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Id: biblio-899577
Autor: Tobar, Marco; Basante, Roberto; Guerrero, María.
Título: Fibrosis endomiocárdica crónica: reporte de caso en área no endémica / Chronic endomyocardial fibrosis: case report in a non-endemic area
Fonte: Rev. chil. cardiol;36(2):127-131, 2017. ilus, tab.
Idioma: es.
Resumo: Endomyocardial fibrosis is a known and prevalent cause of restrictive cardiomyopathy in countries of Equatorial Africa, but very rare elsewhere. Although the diagnosis in endemic countries is established by the presence of certain echocardiographic criteria, the gold standard is the endomyocardial biopsy, which shows fibrous tissue in the endocardium. An acute and subacute phase can be distinguished, with associated mortality due to complications of heart failure. In contrast, the chronic phase presents less aggressive behavior, with progression of symptoms. In this phase, surgical treatment may improve survival. We present the case of a 44-year-old patient with good clinical control under pharmacological treatment after 14 months of follow-up.
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Id: biblio-1013850
Autor: Guzmán F, Patricia; Messina, Antonella.
Título: Cáncer de próstata, el problema del diagnóstico ¿es la resonancia multiparamétrica de próstata la solución? / Prostate cancer, the problem of diagnosis. is multiparametric prostate magnetic resonance imaging the solution?
Fonte: Rev. chil. radiol;25(2):60-66, jun. 2019. tab, ilus.
Idioma: es.
Resumo: Resumen: Junto con un aumento sostenido en la incidencia de cáncer de próstata en los países desarrollados ha habido un cambio en el enfrentamiento diagnóstico en estos pacientes. El diagnóstico tradicional basado en la medición del antígeno prostático específico y la biopsia randomizada ha mostrado tener muchas falencias ya que sobre-diagnostica cánceres no significativos y sub-diagnostica cánceres clínicamente significativos. La resonancia magnética de próstata multiparamétrica ha demostrado ser útil ya que disminuye este tipo de falencias. En este artículo se revisará la historia de la resonancia magnética de próstata y del PI-RADS, con el objeto de revisar el rendimiento de estos métodos y sus indicaciones actuales.

Abstract: Along with a sustained increase in the incidence of prostate cancer in developed countries, there has been a change in the diagnostic approach in these patients. The traditional diagnosis based on the measurement of the specific prostate antigen and randomized biopsy has shown to have many shortcomings as it leads to overdiagnosis of non-significant cancers and underdiagnosis of clinically significant cancers. The multiparametric prostate magnetic resonance imaging has proven to be useful since it diminishes these shortcomings. In this article we will review part of the history of prostate magnetic resonance imaging and PI-RADS, in order to review the performance of these methods and their current indications.
Responsável: CL30.1 - Biblioteca


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Id: biblio-1014992
Autor: Herrera Gana, Ana María.
Título: Diagnóstico de la discinecia ciliar primaria / Diagnosis of the primary ciliary dyskinesia
Fonte: Neumol. pediátr. (En línea);14(2):76-80, jul. 2019. ilus.
Idioma: es.
Resumo: Primary ciliary dyskinesia is a congenital disorder due to abnormal motile ciliary function, especially in the airway epithelium. The mucociliary clearance is impaired, producing reoccurring respiratory tract infections, usually resulting in bronchiectasis as an adult. Patients also have frequent ear and sinus infections and almost 50% of them have situs inversus. Diagnosis of primary ciliary dyskinesia is difficult because there is not a single gold standard test, resulting in the need of a multi-test approach. Until recently in our country we only had transmission electron microscopy, but nasal nitric oxide and high speed video microscopy are now available. In this article we will detail the most important clinical characteristics that make us suspect the presence of primary ciliary dyskinesia at different ages and the methods available for its diagnosis.

La discinesia ciliar primaria es una enfermedad congénita debida a una alteración del movimiento normal de los cilios, especialmente a nivel del epitelio respiratorio. Esto se traduce en una alteración del clearance mucociliar lo que predispone al paciente a tener infecciones respiratorias repetidas, terminando en la aparición de bronquiectasias en la edad adulta. También son frecuentes las infecciones repetidas de oídos y cavidades perinasales. La presencia de situs inverso puede verse en hasta en 50% de los pacientes con esta enfermedad. El diagnóstico de discinesia ciliar primaria es difícil ya que no existe un examen que sea considerado patrón de oro, por lo que se requiere la realización de distintos exámenes. En nuestro país hasta hace poco tiempo solo contábamos con la microscopía electrónica, pero recientemente se ha sumado la medición de óxido nítrico nasal y la videomicroscopía de alta velocidad. En el presente artículo se detallarán las características clínicas más importantes que hacen sospechar la presencia de DCP en las distintas edades y los métodos disponibles para su diagnóstico.
Responsável: CL1.1 - Biblioteca Central


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Id: lil-713675
Autor: Lladó, Ana Cristina Amorim Oliveira Gaia; Mihon, Claudia Elena; Silva, Madalena; Galzerano, Antonio.
Título: Systemic mastocytosis - a diagnostic challenge
Fonte: Rev. bras. hematol. hemoter;36(3):226-229, May-Jun/2014. ilus.
Idioma: en.
Resumo: Mastocytosis refers to a group of disorders characterized by the infiltration of clonally derived mast cells to the skin or extracutaneous tissues resulting in a heterogeneous clinical picture. It is a rare hematologic disorder in all its forms. The exact incidence is unknown; it affects patients of any age and males and females equally. Its molecular pathogenesis is incompletely understood. The clinical features of mastocytosis result from both chronic and episodic mast cell mediator release, signs and symptoms arising from diffuse or focal tissue infiltration, and, occasionally, the presence of an associated non-mast cell clonal hematologic disease. The histopathologic analysis is essential for definitive diagnosis but there is no curative treatment. The authors report a clinical case of a 72-year-old woman with no history of allergies, with bicytopenia, weight loss, and diffuse axial osteolytic lesions. This is a rare clinical case of aggressive systemic mastocytosis for which palliative treatment can improve survival and quality of life. A brief review of the literature about this pathology is also included.
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM


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Id: biblio-895383
Autor: Tochetto, Camila; Silva, Taiara M. da; Fighera, Rafael A; Irigoyen, Luiz Francisco; Kommers, Glaucia D.
Título: Neoplasmas da tireoide em cães: 26 casos / Thyroid neoplasms in dogs: 26 cases
Fonte: Pesqui. vet. bras = Braz. j. vet. res;37(12):1460-1466, dez. 2017. ilus.
Idioma: pt.
Resumo: Foram revisados os protocolos de biópsias e necropsias do Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (LPV/UFSM) entre 2004 e 2014, e todos os casos de tumores que acometeram a glândula tireoide foram selecionados. A partir disso, foram anotados sexo, idade e raça dos cães afetados. Também foi avaliado o significado clínico dos tumores, presença de aumento de volume cervical, lobos afetados, tamanho dos tumores, presença e localização de metástases e padrão histológico dos neoplasmas. Nos 11 anos que compreenderam este estudo, foram diagnosticados 26 tumores de glândula tireoide (quatro eram provenientes de exames de biópsias e 22 de necropsias), 53,9% dos cães eram fêmeas e 46,1% eram machos; 65,4% eram cães com raça definida. Desses, Boxers foram os mais afetados (15,4% dos casos). Dos 23 protocolos em que a idade foi informada, 60,9% dos cães eram idosos e 39,1% eram adultos. A avaliação dos protocolos permitiu constatar que 38,5% dos animais haviam apresentado aumento de volume cervical no momento do exame clínico. Dos cães necropsiados 13,6% morreram ou foram submetidos à eutanásia em decorrência de complicações causadas por metástases dos tumores de tireoide. Dessa forma, em 86,4% dos cães, os neoplasmas foram considerados achados incidentais de necropsia. Nos quatro casos provenientes de material de biópsia, o desfecho não foi conhecido. Em nenhum cão os tumores causaram síndrome clínica devido à hipo ou hiperfunção da tireoide. Em 24 protocolos havia informação sobre os lobos afetados e 75% dos cães tiveram acometimento unilateral da glândula. Os diagnósticos histológicos dos tumores permitiram constatar que 16 (61,5%) neoplasmas eram carcinomas de células foliculares (nesses casos, o padrão folicular-compacto foi o mais frequente [43,75%]), seis (23,1%) eram adenomas de células foliculares, dois (7,7%) eram carcinossarcomas e dois (7,7%) eram tumores de células C (adenoma e carcinoma).(AU)

Biopsy and necropsy reports of the Laboratório de Patologia Veterinária at the Universidade Federal de Santa Maria (LPV/UFSM) were reviewed, including data from 2004 to 2014; all cases of the thyroid tumors were selected. From this point on, it was recorded the gender, age and breed of affected dogs. Additionally, it was evaluated the clinical significance of these tumors, presence of cervical swelling, affected lobes, tumors size, presence and location of metastasis and histological pattern of neoplasms. Twenty six thyroid tumors were diagnosed in the study period (four came from biopsies while the other 22 were from necropsies). Of the affected dogs, 53.8% were females and 46.2% were males; most of the animals (65.4%) were purebred. Of these, Boxers were the most affected (15.4%). In 23 protocols the age was informed; 60.9% of the dogs were elderly and 39.1% were adults. The protocols evaluation allowed establishing that 38.5% of the animals had cervical swelling, at the time of clinical examination. Out of the dogs necropsied, only 13.6% died or were euthanized due to complications caused by metastases of thyroid tumors. Thus, in 86.4% of the dogs, the neoplasms were considered as incidental necropsy findings. In the four cases from biopsy samples, the outcomes were not known. There were no tumors causing clinical syndrome in these dogs, due to thyroid hypo- or hyperfunction. In 24 protocols it was found information about the affected lobes, indicating that 75% of the dogs had unilateral glandular involvement. The histological diagnosis showed that 16 (61.5%) neoplasms were follicular cell carcinomas (in these cases, the follicular-compact pattern was the most frequent [43.8%]); 6 (23.1%) were follicular cells adenoma; two (7.7%) were carcinosarcomas and two (7.7%) were C cells tumors (adenoma and carcinoma).(AU)
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-780434
Autor: Ortiz, José; Almoguer, Emilio.
Título: La eficiencia del índice de PSA libre en el diagnóstico del cáncer de próstata / Efficiency of free PSA index in prostate gland cancer diagnosis
Fonte: An. Fac. Med. (Perú);76(1):27-32, ene.-mar. 2015. tab, graf.
Idioma: es.
Resumo: Determinar la eficiencia de la prueba de índice de PSA libre en el diagnóstico del cáncer de próstata. Diseño: Estudio retrospectivo. Lugar: Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Perú. Participantes: Pacientes sometidos a biopsia prostática. Intervenciones: Recolección de datos de 371 pacientes sometidos a biopsia prostática -104 casos de cáncer de próstata y 267 casos de hiperplasia benigna de próstata-, mediante la revisión de registros médicos hospitalarios y revisión de estudios anatomopatológicos. Principales medidas de resultados: Sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo, curva ROC (receiver operating characteristic) y el área bajo la curva ROC (ABC). Resultados: El índice de PSA libre con el punto de corte utilizado en la práctica clínica de 0,20 demostró una sensibilidad de 0,85, especificidad de 0,51, valor predictivo positivo de 0,41, valor predictivo negativo 0,90. El punto de corte con una sensibilidad de 0,95 se obtuvo en 0,28. El área bajo la curva ROC fue 0,78. Conclusiones: La prueba de índice de PSA libre demostró una mejora de la especificidad del PSA total para evitar las biopsias innecesarias. Sería recomendable elevar el punto de corte utilizado de 0,20 para aumentar la sensibilidad de la prueba a 95 por ciento, a fin de evitar la pérdida de casos detectados de cáncer de próstata...

To determine the efficiency of PSA free index in prostate gland cancer diagnosis. Design: Retrospective study. Setting: Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Peru. Participants: Patients undergoing prostate biopsy. Interventions: Data was collected from hospital medical records and pathology reports of 371 patients undergoing prostate biopsy, 104 with prostate cancer diagnosis and 267 with benign prostatic hyperplasia. Main outcome measures: Sensitivity, specificity, positive predictive value, negative predictive value, ROC (receiver operating characteristic) curve and area under the ROC curve (AUC). Results: Free PSA cutoff level of 0.20 used in clinical practice showed sensitivity of 0.85, specificity 0.51, positive predictive value 0.41, and negative predictive value 0.90. Sensitivity of 0.95 was obtained with cutoff at 0.28. The area under the ROC curve was 0.78. Conclusions: Free PSA index test showed better specificity than total PSA and would avoid unnecessary biopsies. However it would be advisable to raise the 0.20 cutoff in order to increase the test sensitivity to 95 per cent so as to prevent loss of prostate cancer detection...
Responsável: PE13.1 - Oficina de Biblioteca, Hemeroteca y Centro de Documentación


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Id: biblio-1003294
Autor: Scaglioni, Valeria; Scolnik, Marina; Christiansen, Silvia; Varela, Carlos F; Greloni, Gustavo; Soriano, Enrique R.
Título: Rebiopsias en glomerulonefritis asociadas a ANCA: ¿Cuál es su utilidad en la toma de decisiones? / Rebiopsies in ANCA associated glomerulonephritis: What is its use in making decisions?
Fonte: Rev. argent. reumatol;29(4):30-34, dic. 2018. graf, tab.
Idioma: es.
Resumo: El objetivo de este estudio fue evaluar la utilidad de la rebiopsia renal en pacientes con glomerulonefritis ANCA en la toma de decisiones. Se incluyeron en forma retrospectiva todos los pacientes con glomerulonefritis ANCA diagnosticados por biopsia renal entre enero de 2002 y mayo de 2017. Se revisó la histología de las rebiopsias y fue correlacionada con los hallazgos clínicos (hematuria, proteinuria y caída del filtrado) y resultados histológicos de la primera y segunda biopsia. Sesenta pacientes (77% mujeres) fueron incluidos. De ellos, 15 (25%) fueron sometidos a una rebiopsia durante el seguimiento. La media de tiempo hasta la rebiopsia fue de 38,4 meses (DS 20,4). En el grupo de rebiopsia, la presencia de hematuria, proteinuria y caída del filtrado glomerular se observó en el 73%, 73% y 60% de pacientes, respectivamente. No encontramos una correlación entre las lesiones activas (semilunas, necrosis) con la presencia de hematuria o caída del filtrado glomerular. En un gran porcentaje, la histología renal mostró progresión en términos de cronicidad y con menor frecuencia lesiones de actividad. A pesar de esto, en el 67% de los pacientes se realizó un cambio de tratamiento, iniciando una nueva terapia de inducción, alcanzando una respuesta renal en el 85% de los casos.

The aim of this study was to evaluate usefulness of renal re-biopsy in patients with ANCA glomerulonephritis in treatment decisions. We included retrospectively all patients with biopsy-proven ANCA glomerulonephritis between January 2002 and May 2017. We analysed patient's baseline characteristics at the time of re-biopsy, presence of microscopic hematuria, proteinuria and/or decline in glomerular filtration rate (GFR) and time to renal relapse/rebiopsy. Data of physicians' decisions after rebiopsy was collected. 60 patients (77% females) were included. Of those, 15 (25%) underwent renal re-biopsy during the follow up based on clinical manifestations. Mean time until re-biopsy was 38.4 months (SD 20.4). In the re-biopsy group, 73% of patients had new onset hematuria, 73% had new onset or worsening proteinuria (40% and 33% respectably), and 60% had decline in the GFR. When analysing histological changes in the repeat biopsy we didn't find a correlation between active lesions (crescents, necrosis etc.) and hematuria. All patients that underwent repeat biopsy were considered to be active but renal histology showed progression in terms of chronicity and rare active histological lesions. Despite this, in 67% of patients, physicians made a treatment change, initiating a new induction therapy regimen and achieving renal response in 85% of patients.
Responsável: AR423.1 - Biblioteca


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ALVES, Maria Teresa de Seixas
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Id: biblio-1003596
Autor: Garcia, Jairo Greco; Marques, Dayane Screpante; Viola, Dan Carai Maia; Petrilli, Marcelo de Toledo; Alves, Maria Teresa de Seixas; Jesus-Garcia Filho, Reynaldo.
Título: Biopsy Path Contamination in Primary Bone Sarcomas / Contaminação do trajeto de biópsia em sarcomas primários ósseos
Fonte: Rev. bras. ortop;54(1):33-36, Jan.-Feb. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Objective To determine the incidence of contamination of the biopsy pathway in patients with primary bone sarcomas, as well as the clinical characteristics that influenced this outcome. Materials and Methods The anatomopathological reports of the patients who were treated by the Orthopedic Oncology Sector of the Orthopedic and Traumatology Department of this institution were retrospectively evaluated. Results Of the 148 patients included for evaluation in the present study, only 1 presented contamination by neoplastic cells in his biopsy pathway. Conclusion The bone biopsy procedure in patients with primary bone sarcomas presents great safety regarding pathway contamination when performed in specialized centers that treat this type of pathology.

Resumo Objetivo Determinar a incidência da contaminação do trajeto de biópsia nos pacientes com sarcomas primários ósseos, bem como as características clínicas que influenciaram neste desfecho. Método Foram avaliados retrospectivamente os laudos anatomopatológicos de pacientes tratados pelo Serviço de Oncologia Ortopédica do Departamento de Ortopedia e Traumatologia dessa instituição. Resultado Dentre os 148 pacientes incluídos no presente estudo, apenas um apresentou contaminação por células neoplásicas em seu trajeto de biópsia. Conclusão O procedimento de biópsia óssea em pacientes com sarcomas primários ósseos apresenta grande segurança no quesito contaminação quando feito em centros especializados no tratamento dessas patologias.
Responsável: BR26.1 - Biblioteca Central


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Id: biblio-1005255
Autor: León Batallas, Jorge Alberto; Lorenty Ruiz, Luigy Wladimir; Martínez Arboleda, Fabián Hernán.
Título: Biopsia de glándula salival menor en el diagnóstico confirmatorio del Síndrome de Sjögren y Amiloidosis / Minor salivary gland biopsy in the confirmatory diagnosis of Sjögren's Syndrome and Amyloidosis
Fonte: Cambios rev. méd;17(2):89-94, 28/12/2018. ilus.
Idioma: es.
Resumo: INTRODUCCIÓN. El trabajo trata de dos enfermedades con la descripción histopatológica del tejido glandular, que nos ayudará a identificar y a corroborar el diagnóstico del Síndrome de Sjögren y la Amiloidosis, que a pesar de ser de un mismo tejido ductal, tienen características histopatológicas muy diferentes. OBJETIVO. Demostrar el uso de la biopsia de glándula salival menor en diagnósticos confirmatorios de patologías autoinmunes como son: el Síndrome de Sjögren y Amiloidosis, que al ser dos entidades distintas, tienen una misma estructura de afectación. CASO CLÍNICO. Se estudió dos placas histológicas, de una paciente con manifestaciones clínicas de Síndrome de Sjögren y de un paciente con Amiloidosis; se realizó la toma de biopsia de la glándula salival menor y su respectiva histopatología, lo que permitió identificar de forma microscópica las dos entidades. DISCUSIÓN. Abordar la diferente etiología, técnicas y exámenes complementarios en el diagnóstico de estas enfermedades, y el tratamiento, sin descuidar el grado de sensibilidad y especificidad de cada tipo de biopsia y el debate de cuál es el método ideal y eficaz. RESULTADOS. En cuanto a las características de biopsias de glándulas salivales menores que siguieron su patrón histopatológico de las dos enfermedades, Síndrome de Sjögren y Amiloidosis, con la modificación de tejido glandular y asi demostrando la utilidad de la técnica en el diagnostico confirmatorio. CONCLUSIÓN. El uso de la técnica, biopsia de glándula salival menor, fue un método de diagnóstico confirmatorio complementario a estudios de imagenología y laboratorio clínico.

INTRODUCTION. The work deals with two diseases with the histopathological description of glandular tissue, which will help us identify and corroborate the diagnosis of Sjögren's Syndrome and Amyloidosis, which, despite being from the same ductal tissue, have very different histopathological characteristics. OBJECTIVE. To demonstrate the use of minor salivary gland biopsy in confirmatory diagnoses of autoimmune pathologies such as: Sjögren's Syndrome and Amyloidosis, which, being two distinct entities, have the same structure of affectation. CLINICAL CASE. Two histological plates were studied, of a patient with clinical manifestations of Sjögren's Syndrome and of a patient with Amyloidosis; The biopsy of the minor salivary gland and its respective histopathology were performed, which allowed the two entities to be identified microscopically. DISCUSSION. To address the different etiology, techniques and complementary examinations in the diagnosis of these diseases, and treatment, without neglecting the degree of sensitivity and specificity of each type of biopsy and the debate of which is the ideal and effective method. RESULTS As for the characteristics of minor salivary gland biopsies that followed histopathological pattern of the two diseases, Sjögren's Syndrome and Amyloidosis, with the modification of glandular tissue and thus demonstrating the usefulness of the technique in the confirmatory diagnosis. CONCLUSION. The use of the technique, minor salivary gland biopsy, was a confirmatory diagnostic method complementary to imaging and clinical laboratory studies.
Responsável: EC162.1


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Id: biblio-958049
Autor: Kennedy, S; Sánchez, L.
Título: Mesotelioma peritoneal deciduoide / Peritoneal mesotelioma deciduoid
Fonte: Rev. argent. radiol;82(1):45-47, mar. 2018. ilus.
Idioma: es.
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco



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