Base de dados : LILACS
Pesquisa : D12.776.765.199.499 [Categoria DeCS]
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Texto completo SciELO Brasil
Possas, Cristina de Albuquerque
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Id: lil-741621
Autor: Martins, Reinaldo de Menezes; Possas, Cristina de Albuquerque; Homma, Akira.
Título: Historical review of clinical vaccine studies at Oswaldo Cruz Institute and Oswaldo Cruz Foundation - technological development issues
Fonte: Mem. Inst. Oswaldo Cruz;110(1):114-124, 03/02/2015. tab.
Idioma: en.
Resumo: This paper presents, from the perspective of technological development and production, the results of an investigation examining 61 clinical studies with vaccines conducted in Brazil between 1938-2013, with the participation of the Oswaldo Cruz Institute (IOC) and the Oswaldo Cruz Foundation (Fiocruz). These studies have been identified and reviewed according to criteria, such as the kind of vaccine (viral, bacterial, parasitic), their rationale, design and methodological strategies. The results indicate that IOC and Fiocruz have accumulated along this time significant knowledge and experience for the performance of studies in all clinical phases and are prepared for the development of new vaccines products and processes. We recommend national policy strategies to overcome existing regulatory and financing constraints.
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-468185
Autor: Leitao, Louis; Maoret, Jean-José; Biolley, Jean-Philippe.
Título: Changes in PEP Carboxylase, Rubisco and Rubisco activase mRNA levels from maize (Zea mays) exposed to a chronic ozone stress
Fonte: Biol. Res;40(2):137-153, 2007. graf, tab.
Idioma: en.
Resumo: We quantified the ozone impact on levels of Zea mays L. cv. Chambord mRNAs encoding C4-phosphoenolpyruvate carboxylase (C4-PEPc), ribulose-l,5-bisphosphate carboxylase/oxygenase small and large subunits (Rubisco-SSU and Rubisco-LSU, respectively) and Rubisco activase (RCA) using real-time RT-PCR. Foliar pigment content, PEPc and Rubisco protein amounts were simultaneously determined. Two experiments were performed to study the ozone response of the 5th and the 10th leaf. For each experiment, three ozone concentrations were tested in open-top chambers: non-filtered air (NF, control) and non-filtered air containing 40 (+40) and 80 nL L-1 (+80) ozone. Regarding the 5th leaf, +40 atmosphere induced a loss in pigmentation, PEPc and Rubisco activase mRNAs. However, it was unable to notably depress carboxylase protein amounts and mRNAs encoding Rubisco. Except for Rubisco mRNAs, all other measured parameters from 5th leaf were depressed by +80 atmosphere. Regarding the 10th leaf, +40 atmosphere increased photosynthetic pigments and transcripts encoding Rubisco and Rubisco activase. Rubisco and PEPc protein amounts were not drastically changed, even if they tended to be increased. Level of C4-PEPc mRNA remained almost stable. In response to +80 atmosphere, pigments and transcripts encoding PEPc were notably decreased. Rubisco and PEPc protein amounts also declined to a lesser extent. Conversely, the level of transcripts encoding both Rubisco subunits and Rubisco activase that were not consistently disturbed tended to be slightly augmented. So, the present study suggests that maize leaves can respond differentially to a similar ozone stress.
Responsável: BR1.1 - BIREME


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Id: lil-310754
Autor: Gómez García, Felipe.
Título: Eficacia del tratamiento farmacológico de osteoporosis en la prevención de fracturas / Pharmacological treatment efficacy in osteoporosis for prevention of fractures
Fonte: Rev. mex. ortop. traumatol;15(2):78-93, mar.-abr. 2001. tab.
Idioma: es.
Resumo: En el presente artículo se hace una exhaustiva revisión bibliográfica de las investigaciones y resultados clínicos de las drogas más utilizadas para el tratamiento de la osteoporosis, así como de la efectividad de cada una de ellas para prevenir una fractura. También se discuten los problemas más importantes para prevenir, diagnosticar y tratar esta enfermedad con un costo beneficio razonable. Al final se discuten algunas estrategias y sugerencias para definir si es necesaria o no una intervención farmacológica, y si ésta se considera necesaria, de qué tipo debe ser.
Responsável: MX1.1 - CENIDSP - Centro de Información para Decisiones en Salud Pública



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