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Id: lil-784928
Autor: Márquez Gómez, Marco Antonio; Gómez Díaz, Graciela María.
Título: Accidente ofídico en el departamento de Sucre, Colombia / Ophidic accident in the department of Sucre, Colombia
Fonte: NOVA publ. cient;13(24):39-46, July-Dec. 2015.
Idioma: es.
Resumo: Objetivo: Describir el comportamiento del accidente ofídico en el departamento de Sucre. Métodos: Se realizó un estudio descriptivo y retrospectivo, en el cual se analizaron 803 reportes de accidentes ofídicos notificados al sistema de vigilancia epidemiologia del departamento de Sucre, durante los años 2007 a 2012, la información fue suministrada por la dirección de salud pública de la secretaria de salud del departamento de Sucre, en formato Excel©, descargada directamente del aplicativo SIVIGILA. Los datos obtenidos se analizaron estadísticamente empleando medidas de tendencia central. Resultados: En el 48.2% de los casos, el género Bothrops se identificó como el agente agresor y en el 83.9% de los casos la mordedura se localizó en las extremidades del paciente. En 356 casos equivalentes al 44% el paciente no fue hospitalizado o no se consignó esta información en la ficha. En el tratamiento de los casos hospitalizados se empleó un promedio de 4.3 ± 4.5 viales por paciente; estos datos son consistentes con el protocolo para casos leves registrados (n=450), pero al revisar los casos individuales se encontró que 228 pacientes solo recibieron entre 1 y 3 ampollas. En 84 casos solo se administró un vial.

Objective: Describe the behavior of ophidic accident in the department of Sucre. Methods: A descriptive, retrospective study was done from 2007 to 2012, in this study, 803 cases of snakebites were reported to the surveillance system of the epidemiology department of Sucre. In this department, the snakebite accidents occurs along the entire year, mainly affecting men 15 to 44 years. Those affected come from all municipalities in the department and around the rural area, and it is mainly engaged in agriculture and domestic work; however, the town of Sincelejo accounts for 28.8% of all notifications. Results: In 48.2% of cases, the genus Bothrops was identified as the offending agent and in 83.9% of cases, the bite was found in the patient's limbs. In 356 cases or 44% the patients were hospitalized or the information of this records were not found. The treatment of hospitalized cases averaged 4.3 ± 4.5 shots were used per patient; This data is consistent with the protocol for registered mild cases (n = 450), but reviewing individual cases; then, it was found that 228 patients received only 1 to 3 ampoules. In 84 cases only one shot was administered.
Descritores: Mordeduras de Serpentes
-Venenos
Toxicologia
Mortalidade
Limites: Humanos
Responsável: CO332 - Facultad de Medicina


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Id: biblio-905926
Autor: Oliveira, Sarah Carobini Werner de Souza Eller Franco de.
Título: Aplicação da análise multivariada para o mapeamento dos casos de intoxicações agudas atendidos no Centro de Controle de Intoxicações da cidade de São Paulo / Application of multivariate analysis for the mapping of acute intoxication cases attended in Poison Control Center of the São Paulo city.
Fonte: São Paulo; s.n; 2018. 246 p. tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Ciências Farmacêuticas para obtenção do grau de Doutor.
Resumo: A Toxicologia tem desempenhado um importante papel na identificação de efeitos nocivos à população, gerando subsídios para a tomada de decisões na prática clínica, auxiliando desta forma no bom prognóstico de pacientes intoxicados. De acordo com a Pan American Health Organization, o sucesso em qualquer intervenção em saúde somente pode ser obtido com a criação e manutenção de um banco de dados confiável, que seja capaz de predizer as diversas particularidades das intoxicações, como a população-alvo e suas suscetibilidades. Assim, recomenda-se que médicos, especialistas, legisladores e administradores em saúde adotem em sua rotina uma coleta de dados sistêmica e integrada para o mapeamento e caracterização das intoxicações. Neste cenário, técnicas de análises multivariadas poderiam ser empregadas para evidenciar possíveis intercorrelações; entretanto, seu uso ainda não é comum na toxicologia clínica. Neste trabalho foram identificados e quantificados agentes exógenos em amostras biológicas (sangue e urina) provenientes do Centro de Controle de Intoxicações da cidade de São Paulo, correlacionando os dados obtidos dessas análises com o perfil clínico e prognóstico dos pacientes. Fármacos benzodiazepínicos, antidepressivos, anticonvulsivantes, paracetamol, drogas de abuso e praguicidas foram selecionados de acordo com a incidência reportada por esse centro no período de 2013 a 2014. Do total de amostras analisadas (n = 320), 192 foram positivas para alguma substância, sendo 101 positivas para etanol e 131 positivas para as demais substâncias. Os dados obtidos foram submetidos à análise de correspondência múltipla e análise hierárquica de cluster. A partir da análise multivariada foi possível agrupar os indivíduos em 3 clusters, o que correspondeu a 66,5% do total de informações. No primeiro eixo houve a separação dos pacientes do gênero feminino, que se intoxicaram ou foram expostos a medicamentos e drogas de abuso, por tentativa de suicídio, dos pacientes do gênero masculino, de idade entre 30 a 39 anos, que se intoxicaram com drogas de abuso. No segundo eixo fatorial foram agrupados os pacientes que se intoxicaram com etanol isoladamente, juntamente com pacientes que se intoxicaram com diazepam. Este trabalho contribuiu para o mapeamento dos casos de intoxicação atendidos pelo CCI-SP e foi um estudo inicial para a criação de um banco de dados que poderá ser alimentado constantemente e assim, oferecer ao sistema de toxicovigilância uma base para políticas educativas

Toxicology has played an important role in the identification of harmful effects to the population, generating subsidies for decision making in clinical practice, helping in this way the good prognosis of acutely intoxicated patients. According to the Pan American Health Organization, success in any health intervention can only be achieved by creating and maintaining a reliable database that is capable of predicting the various characteristics of intoxications, such as the target population and their susceptibilities. Thus, it is recommended that doctors, specialists, legislators and health administrators adopt in their routine a systemic and integrated data collection for the mapping and characterization of intoxications. In this scenario, multivariate analysis techniques could be used to evidence possible intercorrelations; however, its use is not yet common in clinical toxicology. In this work, were identified and quantified exogenous agents in biological samples (blood and urine) from the Poison Control Center São Paulo city, correlating the data obtained from these analyzes with the clinical and prognostic profile of the patients. Benzodiazepines, antidepressants, anticonvulsants, acetaminophen, drugs of abuse and pesticides were selected according to the incidence reported by this center in the period from 2013 to 2014. Of the total number of samples analyzed (n = 320), 192 samples have shown to be positive for some of the analytes, from these 100 were positive for ethanol and 131 positive for other substances. The data were submitted to multiple correspondence analysis and hierarchical cluster analysis. From the multivariate analysis it was possible to group the individuals into 3 clusters, which corresponded to 66.5% of the total information. In the first axis, the patients were separated from the female gender, who were intoxicated or were exposed to drugs and suicide attempt of the male patients, aged between 30 and 39 years, who became intoxicated with drugs of abuse. In the second factorial axis were grouped the patients who were intoxicated with ethanol, together with patients who became intoxicated with diazepam. This work contributed to the mapping of intoxication cases attended by the CCI-SP and was a initial study for the creation of a database that could be fed constantly and thus provide the toxicovigilance system with a basis for educational policies
Descritores: Centros de Controle de Intoxicações/classificação
Toxicologia/normas
Análise Multivariada
-Envenenamento
Análise por Conglomerados
Métodos de Análise
Coleta de Dados
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas
BR40.1; T615.9, F825a. 30100022447-F


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Id: biblio-1341439
Autor: González Freyre, Yunior; Bestard Pavón, Luis Alberto; Barrero Viera, Laura; García González, Yamilet; Londres Lobaina, Arianna; Iglesias Carrazana, Aliana.
Título: Intoxicación por adelfa, un caso poco frecuente / Oleander poisoning, a rare case
Fonte: Rev. cuba. med. mil;50(2):e1052, 2021. graf.
Idioma: es.
Resumo: Introducción: Las intoxicaciones por plantas son infrecuentes, de complicada orientación diagnóstica, que en general, se dificulta la identificación de la planta, su potencial tóxico y el tratamiento específico. Entre ellas la adelfa, capaz de producir cuadros de intoxicación grave, como un caso consultado a la guardia del Centro Nacional de Toxicología. Objetivos: Presentar un caso clínico de intoxicación grave por adelfa. Caso clínico: Paciente adulto, con intranquilidad, vómitos, dolores abdominales, tensión arterial 150/90 mmHg, frecuencia cardiaca y respiratoria normales, refirió que había consumido vía oral y rectal una poción elaborada con una planta, como tratamiento antiparasitario. El médico de guardia decidió comunicarse con el Centro Nacional de Toxicología. Se identificó la planta como adelfa. A pesar de la aplicación de reposición de volumen, lavado gástrico y la administración de carbón activado; presentó bloqueo auriculoventricular, extrasístoles aisladas y bradicardia. Se suministró atropina endovenosa, luego se trasladó hacia la unidad de cuidados intensivos y posteriormente egresó. Conclusiones: El caso presentó una intoxicación aguda grave por adelfa, con un correcto diagnóstico y tratamiento, que requirió de la labor conjunta de los médicos del cuerpo de guardia del hospital, la terapia intensiva y del Centro Nacional de Toxicología(AU)

Introduction: Poisoning by plants is infrequent, with a complicated diagnostic orientation, which in general makes it difficult to identify the plant, its toxic potential and specific treatment. Among them the oleander, capable of producing serious intoxication, as a case consulted to the National Toxicology Center. Objectives: To present a clinical case of severe oleander poisoning. Clinical case: Adult patient with restlessness, vomiting, abdominal pain, blood pressure 150/90 mmHg, normal heart and respiratory rates, and reported that he had consumed orally and rectally a potion made with a plant, as an antiparasitic treatment. The doctor who assisted him decided to communicate with the National Toxicology Center. The plant was identified as oleander. Despite the application of volume replacement, gastric lavage and the administration of activated charcoal; the patient presented atrioventricular block, isolated extrasystoles and bradycardia, intravenous atropine was administered, and subsequent transfer to the intensive care unit, and later he was discharged. Conclusions: The case presented a severe acute oleander poisoning, there was correct diagnosis and treatment, which required the joint work of the doctors from hospital emergency, the intensive care unit and the National Toxicology Center(AU)
Descritores: Agitação Psicomotora
Toxicologia
Pressão Sanguínea
Cuidados Críticos
Complexos Cardíacos Prematuros
Bloqueio Atrioventricular
Antiparasitários
Limites: Humanos
Masculino
Adulto
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1366937
Autor: Simkin, David O; Pardo, Hugo; Delgado, Daniel; Rubino, Alejandro; Temperley, Guillermo; Lermer, Diego; González Aguilar, Osvaldo.
Título: Cáncer avanzado de orofaringe. Nuevo paradigma de tratamiento / ADVANCED OROPHARYNGEAL CANCER TREATED WITH SEQUENTIAL CHEMORADIATION PRESERVING THE ORGAN
Fonte: Prensa méd. argent;106(7):413-418, 20200000. graf.
Idioma: es.
Resumo: Antecedentes: Hasta la década del 80 los pacientes con esta patología eran intervenidos quirúrgicamente. A partir de 1997 la Cleveland Clinic publica un estudio basado en la quimioradioterapia en el cáncer avanzado de orofaringe con resultados similares a los de la época anterior, pero con preservación del órgano. En nuestro medio no existe bibliografía que analice estadísticamente los resultados y los factores que lo condicionaron. Objetivo: Evaluar los resultados con quimioradioterapia secuencial en el cáncer avanzado de la región orofaríngea. Lugar de aplicación: Hospital de atención terciaria Diseño: Prospectivo no randomizado Material y metodo: Desde Enero del 2002 al 30 de diciembre del 2004 se estudiaron 60 pacientes, 55 pertenecían al sexo masculino, con edad media de 60 años, el 76.7% eran T III y los restantes T IV con tumores malignos de la región orofaríngea mediante quimioradioterapia secuencial. Resultados: La supervivencia a 152 meses fue del 30.1%. El análisis univariado, demostró que el estadío, con p<0,001, la reducción con p=0,010 y la cirugía de rescate con p=0,028 fueron las únicas variables estadísticamente significativas, mientras la edad, el sexo y la localización no tuvieron los mismos resultados. En el análisis multivariado, el estadío con una p< 0.001, el sexo con una p=0.016 y la reducción con una p=0.024 resultaron ser estadisticamente significativos. Conclusiones: El tratamiento de los tumores de la región orofaríngea, en estadíos III y IV, mediante quimioradioterapia secuencial alcanzaron resultados similares a los tratados con cirugía seguida de radioterapia, pero con preservación del órgano

Background: Until the 80th decade, patients with advanced oropharyngeal cancer were surgically treated. In 1997 the Cleveland Clinic published similar results with chemoradiotherapy but preserving the organ. In our country there are not papers analyzing those results and conditional factors. Objective: Evaluation of sequential chemoradiation results in advanced oropharyngeal cancer Setting: Public tertiary care Hospital of tumours Design: Prospective not randomized. Population and methods: From January 2002 to December 2008, 60 patients were analysed, 55 of them were male with a mean age of 60, 76.7% TIII/IV oropharyngeal carcinomas treated with sequential chemoradiation. Results: The overall 152 months of survival was 30.1%. Univariate analize showed stage p<001, reduce of lesion p:0.010 and rescue surgery p:0.028 were statiscally significative. Age, gender and subsite had not similar results. In multivariate analize only stage p:0.001, gender p: 0.016 and reduce of lesion p:0.024 resulted statiscally significative. Conclusions: Sequential chemoradiation of III and IV stage tumours of oropharyngeal area have similar long terms results than those treated with surgery plus radiation but with organ preservation
Descritores: Preservação de Órgãos
Radioterapia
Toxicologia
Neoplasias Orofaríngeas/terapia
Fatores de Risco
Tratamento Farmacológico
Estadiamento de Neoplasias
-Análise Multivariada
Limites: Humanos
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: AR392.1 - Biblioteca


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Id: biblio-1365076
Autor: Marchi, Filipi Calbaizer; Mendes-Silva, Edneia; Rodrigues-Ribeiro, Lucas; Bolais-Ramos, Lucas Gabriel; Verano-Braga, Thiago.
Título: Toxinology in the proteomics era: a review on arachnid venom proteomics
Fonte: J. venom. anim. toxins incl. trop. dis;28:20210034, 2022. tab, graf.
Idioma: en.
Resumo: The word venomics was coined to acknowledge the studies that use omics to investigate venom proteins and peptides. Venomics has evolved considerably over the last 20 years. The first works on scorpion or spider venomics were published in the early 2000's. Such studies relied on peptide mass fingerprinting (PMF) to characterize venom complexity. After the introduction of new mass spectrometers with higher resolution, sensitivity and mass accuracy, and the next-generation nucleotide sequencing, the complexity of data reported in research on scorpion and spider venomics increased exponentially, which allowed more comprehensive studies. In the present review article, we covered key publications on scorpion venomics and spider venomics, presenting historical grounds and implemented technologies over the last years. The literature presented in this review was selected after searching the PubMed database using the terms "(scorpion venom) AND (proteome)" for scorpion venomics, and "(spider venom) AND (proteome)" for publications on spider venomics. We presented the key aspects related to proteomics in the covered papers including, but not restricted to, the employed proteomic strategy (i.e., PMF, two-dimensional gel electrophoresis, shotgun/bottom-up and/or top-down/peptidome), and the type of mass spectrometer used. Some conclusions can be drawn from the present study. For example, the scorpion genus Tityus is the most studied concerning venomics, followed by Centruroides; whereas for spiders the studied genera were found more equally distributed. Another interesting conclusion is the lack of high throughput studies on post-translational modifications (PTMs) of scorpion and spider proteins. In our opinion, PTMs should be more studied as they can modulate the activity of scorpion and spider toxins.(AU)
Descritores: Venenos de Artrópodes
Venenos de Escorpião
Venenos de Aranha
Toxicologia
Proteoma
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-656908
Autor: Salcedo Monsalve, Alejandra.
Título: Editorial / Editorial
Fonte: Rev. cienc. salud (Bogotá);10(supl.1):5-7, mar. 2012.
Idioma: es.
Resumo: La Toxicología puede ser vista por algunos como una rama de la Farmacología y por otros como un área específica de la Medicina, definiéndose como la ciencia que estudia los efectos adversos de las sustancias en los organismos vivos. Es un campo de conocimiento que se ha desarrollado de manera permanente y cuyo trabajo se ha especializado en diversas ramas como son Toxicología Analítica, Forense, Clínica, Ocupacional, Ambiental, Veterinaria, Industrial, Bromatológica y Toxinología, entre otras. Como lo menciona el profesor Mateo Sancho, desde el punto de vista químico la Toxicología sería la "ciencia de los venenos" y desde el punto de vista médico sería la "ciencia de las intoxicaciones". Hablar de Toxicología es hablar de la historia de la humanidad y esto obliga a referenciar importantes representantes e investigadores en áreas del conocimiento como la Física, la Química, la Medicina, el Derecho y la Ciencia Forense, por nombrar algunas; la Toxicología está presente en la Mitología, la Historia Antigua, la Edad Media, el Renacimiento, la Historia Moderna y por supuesto en la ciencia actual. Así, la Toxicología puede ser rastreada en todas las culturas y forma parte de la vida humana

Toxicology can be seen by some as a branch of Pharmacology and by others as a specific area of Medicine, being defined as the science that studies the adverse effects of substances on living organisms. It is a field of knowledge that has developed permanently and whose work has been specialized in various branches such as Analytical, Forensic, Clinical, Occupational, Environmental, Veterinary, Industrial, Bromatological and Toxinology Toxicology, among others. As mentioned by Professor Mateo Sancho, from the chemical point of view, Toxicology would be the "science of poisons" and from the medical point of view it would be the "science of intoxications". To speak of Toxicology is to speak of the history of mankind and this makes it necessary to refer to important representatives and researchers in areas of knowledge such as Physics, Chemistry, Medicine, Law and Forensic Science, to name a few; Toxicology is present in Mythology, Ancient History, the Middle Ages, the Renaissance, Modern History and of course in current science. Thus, Toxicology can be traced in all cultures and is part of human life
Descritores: Toxicologia
-Psicotrópicos
História
Limites: Humanos
Tipo de Publ: Editorial
Responsável: CO285.1 - Biblioteca


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Id: lil-339404
Autor: Miyamaru, Lígia L; Santa Bárbara, Maria Cristina; Iha, Maria Helena; Teixeira, Deusdete A; Zenebon, Odair.
Título: Determinaçäo do teor do princípio ativo e avaliaçäo da inocuidade térmica e ocular de produtos para o tratamento de ectoparasitoses contendo lindano / Quantitative determination of active principle and evaluation of the dermal and ocular safety to treatment of ectoparasitosis products containing lindane
Fonte: Rev. Inst. Adolfo Lutz;60(2):e35922, 2001. tab, graf.
Idioma: pt.
Resumo: O objetivo deste estudo foi determinar o teor do princípio ativo e avaliar a inocuidade dérmica e ocular em amostras de produtos contendo 1 por cento de lindano (m/m), que säo utilizados para o tratamento de ectoparasitoses: pediculoses e escabioses. Foram analisadas 06 (seis) amostras de produtos: um xampu, um creme, dois sabonetes e duas loçöes, de diferentes marcas. O teor de lindano das amostras foi realizado de acordo com a Farmacopéia Americana, 1995. Os testes de irritaçäo dérmica e ocular foram realizados de acordo com o método de Draize modificado nas amostra e nas soluçöes alcoólicas de lindano em diferentes concentraçöes. Foi efetuado também o teste nas amostras conforme o modo de uso, isto é, de acordo com as instruçöes fornecidas pelos fabricantes dos produtos analisados. Os resultados obtidos referentes ao teror de lindano mostraram que as amostras analisadas estavam de acordo com o ter especificado no rótulo. Os resutados dos exames toxicológicos das amostras demonstraram que os produtos aplicados de acordo com o modo de uso näo evidenciaram danos à pele dos animais testados. Porém, quando submetidos ao teste de irritaçäo dérmica cumulativa, isto é, através de repetidas aplicaçöes do produto, apresentaram irritaçäo, mostrando que o produto utilizado de forma näo correta poderá acarretar lesäo à pele e consequentemente comprometer a saúde do consumidor devido à toxicidade do lindano. (AU)

The aim of this study was the quantification of the drug as well as dermal and ocularsafety evaluation in samples containing 1% lindane (w/w), that are used in the treatment of ectoparasitosis:pediculosis and scabies. Six samples were analyzed: a shampoo, a cream, two bars of toilet soap andtwo lotions of different brands. The quantification method was described in the United StatesPharmacopeia, 1995. Tests of dermal and ocular irritation using the method of Draize with modificationwere done in samples and lindane alcoholic solutions in different concentrations. In samples, also thetest was done according to the manufacturer's directions for use and composition. The results of thelindane antification showed that the analyzed samples were in accordance with the label. The resultsof the toxicological tests showed that, when applied according to manufacturer's directions, the productsusing did not damage the skin or the eyes of the animal. However, when the samples were submitted tothe cumulative dermal test, implying repeated application of the product, they showed dermal irritation.So the incorrect use was proved to cause skin damage and compromise the customers's health due to thelindane toxicity. (AU)
Descritores: Toxicologia
Hexaclorocicloexano
Ectoparasitoses
Responsável: BR91.2 - Centro de Documentação


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Id: biblio-1145762
Autor: Medel-Jara, Patricio Andrés; Cerda Lorca, Jaime; López-Nuñez, Alberto; Silva, Lorena; Solari Gajardo, Sandra; Ríos Bustamante, Juan Carlos.
Título: Estudio exploratorio: relación entre nivel de pobreza y exposiciones agudas a sustancias potencialmente tóxicas en Chile / Exploratory study: Association between the poverty level and acute exposures to potentially toxic substances in Chile
Fonte: ARS med. (Santiago, En línea);44(4):24-30, dic-2019. Artículo de investigación.
Idioma: es.
Resumo: Objetivo: explorar la siguiente pregunta de investigación: ¿De qué manera el nivel socioeconómico de una persona, específicamente el nivel de pobreza se asocia a las características de las exposiciones agudas a sustancias con potencial tóxico en Chile? Métodos: estudio epidemiológico, de diseño transversal y semi-ecológico. Se recopiló información proveniente de una muestra de casos atendidos por el Centro de información toxicológica y de medicamentos de la Pontificia Universidad Católica de Chile (CITUC). La variable independiente corresponde al índice de pobreza comunal de la Encuesta de Caracterización Socioeconómica Nacional (CASEN). Las variables dependientes fueron las características de las exposiciones registradas por el centro toxicológico de acuerdo con el nivel de pobreza de los casos observados. Se analizó el fenómeno a través de tablas cruzadas, cálculo de Odds Ratio con análisis estratificado. Resultados: se observan diferencias significativas en las circunstancias de las exposiciones: las personas que viven en comunas con mayor porcentaje de pobreza muestran más exposiciones intencionales versus aquellas con menor porcentaje de pobreza. Otro hallazgo significativo es el uso del sistema de salud en casos de exposiciones dependiente de la situación socioeconómica. Para las otras variables no se encuentran diferencias significativas entre los grupos comparados. Conclusio-nes: se observa una relación entre el nivel de pobreza y las exposiciones a sustancias potencialmente tóxicas. Los resultados abren una línea investigativa y nuevas interrogantes que podrían generar medidas de control de las intoxicaciones en Chile.Palabras clave:toxicología; exposición a compuestos químicos; envenenamiento; determinantes sociales de la saludAbstractObjective: explore the following research question: How is a person's socio-economic level, the poverty, associated with the characteristics of acute exposures to substances with toxic potential in Chile?. Methods: epidemiological, cross-sectional and semi-ecological study. Information collected from a sample of cases attended by the Centre for Toxicological and Drug Information of the Pontifical Catholic University of Chile (CITUC). The independent variable corresponds to the communal poverty index of the National Socioeconomic Characterization Survey. Dependent variables were the characteristics of the exposures recorded by the toxicological center according to the poverty level of the cases observed. The phenomenon is analyzed through cross-tables, calculating Odds Ratios with stratified analysis. Results: significant differences observed in the circumstances of exposures: people living in communes with higher poverty rates show more intentional exposures versus those with lower poverty rates. Another significant finding is the use of the health system in cases of exposures, depending on the socio-economic situation. For the other variables, there are no significant differences between the compared groups. Conclusions: there is a link between the poverty level and acute exposures to potentially toxic substances. The results open a research line and new questions that could generate measures to control poisonings in Chile.Keywords:poisoning; social determinants of health; poverty(1) Centro de Información Toxicológica y de Medicamentos, Pontificia Universidad Católica de Chile.(2) Unidad docente de Farmacología y Toxicología, Facultad de Medicina, Pontificia Universidad Católica de Chile.(3) Departamento de Salud del Adulto y Senescente, Escuela de Enfermería, Pontificia Universidad Católica de Chile.(4) Departamento de Laboratorios Clínicos, Facultad de Medicina, Pontificia Universidad Católica de Chile.(5) Departamento de Salud Pública, Facultad de Medicina, Pontificia Universidad Católica de Chile.Autor de correspondencia: Juan Carlos Ríos jriosb@uc.clFecha de envío: 19 de agosto de 2019 - Fecha de aceptación: 26 de diciembre de 2019
Descritores: Exposição a Produtos Químicos
Determinantes Sociais da Saúde
-Envenenamento
Toxicologia
Chile
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: CL10.1 - Biblioteca Biomédica


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Id: lil-417714
Autor: Camargo, Antonio Carlos Martins de.
Título: Perspective for pharmaceutical innovation in Brazil - center for applied toxinology (CEPID- center for research, innovation and dissemination - FAPESP)
Fonte: J. venom. anim. toxins incl. trop. dis;11(4):384-390, out.-dez. 2005.
Idioma: en.
Resumo: The Center for Applied Toxinology (CAT), an institutional research organization based at the Butantan Institute, is one of the several Centers of Research, Innovation and Dissemination (CEPID) created in September 1998. CEPID, a pioneering program of the The State of São Paulo Research Foundation (FAPESP), was established to stimulate research, disseminate knowledge and foster contact between science and industry. CAT aims at conducting research on compounds derived from naturally occurring toxins, which might be of medical, ecological and economic interest. CAT takes a multidisciplinary approach in the investigation of natural toxins, including isolation and purification, pharmacological action, structural determination, structure-function studies, and molecular biology aspects. The following institutions will be involved in this endeavor: University of São Paulo (USP) [Marine Biology Center; Departments of Physiology and Anatomy, Institute for Biomedical Sciences; Department of Biochemistry, Institute of Chemistry]; São Paulo State University (UNESP) [Laboratory of Structural Biology and Zoochemistry, Institute of Biosciences, Rio Claro; Laboratory of Crystallography, Department of Physics, Institute of Biosciences, Humanities, and Exact Sciences, São José do Rio Preto]; and the Federal University of São Paulo (UNIFESP).(AU)
Descritores: Bioquímica
Preparações Farmacêuticas
Cristalografia
Indústrias
Biologia Marinha
-Toxicologia
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-525827
Autor: Lima, Maria Elena de; Pimenta, Adriano Monteiro de Castro; Martin-Eauclaire, Marie France; Zingali, Russolina Benedeta; Rochat, Hervé.
Título: Animal toxins: state of the art - perspectives in health and biotechnology
Fonte: J. venom. anim. toxins incl. trop. dis;15(3):585-586, 2009. ilus.
Idioma: en.
Descritores: Toxicologia/tendências
Biotecnologia
Saúde
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice



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