||Shen, Hai-Mo; Chen, Shen-Bo; Wang, Yue; Chen, Jun-Hu.|
||Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area|
||Mem. Inst. Oswaldo Cruz;110(6):814-816, Sept. 2015. tab, graf.
||International S&T Cooperation Program; . National Science and Technology Major Program; . Health Research in the Public Interest.
||Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics.|
||DNA de Protozoário/análise|
Genoma de Protozoário
Análise de Sequência de DNA
Plasmodium vivax/isolamento & purificação
| Tipo de Publ:
||Research Support, Non-U.S. Gov't|
||BR1.1 - BIREME|