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Pesquisa : L01.313.500.750.300.188.400.300.750 [Categoria DeCS]
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Texto completo SciELO Brasil
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Id: lil-763142
Autor: Catré, Dora; Lopes, Maria Francelina; Viana, Joaquim Silva; Cabrita, António Silvério.
Título: Perioperative morbidity and mortality in the first year of life: a systematic review (1997-2012) / Morbimortalidade perioperatória no primeiro ano de idade: revisão sistemática (1997-2012)
Fonte: Rev. bras. anestesiol;65(5):384-394, Sept.-Oct. 2015. tab.
Idioma: en.
Resumo: ABSTRACTBACKGROUND AND OBJECTIVES: Although many recognize that the first year of life and specifically the neonatal period are associated with increased risk of anesthetic morbidity and mortality, there are no studies directed to these pediatric subpopulations. This systematic review of the scientific literature including the last 15 years aimed to analyze the epidemiology of morbidity and mortality associated with general anesthesia and surgery in the first year of life and particularly in the neonatal (first month) period.CONTENT: The review was conducted by searching publications in Medline/PubMed databases, and the following outcomes were evaluated: early mortality in the first year of life (<1 year) and in subgroups of different vulnerability in this age group (0-30 days and 1-12 months) and the prevalence of cardiac arrest and perioperative critical/adverse events of various types in the same subgroups.CONCLUSIONS: The current literature indicates great variability in mortality and morbidity in the age group under consideration and in its subgroups. However, despite the obvious methodological heterogeneity and absence of specific studies, epidemiological profiles of morbidity and mortality related to anesthesia in children in the first year of life show higher frequency of morbidity and mortality in this age group, with the highest peaks of incidence in the neonates' anesthesia.

RESUMOJUSTIFICATIVA E OBJETIVOS: Embora muitos reconheçam que a idade inferior a um ano e especificamente o período neonatal estejam associados a maior risco de morbimortalidade anestésica, não existem estudos dirigidos a essas subpopulações pediátricas. Esta revisão sistemática das publicações científicas dos últimos 15 anos teve como objetivo analisar o perfil epidemiológico da morbimortalidade relacionada com a anestesia geral e cirurgia no primeiro ano de idade e em particular no período neonatal (primeiro mês de idade).CONTEúDO: A revisão foi conduzida por pesquisa de publicações nas bases de dados Medline/PubMed. Foram avaliados os seguintes desfechos: mortalidade precoce no primeiro ano de idade (< 1A) e em subgrupos de diferente vulnerabilidade nesta faixa etária (0-30 dias e 1-12 meses) e prevalência de parada cardíaca e eventos críticos/adversos perioperatórios de diversos tipos nos mesmos subgrupos.CONCLUSÕES: A literatura corrente indica grande variabilidade nos índices de mortalidade e morbidade na faixa etária em análise, bem como nos seus subgrupos. No entanto, apesar da óbvia heterogeneidade metodológica e da ausência de estudos específicos, os perfis epidemiológicos de morbimortalidade relacionada com a anestesia de crianças no primeiro ano de idade mostram frequência mais alta de morbimortalidade nessa faixa etária, com os maiores picos de incidência na anestesia de neonatos.
Descritores: Sítios de Ligação
Ligação Proteica
Conformação Proteica
Proteínas/química
Proteínas/metabolismo
-Biologia Computacional
Bases de Dados de Proteínas
Modelos Moleculares
Ressonância Magnética Nuclear Biomolecular
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Cavalcanti, Silvia Maria Baêta
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Id: lil-763058
Autor: Koifman, Leandro; Ornellas, Paulo; Ornellas, Antonio Augusto; Pereira, Denise de Abreu; Zingali, Benedeta Russolina; Cavalcanti, Silvia Maria Baeta; Afonso, Larissa Alves; Sandim, Vanessa; Alves, Gilda.
Título: Proteomics analysis of tissue samples from patients with squamous cell carcinoma of the penis and positive to human papillomavirus
Fonte: Int. braz. j. urol;41(4):642-654, July-Aug. 2015. tab, graf.
Idioma: en.
Projeto: FAPERJ.
Resumo: ABSTRACTPurpose:The aim of this study was to identify possible protein biomarkers and/or candidates for therapeutic targets in tissues of patients with SCCP, infected by HPV, applying one dimensional electrophoresis (1DE), followed by direct mass spectrometry (MS) analysis.Materials and Methods:Tissues from 10 HPV positive patients with SCCP and from 10 patients with HPV negative non-tumorous penile foreskins were analyzed applying 1D electrophoresis, followed by analysis with direct mass spectrometry (MS).Results:Sixty-three different proteins were identified in the first group and 50 in the second group. Recognition was possible for 28 proteins exclusively detected in Group 1 and 21 proteins presented only in Group 2.Conclusion:Some proteins in the first group are directly involved in the development of other types of cancer, and therefore, suitable for analysis. Complement C3 protein is a strong candidate for evaluating SCCP patients.
Descritores: Carcinoma de Células Escamosas/química
Proteínas de Neoplasias/análise
Proteômica
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/complicações
Neoplasias Penianas/química
-Biomarcadores Tumorais/análise
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/virologia
/análise
COMPLEMENT CABATTOIRS/análise
Bases de Dados de Proteínas
Eletroforese
/isolamento & purificação
HUMAN PAPILLOMAVIRUS 1ABDOMINAL NEOPLASMS/isolamento & purificação
/isolamento & purificação
HUMAN PAPILLOMAVIRUS ABNORMALITIES, MULTIPLE/isolamento & purificação
Espectrometria de Massas
Dados de Sequência Molecular
Neoplasias Penianas/patologia
Neoplasias Penianas/virologia
Limites: Seres Humanos
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  3 / 18 LILACS  
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Id: lil-762908
Autor: Song, Y.R.; Wu, B.; Yang, Y.T.; Chen, J.; Zhang, L.J.; Zhang, Z.W.; Shi, H.Y.; Huang, C.L.; Pan, J.X.; Xie, P..
Título: Specific alterations in plasma proteins during depressed, manic, and euthymic states of bipolar disorder
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;48(11):973-982, Nov. 2015. tab, graf.
Idioma: en.
Projeto: National Key Scientific Program of China.
Resumo: Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2% of the general population of different European countries. Unfortunately, there is no objective laboratory-based test to aid BD diagnosis or monitor its progression, and little is known about the molecular basis of BD. Here, we performed a comparative proteomic study to identify differentially expressed plasma proteins in various BD mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched healthy control subjects were recruited. Seven high-abundance proteins were immunodepleted in plasma samples from the 4 experimental groups, which were then subjected to proteome-wide expression profiling by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem mass spectrometry. Proteomic results were validated by immunoblotting and bioinformatically analyzed using MetaCore. From a total of 32 proteins identified with 1.5-fold changes in expression compared with healthy controls, 16 proteins were perturbed in BD independent of mood state, while 16 proteins were specifically associated with particular BD mood states. Two mood-independent differential proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be associated with early perturbations in lipid metabolism. Moreover, down-regulation of one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be associated with early perturbations in lipid metabolism that are independent of mood state, while CA-1 may be involved in the pathophysiology of depressive episodes.
Descritores: Apolipoproteína A-I/sangue
Apolipoproteínas/sangue
Transtorno Bipolar/sangue
Anidrase Carbônica I/sangue
Transtornos do Metabolismo dos Lipídeos/metabolismo
Lipoproteínas HDL/sangue
Proteômica
-Transtorno Bipolar/complicações
Transtorno Bipolar/diagnóstico
Bases de Dados de Proteínas
Diagnóstico Diferencial
Progressão da Doença
Regulação para Baixo
Transtorno Depressivo Maior/diagnóstico
Eletroforese em Gel Bidimensional
Immunoblotting
Imunoprecipitação
Transtornos do Metabolismo dos Lipídeos/complicações
Espectrometria de Massas/métodos
Limites: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-750246
Autor: Belloze, Kele Teixeira.
Título: Priorização de alvos para fármacos no combate a doenças tropicais negligenciadas causadas por protozoários / Prioritization of targets for drugs to fight neglected tropical diseases caused by protozoan.
Fonte: Rio de Janeiro; s.n; 2013. xiv,272 p. ilus, graf, tab, mapas.
Idioma: pt.
Tese: Apresentada a Instituto Oswaldo Cruz para obtenção do grau de Doutor.
Resumo: As doenças negligenciadas são doenças infecciosas que afetam principalmente a população mais pobre do mundo. Os fármacos existentes para o combate a essas doenças causam muitos efeitos colaterais aos pacientes e não são suficientes ou são inacessíveis à eles. Além disso, ainda há a resistência aos fármacos. Neste sentido, identificar alvos para a descoberta de novos fármacos se faz necessário. Este trabalho propõe uma metodologia para apoiar a priorização de alvos no combate a doenças tropicais negligenciadas causadas por cinco protozoários: Entamoeba histolytica, Leishmania major, Plasmodium falciparum, Trypanosoma brucei e T. cruzi, baseando-se nos conceitos de essencialidade e drogabilidade da proteína. A metodologia aproveita-se da vasta quantidade de dados e informações disponíveis publicamente em bases de dados genômicas, bioquímicas e farmacológicas, além da literatura biomédica, para buscar e integrar dados e informações de organismos modelo e proteínas alvo de fármaco para sugerir candidatos (proteínas alvo) essenciais e drogáveis para os protozoários, levantando assim, possíveis alvos para posteriores estudos e experimentosPara a obtenção destes dados foi utilizada a abordagem de anotação semântica baseada em ontologia para extrair dados a partir de artigos científicos e os conceitos de homologia e ortologia entre sequências de proteínas armazenadas em bases de dados semi-estruturadas de modo a levantar candidatos essenciais e drogáveis. Exemplos dos resultados gerados são mostrados, assim como algumas relações encontradas, e possíveis integrações entre os dados extraídos da literatura e dos resultados de homologia e ortologia...

Neglected diseases are infectious diseases that primarily affect the poorest people inthe world. The existing drugs to fight these diseases cause many side effects topatients and are not sufficient or inaccessible. Another problem is that there still isdrug resistance. Accordingly, it is very important to identify targets for new drugs.This study proposes a methodology to support the prioritization of targets to combatneglected tropical diseases caused by five protozoan Entamoeba histolytica,Leishmania Major, Plasmodium falciparum, Trypanosoma cruzi and T. brucei, basedon the concepts of protein essentiality and druggability. The methodology takesadvantage of the large amount of data and information publicly available on genomic,biochemical and pharmacological databases, and also the biomedical literature to seekand integrate data and information from model organisms and drug target proteins tosuggest essential and druggable candidates (target proteins) for protozoa, raising thepossibility of targets for future studies and experiments. To obtain these data we usedthe approach of ontology-based semantic annotation to extract data from scientificarticles and the concepts of homology and orthology between protein sequencesstored in semi-structured databases, in order to raise essential and drugablecandidates. Examples of the results generated are shown, as well as somerelationships found, and possible integration between the data extracted from theliterature and the results of homology and orthology...
Descritores: Bases de Dados de Proteínas
Preparações Farmacêuticas
Infecções por Protozoários
Homologia Estrutural de Proteína
Limites: Seres Humanos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


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Texto completo SciELO Chile
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Id: lil-645593
Autor: García, Patricia; Allende, Fidel; Legarraga, Paulette; Huilcaman, Marcos; Solari, Sandra.
Título: Identificación bacteriana basada en el espectro de masas de proteínas: Una nueva mirada a la microbiología del siglo XXI / Bacterial identification based on protein mass spectrometry: A new insight at the microbiology of the 21st century
Fonte: Rev. chil. infectol;29(3):263-272, jun. 2012. graf, tab.
Idioma: es.
Resumo: Bacterial identification is important for the proper treatment of infected patients hospitalized with serious infections especially in critical care units. Identification by conventional methods used in microbiology laboratories takes at least 16 hours since a culture is positive. The introduction of mass spectrometry, specifically MALDI-TOF MS (matrix-assisted laser desorption/ ionization time-of-flight mass spectrometer) in the microbiology laboratory could mean a radical change in the identification accuracy, turn around time (6 minutes per bacteria) and cost (about 5 times cheaper than conventional identification). Since its introduction in clinical microbiology laboratories in 2008, many reports about its usefulness in identifying microorganisms from colonies, as well as directly from positive blood cultures and urine samples have been published. This review describes MALDI-TOF MS methodology, its identification performance for bacteria (aerobic and anaerobic), mycobacterium and yeasts, its future applications in microbiology and its main disadvantages.

La identificación bacteriana es muy importante en el manejo adecuado de los pacientes infectados, especialmente aquellos con infecciones graves hospitalizados en unidades de pacientes críticos. La identificación por los métodos convencionales utilizados en los laboratorios de microbiología clínica demora al menos 16 horas desde que un cultivo es positivo. La introducción de la espectrometría de masas, específicamente del espectrómetro de masas por tiempo de migración (tiempo de vuelo) con desorción/ionización laser asistida por una matriz (MALDI-TOF MS, por su sigla en inglés matrix-assisted laser desorption/ionization time-of-flight mass spectrometer), en el laboratorio de microbiología podría significar un cambio radical en la precisión de la identificación, el tiempo de detección (6 minutos por bacterias) y el costo (aproximadamente 5 veces más económico que la identificación convencional). Desde su introducción en los laboratorios de microbiología clínica en el año 2008, se han escrito numerosas publicaciones sobre su utilidad en la identificación de microorganismos desde colonias, así como directamente desde hemocultivos positivos y de muestras de orina. Esta revisión describe la metodología de MALDI-TOF MS, su rendimiento en la identificación de bacterias aerobias, anaerobias, micobacterias y levaduras, sus futuras aplicaciones en microbiología y sus principales desventajas.
Descritores: Bactérias/classificação
Proteínas de Bactérias/isolamento & purificação
Filogenia
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
-Bactérias/isolamento & purificação
Proteínas de Bactérias/sangue
Proteínas de Bactérias/urina
Bases de Dados de Proteínas
Espectrometria de Massas/tendências
Mycobacterium/classificação
Proteínas Ribossômicas/isolamento & purificação
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Leveduras/classificação
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: lil-634511
Autor: Mollerach, Marta.
Título: Genómica y Proteómica: oportunidades y desafíos para la Microbiología
Fonte: Rev. argent. microbiol;38(1):1-3, ene.-mar. 2006.
Idioma: es.
Descritores: Genômica
Microbiologia
Proteômica
-Bases de Dados Genéticas
Bases de Dados de Proteínas
Previsões
Microbiologia/tendências
Especificidade da Espécie
Tipo de Publ: Estudo Comparativo
Editorial
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


  7 / 18 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: lil-610970
Autor: Kawano, Daniel Fábio; Silva, Vinicius Barreto da; Jorge, Daniel Macedo de Melo; Silva, Carlos Henrique Tomich de Paula da; Carvalho, Ivone.
Título: Search for a platelet-activating factor receptor in the Trypanosoma cruzi proteome: a potential target for Chagas disease chemotherapy
Fonte: Mem. Inst. Oswaldo Cruz;106(8):957-967, Dec. 2011. ilus, tab.
Idioma: en.
Resumo: Chagas disease (CD) causes the highest burden of parasitic diseases in the Western Hemisphere and is therefore a priority for drug research and development. Platelet-activating factor (PAF) causes the CD parasite Trypanosoma cruzi to differentiate, which suggests that the parasite may express PAF receptors. Here, we explored the T. cruzi proteome for PAF receptor-like proteins. From a total of 23,000 protein sequences, we identified 29 hypothetical proteins that are predicted to have seven transmembrane domains (TMDs), which is the main characteristic of the G protein-coupled receptors (GPCRs), including the PAF receptor. The TMDs of these sequences were independently aligned with domains from 25 animal PAF receptors and the sequences were analysed for conserved residues. The conservation score mean values for the TMDs of the hypothetical proteins ranged from 31.7-44.1 percent, which suggests that if the putative T. cruzi PAF receptor is among the sequences identified, the TMDs are not highly conserved. These results suggest that T. cruzi contains several GPCR-like proteins and that one of these GPCRs may be a PAF receptor. Future studies may further validate the PAF receptor as a target for CD chemotherapy.
Descritores: Glicoproteínas da Membrana de Plaquetas/análise
Proteoma/química
Proteínas de Protozoários/análise
Receptores Acoplados a Proteínas-G/análise
Trypanosoma cruzi/química
-Biologia Computacional
Doença de Chagas/tratamento farmacológico
Bases de Dados de Proteínas
Terapia de Alvo Molecular
Filogenia
Análise de Sequência de Proteína
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  8 / 18 LILACS  
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Id: lil-520057
Autor: Oliveira, S. R. M; Almeida, G. V; Souza, K. R. R; Rodrigues, D. N; Kuser-Falcão, P. R; Yamagishi, M. E. B; Santos, E. H; Vieira, F. D; Jardine, J. G; Neshich, G.
Título: Sting_RDB: a relational database of structural parameters for protein analysis with support for data warehousing and data mining
Fonte: Genet. mol. res. (Online);6(4):911-922, 2007. ilus, graf.
Idioma: en.
Conferência: Apresentado em: X-Meeting 2006 - International Conference of the AB3C, 2, Apresentado em: Annual International Conference on Intelligent Systems for Molecular Biology, 14, Fortaleza, Aug. 6-10, 2006.
Resumo: An effective strategy for managing protein databases is to provide mechanisms to transform raw data into consistent, accurate and reliable information. Such mechanisms will greatly reduce operational inefficiencies and improve one's ability to better handle scientific objectives and interpret the research results. To achieve this challenging goal for the STING project, we introduce Sting_RDB, a relational database of structural parameters for protein analysis with support for data warehousing and data mining. In this article, we highlight the main features of Sting_RDB and show how a user can explore it for efficient and biologically relevant queries. Considering its importance for molecular biologists, effort has been made to advance Sting_RDB toward data quality assessment. To the best of our knowledge, Sting_RDB is one of the most comprehensive data repositories for protein analysis, now also capable of providing its users with a data quality indicator. This paper differs from our previous study in many aspects. First, we introduce Sting_RDB, a relational database with mechanisms for efficient and relevant queries using SQL. Sting_rdb evolved from the earlier, text (flat file)-based database, in which data consistency and integrity was not guaranteed. Second, we provide support for data warehousing and mining. Third, the data quality indicator was introduced. Finally and probably most importantly, complex queries that could not be posed on a text-based database, are now easily implemented. Further details are accessible at the Sting_RDB demo web page: http://www.cbi.cnptia.embrapa.br/StingRDB.
Descritores: Biologia Computacional/métodos
Sistemas de Gerenciamento de Base de Dados
Bases de Dados de Proteínas
Proteínas/química
-Estrutura Secundária de Proteína
Responsável: BR26.1 - Biblioteca Central


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Id: lil-520056
Autor: Rocchia, W; Neshich, G.
Título: Electrostatic potential calculation for biomolecules - creating a database of pre-calculated values reported on a per residue basis for all PDB protein structures
Fonte: Genet. mol. res. (Online);6(4):923-936, 2007. ilus, tab.
Idioma: en.
Conferência: Apresentado em: X-Meeting 2006 - International Conference of the AB3C, 2, Apresentado em: Annual International Conference on Intelligent Systems for Molecular Biology, 14, Fortaleza, Aug. 6-10, 2006.
Resumo: STING and JavaProtein Dossier provide a collection of physical-chemical parameters, describing protein structure, stability, function, and interaction, considered one of the most comprehensive among the available protein databases of similar type. Particular attention in STING is paid to the electrostatic potential. It makes use of DelPhi, a well-known tool that calculates this physical-chemical quantity for biomolecules by solving the Poisson Boltzmann equation. In this paper, we describe a modification to the DelPhi program aimed at integrating it within the STING environment. We also outline how the "amino acid electrostatic potential" and the "surface amino acid electrostatic potential" are calculated (over all Protein Data Bank (PDB) content) and how the corresponding values are made searchable in STING_DB. In addition, we show that the STING and JavaProtein Dossier are also capable of providing these particular parameter values for the analysis of protein structures modeled in computers or being experimentally solved, but not yet deposited in the PDB. Furthermore, we compare the calculated electrostatic potential values obtained by using the earlier version of DelPhi and those by STING, for the biologically relevant case of lysozyme-antibody interaction. Finally, we describe the STING capacity to make queries (at both residue and atomic levels) across the whole PDB, by looking at a specific case where the electrostatic potential parameter plays a crucial role in terms of a particular protein function, such as ligand binding. BlueStar STING is available at http://www.cbi.cnptia.embrapa.br.
Descritores: Aminoácidos/química
Bases de Dados de Proteínas
Modelos Químicos
Proteínas/química
Software
-Reações Antígeno-Anticorpo
Estrutura Secundária de Proteína
Eletricidade Estática
Responsável: BR26.1 - Biblioteca Central


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Id: lil-520055
Autor: Faria-Campos, A. C; Gomes, R. R; Moratelli, F. S; Rausch-Fernandes, H; Franco, G. R; Campos, S. V. A.
Título: BNDb - Biomolecules Nucleus Database: an integrated proteomics and transcriptomics database
Fonte: Genet. mol. res. (Online);6(4):937-945, 2007. ilus, tab.
Idioma: en.
Conferência: Apresentado em: X-Meeting 2006 - International Conference of the AB3C, 2, Apresentado em: Annual International Conference on Intelligent Systems for Molecular Biology, 14, Fortaleza, Aug. 6-10, 2006.
Resumo: Proteomics correspond to the identification and quantitative analysis of proteins expressed in different conditions or life stages of a cell or organism. Methods used in proteomics analysis include mainly chromatography, two-dimensional electrophoresis and mass spectrometry. Data generated in proteomics analysis vary significantly, and to identify a protein it is often necessary to perform a series of experiments, comparing its results to those found in proteomics databases. Existing proteomics databases are usually related to only one type of experiment or represent processed results, not raw data. Therefore, proteomics researchers frequently have to resort to several data repositories in order to be able to perform the identification. In this paper, we propose an integrated proteomics and transcriptomics database that stores raw and processed data, which are indexed allowing them to be retrieved together or individually. The proposed database, dubbed BNDb for Biomolecules Nucleus Database, is implemented using an MySQL server and is being used to store data from the parasite Schistosoma mansoni, the scorpion Tittyus serrulatus and the spider Phoneutria nigriventer. The database construction uses a relational approach and data indexes. The data model proposed uses groups of tables for each data subtype, which store details regarding the experimental procedure as well as raw data, analysis results and associated publications. BNDb also stores transcriptomics data publicly available which are associated with identifications performed on new samples. By using BNDb, we expect not only to contribute to proteomics research but also to provide a useful service for the scientific community.
Descritores: Bases de Dados de Ácidos Nucleicos
Bases de Dados de Proteínas
Proteômica/métodos
Transcrição Genética
-Sistemas de Gerenciamento de Base de Dados
Interface Usuário-Computador
Limites: Animais
Responsável: BR26.1 - Biblioteca Central



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