este trabajo es realizar una actualización sobre los conocimientos de los últimos quince años referidos a la variabilidad genética de Streptococcus mutans y su relación con la caries dental. Streptococcus mutans, de amplia distribución mundial, es una de las bacterias más fuertemente asociada a dicha enfermedad. En este trabajo se muestran resultados de numerosos estudios realizados en diferentes países que utilizando métodos moleculares y bioquímicos revelaron asociaciones entre diferentes serotipos y la actividad de caries. Además, se reporta que la estructura genética poblacional de Streptococcus mutans de Argentina es de alto nivel recombinante, lo que reflejaría las grandes oleadas inmigratorias humanas ocurridas en los siglos 19thy 20th. Por otra parte, los análisis demográficos sugieren que esta bacteria experimentó una expansión poblacional coincidente con el comienzo del desarrollo de la agricultura
Descritores: Streptococcus mutans/genética
Variação Genética
Cárie Dentária/microbiologia
-Argentina/epidemiologia
Demografia
Emigração e Imigração
Sorogrupo
Genética Populacional
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL30.1 - Biblioteca


  7 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-989863
Autor: Barahona, Ana.
Título: Karyotyping and population genetics in Cold War Mexico: Armendares's and Lisker's characterization of child and indigenous populations, 1960s-1980s / Cariotipia e genética de populações no México da Guerra Fria: as caracterizações de Armendares e Lisker sobre as populações infantil e indígena, 1960-1980
Fonte: Hist. ciênc. saúde-Manguinhos;26(1):245-264, Jan.-Mar. 2019.
Idioma: en.
Projeto: Conacyt Integra.
Resumo: Abstract This paper focuses on geneticists Salvador Armendares's and Rubén Lisker's studies from the 1960s to the 1980s, to explore how their work fits into the post-1945 human biological studies, and also how the populations they studied, child and indigenous, can be considered laboratories of knowledge production. This paper describes how populations were considered for different purposes: scientific inquiry, standardization of medical practices, and production or application of medicines. Through the narrative of the different trajectories and collaborations between Armendares and Lisker, this paper also attempts to show the contact of their scientific practices, which brought cytogenetics and population genetics together at the local and global levels from a transnational perspective.

Resumo Aborda o trabalho dos geneticistas Salvador Armendares e Rubén Lisker, entre 1960 e 1980, para analisar como se insere nos estudos biológicos humanos do pós-1945, e demonstra como as populações estudadas por eles, a infantil e a indígena, podem ser consideradas laboratórios de produção de conhecimento. O artigo revela como as populações foram consideradas para diversos propósitos: investigação científica, padronização das práticas médicas e produção ou aplicação de suas medicinas. Por meio da narrativa das diferentes trajetórias e colaborações entre Armendares e Lisker, também procura discutir o contato de suas práticas científicas, que colocaram a citogenética e a genética de populações lado a lado nos níveis local e global a partir de uma perspectiva transnacional.
Descritores: Genética Humana/história
Povos Indígenas/história
Genética Populacional/história
-Erros Inatos do Metabolismo dos Carboidratos/história
Citogenética/história
Lactase/deficiência
Lactase/história
Povos Indígenas/genética
Deficiência de Glucosefosfato Desidrogenase/história
Cariotipagem/história
México
Limites: Humanos
Criança
História do Século XX
Tipo de Publ: Artigo Histórico
Bibliografia
Responsável: BR1.1 - BIREME


  8 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-886813
Autor: SILVA, RAIMUNDO DA; SILVA, DANILLO; VENEZA, IVANA; SAMPAIO, IRACILDA; SCHNEIDER, HORACIO; GOMES, GRAZIELLE.
Título: Development of EPIC-PCR Markers for Lutjanus purpureus (Lutjanidae-Perciformes) and their Potential Applicability in Population Analyses
Fonte: An. acad. bras. ciênc;89(3,supl):2095-2100, 2017. tab.
Idioma: en.
Resumo: ABSTRACT In the present study, a novel set of eight EPIC primers were developed for Lutjanus purpureus and assayed in five other marine teleosts including three lutjanids, one scianid and one anablepid. Most of the genomic regions used in this study presented genetic diversity indexes equal or greater than the intragenic regions commonly used in population genetics studies. Moreover, six out of eight markers showed cross-amplification with other taxa. Thus, the primers described here may be used to elucidate questions at the intraspecific level for a large number of taxa.
Descritores: Perciformes/genética
Reação em Cadeia da Polimerase/métodos
-Filogenia
Variação Genética
Perciformes/classificação
Marcadores Genéticos
Análise de Sequência de DNA
Genética Populacional
Limites: Animais
Responsável: BR1.1 - BIREME


  9 / 375 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1118836
Autor: PENHA, Diego dos Santos; SOUZA, Felipe Pinheiro de; LIMA, Ed Christian Suzuki de; URREA-ROJAS, Angela Maria; PANDOLFI, Victor César Freitas; YAMACHITA, Andrei Lincoln; POVH, Jayme Aparecido; LEITE, Natalia Gonçalves; PEREIRA, Ulisses de Pádua; LOPERA-BARRERO, Nelson Mauricio.
Título: Transferability of heterologous primers in Brycon falcatus
Fonte: Acta amaz;50(3):232-238, jul. - set. 2020.
Idioma: en.
Resumo: The genus Bryconcomprises fish species of significant socioeconomic and biological importance in Brazil. Despite that, the genetic knowledge about these species is scarce, especially regardingBrycon falcatus. Thus, the objective of this study was to evaluate the transferability of heterologous microsatellite primers inB. falcatus for the first time. Heterologous primers obtained from B. opalinus, B. hilarii, B. insignis, B. orbignyanus, B. amazonicus, Prochilodus argenteus, Prochilodus lineatus, Piaractus mesopotamicus, and Colossoma macropomum were evaluated. The primers that showed the best amplification patterns were applied to a sample of 22 individuals and the genetic parameters were calculated. Nine primers displayed satisfactory cross-amplification withB. falcatus: BoM5 (Brycon opalinus); Bh8, Bh13 and Bh16 (B. hilarii); Borg59 (B. orbignyanus); Bag22 (B. amazonicus); Par12 and Par80 (P. argenteus), and Cm1A8 (C. macropomum). The genetic parameters (number of alleles, effective alleles, allele richness, and expected and observed heterozygosity) and the polymorphic information content (PIC) confirmed the viability of these primers for population genetics analyses. Our study demonstrates the potential of transferability of microsatellite markers from related species and even different genera to B. falcatus, providing usefull tools for future population genetic studies in this species. (AU)
Descritores: Variação Genética
Repetições de Microssatélites
Parâmetros de Referência/classificação
Genética Populacional
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


  10 / 375 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-609589
Autor: Acosta, Oscar; Solano, Luis; Escobar, Juan; Fernández, Miguel; Solano, Carlos.
Título: Enfoque genético evolutivo de la enfermedad de Carrión: polimorfismos de los grupos sanguíneos MN, Ss, Diego, Duffy y fases clínicas en zonas endémicas de Bagua, Amazonas / Evolutionary genetic approach of Carrion's disease: MN, Ss, Diego, Duffy blood groups polymorphisms and clinical stages in endemic areas of Bagua, Amazonas, Peru
Fonte: An. Fac. Med. (Perú);72(2):101-106, abr.-jun. 2011. ilus, tab.
Idioma: es.
Resumo: Objetivos: Establecer la relación entre las frecuencias fenotípicas y/o alélicas de los grupos sanguíneos MN, Ss, Diego, Duffy y las fases clínicas de la enfermedad de Carrión, interpretado en un contexto genético coevolutivo del hospedero amerindio con la bacteria Bartonella bacilliformis. Diseño: Estudio asociativo y analítico. Lugar: Instituto de Medicina Tropical Daniel A. Carrión, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Participantes: Pobladores de Bagua Grande, Amazonas, Perú. Intervenciones: Se determinó los grupos sanguíneos MN, Ss, Diego y Duffy, según metodología estándar, en 40 pobladores de las zonas de Tomocho-Collicate-Vista Hermosa (antecedente de casos en fase verrucosa o benigna, sin aparente fase aguda previa) y 36 pobladores de la zona de Miraflores (antecedente de casos solo en fase aguda), de Bagua Grande, Amazonas. Principales medidas de resultados: Frecuencias fenotípicas y alélicas de los referidos grupos sanguíneos en las localidades estudiadas. Resultados: No existieron diferencias significativas entre las frecuencias fenotípicas, genotípicas y/o alélicas de los grupos sanguíneos MN, Ss, Diego, Duffy en las zonas de Tomocho-Collicate-Vista Hermosa (predominancia de fase verrucosa) y en la zona de Miraflores (predominancia de fase aguda). La más variable fue la del grupo MN, pero encontrándose en equilibrio de Hardy-Weinberg. Conclusiones: Los marcadores sanguíneos Ss, Diego y Duffy -inclusive el MN, que aparentemente mostró la mayor variabilidad-, no tuvieron relación con las fases clínicas de la enfermedad de Carrión, en las localidades estudiadas. Sin embargo, en el contexto de un enfoque genético evolutivo, es necesario evaluar dicha asociación en otras zonas endémicas del país, así como la susceptibilidad, resistencia y otras carácterísticas clínicas de esta ancestral enfermedad.

Objectives: To determine the relationship between MN, Ss, Diego, Duffy blood groups phenotypic or alleles frequencies and clinical phases of Carrion's disease, interpreted in a coevolutive genetic context of amerindian hosts with Bartonella bacilliformis. Design: Associative and analytical study. Setting: Daniel A. Carrion Tropical Medicine Institute, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Participants: Bagua Grande, Amazonas, Peru settlers. Interventions: MN, Ss, Duffy and Diego blood groups were determined using standard methodology in 40 Tomocho-Collicate-Vista Hermosa settlers (background of benign or verrucose phase cases without apparent acute phase) and 36 residents of Miraflores area (background of only acute phase cases), Bagua Grande, Amazonas. Main outcomes measures: Phenotypic and allele frequencies of these blood groups in the localities studied. Results: There were no significant differences between the phenotypic, genotypic or alleles frequencies of the MN, Ss, Diego, Duffy blood groups in the Tomocho-Collicate-Vista Hermosa areas (predominance of the verrucose phase) and the Miraflores area (predominance of the acute phase), Bagua Grande, Amazonas. The most variable frequency was found in the MN group, but it was within Hardy-Weinberg equilibrium. Conclusions: Ss, Duffy and Diego blood markers, including the most variable MN, were unrelated to Carrion's disease clinical phases in the localities studied. However, in the context of evolutionary genetic approach, association must be assessed in other endemic areas of the country, as well as susceptibility, resistance and other clinical features of this ancient disease.
Descritores: Antígenos de Grupos Sanguíneos
Genética Populacional
Infecções por Bartonella/genética
-Epidemiologia Analítica
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: PE13.1 - Oficina de Biblioteca, Hemeroteca y Centro de Documentación



página 1 de 38 ir para página                         
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde