Base de dados : LILACS
Pesquisa : D02.033.455.706.690 [Categoria DeCS]
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Id: lil-402665
Autor: Gerová, M; Kristek, F; Cacányiová, S; Cebová, M.
Título: Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;38(6):959-966, June 2005. ilus, tab.
Idioma: en.
Projeto: VEGA.
Resumo: Discrepancy was found between enhanced hypotension and attenuated relaxation of conduit arteries in response to acetylcholine (ACh) and bradykinin (BK) in nitric oxide (NO)-deficient hypertension. The question is whether a similar phenomenon occurs in spontaneously hypertensive rats (SHR) with a different pathogenesis. Wistar rats, SHR, and SHR treated with NO donors [molsidomine (50 mg/kg) or pentaerythritol tetranitrate (100 mg/kg), twice a day, by gavage] were studied. After 6 weeks of treatment systolic blood pressure (BP) was increased significantly in experimental groups. Under anesthesia, the carotid artery was cannulated for BP recording and the jugular vein for drug administration. The iliac artery was used for in vitro studies and determination of geometry. Compared to control, SHR showed a significantly enhanced (P < 0.01) hypotensive response to ACh (1 and 10 æg, 87.9 ± 6.9 and 108.1 ± 5.1 vs 35.9 ± 4.7 and 64.0 ± 3.3 mmHg), and BK (100 æg, 106.7 ± 8.3 vs 53.3 ± 5.2 mmHg). SHR receiving NO donors yielded similar results. In contrast, maximum relaxation of the iliac artery in response to ACh was attenuated in SHR (12.1 ± 3.6 vs 74.2 ± 8.6 percent in controls, P < 0.01). Iliac artery inner diameter also increased (680 ± 46 vs 828 ± 28 æm in controls, P < 0.01). Wall thickness, wall cross-section area, wall thickness/inner diameter ratio increased significantly (P < 0.01). No differences were found in this respect among SHR and SHR treated with NO donors. These findings demonstrated enhanced hypotension and attenuated relaxation of the conduit artery in response to NO activators in SHR and in SHR treated with NO donors, a response similar to that found in NO-deficient hypertension.
Responsável: BR1.1 - BIREME


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Id: lil-53718
Autor: Ramos Emperador, Carlos; Supervielle Mesquida, Luis; Fernández Magriñat, Roberto; Rivero Varona, Martha; Toruncha Chukram, Alberto; Felipe Perea, Ernesto.
Título: Eficacia del tetranitrato de pentaeritritol en pacientes con angina de esfuerzo estable / Efficiency of pentaerythritol tetranitrate in patients with stable angina
Fonte: Rev. cuba. cardiol. cir. cardiovasc;1(2):51-8, jul.-dic. 1987. tab.
Idioma: es.
Resumo: Se estudiaron 18 pacientes (13 hombres) con una edad promedio de 57 años, los cuales presentaron angina de esfuerzo estable. Se realizó la prueba ergométrica sin tratamiento y después se administró un ciclo de tetranitrato de pentaeritritol y otro de propranolol durante 14 días; al finalizar cada uno se repitió la prueba de esfuerzo. La dosis de tetranitrato de pentaeritritol fluctuó entre 120 y 240 mg y la dosis media de propranolol fue de 122 mg. Ambos medicamentos prolongaron el tiempo total de ejercicio, redujeron el desnivel del segmento RS-T y el doble producto. No hubo diferencias significativas al comparar las 2 drogas. Los resultados sugieren que el tetranitrato de pentaeritritol mejora la capoacidad de esfuerzo físico en pacientes con angina de esfuerzo estable, por lo que se considera útil en el tratamiento de esta afección
Responsável: CU1 - INFOMED - Centro Nacional de Información de Ciencias Médicas



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