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Id: biblio-1139682
Autor: Vieira, Luisane Maria Falci; Emery, Eduardo; Andriolo, Adagmar.
Título: COVID-19: laboratory diagnosis for clinicians. An updating article
Fonte: Säo Paulo med. j;138(3):259-266, May-June 2020. tab.
Idioma: en.
Resumo: ABSTRACT COVID-19 (coronavirus disease 2019) is an infectious disease caused by the new coronavirus associated with severe acute respiratory syndrome 2 (SARS-CoV-2). Coronaviridae comprises a large family, of which at least seven members are known to cause respiratory diseases in humans. Coronaviruses have the ability to infect virtually all major groups of animals and, eventually, can infect humans. SARS-CoV-2 is the third coronavirus to cross the species barrier and infect humans. This virus was identified in an outbreak of pneumonia cases in Wuhan city, Hubei province, China, in December 2019. Its entire genome is inscribed on a single strand of ribonucleic acid. Some proteins present on the surface of the virus act as facilitators for its entry into host cells, while others, apparently, are related to its pathogenesis. Coronaviruses are responsible for respiratory infections in humans and some animals. The infection is often mild to moderate in intensity, but some coronaviruses may cause serious illnesses, such as severe acute respiratory syndrome (SARS), which occurred in 2002, and the Middle East respiratory syndrome (MERS). Coronaviruses can activate an excessive and unregulated immune response, which may promote SARS development. Although the lungs are one of the target organs, the hypoxia mechanism is systemic and other organs begin to suffer both through lack of oxygen and through deregulation of inflammation control mechanisms.
Descritores: Pneumonia Viral/diagnóstico
Infecções por Coronavirus/diagnóstico
Técnicas de Laboratório Clínico
Pandemias
-China
Betacoronavirus
Teste para COVID-19
SARS-CoV-2
COVID-19
Limites: Humanos
Animais
Responsável: BR1.1 - BIREME


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Id: biblio-1139713
Autor: Department of AnesthesiologyLiang, DongDong; Department of AnesthesiologyShan, YuanLu; Department of AnesthesiologyWang, Leilei.
Título: The effect of prophylactic rewarming on postoperative nausea and vomiting among patients undergoing laparoscopic hysterectomy: a prospective randomized clinical study
Fonte: Säo Paulo med. j;138(5):414-421, Sept.-Oct. 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT BACKGROUND: Postoperative nausea and vomiting (PONV) is a common complication from general anesthesia that impacts on postoperative recovery. OBJECTIVE: To evaluate prophylactic rewarming following general anesthesia, so as to decrease the incidence of PONV among patients undergoing laparoscopic hysterectomy. DESIGN AND SETTING: Prospective randomized clinical study at a hospital in China. METHODS: Sixty-two patients were randomly assigned into two groups. The forced air warming (FAW) group received pre-warmed Ringer's solution with FAW until the end of surgery. The control group received Ringer's solution without FAW. The pre-warmed Ringer's solution was stored in a cabinet set at 40 °C. The FAW tube was placed beside the patient's shoulder with a temperature of 43 °C. RESULTS: Sixty patients completed the study. The FAW group showed significant differences versus the controls regarding temperature. At 6, 24 and 48 hours postoperatively, the incidences of PONV were 53.3%, 6.7% and 3.3% in the FAW group versus 63.3%, 30% and 3.3% in the controls. VAS scores were significantly lower in the FAW group than in the controls at 24 hours (P= 0.035). Forty-item questionnaire total scores in the FAW group were significantly higher than in the controls. The physical independence and pain scores at 24 hours and emotional support and pain scores at 48 hours in the FAW group were higher than in the controls (P < 0.05). There was no difference in hemodynamics or demographics between the two groups (P > 0.05). CONCLUSIONS: Prophylactic rewarming relieved PONV and improved the quality of postoperative recovery. CHINESE CLINICAL TRIAL REGISTER (ChiCTR): ChiCTR-IOR-17012901.
Descritores: Laparoscopia/efeitos adversos
Reaquecimento
Náusea e Vômito Pós-Operatórios/prevenção & controle
Histerectomia/efeitos adversos
Histerectomia/métodos
-China
Estudos Prospectivos
Resultado do Tratamento
Limites: Humanos
Feminino
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-1289523
Autor: López Hernández, Silvia M; Du, Lu; Benítez Merino, María del Carmen; Pérez Parra, Zaadia; Padilla González, Carmen Ma.
Título: Comparación de las características de la córnea entre individuos chinos y cubanos / Comparison between corneal features of Chinese and Cuban subjects
Fonte: Rev. cuba. oftalmol;34(1):e964, 2021. tab.
Idioma: es.
Resumo: Objetivo: Comparar las características de la córnea entre individuos chinos y cubanos adultos sanos. Métodos: Se realizó un estudio observacional, descriptivo, transversal, en 120 ojos de individuos sanos (60 chinos y 60 cubanos), entre 18 y 29 años de edad, entre septiembre del año 2016 y diciembre de 2017 en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer". Se evaluó la edad, el sexo, la queratometría, la paquimetría y las características del endotelio corneal. Resultados: Predominó el sexo femenino (53,3 por ciento en los cubanos y 66,6 por ciento en los chinos). La edad promedio fue de 24,4 años en ambos grupos. La queratometría promedio resultó mayor en el grupo de estudio de cubanos, con un valor de 44,7 y 44,6 dioptrías en ambos ojos, respectivamente. El espesor corneal fue de 607,3-629,9 en los cubanos y de 575,4-607,2 en los chinos. El coeficiente de variación, la desviación estándar y la densidad celular se diferenciaron mínimamente en ambos ojos para ambas nacionalidades, y resultaron superiores en los ojos izquierdos con un coeficiente de 32,0 (±11,0) en los chinos. La desviación estándar promedio fue de 112,0 (± 36,5) en ambos grupos y en el ojo derecho la densidad celular fue 2 857,1 (± 240,0 cél/mm2) en los chinos y 2 760,0 (± 367,2) en los cubanos. El average de los cubanos estuvo entre 369,0 y 380, y para los chinos entre 352,4 y 358,4 en los ojos derecho e izquierdo. Conclusiones: Existen diferencias significativas en los valores queratométricos. El espesor corneal resulta discretamente más reducido en los chinos. El coeficiente de variación, la densidad celular, el average y la desviación estándar no presentan diferencias estadísticamente significativas(AU)

Objective: Compare the corneal features of Chinese and Cuban healthy adult subjects. Methods: A cross-sectional observational descriptive study was conducted of 120 eyes of healthy 18-29 year old individuals (60 Chinese and 60 Cuban) from September 2016 to December 2017 at Ramón Pando Ferrer Cuban Institute of Ophthalmology. The variables analyzed were sex, keratometry, pachymetry and characteristics of the corneal endothelium. Results: Female sex prevailed (53.3 percent among Cuban and 66.6 percent among Chinese subjects). Mean age was 24.4 years in both groups. Mean keratometry was higher in the Cuban group, with values of 44.7 and 44.6 diopters for both eyes, respectively. Corneal thickness was 607.3-629.9 among Cuban and 575.4-607.2 among Chinese subjects. Variation coefficient, standard deviation and cell density were minimally different between the two eyes in both groups, and were higher in left eyes of Chinese subjects with a coefficient of 32.0 (±11.0). Mean standard deviation was 112.0 (± 36.5) in both groups, whereas right eye cell density was 2 857.1 (± 240.0 cell/mm2) among Chinese and 2 760.0 (± 367.2) among Cuban subjects. Average between right and left eyes ranged from 369.0 to 380 for the Cubans and from 352.4 to 358.4 for the Chinese. Conclusions: Significant differences were found between keratometric values. Corneal thickness was slightly lower among Chinese subjects. Variation coefficient, cell density, average and standard deviation did not show any statistically significant differences(AU)
Descritores: Endotélio Corneano/diagnóstico por imagem
Contagem de Células/métodos
Paquimetria Corneana/métodos
-China
Epidemiologia Descritiva
Estudos Transversais
Cuba
Estudos Observacionais como Assunto
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1181008
Autor: Gunduz, Zahide Betül.
Título: Venous sinus thrombosis during COVID-19 infection in pregnancy: a case report
Fonte: Säo Paulo med. j;139(2):190-195, Mar.-Apr. 2021. tab, graf.
Idioma: en.
Resumo: ABSTRACT BACKGROUND: Although it is known that the new coronavirus disease (COVID-19), which was first seen in Wuhan, China, in December 2019 and has affected the whole world, mainly targets the respiratory tract, cases of this disease with a wide clinical spectrum are emerging as information is shared. CASE REPORT: We present the case of a pregnant woman who was diagnosed with venous sinus thrombosis after she developed headache and hemiparesis. Polymerase chain reaction (PCR) positivity lasted for two weeks after COVID-19 had been diagnosed. CONCLUSIONS: In patients with suspected COVID-19, especially in the presence of causes of hypercoagu- lability and presence of atypical features, venous sinus thrombosis needs to be kept in mind in making the differential diagnosis.
Descritores: Trombose Venosa/diagnóstico
SARS-CoV-2/isolamento & purificação
SARS-CoV-2/genética
COVID-19/complicações
Cefaleia/etiologia
-Paresia/etiologia
Trombose dos Seios Intracranianos/diagnóstico por imagem
China
Reação em Cadeia da Polimerase
Trombofilia
Teste para COVID-19
COVID-19/diagnóstico
Limites: Humanos
Feminino
Gravidez
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Tufik, Sérgio
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Id: biblio-1154091
Autor: Pires, Gabriel Natan; Bezerra, Andréia Gomes; Oliveira, Thainá Baenninger de; Chen, Samuel Fen I; Malfatti, Victor Davis Apostolakis; Mello, Victoria Feiner Ferreira de; Niyama, Alyne; Pinto, Vitor Luiz Selva; Andersen, Monica Levy; Tufik, Sergio.
Título: COVID-19 meta-analyses: a scoping review and quality assessment / Metanálises sobre COVID-19: revisão de escopo e análise de qualidade
Fonte: Einstein (Säo Paulo);19:eAO6002, 2021. graf.
Idioma: en.
Projeto: CAPES.
Resumo: ABSTRACT Objective: To carry out a scoping review of the meta-analyses published regarding about coronavirus disease 2019 (COVID-19), evaluating their main characteristics, publication trends and methodological quality. Methods: A bibliometric search was performed in PubMed®, Scopus and Web of Science, focusing on meta-analyses about COVID-2019 disease. Bibliometric and descriptive data for the included articles were extracted and the methodological quality of the included meta-analyses was evaluated using A Measurement Tool to Assess Systematic Reviews. Results: A total of 348 meta-analyses were considered eligible. The first meta-analysis about COVID-19 disease was published on February 26, 2020, and the number of meta-analyses has grown rapidly since then. Most of them were published in infectious disease and virology journals. The greatest number come from China, followed by the United States, Italy and the United Kingdom. On average, these meta-analyses included 23 studies and 15,200 participants. Overall quality was remarkably low, and only 8.9% of them could be considered as of high confidence level. Conclusion: Although well-designed meta-analyses about COVID-19 disease have already been published, the majority are of low quality. Thus, all stakeholders playing a role in COVID-19 deseases, including policy makers, researchers, publishers and journals, should prioritize well-designed meta-analyses, performed only when the background information seem suitable, and discouraging those of low quality or that use suboptimal methods.

RESUMO Objetivo: Realizar uma revisão de escopo das metanálises publicadas sobre a doença pelo coronavírus 2019 (COVID-19), avaliando suas principais características, tendências de publicação e qualidade metodológica. Métodos: Uma busca bibliométrica foi realizada em PubMed®, Scopus e Web of Science, com foco em metanálises sobre a doença pelo COVID-19. Foram extraídos dados bibliométricos e descritivos dos artigos incluídos, e a qualidade metodológica foi avaliada usando a ferramenta A Measurement Tool to Assess Systematic Reviews. Resultados: Um total de 348 metanálises foram consideradas elegíveis. A primeira delas foi publicada em 26 de fevereiro de 2020, e, desde então, o número dessas publicações cresceu rapidamente. A maioria foi publicada em periódicos de infectologia e virologia. Grande parte é proveniente da China, seguida dos Estados Unidos, da Itália e do Reino Unido. Em média, as metanálises incluíram 23 estudos e 15.200 participantes. Em geral, a qualidade metodológica foi baixa, e apenas 8,9% delas podem ser consideradas de algum grau de confiabilidade Conclusão: Embora algumas metanálises bem conduzidas sobre a doença pelo COVID-19 tenham sido publicadas, a maioria apresenta baixa qualidade. Todos os envolvidos na abordagem da doença pelo COVID-19, incluindo formuladores de políticas, pesquisadores, editoras e periódicos, devem dar prioridade a metanálises de alta qualidade, realizadas apenas quando os dados são viáveis, e desencorajar as de baixa qualidade ou conduzidas com métodos subótimos.
Descritores: Bibliometria
COVID-19
-Estados Unidos
China
Metanálise como Assunto
Bases de Dados Bibliográficas
Revisões Sistemáticas como Assunto
Reino Unido
Itália
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-1146257
Autor: Pedrosa, Nathália Lima; Albuquerque, Nila Larisse Silva de.
Título: Série histórica da COVID-19 em diferentes países / Historical data series of COVID-19 in different countries / Serie de datos históricos de COVID-19 en diferentes países
Fonte: Rev. enferm. UERJ;28:e50470, jan.-dez. 2020.
Idioma: en; pt.
Resumo: Objetivo: analisar casos acumulados da COVID-19 em Brasil, Espanha, Itália, China e EUA. Métodos: estudo ecológico, com uso de dados secundários. Realizou-se série temporal de casos cumulativos de COVID-19 por 28 dias, após o 100º caso confirmado de cada país (baseado nas estatísticas do Worldometer 2020). Modelos de tendência linear, exponencial, potencial e logaritmo foram testados, sendo escolhido o melhor coeficiente de determinação (R²). No Brasil, a linha de tendência foi segmentada em 1º-14º dia e 15º-28º dia. Resultados: no 100º dia, os EUA possuíam maior número de casos e o Brasil, o menor. Houve linha de tendência em sua maioria exponencial, com maior velocidade de crescimento nos EUA. No Brasil, houve tendência de crescimento mais lento no segundo período. Conclusão: as linhas de tendência calculadas demonstraram pior prognóstico para os EUA. No Brasil, o crescimento do número cumulativo de casos foi mais lento na no segundo período do estudo.

Objective: to examine cumulative cases of COVID-19 in Brazil, Spain, Italy, China, and USA. Method: in this ecological study, secondary data were used to produce time series of cumulative cases of COVID-19 over 28 days after the 100th case confirmed in each country (from Worldometer 2020 statistics). Linear, exponential, potential and logarithmic trend models were tested, and the best coefficient of determination (R²) was chosen. In Brazil, the trend line was segmented into days 1-14 and 15-28. Results: on day 100, the USA had the highest number of cases and Brazil, the lowest. The trend lines were mostly exponential, with highest growth rate in the USA. In Brazil, the growth trend was slower in the second period. Conclusion: the calculated trend lines showed a worse prognosis for the USA. In Brazil, the cumulative number of cases grew more slowly in the second period of the study.

Objetivo: examinar casos acumulados de COVID-19 en Brasil, España, Italia, China y Estados Unidos. Método: en este estudio ecológico, se utilizaron datos secundarios para producir series de tiempo de casos acumulados de COVID-19 durante 28 días después del 100o caso confirmado en cada país (de las estadísticas del Worldometer 2020). Se probaron modelos de tendencia lineal, exponencial, potencial y logarítmica y se eligió el mejor coeficiente de determinación (R²). En Brasil, la línea de tendencia se segmentó en los días 1-14 y 15-28. Resultados: el día 100, EE.UU. tuvo el mayor número de casos y Brasil, el menor. Las líneas de tendencia fueron en su mayoría exponenciales, con la tasa de crecimiento más alta en los EE. UU. En Brasil, la tendencia de crecimiento fue más lenta en el segundo período. Conclusión: las líneas de tendencia calculadas mostraron un peor pronóstico para EE. UU. En Brasil, el número acumulado de casos creció más lentamente en el segundo período del estudio.
Descritores: Infecções por Coronavirus/epidemiologia
Betacoronavirus
-Espanha/epidemiologia
Estados Unidos/epidemiologia
Brasil/epidemiologia
China/epidemiologia
Estudos de Séries Temporais
Estudos Ecológicos
Itália/epidemiologia
Limites: Humanos
Responsável: BR1366.1 - Biblioteca Biomédica B - CB/B (Odontologia e Enfermagem)


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Id: biblio-1253080
Autor: Liu, Fei; Qu, Yun-Kun; Geng, Chao; Wang, Ai-Ming; Zhang, Jia-Hong; Li, Jin-Feng; Chen e, Kai-Jian; Liu, Bo; Tian, Hong-Yan; Yang, Wen-Ping; Yu, Ye-Bing.
Título: Analysis of the population structure and genetic diversity of the red swamp crayfish (Procambarus clarkii) in China using SSR markers
Fonte: Electron. j. biotechnol;47:59-71, sept. 2020. tab, ilus, graf.
Idioma: en.
Projeto: Jiangsu Province Agricultural Science and Technology Independent Innovation Fund Project; . Jiangsu Agricultural Industry Technology System (Red Swamp Crayfish; . China Agriculture Research System; . Yancheng Institute of Technology Talent Introduction Project; . Jiangsu Science and Technology Project - Northern; . Jiangsu Science and Technology Special Project.
Resumo: BACKGROUND: Procambarus clarkii produces high-quality, delicious meat that is high in protein, low in fat, and rich in calcium and phosphorus. It has become an important aquatic resource in China. Our objectives are (i) to analyze the level of genetic diversity of P. clarkii populations; (ii) to explore the genetic differentiation (Gst); and (iii) to propose appropriate strategies for the conservation. RESULTS: In this study, Shannon's index (I) and Nei's gene diversity index (H) for P. clarkii were high (I = 0.3462 and H = 0.2325 on average and I = 0.6264, H = 0.4377 at the species level) based on the SSR markers. The expected heterozygosity value of 17 microsatellite loci in 25 crayfish populations was 0.9317, the observed heterozygosity value was 0.9121, and the observed number of alleles per locus was 2.000; and the effective number of alleles per locus was 1.8075. Among the P. clarkii populations, the inbreeding coefficient within populations (Fis) was 0.2315, overall inbreeding coefficient (Fit) was 0.4438, genetic differentiation coefficient among populations (Fst) was 0.3145 and gene differentiation (Gst) was 0.4785 based on SSR analyses. The cluster analysis results obtained by unweighted pair-group method with arithmetic mean (UPGMA) analysis, principal coordinate analysis (PCoA) and STRUCTURE analysis were similar. A mantel test showed that the isolation-by-distance pattern was not significant. CONCLUSIONS: The high Gst among P. clarkii populations is attributed to genetic drift and geographic isolation. The results indicated that more P. clarkii populations should be collected when formulating conservation and aquaculture strategies.
Descritores: Variação Genética
Repetições de Microssatélites
Astacoidea/genética
-Filogenia
China
Reação em Cadeia da Polimerase
Aquicultura
Ambiente Aquático
Áreas Alagadas
Triagem de Portadores Genéticos
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1045653
Autor: Ye, P; Wu, X; Keita, H; Zhou, W; Lin, J; Luo, Y; Hu, J; Chen, Q.
Título: Knowledge, attitudes and behaviours related to HIV/AIDS among female migrant workers in the restaurant industry in Guangzhou, China / Conocimientos, actitudes y comportamientos relacionados con el VIH/SIDA entre las trabajadoras emigrantes en la industria de restaurantes en Guangzhou, China
Fonte: West Indian med. j;62(4):329-336, 2013. tab.
Idioma: en.
Projeto: Major Science and Technology projects in Guangzhou. Guangdong Province 211 Project.
Resumo: OBJECTIVE: The goal of the present study was to assess knowledge and attitudes related to HIV/AIDS among the migrant female workers in the restaurant industry in Guangzhou City, China. METHODS: We performed a questionnaire survey using a judgmental sampling method in the health examination clinic of Yuexiu District of Guangzhou during March 2011. A total of 428 participants completed and returned the questionnaires and data were analysed by descriptive statistics, t-test, one way ANOVA, and Wilcoxon test. RESULTS: Of 428 respondents, the average score of HIV/AIDS-related knowledge was 19.6 (full marks, 26). Knowledge on HIV/AIDS among respondents was classified as poor for 8.2%, fair for 42.5%, and good for 49.3%. The average score of AIDS-related attitudes of respondents was 7.2 (full marks, 10). Most of the respondents (88.8%) had relatively positive attitudes toward AIDS. Unmarried status, ages less than 30 years old and higher levels of education had higher scores of knowledge. Among the respondents who had sex experiences, 57.7% (130/225) reported that they never or only some of the time used condom. The young, unmarried women had significantly higher proportion of condom use than those above 30 years old, and/or married ones. CONCLUSIONS: Overall, a half of respondents had only moderate and low levels of awareness about HIV/AIDS knowledge, although most of them had tolerant and positive attitudes toward HIV/AIDS. In addition, a relatively lower rate of condom use was reported. The findings indicate that there exists broad space for improvement of knowledge and behaviours toward HIV/AIDS for migrant women in China.

OBJETIVO: El objetivo del presente estudio fue evaluar los conocimientos y actitudes relacionadas con el VIH/SIDA entre las trabajadoras emigrantes en la industria de restaurantes en la ciudad de Guangzhou, China. MÉTODOS: Realizamos una encuesta en forma de cuestionario utilizando un método de muestreo a juicio en la clínica de examen de salud del distrito de Yuexiu de Guangzhou en marzo de 2011. Un total de 428 participantes llenaron y entregaron los cuestionarios, y los datos fueron analizados mediante estadísticas descriptivas, prueba t, ANOVA unidireccional, y prueba de Wilcoxon. RESULTADOS: De las 428 encuestadas, la puntuación media de los conocimientos relacionados con el VIH/SIDA fue 19.6 (puntuación máxima, 26). El conocimientos sobre el VIH/SIDA entre las encuestadas fue clasificado de pobre por el 8.2 por ciento, aceptable por el 42.5%, y bueno por el 49.3%. La puntuación promedio de las actitudes relacionadas con el SIDA entre las encuestadas fue 7.2 (puntuación máxima, 10). La mayoría de las encuestadas (88.8%) tenían actitudes relativamente positivas hacia el SIDA. El estado civil de soltero, las edades menores de 30 años, y los niveles de educación más altos, estuvieron asociados con puntuaciones más altas de conocimiento. Entre las encuestadas que tenían experiencias sexuales, el 57.7% (130/225) reportó no haber usado condones nunca, o sólo algunas veces. Las mujeres jóvenes solteras hicieron un uso del condón en proporción significativamente mayor que las mujeres mayores de 30 años, y/o las casadas. CONCLUSIONES: En general, la mitad de las encuestadas tenía sólo niveles de conciencia moderados y bajos en cuanto a conocimientos de VIH/SIDA, aunque la mayoría de ellas tenía actitudes tolerantes y positivas hacia el VIH/SIDA. Además, se reportó una tasa relativamente baja de uso del condón. Los hallazgos indican que existe un amplio espacio para mejorar tanto los conocimientos como las conductas hacia el VIH/SIDA para las mujeres emigrantes en China.
Descritores: Comportamento Sexual/estatística & dados numéricos
Migrantes/estatística & dados numéricos
Infecções por HIV/prevenção & controle
Conhecimentos, Atitudes e Prática em Saúde
-Restaurantes
Infecções por HIV/transmissão
China
Estudos Transversais
Inquéritos e Questionários
Fatores Etários
Estado Civil
Preservativos/estatística & dados numéricos
Escolaridade
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-1045583
Autor: YuanI, P; Wang, Q; Huang, R; Cao, F; Zhu, Z; Sun, D; Zhou, H; Yu, B.
Título: Clinical evaluation with self-sequential longitudinal reference intervals: pregnancy outcome and neonatal thyroid stimulating hormone level associated with maternal thyroid diseases / Evaluación clínica con intervalos de referencia longitudinal auto-secuencial: evolución clínica del embarazo y niveles de la hormona estimulante de la tiroides en neonatos asociados con enfermedades tiroideas maternas
Fonte: West Indian med. j;62(1):28-34, Jan. 2013. ilus, tab.
Idioma: en.
Resumo: OBJECTIVE: We attempted to evaluate maternal thyroid function in a new self-sequential longitudinal reference interval (SLRI) which we established recently. By this method, we analysed the correlation between pregnancy outcome, neonatal thyroid stimulating hormone (TSH) level and maternal thyroid diseases. METHODS: A total of 1744 pregnant women participated in the study and 1747 babies were born from those women (three bore twins). The levels of TSH, free thyroxine (FT4) and thyroid peroxidase antibodies (TPO-Ab) of mothers were quantified by electrochemistry immunoassay (ECL). The levels of neonatal blood TSH were detected by time-resolved fluorescence immunoassay (TRFIA). All data were collected and statistically analysed by SPSS 13.0 software. RESULTS: With our new SLRI method, we found that 0.11%~3.84% pregnant women would get thyroid diseases. Subclinical hypothyroidism was the most common maternal thyroid disorder. Being positive for thyroid peroxidase antibodies was a significant risk factor of subclinical hypothyroidism during pregnancy. The median, P2.5~P97.5, and interquartile range (IQR) of neonatal TSH (N-TSH) of 1747 babies were 2.72 mIU/L, 0.10~8.01 mIU/L and 2.62 mIU/L, respectively; 28.6% of pregnant women with thyroid diseases developed pregnancy complications. The prevalence was significantly higher than in the normal thyroid function group (p< 0.001). The levels of N-TSH were low correlated with maternal TSH levels (p < 0.05), but there were no significant correlations between N-TSH and maternal FT4 and maternal TPO-Ab (p > 0.05). CONCLUSIONS: Thyroid disorders, especially subclinical hypothyroidism, are common in pregnant women. These disorders are associated with pregnancy and fetal outcome. Routine maternal thyroid function screening is important and should be recommended.

OBJETIVO: Intentamos evaluar la función tiroidea materna en un nuevo intervalo de referencia longitudinal auto-secuencial (SLRI) que establecimos recientemente. Por este método, analizamos la correlación entre el resultado del embarazo, el nivel de la hormona estimulante de la tiroides (TSH) en neonatos, y las enfermedades tiroideas maternas MÉTODOS: Un total de 1744 mujeres embarazadas participó en el estudio y 1747 bebés nacieron de esas mujeres (tres de ellas tuvieron gemelos). Los niveles de TSH, la tiroxina libre (FT4), y los anticuerpos de la peroxidasa tiroidea (TPO-Ab) de las madres, fueron cuantificados mediante inmunoensayo electroquímico (ECL). Los niveles de TSH en la sangre de los neonatos, fueron determinados mediante inmunoensayo por fluorescencia resuelto en el tiempo (TRFIA). Todos los datos fueron recogidos y analizados estadísticamente usando el software SPSS 13.0 RESULTADOS: Con nuestro nuevo método SLRI, encontramos que 0.11%~3.84% de las mujeres embarazadas contraerán enfermedades tiroideas. El hipotiroidismo subclínico fue el trastorno de la tiroides materna más común. Ser positivo a los anticuerpos de la peroxidasa tiroidea fue un factor de riesgo significativo del hipotiroidismo subclínico durante el embarazo. La mediana, P2.5~P97.5, y el rango intercuartil (IQR) de la TSH (N-TSH) neonatal de los 1747 bebés fueron 2.72 mIU/L, 0.10~8.01 mIU/L y 2.62 mIU/L respectivamente. El 28.6% de las mujeres embarazadas que tenían enfermedades tiroideas, desarrollaron complicaciones del embarazo. La prevalencia fue significativamente más alta que en el grupo con función tiroidea normal (p < 0.001). Los niveles de N-TSH fueron bajos en correlación con los niveles de TSH maternos (p < 0.05), pero no hubo ninguna correlación significativa entre la N-TSH y la FT4 materna, y la TPO-Ab materna (p > 0.05). CONCLUSIÓNS: Los trastornos tiroideos, especialmente el hipotiroidismo, son comunes en las mujeres embarazadas.Estos trastornos se hallan asociados con el resultado del embarazo y el resultado fetal. El tamizaje de rutina de la función tiroidea materna es importante y debe recomendarse.
Descritores: Peroxidases/sangue
Complicações na Gravidez/diagnóstico
Doenças da Glândula Tireoide/diagnóstico
Tireotropina/sangue
-Complicações na Gravidez/sangue
Complicações na Gravidez/epidemiologia
Trimestres da Gravidez/sangue
Valores de Referência
Doenças da Glândula Tireoide/sangue
Doenças da Glândula Tireoide/epidemiologia
Testes de Função Tireóidea/métodos
Resultado da Gravidez
China/epidemiologia
Triagem Neonatal
Limites: Humanos
Feminino
Recém-Nascido
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-1278911
Autor: Yang, Chongzhe; Deng, Zhiyong; Li, Jie; Ren, Zhilei; Liu, Feng.
Título: Meta-analysis of the relationship between interleukin-6 levels and the prognosis and severity of acute coronary syndrome
Fonte: Clinics;76:e2690, 2021. tab, graf.
Idioma: en.
Resumo: This study aimed to explore the relationship between plasma interleukin 6 (IL-6) levels, adverse cardiovascular events, and the severity of acute coronary syndrome (ACS). A literature review was performed of studies regarding IL-6 and ACS extracted from databases including EMBASE, Cqvip, MEDLINE, Web of Knowledge, PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang data. The Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the literature. The literature was screened, its quality was evaluated, and relevant data were extracted for performing meta-analysis using RevMan software (version 5.3). A total of 524 studies were included in the initial survey. After several rounds of screening and analysis, six studies met the inclusion criteria and underwent meta-analysis using a fixed-effect model. Patients were divided into non-severe and severe groups based on the concentration of high-sensitivity C-reactive protein. Meta-analysis of the relationship between IL-6 and the severity of ACS showed that the plasma IL-6 level of patients in the severe group was significantly higher than that of patients in the non-severe group (p<0.00001). Additionally, patients with experience of major adverse cardiovascular events had significantly higher plasma IL-6 levels than did patients without experience of such events (p<0.00001). In summary, patients with ACS and high IL-6 levels tended to be in a critical condition, with a higher risk of adverse cardiovascular events and worse prognosis. Thus, IL-6 levels could indicate whether patients with ACS may have adverse cardiovascular events and determine the severity of ACS.
Descritores: Interleucina-6
Síndrome Coronariana Aguda
-Prognóstico
Proteína C-Reativa
China
Limites: Humanos
Tipo de Publ: Revisão
Metanálise
Responsável: BR1.1 - BIREME



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