||Arteaga de Murphy, Consuelo; Meléndez Alafort, Laura; Montoya Molina, Carlos; Sepúlveda Méndez, Jesús.|
||Technetium-99m-alendronate: a new radiopharmaceutical for bone scanning|
||Arch. med. res;27(4):481-3, 1996. ilus.
||The purpose of this paper is to report the preparation of a new technetium-99m-radiopharmaceutical for bone scanning. The chelating agent for99mTc is a new bisphosphonate, alendronate, 4-amino-1-hydroxy-butylidene-1,1-bisphosphonate (ABP) used as a treatment for osteoporosis. ABP, because of its amino group, seems to be better suited to form a strong and stable complex with technetium-99m and therefore might be better than 99mTc-etidronate (HEDP) or 99mTc-medronate (MDP) for bone scanning. A sterile dry kit containing APB, a reducing agent and a stabilizer was prepared. The parameters studied were molar concentrations, pH, shelf life, labeling efficiency and radiochemical purity. the oven dried sterile kit was formulated with 5 mg ABP, 0.25 mg stannous fluoride and 0.025 mg gentisic acid at pH2.5-3.5. The labeling efficiency with 20 - 1500 MBq of pertechnetate (99mTcO4-) was over 95 percent at room temperature and was stable for 5 h. Technetium-99m-alendronate was tested in two rabbits and it proved to be a promising new radiopharmaceutical for bone scanning. Work is underway to study underway to study 99m-Tc-ABP biodistribution in a statistically significant number of laboratory animals and, later on, to determine radiopharmacokinetic parameters in normal volunteers|
||Osso e Ossos|
Microscopia Eletrônica de Varredura/métodos
Compostos de Tecnécio
||MX1.1 - CENIDSP - Centro de Información para Decisiones en Salud Pública|