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Id: biblio-1056890 LILACS-Express
Autor: Patil, Santosh Rayagouda; Maragathavalli, G; Ramesh, D N S V; Vargheese, Sheeja; Al-Zoubi, Ibrahim A; Alam, Mohammad Khursheed.
Título: Assessment of Maximum Bite Force in Oral Submucous Fibrosis Patients: A Preliminary Study
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e4871, 2020. tab.
Idioma: en.
Resumo: Abstract Objective: To determine the maximum bite force (MBF) in oral submucous fibrosis (OSMF) patients and to compare them with that of healthy subjects. Material and Methods: Twenty patients who were clinically confirmed, as OSMF and 20 healthy controls matched for age, gender, and number of intact functional teeth were included in this study. For each subject, age, gender, weight, height and body mass index (BMI) were recorded. The MBF registration was carried out by the two evaluators, who were previously calibrated. Bite force was measured in the first molar region using a force transducer occlusal force meter for each subject seated at the upright position, with Frankfort's plane nearly parallel to the floor, and no head support. The Student's independent t-test was used to determine the statistical significance in relation to mean height, weight, BMI and the presence of number of intact teeth and MBF between the healthy subjects and OSMF individuals. A comparison of grades of OSMF with all variables was carried out by one-way ANOVA test. Results: No significant difference was found in mean age, mean height, weight, BMI and the presence of the number of intact teeth between healthy individuals and OSMF patients. The mean MBF in healthy subjects was 628.23 ± 24.39 N and 635.47 ± 31.22 N in OSMF patients. Even though the healthy subjects reported a higher MBF than OSMF patients did, the difference was statistically non-significant. With regards to sides, no significant difference was observed in mean MBF in healthy subjects and OSMF patients on the right (p=0.7818) and left side (p=0.6154). Conclusion: The healthy subjects reported higher MBF values than OSMF patients did and the difference was statistically non-significant.
Descritores: Fibrose Oral Submucosa
Força de Mordida
Doenças Estomatognáticas/patologia
Dente Molar
-Índice de Massa Corporal
Estudos Transversais/métodos
Análise de Variância
Índia
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Estudo Comparativo
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-1056878 LILACS-Express
Autor: Siddiq, Hanan; Pentapati, Kalyana Chakravarthy; Shenoy, Revathi; Velayutham, Anupama; Acharya, Shashidhar.
Título: Evaluation of Sugar Content and Erosive Potential of the Commonly Prescribed Liquid Oral Medications
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e5025, 2020. tab.
Idioma: en.
Resumo: Abstract Objective: To assess the total sugar content, endogenous pH, total soluble solids content (TSSC) and titratable acidity of the commonly prescribed long-term and short-term liquid oral medicines (LOM) for children and to compare the erosive potential with the total sugar content and total soluble solids of the LOM. Material and Methods: Twenty-three most commonly prescribed pediatric LOM were evaluated in-vitro for the cariogenic and erosive potential. Manufacturers' information on labels, endogenous pH, titratable acidity, TSSC, and the total sugar content was determined. Descriptive statistics and the Mann-Whitney U test were applied. Results: Overall, 22 LOM contained sugar. Only 3 LOM revealed the sugar content of the formulation but did not disclose the quantity (Cheston, Ventorlin and Eptoin). None of the samples revealed the sugar content as well as endogenous pH in their labels. The overall mean total sugar content was 6.92 ± 3.49 g/100ml, ranging from 3.40 ± 0.00 (corticosteroids) to 9.67 ± 0.61 (antitussive/expectorant). The mean endogenous pH for the total sample of medicines was 5.91 ± 1.51 (range of 3.5 to 10.3). Eptoin (0.013%) presented the lowest titratable acidity and Imol (1.171%) presented the highest titratable acidity with an overall mean of 0.40 ± 0.73. Omnacortil and Epilex presented the highest TSS content (19.3%), and Ventorlin presented the lowest TSS content (18.7%) with an overall mean of 18.97 ± 0.19. Over twelve medicines were identified to have the potential to cause dental erosion. No significant differences were seen in the total sugar content, total soluble solids, titratable acidity, and the endogenous pH between the short-term and long-term LOMs (p=0.145, p=0.263, p=0.067 and p=0.107), respectively. Conclusion: The pediatric LOMs showed the presence of the sugar, low endogenous pH, high titratable acidity and high total soluble solids.
Descritores: Sacarose
Erosão Dentária/diagnóstico
Criança
Cárie Dentária
Acidez
-Técnicas In Vitro/métodos
Estatísticas não Paramétricas
Concentração de Íons de Hidrogênio
Índia
Tipo de Publ: Estudo de Avaliação
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-1056885 LILACS-Express
Autor: Bhattacharya, Swastika; Purayil, Tina Puthen; Ginjupalli, Kishore; Kini, Sandya; Pai, Swathi.
Título: Effect of Thermocycling on the Colour Stability of Aesthetic Restorative Materials: An in-vitro Spectrophotometric Analysis
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e5174, 2020. tab.
Idioma: en.
Resumo: Abstract Objective: To compare the color stability of Cention N, Fuji IX GP Extra, and Fuji IX GP after thermocycling. Material and Methods: Ten discs of each material of dimension 10 x 1 mm were prepared using a split mold. The preparations of the specimens were done according to the powder/liquid ratio as recommended by the manufacturers [4.6:1, 3.4:1 and 3.6:1 for the groups I, II, and III, respectively]. After setting, the samples were retrieved, and the thickness of each specimen was measured using a micrometer at five different locations. The specimens with variations in thickness, porosity or cracks were discarded and thus not included in the study. The selected specimens were stored in distilled water for 24 hours prior to testing. The prepared specimens were thermocycled at 5°C and 55°C, with a dwell time of 15 seconds for 250 or 500 cycles. Subsequently, the color parameters of the discs were measured using a spectrophotometer. The data were analyzed using two way ANOVA test, and a p-value <0.001 was considered. Results: Thermocycling resulted in changes in the color of both Glass Ionomer cement and Cention N (p<0.001). Among the materials tested, Cention N showed superior color stability. Conclusion: Cention N exhibited better color stability compared to Glass ionomer cements.
Descritores: Espectrofotometria/métodos
Materiais Dentários
Estética Dentária
Cimentos de Ionômeros de Vidro
-Análise de Variância
Índia
Tipo de Publ: Estudo Comparativo
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-1091640 LILACS-Express
Autor: Singh, Harpreet; Rashmi, Shashi; Pai, Swathi; Kini, Sandya.
Título: Comparative Evaluation of Fluoride Release From Two Different Glass Ionomer Cement and a Novel Alkasite Restorative Material - An in Vitro Study
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e5209, 2020. tab.
Idioma: en.
Resumo: Abstract Objective: To compare the fluoride release from Conventional Glass Ionomer Cement (GIC), Resin Modified GIC (RMGIC), and Cention N Alkasite Material. Material and Methods: Forty- five disc-shaped specimens of three different restorative materials (Conventional GIC, RMGIC, and Alkasite material) were made and divided into 3 groups (n=15). Fluoride release was evaluated at the end of Day 1, 7, 14, and Day 28 using fluoride ion-selective electrode. Intergroup and Intra-group analysis was done using One-way ANOVA with a Post-hoc test. A p-value of <0.05 was considered statistically significant. Results: Cention showed more fluoride release (in parts per million) than GIC and RMGIC at increased time duration. However, at the end of day 1, there was lesser fluoride release with Cention, as compared with the other groups. Conclusion: The new Alkasite restorative material showed promising results in terms of fluoride release and is better than GIC and RMGIC at increased time duration.
Descritores: Técnicas In Vitro
Eletrodos Íon-Seletivos
Fluoretos/química
Cimentos de Ionômeros de Vidro
-Teste de Materiais/instrumentação
Análise de Variância
Índia
Tipo de Publ: Estudo Comparativo
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-828238
Autor: Manche, Santoshi Kumari; Madhavi, Jangala; Meganadh, Koralla Raja; Jyothy, Akka.
Título: Association of tinnitus and hearing loss in otological disorders: a decade-long epidemiological study in a South Indian population / Associação de zumbido e perda auditiva em distúrbios otológicos: estudo epidemiológico de uma década em uma população do Sul da Índia
Fonte: Braz. j. otorhinolaryngol. (Impr.);82(6):643-649, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Introduction: Tinnitus is a common disorder that occurs frequently across all strata of population and has an important health concern. Tinnitus is often associated with different forms of hearing loss of varying severity. Objective: The present study aimed to identify the association of tinnitus with hearing loss in various otological disorders of a South Indian population. Methods: A total of 3255 subjects referred to the MAA ENT Hospital, Hyderabad, from 2004 to 2014, affected with various otological diseases have been included in the present cross-sectional study. Diagnosis of the diseases was confirmed by an ear, nose, and throat (ENT) specialist using detailed medical and clinical examination. Statistical analysis was performed using the χ 2 test and binary logistic regression. Results: Tinnitus was observed in 29.3% (956) of the total study subjects that showed an increased prevalence in greater than 40 years of age. There was a significant increase in risk of tinnitus with middle (OR = 1.79, 95% CI = 1.02-3.16) and inner (OR = 3.00, 95% CI = 1.65-5.45) inner ear diseases. It was noted that 96.9% (n = 927) of the tinnitus subjects was associated with hearing loss. Otitis media (60.9%), presbycusis (16.6%) and otosclerosis (14.3%) are the very common otological disorders leading to tinnitus. Tinnitus was significantly associated with higher degree of hearing loss in chronic suppurative otitis media (CSOM) subjects. Conclusion: The present study could identify the most prevalent otological risk factors leading to development of tinnitus with hearing loss in a South Indian population.

Resumo Introdução: O zumbido é um distúrbio comum que ocorre com frequência em todos os estratos da população, constituindo um problema importante de saúde. O zumbido é frequentemente associado a diferentes formas de perda auditiva e sua gravidade é variada. Objetivo: O presente estudo teve como objetivo identificar a associação entre zumbido e perda auditiva em várias doenças otológicas na população do Sul da Índia. Método: No total, 3.255 indivíduos encaminhados ao Hospital MAA ENT em Hyderabad de 2004 a 2014, com diversas doenças otológicas, foram incluídos neste estudo transversal. O diagnóstico das doenças foi confirmado pelo otorrinolaringologista por meio de exames médico e clínico detalhados. A análise estatística foi realizada com o teste do χ2 e regressão logística binária. Resultados: Zumbido foi observado em 29,3% (956) do total de participantes do estudo, com maior prevalência em indivíduos com mais de 40 anos de idade. Houve um aumento significante do risco de zumbido em doenças da orelha média (OR = 1,79, IC 95% = 1,02-3,16) e interna (OR = 3,00, IC 95% = 1,65-5,45). Observamos que em 96,9% (n = 927) dos indivíduos com zumbido houve associação com perda auditiva. Conclusão: O presente estudo pôde identificar os fatores etiológicos mais prevalentes que levam ao desenvolvimento de zumbido associado à perda auditiva em uma população do Sul da Índia. Otite média (60,9%), presbiacusia (16,6%) e otosclerose (14,3%) são doenças otológicas frequentemente associadas ao zumbido. Em indivíduos com otite média crônica supurativa (OMCS), o zumbido foi significantemente associado ao maior grau de perda auditiva.
Descritores: Zumbido/etiologia
Otopatias/complicações
Perda Auditiva/etiologia
-Zumbido/epidemiologia
Doença Crônica
Prevalência
Estudos Transversais
Fatores de Risco
Otopatias/epidemiologia
Perda Auditiva/epidemiologia
Índia/epidemiologia
Limites: Humanos
Masculino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-1133185
Autor: Senthilkumar, Chinnu Sugavanam; Malla, Tahir Mohi-Ud-Din; Akhter, Sameena; Sah, Nand Kishore; Ganesh, Narayanan.
Título: Susceptibility of the Bhopal-methyl isocyanate (MIC)-gas-tragedy survivors and their offspring to COVID-19: What we know, what we dont and what we should? / Suscetibilidade dos sobreviventes da tragédia de Bhopal-isocianato de metila (CIM)-gás e seus filhos ao COVID-19: O que sabemos, o que não sabemos e o que devemos?
Fonte: Ciênc. Saúde Colet;25(supl.2):4225-4230, Mar. 2020. graf.
Idioma: en.
Resumo: Abstract There is credible evidence that the 1984-Bhopal-methyl isocyanate (MIC)-gas-exposed long-term survivors and their offspring born post-exposure are susceptible to infectious/communicable and non-communicable diseases. Bhopal's COVID-19 fatality rate suggests that the MIC-gas tragedy survivors are at higher risk, owing to a weakened immune system and co-morbidities. This situation emboldened us to ponder over what we know, what we don't, and what we should know about their susceptibility to COVID-19. This article aims at answering these three questions that emerge in the minds of public health officials concerning prevention strategies against COVID-19 and health promotion in the Bhopal MIC-affected population (BMAP). Our views and opinions presented in this article will draw attention to prevent and reduce the consequences of COVID-19 in BMAP. From the perspective of COVID-19 prophylaxis, the high-risk individuals from BMAP with co-morbidities need to be identified through a door-to-door visit to the severely gas-affected regions and advised to maintain good respiratory hygiene, regular intake of immune-boosting diet, and follow healthy lifestyle practices.

Resumo Há evidências plausíveis de que os sobreviventes a longo prazo da exposição a gás de 1984 e isocianato de metila (CIM), em Bhopal, e seus filhos nascidos após esse fato estão suscetíveis a doenças infecciosas/transmissíveis e não transmissíveis. A taxa de fatalidade COVID-19 de Bhopal sugere que os sobreviventes da tragédia do gás MIC estão em maior risco, devido a um sistema imunológico enfraquecido e comorbidades. Essa situação nos encorajou a refletir sobre o que sabemos, o que não sabemos e o que devemos saber sobre a suscetibilidade deles ao COVID-19. Este artigo objetiva responder a essas três perguntas que surgem na mente dos funcionários de saúde pública sobre estratégias de prevenção contra o COVID-19 e promoção da saúde na população afetada pelo Bhopal MIC (BMAP). Nossas visões e opiniões apresentadas neste artigo chamam a atenção para prevenir e reduzir as consequências do COVID-19 no BMAP. Da perspectiva da profilaxia com COVID-19, os indivíduos de alto risco do BMAP com condições comórbidas precisam ser identificados por meio de uma visita de porta em porta nas regiões severamente afetadas por gases e aconselhados a manter uma boa higiene respiratória, ingestão regular de dieta que estimule o sistema imunológico e seguir práticas de estilo de vida saudáveis.
Descritores: Pneumonia Viral/prevenção & controle
Sobreviventes
Isocianatos/toxicidade
Infecções por Coronavirus/prevenção & controle
Suscetibilidade a Doenças
Exposição Ambiental/efeitos adversos
Pandemias/prevenção & controle
-Pneumonia Viral/transmissão
Pneumonia Viral/epidemiologia
Autocuidado
Controle de Doenças Transmissíveis
Hospedeiro Imunocomprometido
Infecções por Coronavirus
Infecções por Coronavirus/transmissão
Infecções por Coronavirus/epidemiologia
Populações Vulneráveis
Desastres
Betacoronavirus
Índia/epidemiologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-951849
Autor: Gurramkonda, Venkatesh Babu; Syed, Altaf Hussain; Murthy, Jyotsna; Lakkakula, Bhaskar V K S.
Título: IRF6 rs2235375 single nucleotide polymorphism is associated with isolated non-syndromic cleft palate but not with cleft lip with or without palate in South Indian population / Polimorfismo de nucleotídeo único do gene IRF6 rs2235375 está associado com à fenda palatina isolada não sindrômica, mas não com fenda labial com ou sem fenda palatina em população do sul da Índia
Fonte: Braz. j. otorhinolaryngol. (Impr.);84(4):473-477, July-Aug. 2018. tab.
Idioma: en.
Projeto: Indian Council of Medical Research.
Resumo: Abstract Introduction Transcription factors are very diverse family of proteins involved in activating or repressing the transcription of a gene at a given time. Several studies using animal models demonstrated the role of transcription factor genes in craniofacial development. Objective We aimed to investigate the association of IRF6 intron-6 polymorphism in the non-syndromic cleft lip with or without palate in a South Indian population. Methods 173 unrelated nonsyndromic cleft lip with or without cleft palate patients and 176 controls without clefts patients were genotyped for IRF6 rs2235375 variant by allele-specific amplification using the KASPar single nucleotide polymorphism genotyping system. The association between interferon regulatory factor-6 gene intron-6 dbSNP208032210:g.G>C (rs2235375) single nucleotide polymorphism and non-syndromic cleft lip with or without palate risk was investigated by chi-square test. Results There were significant differences in genotype or allele frequencies of rs2235375 single nucleotide polymorphism between controls and cases with non-syndromic cleft lip with or without palate. IRF6 rs2235375 variant was significantly associated with increased risk of non-syndromic cleft lip with or without palate in co-dominant, dominant (OR: 1.19; 95% CI 1.03-2.51; p = 0.034) and allelic models (OR: 1.40; 95% CI 1.04-1.90; p = 0.028). When subset analysis was applied significantly increased risk was observed in cleft palate only group (OR dominant: 4.33; 95% CI 1.44-12.97; p = 0.005). Conclusion These results suggest that IRF6 rs2235375 SNP play a major role in the pathogenesis and risk of developing non-syndromic cleft lip with or without palate.

Resumo Introdução Fatores de transcrição constituem uma família de proteínas muito diversa envolvida na ativação ou repressão da transcrição de um gene, em um determinado momento. Vários estudos usando modelos animais demonstraram o papel dos genes do fator de transcrição no desenvolvimento craniofacial. Objetivo Nosso objetivo foi investigar a associação do polimorfismo IRF6 intron-6 na fenda labial não sindrômica com ou sem fenda palatina em uma população do sul da Índia. Método Um total de 173 pacientes com fenda labial não sindrômica com ou sem fenda palatina e 176 controles sem fendas foram genotipados para a variante IRF6 rs2235375 por amplificação alelo-específica utilizando o sistema KASPar de genotipagem de polimorfismo de nucleotídeo único. A associação entre o polimorfismo de nucleotídeo único Fator 6 Regulatório do Interferon (IRF6) intron-6 dbSNP208032210:g.G>C (rs2235375) e o risco de fenda labial não sindrômica com ou sem fenda palatina foi investigado pelo teste qui-quadrado. Resultados Houve diferenças significativas nas frequências de genótipos ou alelos do rs2235375 SNP entre controles e casos com fenda labial não sindrômica com ou sem fenda palatina. A variante IRF6 rs2235375 foi significativamente associada ao aumento do risco de fenda labial não sindrômica com ou sem fenda palatina em modelos codominantes, dominantes (OR: 1,19; IC 95%: 1,03-2,51; p = 0,034) e alélicos (OR: 1,40; IC 95%: 1,04-1,90; p = 0,028). Quando a análise do subgrupo foi realizada, um risco significativamente aumentado foi observado no grupo Fenda Palatina Isolada (OR dominante: 4,33; IC 95%: 1,44-12,97; p = 0,005). Conclusões Esses resultados sugerem que o polimorfismo de nucleotídeo único IRF6 rs2235375 desempenha um papel importante na patogênese e no risco de desenvolvimento de fenda labial não sindrômica com ou sem fenda palatina.
Descritores: Fenda Labial/genética
Fissura Palatina/genética
Polimorfismo de Nucleotídeo Único/genética
Fatores Reguladores de Interferon/genética
-Estudos de Casos e Controles
Fatores de Risco
Fenda Labial/etnologia
Fissura Palatina/etnologia
Estudos de Associação Genética
Técnicas de Genotipagem
Frequência do Gene
Índia
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-975428
Autor: Silva, Matheus Alves Duarte da.
Título: De Bombaim ao Rio de Janeiro: circulação de conhecimento e a criação do Laboratório de Manguinhos, 1894-1902 / From Bombay to Rio de Janeiro: the circulation of knowledge and the establishment of the Manguinhos laboratory, 1894-1902
Fonte: Hist. ciênc. saúde-Manguinhos;25(3):639-657, jul.-set. 2018.
Idioma: pt.
Projeto: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Resumo: Resumo Para se compreender a fundação, em 1900, e os primeiros trabalhos científicos do Instituto Soroterápico Federal, é necessário analisar a circulação de conhecimento e a disputa internacional envolvendo os soros antipestosos e as vacinas antipestosas. O artigo discute a criação do primeiro soro antipestoso, em Paris, e os testes realizados a partir de 1897 na Índia. Paralelamente, examina a invenção da vacina antipestosa na mesma época em Bombaim e a oposição construída entre ela e o soro antipestoso francês. Em seguida, observa os diferentes caminhos pelos quais esses objetos chegaram ao Brasil e como questões locais se conectaram à disputa científica internacional e justificaram, no Rio de Janeiro, reconfigurações em torno desses dois objetos.

Abstract In order to understand the 1900 establishment of the Federal Serum Therapy Institute of Manguinhos and its earliest scientific work, we must analyze the circulation of knowledge and international disputes surrounding antiplague serums and vaccines. This article discusses the development of the first antiplague serum, in Paris, and the trials conducted in India, which started in 1897. It also examines the invention of an antiplague vaccine in Bombay around the same time and the ensuing controversy involving it and the French serum. The article then explores the pathways by which these objects reached Brazil and also looks at how local issues there meshed with the international scientific dispute, ultimately justifying reconfigurations of the two objects in Rio de Janeiro.
Descritores: Peste/história
Vacina contra a Peste/história
Laboratórios/história
-Peste/prevenção & controle
Brasil
Soro
Índia
Limites: Humanos
História do Século XIX
História do Século XX
Tipo de Publ: Artigo Histórico
Responsável: BR1.1 - BIREME


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Id: biblio-839225
Autor: Marupuru, Srujitha; Senapati, Padmanav; Pathadka, Swathi; Miraj, Sonal Sekhar; Unnikrishnan, Mazhuvancherry Kesavan; Manu, Mohan K.
Título: Protective effect of metformin against tuberculosis infections in diabetic patients: an observational study of south Indian tertiary healthcare facility
Fonte: Braz. j. infect. dis;21(3):312-316, May-June 2017. tab.
Idioma: en.
Resumo: ABSTRACT Background: World Health Organization estimated that people with diabetes (DM) are at 2-3 times higher risk for tuberculosis (TB). Studies have shown that DM not only increases the risk of active TB, but also puts co-affected persons at increased risk of poor outcomes. Objectives: To determine the protective effect of metformin against TB in DM patients and also, to investigate the relationship between poor glycemic control and TB. Methods: A case-control study was conducted over 8 months, where cases and controls were selected based on the inclusion and exclusion criteria of the study. The diabetics diagnosed with TB were selected as study group (SG = 152) and without TB were as control group (CG = 299). Exposure status of metformin in both groups were analyzed. Results: The mean (SD) age of both CG and SG were 55.54 ± 11.82 and 52.80 ± 11.75, respectively. Majority of the subjects in the study were males. The mean hospital stay of SG and CG were 7 days and 6 days, respectively. Poor glycemic control (HbA1c > 8) observed in SG (51.7%) vs CG (31.4%). HbA1c value <7 is associated protective factor for TB occurrence [OR = 0.52 (95% CI 0.29-0.93)]. The protective effect of metformin against TB was 3.9-fold in diabetics (OR = 0.256, 0.16-0.40). Conclusion: Poor glycemic control among diabetics is a risk factor for TB occurrence. The result shows metformin use is a protective agent against TB infection in diabetics. Hence, incorporation of metformin into standard clinical care would offer a therapeutic option for the prevention of TB.
Descritores: Tuberculose Pulmonar/prevenção & controle
Diabetes Mellitus/tratamento farmacológico
Hipoglicemiantes/uso terapêutico
Metformina/uso terapêutico
-Tuberculose Pulmonar/etiologia
Tuberculose Pulmonar/sangue
Atenção Terciária à Saúde
Estudos de Casos e Controles
Índia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


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Id: biblio-888893
Autor: Chaudhary, Manu; Mir, Mohd Amin; Ayub, Shiekh Gazalla.
Título: Safety and efficacy of a novel drug elores (ceftriaxone + sulbactam + disodium edetate) in the management of multi-drug resistant bacterial infections in tertiary care centers: a post-marketing surveillance study
Fonte: Braz. j. infect. dis;21(4):408-417, July-Aug. 2017. tab.
Idioma: en.
Resumo: Abstract Objective: In India, Elores (CSE-1034: ceftriaxone + sulbactam + disodium edetate) was approved as a broad spectrum antibiotic in year 2011 and is used for management of Extended Spectrum Beta Lactamases/Metallo Beta lactamases infections in tertiary care centers. The objective of this study was to investigate the efficacy of this drug in patients with Extended Spectrum Beta Lactamases/Metallo Beta lactamases infections and identify the incidence of adverse events in real clinical settings. Methods: This Post Marketing Surveillance study was conducted at 17 centers across India and included 2500 patients of all age groups suffering from various bacterial infections and treated with Elores (CSE1034). Information regarding demographic, clinical and microbiological parameters, dosage and treatment duration, efficacy and adverse events (AEs) associated with the treatment were recorded. Results: A total of 2500 patients were included in the study and efficacy was evaluated in 2487 patients. In total, 409 AEs were reported in 211 (8.4%) patients. The major AEs reported were vomiting (3.0%), pain at injection site (2.5%), nausea (2.3%), redness at site (1.96%), thrombophlebitis (1.4%). Of total reported AEs, 40 (5.3%) AEs were reported in pediatric, 310 (20.6%) in adult, and 59 (23.6%) in geriatric group. No AE belonging to grade IV or V was reported in any patient. In terms of efficacy, 1977 (79.4%) patients were cured, 501 (20.1%) patients showed clinical improvement and 5 (0.2%) patients were complete failure. The treatment duration varied from 5 to 7 days in different patients depending on the infection type. Conclusion: In this post-marketing surveillance study, CSE-1034 was found to be an effective and safe option against Pip tazo and meropenem in management of patients with multi-drug resistant (MDR) bacterial infections under routine ward settings.
Descritores: Infecções por Bactérias Gram-Positivas/microbiologia
Infecções por Bactérias Gram-Negativas/microbiologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
-Ceftriaxona/administração & dosagem
Ceftriaxona/efeitos adversos
Sulbactam/administração & dosagem
Sulbactam/efeitos adversos
Infecções por Bactérias Gram-Positivas/tratamento farmacológico
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Ácido Edético/administração & dosagem
Ácido Edético/efeitos adversos
Farmacorresistência Bacteriana
Combinação de Medicamentos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Bactérias Gram-Negativas/classificação
Bactérias Gram-Positivas/classificação
Índia
Antibacterianos/administração & dosagem
Antibacterianos/efeitos adversos
Antibacterianos/química
Limites: Humanos
Criança
Adulto
Idoso
Responsável: BR1.1 - BIREME



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