Base de dados : LILACS
Pesquisa : D12.776.124.486.485 [Categoria DeCS]
Referências encontradas : 604 [refinar]
Mostrando: 1 .. 10   no formato [Longo]

página 1 de 61 ir para página                         

  1 / 604 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Machado, Luís dos Ramos
Livramento, José Antonio
Id: lil-154959
Autor: Carvalho, Otávio Augusto Moreno de.
Título: Reaçöes cruzadas e falso positivas no LCR em neuroinfecçäo / Cross and false positive reactions at the CSF in neuroinfection
Fonte: In: Machado, Luis dos Ramos; Nóbrega, José Paulo Smith; Livramento, José Antonio; Spina França Netto, Antonio. Neuroinfecçäo 94. Säo Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de Säo Paulo. Clínica Neurológica, 1994. p.74-74, tab.
Idioma: pt.
Conferência: Apresentado em: Simpósio Neuroinfecçäo-94, Säo Paulo, 18-19 mar. 1994.
Responsável: BR1.1 - BIREME
BR1.1; 2617.14; BR599.1; 10001009554, AG


  2 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-623604
Autor: Sadigursky, Moysés; Von Kreuter, Betsy F; Santos-Buch, Charles A.
Título: Development of Chagasic autoimmune myocarditis associated with anti-idiotype reaction
Fonte: Mem. Inst. Oswaldo Cruz;83(supl.1):363-366, Nov. 1988. graf.
Idioma: en.
Conferência: Apresentado em: Annual Meeting on Basic Research in Chagas's disease, 15, Apresentado em: Meeting of the Brazilian Society of Protozoology4, Caxambu, 7-10 Nov. 1988.
Responsável: BR1.1 - BIREME


  3 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-954857
Autor: Squaiella-Baptistão, Carla Cristina; Magnoli, Fábio Carlos; Marcelino, José Roberto; Sant'Anna, Osvaldo Augusto; Tambourgi, Denise V.
Título: Quality of horse F(ab')2 antitoxins and antirabies immunoglobulins: protein content and anticomplementary activity
Fonte: J. venom. anim. toxins incl. trop. dis;24:16, 2018. tab, ilus.
Idioma: en.
Projeto: FAPESP.
Resumo: Among other applications, immunotherapy is used for the post-exposure treatment and/or prophylaxis of important infectious diseases, such as botulism, diphtheria, tetanus and rabies. The effectiveness of serum therapy is widely proven, but improvements on the immunoglobulin purification process and on the quality control are necessary to reduce the amount of protein aggregates. These may trigger adverse reactions in patients by activating the complement system and inducing the generation of anaphylatoxins. Herein, we used immunochemical methods to predict the quality of horse F(ab′)2 anti-botulinum AB, anti-diphtheric, antitetanic and anti-rabies immunoglobulins, in terms of amount of proteins and protein aggregates. Methods Samples were submitted to protein quantification, SDS-PAGE, Western blot analysis and molecular exclusion chromatography. The anticomplementary activity was determined in vitro by detecting the production of C5a/C5a desArg, the most potent anaphylatoxin. Data were analyzed by one-way ANOVA followed by Tukey's post-test, and differences were considered statistically significant when p < 0.05. Results Horse F(ab′)2 antitoxins and anti-rabies immunoglobulin preparations presented different amounts of protein. SDS-PAGE and Western blot analyses revealed the presence of protein aggregates, non-immunoglobulin contaminants and, unexpectedly, IgG whole molecules in the samples, indicating the non-complete digestion of immunoglobulins. The chromatographic profiles of antitoxins and anti-rabies immunoglobulins allowed to estimate the percentage of contaminants and aggregates in the samples. Although protein aggregates were present, the samples were not able to induce the generation of C5a/C5a desArg in vitro, indicating that they probably contain acceptable levels of aggregates. Conclusions Anti-botulinum AB (bivalent), anti-diphtheric, antitetanic and anti-rabies horse F(ab′)2 immunoglobulins probably contain acceptable levels of aggregates, although other improvements on the preparations must be carried out. Protein profile analysis and in vitro anticomplementary activity of F(ab′)2 immunoglobulin preparations should be included as quality control steps, to ensure acceptable levels of aggregates, contaminants and whole IgG molecules on final products, reducing the chances of adverse reactions in patients.(AU)
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação


  4 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Id: lil-90902
Autor: Cairutas, Cândida Mendes.
Título: Componentes e derivados do sangue para uso terapêutico / Blood components and derivatives for terapeutic use.
Fonte: s.l; Ed. Universitária; 1985. 379 p. tab.
Idioma: pt.
Responsável: BR1.1 - BIREME
BR1.1/1627.00; BR599.1; 615.38, C136c, AG. 10001008523


  5 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Albernaz, Pedro Luiz Mangabeira
Id: lil-263074
Autor: Fukuda, Yotaka; Neves, Beatrice Maria Jordäo; Cunha, José da; Albernaz, Pedro Luiz Mangabeira.
Título: Estudo clínico-imunológico da eficácia de timomodulina (Leucogen©) na otite média aguda recorrente e na amigdalite de repetição / Assessment of efficacy and safety of thymomodulin (Leucogen©) in the prevention of recurrent otitis media and recurrent tonsillitis
Fonte: Pediatr. mod;35(10):828-34, out. 1999. tab, graf.
Idioma: pt.
Resumo: Os autores realizaram estudo em 35 crianças portadoras de otite média aguda recorrente e amigdalite de repetiçäo em um estudo duplo-cego com timomodulina e placebo. As crianças tratadas com timomodulina© receberam 4mg/kg/dia do medicamento diariamente durante três meses. Foi realizado controle bioquímico antes do tratamento e com cinco meses e nove meses após o término do tratamento. Além da avaliaçäo clínica foram realizados os seguintes exames: hemograma, TGO, TGP dosagem de IgA, IgG, IgM e IgE antes do início do tratamento e nos controles. Os resultados evidenciaram tendência à diminuiçäo do número de infecçöes e o número de ciclos de antibióticos, em relaçäo a informaçäo do último ano (pré-tratamento), principalmente no grupo tratado com timomodulina, assim como tendência ao aumento do IgA e IgG após tratamento com timomodulina, o que näo ocorreu no grupo placebo. Os exames laboratoriais, contagem de eritrócitos, de hematócrito, hemoglobina, leucócitos e transaminases (TGO e TGP) näo mostraram diferenças entre os grupos, nem alteraçöes 12 meses após o início da medicaçäo, evidenciando a ausência total de toxicidade da timomodulina. Houve apenas um efeito colateral com o uso de timomodulina (náusea e vômito) numa criança com amigdalite purulenta que tomou cefalexina concomitantemente
Responsável: BR11.1 - Biblioteca


  6 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Costa, Holmes Campanelli
Souza, Luiz Carlos Duarte de
Id: lil-120672
Autor: Costa, Holmes Campanelli; Souza, Luiz Carlos Duarte de; Dalpino, Dirceu.
Título: Avaliaçäo imunológica em crianças mal nutridas portadoras de enteroparasitos / Immunological evaluation in malnourished children carried of enteroparasites
Fonte: Rev. Salusvita (Impr.);9(1):81-95, 1990. tab.
Idioma: pt.
Resumo: Os autores estudaram os níveis séricos de IgA, IgG, IgM, C3 e C4 em crianças, com graus diferentes de desnutriçäo, portadoras de paristoses intestinais, atendidas na Clínica de Educaçäo Para a Saúde, da Universidade do Sagrado Coraçäo, Bauru - SP. Concluíram que, embora pareça paradoxal, a IgG é mais elevada à medida que aumenta o grau de desnutriçäo. A IgA sérica decresce à medida que aumenta a desnutriçäo, enquanto que a IgM apresenta poucas variaçöes nos 3 grupos estudados. A atividade do sistema complemento é maior no grupo de indivíduos mais desnutridos, ocorrendo níveis séricos mais elevados do que os parâmetros normais para indivíduos sadios
Responsável: BR1.1 - BIREME


  7 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Arruda, Maria Sueli Parreira de
Costa, Holmes Campanelli
Souza, Luiz Carlos Duarte de
Id: lil-60142
Autor: Arruda, Maria Sueli Parreira de; Costa, Holmes Campanelli; Souza, Luiz Carlos Duarte de; Nobre, Lourdes A. Santos.
Título: Avaliaçäo das imunoglobulinas séricas em pacientes com hanseniase virchoviana / Serum immunoglobulin evaluation in virchowean leprosy patients
Fonte: Rev. Salusvita (Impr.);6(1):96-101, 1987. tab.
Idioma: pt.
Resumo: Com o objetivo de averiguar o possível envolvimento das imunoglobulinas (Ig) na reaçäo de Rubino, 33 pacientes virchovianos foram avaliados quanto aos níveis de IgG e IgM séricos. Os resultados sugerem o näo envolvimento destas classes de Ig na reaçäo de Rubino
Responsável: BR1.1 - BIREME


  8 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
Id: biblio-1005300
Autor: Montaño E, Dolly E; Alvarado R, Moisés G; Burgos Q, Maritza J.
Título: Validación del método de formación de coágulo para la determinación de endotoxinas bacterianas en inmunoglobulinas (IgG) nacionales / Method validation clot formation for determining bacterial endotoxins national immunoglobulin (IgG)
Fonte: Rev. Inst. Nac. Hig;47(1-2):41-48, 2016. graf, tab.
Idioma: es.
Resumo: Las endotoxinas bacterianas son lipopolisacáridos (LPS) localizados exclusivamente en la membrana externa de las bacterias gramnegativas, su ingreso al organismo a través de productos parenterales puede causar fiebre, taquicardia, aumento de presión sanguínea y en algunos casos ocasiona la muerte. Existen normativas internacionales acerca del límite de endotoxina para productos farmacéuticos inyectables, tal como las inmunoglobulinas (IgG), que pueden estar expuestas a contaminación durante el proceso de producción y por lo tanto es necesario realizar pruebas para la determinación de endotoxinas bacterianas. El método del lisado de amebocitos de Limulus (LAL) es una de ellas.Este método se fundamenta en la reacción del LAL, el cual es un extracto de células sanguíneas que interaccionan con endotoxinas, activando la cascada del proceso de coagulación y originando la formación de la coagulina. En diversas ocasiones algunas proteínas intervienen en la activación o desactivación de esta cascada, bien sea potenciando o inhibiendo la formación del coágulo. En el caso de la potenciación, el calentamiento es uno de los métodos recomendados por la farmacopea estadounidense (USP) para eliminar interferencias, puesto que desnaturaliza las proteínas que causan la potenciación sin pérdida de endotoxinas. En este trabajo se validó la determinación de endotoxinas bacterianas en IgG mediante el método LAL, el cual es un método rápido y de fácilejecución, por lo que puede implementarse como ensayo de rutina en control de calidad y por ende nos permite agilizar las Liberaciones de Lotes de estos productos.

Bacterial endotoxins are lipopolysaccharides (LPS) located exclusively in the outer membrane of gram-negative bacteria, their entry into the body through parenteral products can cause fever, tachycardia, increased blood pressure and in some cases cause death. There are international standards for endotoxin limit for injectable pharmaceuticals, such as immunoglobulins (IgG), which may be exposed to contamination during the production process and therefore it is necessary to test for determination of bacterial endotoxins. The method of the Limulus amebocyte lysate (LAL) is one of them. This method is based on the LAL reaction, which is an extract of blood cells which interact with endotoxin, triggering the cascade of the coagulation process and causing the formation of coagulin. On several occasions some proteins involved in the activation or deactivation of this waterfall, either by enhancing or inhibiting clot formation. In the case of empowerment, the warming is one of those recommended by the US Pharmacopoeia (USP) to eliminate interference, since denatures proteins that cause endotoxin enhancement lossless methods. In this paper the determination of bacterial endotoxins in IgG was standardized by the LAL method, which is quick and easy to implement method, which can be implemented as a routine test in quality control and thus allows us to streamline releases Lots of these products.
Responsável: VE9.1 - Biblioteca


  9 / 604 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Battistella, Linamara Rizzo
Texto completo
Id: lil-704981
Autor: Tuacek, Tatiana Amadeo; Tsukimoto, Gracinda Rodrigues; Figliolia, Carmen Silvia; Cardoso, Maiara Celina de Carvalho; Tsukimoto, Denise Rodrigues; Rosa, Chennyfer Dobbins Paes; Imamura, Marta; Battistella, Linamara Rizzo.
Título: Neuropatias: Síndrome de Guillain-Barré: reabilitação / Neuropathies: Guillain-Barré syndrome: rehabilitation
Fonte: Acta fisiátrica;20(2), jun. 2013.
Idioma: pt.
Resumo: A estratégia de busca utilizada baseou-se em perguntas estruturadas na forma P.I.C.O. (das iniciais "Paciente", "Intervenção", "Controle", "Outcome"). Foram utilizados como descritores: Exercise, Physical OR Physical Exercise OR Physical Exercises OR prevention and control OR preventive therapy OR preventive measures OR prophylaxis OR preventions OR control OR Guillain-Barre Syndrome OR Syndrome, Guillain-Barre OR Guillaine-Barre Syndrome OR Guillaine Barre Syndrome OR Syndrome, Guillain Barre OR Polyneuropathy, Acute Inflammatory OR Acute Autoimmune Neuropathy OR Acute Autoimmune Neuropathies OR Plasmaphereses OR Plasmapheresis OR Plasma Exchange OR Immunoglobulins/therapeutic use OR Immunoglobulins/administration and dosage OR Exercise Therapy OR Physical Therapy OR Physical Therapies OR Exercise therapies OR Resistant Training OR Strength Training OR rehabilitation OR Splints OR Splint OR Orthopedic Fixation Devices OR Orthotic Devices OR device orthotic OR devices orthotic OR Orthoses OR Orthosis OR Upper Extremity OR Upper Extremities OR Upper Limb OR Upper limbs OR Membrum Superius OR Extremities, Upper OR Limb, Upper OR Limbs, Upper OR hand deformities OR Hand Deformities, acquired OR Rehabilitation OR Lower Extremity OR Extremities, Lower OR Lower Extremities OR Lower Limb OR Limb, Lower OR Lower Limbs OR Membrum Inferius OR Walking OR Ambulation OR dependent ambulation OR Ambulation, Dependent OR gait OR gaits OR Functional Electrical Stimulation OR Electrical Stimulation, Functional OR Fes OR Electric Stimulation Therapy OR Stimulation Therapy, Electric OR Therapeutic Electrical Stimulation OR Electrical Stimulation, Therapeutic OR Stimulation, Therapeutic Electrical OR Therapy, Electric Stimulation OR Therapeutic Electric Stimulation OR Electric Stimulation, Therapeutic OR Stimulation, Therapeutic Electric OR Electrical Stimulation Therapy OR Stimulation Therapy, Electrical OR Therapy, Electrical Stimulation OR Self-help devices OR Self-help device OR Device, Self-Help device OR Assistive Technology OR Assistive Technologies OR Technologies, Assistive OR Technology, Assistive OR Assistive Devices OR Assistive Device OR Device, Assistive OR Devices, Assistive OR daily activities OR daily activity OR activity of daily living OR activities of daily living OR activities of self care OR activity of self care OR usual activities OR usual activity OR usual activity of daily living OR usual activities of daily living OR Patient Positioning OR Patient Positionings OR Positioning, Patient OR Positionings, Patient OR pressure ulcer OR pressure ulcer/prevention & control OR Guillain-Barre OR Guillain-Barre Syndrome/therapy* OR Guillain-Barre Syndrome/rehabilitation* OR Nursing care OR Pressure Ulcer OR Pressure Ulcers OR Pressure Sore OR Pressure Sores OR Decubitus ulcer OR Bed sore OR Bedsore OR Weaning Mechanical Ventilation OR Extubation OR Mechanical Ventilation Predictors OR Weaning Mechanical Ventilator Predictors OR Extubation Predictors.

The search strategy used was based on structured questions in the P.I.C.O. format (from the initials: Patient, Intervention, Control and Outcome). The descriptors used were: Exercise, Physical OR Physical Exercise OR Physical Exercises OR prevention and control OR preventive therapy OR preventive measures OR prophylaxis OR preventions OR control OR Guillain-Barre Syndrome OR Syndrome, Guillain-Barre OR Guillaine-Barre Syndrome OR GuillaineBarre Syndrome OR Syndrome, GuillainBarre OR Polyneuropathy, Acute Inflammatory OR Acute Autoimmune Neuropathy OR Acute Autoimmune Neuropathies OR Plasmaphereses OR Plasmapheresis OR Plasma Exchange OR Immunoglobulins/therapeutic use OR Immunoglobulins/administration and dosage OR Exercise Therapy OR Physical Therapy OR Physical Therapies OR Exercise therapies OR Resistant Training OR Strength Training OR rehabilitation OR Splints OR Splint OR Orthopedic Fixation Devices OR Orthotic Devices OR device orthotic OR devices orthotic OR Orthoses OR Orthosis OR Upper Extremity OR Upper Extremities OR Upper Limb OR Upper limbs OR Membrum Superius OR Extremities, Upper OR Limb, Upper OR Limbs, Upper OR hand deformities OR Hand Deformities, acquired OR Rehabilitation OR Lower Extremity OR Extremities, Lower OR Lower Extremities OR Lower Limb OR Limb, Lower OR Lower Limbs OR Membrum Inferius OR Walking OR Ambulation OR dependent ambulation OR Ambulation, Dependent OR gait OR gaits OR Functional Electrical Stimulation OR Electrical Stimulation, Functional OR Fes OR Electric Stimulation Therapy OR Stimulation Therapy, Electric OR Therapeutic Electrical Stimulation OR Electrical Stimulation, Therapeutic OR Stimulation, Therapeutic Electrical OR Therapy, Electric Stimulation OR Therapeutic Electric Stimulation OR Electric Stimulation, Therapeutic OR Stimulation, Therapeutic Electric OR Electrical Stimulation Therapy OR Stimulation Therapy, Electrical OR Therapy, Electrical Stimulation OR Self-help devices OR Self-help device OR Device, Self-Help device OR Assistive Technology OR Assistive Technologies OR Technologies, Assistive OR Technology, Assistive OR Assistive Devices OR Assistive Device OR Device, Assistive OR Devices, Assistive OR daily activities OR daily activity OR activity of daily living OR activities of daily living OR activities of self care OR activity of self care OR usual activities OR usual activity OR usual activity of daily living OR usual activities of daily living OR Patient Positioning OR Patient Positionings OR Positioning, Patient OR Positionings, Patient OR pressure ulcer OR pressure ulcer/prevention & control OR Guillain-Barre OR Guillain-Barre Syndrome/therapy* OR Guillain-Barre Syndrome/rehabilitation* OR Nursing care OR Pressure Ulcer OR Pressure Ulcers OR Pressure Sore OR Pressure Sores OR Decubitus ulcer OR Bed sore OR Bedsore OR Weaning Mechanical Ventilation OR Extubation OR Mechanical Ventilation Predictors OR Weaning Mechanical Ventilator Predictors OR Extubation Predictors.
Responsável: BR1.1 - BIREME


  10 / 604 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1012759
Autor: Filippo, Paula A. Di; Lannes, Saulo T; Meireles, Marcos A. D; Nogueira, Andressa F. S; Quirino, Célia R.
Título: Concentrations of acute-phase proteins and immunoglobulins in serum and synovial fluid in clinically healthy heifers and steers / Concentração de proteínas de fase aguda e de imunoglobulinas no soro e no líquido sinovial de bovinos clinicamente saudáveis
Fonte: Pesqui. vet. bras = Braz. j. vet. res;39(6):388-392, June 2019. tab.
Idioma: en.
Resumo: The aim of the study was to determine the concentration pattern of intra-articular acute phase proteins (APPs) and immunoglobulins in healthy crossbred cattle. Synovial fluid (SF) samples were collected from the radiocarpal joint of 25 heifers and 25 steers. Concentrations of APPs were measured by SDS-PAGE. The results were submitted to analysis of variance using the SAS statistical program, and means were compared by the Student-Newman-Keuls test (P<0.05). Thirty-seven proteins with molecular weights ranging from 7 to 37kDa were identified in SF of all animals. Eight were nominally identified with immunoglobulin A (IgA) and G (IgG), ceruloplasmin (Cp), transferrin (Tf), albumin (Ab), α1-antitripsin (AAT), α1-acid glycoprotein (AGP), and haptoglobin (Hp). The α1-antitripsin was only identified in the Sf of the heifers. The SF values of Cp, Hp, AGP and IgA were significantly higher in heifers than in steers. In sera, 34 proteins with molecular weights between 7 and 244kDa were identified in heifers and steers. Similar proteins were nominally identified in the sera, however the α1-antitrypsin was identified only in SF. The serum values Tf, AGP and IgG were significantly higher in heifers compared with steers. In conclusion, the physiological acute-phase proteins concentrations in synovial fluid of healthy ruminants can be useful in the interpretation of samples from animals with joint diseases. The SF electrophoretic profile of healthy ruminants differs depending on gender. Similar proteins were nominally identified in the sera, but only the SF of α1-antitrypsin.(AU)

O objetivo do estudo foi determinar o padrão de concentração de proteínas de fase aguda e de imunoglobulinas intra-articulares (APPs) em bovinos mestiços saudáveis. As amostras de fluido sinovial (SF) foram coletadas da articulação radiocárpica de 25 novilhas e 25 novilhos. As concentrações de APPs foram mensuradas por SDS-PAGE. Os resultados foram submetidos à análise de variância usando o programa estatístico SAS, e os meios foram comparados pelo teste Student-Newman-Keuls (P<0,05). Trinta e sete proteínas com pesos moleculares variando de 7 a 37kDa foram identificadas no SF de todos os animais. Oito foram nominalmente identificadas como imunoglobulina A (IgA) e G (IgG), ceruloplasmina (Cp), transferrina (Tf), albumina (Ab), a1-antitripsina (AAT), glicoproteína a1-ácido (AGP) e haptoglobina (Hp). A α1-antitripsina foi identificada apenas no SF das novilhas. Os valores de Cp, Hp, AGP e IgA no SF foram significativamente maiores em novilhas do que em novilhos. No soro, 34 proteínas com pesos moleculares entre 7 e 244kDa foram identificadas nas novilhas e novilhos. Proteínas similares foram identificadas nos soros, mas apenas o SF das novilhas apresentou a α1-antitripsina. Os valores séricos de Tf, AGP e IgG foram significativamente maiores em novilhas em relação aos novilhos. Conclui-se que a mensuração das concentrações das proteínas da fase aguda no líquido sinovial de animais saudáveis pode ser útil na avaliação de amostras oriundas de bovinos com afecções articulares. O perfil eletroforético do SF de ruminantes saudáveis difere em função do gênero e as diferenças devem ser levadas em consideração na interpretação dos achados.(AU)
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice



página 1 de 61 ir para página                         
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde