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Id: biblio-998188
Autor: Anisuzzaman, Mostafa Md; Alam, Mohammad Khursheed; Khan, Safiqur Rahman; Ahmed, Anser Uddin.
Título: Fresh Frozen Amniotic Membrane and Buccal Pad of Fat for Reconstruction of Oral Mucosal Defect After Surgical Excision of Leukoplakia
Fonte: Pesqui. bras. odontopediatria clín. integr;19(1):4471, 01 Fevereiro 2019. tab, ilus.
Idioma: en.
Resumo: Objective: To compare the use of Fresh Frozen Amniotic Membrane (FFAM) and Buccal Pad of Fat (BPF) for reconstruction of oral mucosal defect after surgical excision of leukoplakia. Material and Methods: Twenty patients were randomly selected and divided into two groups. Group 1 use amniotic membrane graft and Group 2 BPF. Both groups were evaluated preoperatively and postoperatively. Incisal opening, epithelialization and fibrosis were evaluated after one month of surgery. Chi square and Student t tests were used. Results: According to the presence of smoking habits, the highest frequencies were for smoking (30%) and betel leaf areca nut with tobacco (30%). Regarding the diameter of oral leukoplakia, in 40% of the participants it was 2x3 cm2. In Group1, after one month of surgery preoperative and postoperative inter-incisal opening values were 44.20 ± 3.37 and 42.05 ± 3.47 (p<0.001). In Group 2, preoperative and postoperative inter-incisal opening values were 44.09 ± 3.32 and 43.01±3.38 (p>0.05). When FFAM was used complete epithelialization in 70% and incomplete epithelialization in 30% patients. When BPF was used the results were almost similar. Fibrosis occurred in 30% in Group 1. There were no complications like flap necrosis, infectiona and hematoma formation. Conclusion: Incisal opening was significantly better in Fresh Frozen Amniotic Membrane Group, epithelialization and fibrosis were almost same in both groups after surgical excision of oral leukoplakia.
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-1009443
Autor: Velásquez S, Rosirys; Briceño V, Adriana; Brizuela, Alberto; Rojas, Rubén; Rodríguez, Melanie.
Título: Tromboembolismo pulmonar y comunicación interauricular tipo osteum secundum / Pulmonary embolism and interatrial osteum secundum
Fonte: Med. interna (Caracas);32(3):259-263, 2016. ilus.
Idioma: es.
Resumo: Se presenta el caso de una paciente de 45 años, de edad con antecedente de Cardiopatía Congénita Acianógena: comunicación interauricular (CIA) tipo Osteum Secundum (OS), quien de manera ambulatoria consultó para la realización de la evaluación Cardiovascular en preoperatorio de colecistectomía. En Rayos X y Angiotomografia de tórax, se evidenció tromboembolismo pulmonar (TEP). Paciente refiere disnea leve, inspiratoria, habitualmente asociada a leves esfuerzos por más de tres meses, negando otro síntoma pertinente. La ausencia de Enfermedad Tromboembólica venosa (ETV) del tipo Trombosis venosa profunda(TVP) y de factores de riesgo para un Síndrome de Hipercoagulabilidad, excepto el hábito tabáquico, aunado al antecedente de CIA tipo Osteum secundum y la falta de correlación clínica-imagenológica convergen para que la presentación de este caso clínico pudiendo ser mortal sea una condición rara, dado que durante la hospitalización se confirmaron los diagnósticos de TEP Crónico, Hipertensión pulmonar severa (HPS), en ausencia de criterios para Embolismo paradójico (EP), complicación descrita en este tipo de cardiopatía cuando hay hipertensión pulmonar asociada. Los métodos de imagen fueron esenciales para el correcto diagnóstico y el manejo terapéutico de la paciente, la cual evoluciona satisfactoriamente(AU)

A 45-year-old woman came to the office with mild shortness of breath for the past 3 months and the chest X-ray (CXR) and CT showed chronic pulmonary embolism (PE). She had a past medical history of non-cyanotic congenital ostium secundum atrial septal defect, severe pulmonary hypertension and active smoking status. The uncommon clinical presentation in this patient could have been fatal without the appropriate diagnose and treatment(AU)
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


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Texto completo SciELO Chile
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Id: lil-679037
Autor: Rahal E, Maritza; Herrera J, María José; Quiñones S, Luis; Farfán T, Nancy; Cáceres L, Dante; Roco A, Ángela.
Título: Frecuencia de los polimorfismos CYP1A1*2A y deleción del gen GSTM1 en pacientes con carcinoma de células escamosas de laringe en relación al hábito tabáquico: estudio piloto en Chile / Frequency of CYP1A1*2A and GSTM1 gene polymorphisms in Chilean patients with squamous cell carcinoma of the larynx in relation to smoking habit: a pilot study
Fonte: Rev. otorrinolaringol. cir. cabeza cuello;73(1):7-16, abr. 2013. ilus, tab.
Idioma: es.
Resumo: Introducción: Entre los factores de riesgo para cáncer laríngeo (CL) son relevantes el consumo de tabaco y alcohol. Estos xenobióticos son metabolizados por un grupo de enzimas, entre las cuales están CYP1A1 y GSTM1, cuyas variantes polimórficas se postulan como factores de riesgo para esta enfermedad. Objetivos: Describir la frecuencia de las variantes de los polimorfismos de CYP1A1 y GSTM1 en un grupo de pacientes diagnosticados con CL. Analizar la posible correlación entre las variantes genéticas de ambas enzimas y la presencia de CL. Evaluar la influencia del hábito tabáquico en el riesgo de aparición de cáncer escamoso de laringe en pacientes con genotipos de riesgo. Material y método: Se seleccionaron 35 pacientes con CL entre los años 2000 y 2010 en Servicio de Otorrinolaringología del HBLT y 124 controles reclutados en el Centro de Investigaciones Farmacológicas y Toxicológicas (IFT). A todos los individuos se les registraron datos demográficos y extrajo una muestra de sangre para analizar las variantes polimórficas de CYP1A1 y GSTM1, mediante PCR-RFLP. Resultados: De un total de 35pacientes 54,3% presentan el genotipo GSTM1 (-/-) y 17,1% el genotipo CYP1A1*2A C/C. En el grupo control (n =140) estas frecuencias fueron de 19,35°% y 10,48%o, respectivamente. Se observó una correlación entre GSTM1 y el CL, estratificado por el hábito tabáquico y alcohólico. No se encontraron relaciones estadísticamente significativas con el hábito alcohólico y/o tabáquico. No se observaron asociaciones entre la patología y la combinación de genotipos o entre genotipos y el hábito tabáquico o alcohólico. Conclusiones: Los resultados muestran una asociación estadísticamente significativa entre la deleción de GSTM1 (-/-) y el riesgo de presentar CL, lo que refleja el importante papel que juega esta enzima en la desintoxicación de compuestos cancerígenos. Sin embargo, se requiere incrementar el número de pacientes para establecer apropiadamente la relación genético-ambiental que permite adjudicar un papel relevante a estos biomarcadores.

Introduction: Tobacco and alcohol consumption are recognized risk factors for squamous cell carcinoma of the larynx. These xenobiotics are metabolized by numerous enzymes, among which, CYP1A1 and GSTM1 gene polymorphisms have been identified as risk factors for developing tobacco related cancers as lung and laryngeal carcinomas. Nevertheless, these polymorphisms have not been studied in Chilean patients with squamous cell carcinoma of the larynx. Aim: To describe, for the first time, the frequency of CYP1A1 and GSTM1 gene polymorphisms in Chilean patients with squamous cell carcinoma of the larynx. Material and method: We conducted a case-control study. The case group consisted of 35 Chilean patients with squamous cell carcinoma of the larynx; the control group was formed by 124 Chilean subjects without cancer diagnosis. Demographic data as age, sex and quantification of tobacco smoking and alcohol consumption were recorded in all individuals. CYP1A1 and GSTM1 gene polymorphisms were evaluated by polymerase chain reaction and restriction enzymes (PCR-RFLP). Results: The frequency of CYP1A1*2A C/C genotype was 54, 3°% among laryngeal cancerpatients and 17,1%% among control subjects. The frequency ofGSTM1 (-/-) genotype was 19,35 %% among laryngeal cancer patients and 10,48%% among control subjects. There were no statistically significant relationships between this gene polymorphisms and tobacco smoking or alcohol consumption. There were no associations between the presence of both gene polymorphisms in the same individual and the presence of laryngeal cancer. Interestingly we found an OR of 8.69 (CI 2.90 to 26.01) for GSTM1 (-/-) polymorphism and laryngeal cancer, stratified by tobacco smoking and alcohol consumption. Conclusions: Our work shows that the deletion of GSTM1 could be an important risk factor for squamous cell carcinoma of the larynx in Chilean patients. This finding reflects the important role that detoxification of carcinogenic compounds plays in Chilean population. However, it is necessary to increase the number of studied patients to properly establish the genetic-environmental relationship ascribed to these biomarkers.
Responsável: CL30.1 - Biblioteca


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Id: biblio-1005783
Autor: Gualdrini, Ubaldo Alfredo.
Título: Capítulo 3: Historia natural y factores de riesgo del cáncer colorrectal / Chapter 3: Natural history and risk factors for colorectal cancer
Fonte: Rev. argent. coloproctología;27(1):19-29, Nov. 2016. graf.
Idioma: es.
Conferência: Apresentado em: Congreso Argentino de Coloproctología, 41, Ciudad Autónoma de Buenos Aires, 14-17 nov. 2016.
Responsável: AR1.1 - Biblioteca Rafael Herrera Vegas


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Texto completo SciELO Saúde Pública
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Id: biblio-830730
Autor: Ramos-Carbajales, Alejandro; González-Rozada, Martín; Vallarino, Hugo.
Título: La demanda de cigarrillos y el aumento de impuestos en El Salvador / Demand for cigarettes and tax increases in El Salvador
Fonte: Rev. panam. salud pública = Pan am. j. public health;40(4):237-242, Oct. 2016. tab, graf.
Idioma: es.
Resumo: RESUMEN Objetivo Analizar las elasticidades de corto plazo y de largo plazo de la demanda de cigarrillos en El Salvador como instrumento para apoyar recomendaciones sobre aumentos de impuestos para reducir la prevalencia y el consumo vía aumento de precios. Métodos Se analizó la demanda de cigarrillos en El Salvador mediante un modelo econométrico de series de tiempo con una base de datos proveniente de la Dirección General de Impuestos Internos (DGII) y la Dirección General de Estadística y Censos (DIGESTYC) de El Salvador. El período de análisis fue trimestral: 2000Q1-2012T4. Se realizaron las pruebas habituales para evitar que la estimación econométrica fuera espuria. Se halló que las variables ventas en volumen, los precios reales de venta y el ingreso real per cápita estaban cointegradas de primer orden; este resultado permite utilizar un modelo de corrección de error con estimaciones de las elasticidades en el corto plazo y en el largo plazo. Resultados Se halló que solo las elasticidades de largo plazo son estadísticamente significativas al 5% de probabilidad. Los resultados señalan una elasticidad precio de largo plazo (cinco trimestres) de -0,9287 e ingreso de 0,9978. Conclusiones El nivel del valor absoluto de la elasticidad precio es algo elevada, aunque está dentro de los niveles estimados en otros estudios en los países de menores ingresos per cápita. Un aumento del impuesto de un monto base de USD (dólares estadounidenses) 1,04 por cajetilla de 20 cigarrillos a USD 1,66 en un período de tres años reduciría la demanda entre 20% y 31% y aumentaría los ingresos fiscales entre 9% y 22%.

ABSTRACT Objective Analyze short- and long-term elasticities of demand for cigarettes in El Salvador as a tool for supporting recommendations on tax increases to reduce prevalence and consumption through price increases. Methods Demand for cigarettes in El Salvador was analyzed through an econometric time-series model using a database from El Salvador’s General Directorate of Internal Taxes (DGII) and the General Directorate of Statistics and Census (DIGESTYC). The analysis period was quarterly: 2000Q1-2012Q4. The usual tests were done to prevent a spurious econometric estimation. It was found that the variables volume sales, actual sale prices, and actual per capita income exhibited first-order cointegration; this result makes it possible to use an error correction model with short- and long-term elasticity estimates. Results Only long-term elasticities were found to be statistically significant to 5%. Results show long-term price elasticity (5 quarters) of –0.9287 and income price elasticity of 0.9978. Conclusions Absolute price elasticity is somewhat high, although it is within the levels estimated in other studies in low per-capita income countries. A tax increase from a base amount of US$1.04 per pack of 20 cigarettes to US$1.66 within three years would reduce demand by 20% to 31% and would increase tax revenues by 9% to 22%.
Responsável: BR1.1 - BIREME


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Texto completo SciELO Saúde Pública
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Id: biblio-830727
Autor: Pichon-Riviere, Andrés; Bardach, Ariel; Augustovski, Federico; Alcaraz, Andrea; Reynales-Shigematsu, Luz Myriam; Pinto, Márcia Teixeira; Castillo-Riquelme, Marianela; Torres, Esperanza Peña; Osorio, Diana Isabel; Huayanay, Leandro; Munarriz, César Loza; de Miera-Juárez, Belén Sáenz; Gallegos-Rivero, Verónica; Puente, Catherine De La; Navia-Bueno, María del Pilar; Caporale, Joaquín.
Título: Impacto económico del tabaquismo en los sistemas de salud de América Latina: un estudio en siete países y su extrapolación a nivel regional / Financial impact of smoking on health systems in Latin America: A study of seven countries and extrapolation to the regional level
Fonte: Rev. panam. salud pública = Pan am. j. public health;40(4):213-221, Oct. 2016. tab, graf.
Idioma: es.
Resumo: RESUMEN Objetivo Estimar los costos médicos directos atribuibles al tabaquismo en los sistemas de salud de América Latina. Métodos Se utilizó un modelo de microsimulación para cuantificar el impacto económico en enfermedad cardiovascular y cerebrovascular, enfermedad pulmonar obstructiva crónica (EPOC), neumonía, cáncer de pulmón y otras nueve neoplasias. Se realizó una búsqueda sistemática de datos epidemiológicos y de costos de los eventos. El modelo se calibró y validó para Argentina, Bolivia, Brasil, Chile, Colombia, México y Perú, países que representan el 78% de la población de América Latina; luego se extrapolaron los resultados a nivel regional. Resultados Cada año el tabaquismo es responsable de 33 576 millones de dólares en costos directos para el sistema de salud. Esto equivale a 0,7% del producto interno bruto (PIB) de la región y a 8,3% del presupuesto sanitario. La enfermedad cardiovascular, la EPOC y el cáncer fueron responsables de 30,3%, 26,9% y 23,7% de este gasto, respectivamente. El costo atribuible al tabaquismo varió entre 0,4% (México y Perú) y 0,9% (Chile) del PIB y entre 5,2% (Brasil) y 12,7% (Bolivia) del gasto en salud. En la región, la recaudación impositiva por la venta de cigarrillos apenas cubre 37% del gasto sanitario atribuible al tabaquismo (8,1% en Bolivia y 67,3% en Argentina). Conclusiones El tabaquismo es responsable de una importante proporción del gasto sanitario en América Latina, y la recaudación impositiva por la venta de cigarrillos está lejos de llegar a cubrirlo. La profundización de medidas como el aumento de impuestos al tabaco debería ser seriamente considerada por los países de la región.

ABSTRACT Objective Estimate smoking-attributable direct medical costs in Latin American health systems. Methods A microsimulation model was used to quantify financial impact of cardiovascular and cerebrovascular disease, chronic obstructive pulmonary disease (COPD), pneumonia, lung cancer, and nine other neoplasms. A systematic search for epidemiological data and event costs was carried out. The model was calibrated and validated for Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, and Peru, countries that account for 78% of Latin America’s population; the results were then extrapolated to the regional level. Results Every year, smoking is responsible for 33 576 billion dollars in direct costs to health systems. This amounts to 0.7% of the region’s gross domestic product (GDP) and 8.3% of its health budget. Cardiovascular disease, COPD, and cancer were responsible for 30.3%, 26.9%, and 23.7% of these expenditures, respectively. Smoking-attributable costs ranged from 0.4% (Mexico and Peru) to 0.9% (Chile) of GDP and from 5.2% (Brazil) to 12.7% (Bolivia) of health expenditures. In the region, tax revenues from cigarette sales barely cover 37% of smoking-attributable health expenditures (8.1% in Bolivia and 67.3% in Argentina). Conclusions Smoking is responsible for a significant proportion of health spending in Latin America, and tax revenues from cigarette sales are far from covering it. The region’s countries should seriously consider stronger measures, such as an increase in tobacco taxes.
Responsável: BR1.1 - BIREME


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Id: lil-341980
Autor: Anon.
Título: La cobertura por Medicaid de los tratamientos para el control del hábito de fumar / Medicaid coverage of treatments for smoking control
Fonte: Rev. panam. salud pública = Pan am. j. public health;14(1):43-44, jul. 2003.
Idioma: es.
Responsável: BR1.1 - BIREME


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Id: lil-767237
Autor: Kanno, Daniela Tiemi; Sella, Luiz Fernando; OLIVEIRA, Natália Cristina de.
Título: Estilo de vida de adventistas do sétimo dia e de não adventistas do município de Cotia, São Paulo / Lifestyle of Seventh-Day Adventists and non-Adventists from the city of Cotia, São Paulo
Fonte: Rev. ciênc. méd., (Campinas);23(3):137-144, set.-dez. 2014. tab.
Idioma: pt.
Resumo: ObjetivoAvaliar e comparar o estilo de vida de adventistas do sétimo dia e de não adventistas de uma comunidade no município de Cotia (SP). MétodosForam estudados 238 sujeitos maiores de 18 anos (média de 37,3 ± 11,5 anos): 130 homens (54,6%) e 108 mulheres (45,4%). Os sujeitos foram selecionados aleatoriamente e preencheram um questionário com dados demográficos, antropométricos e de estilo de vida. Também foi calculado o índice de massa corporal e a idade biológica. ResultadosAdventistas (51,2%) e não adventistas (48,8%) não diferiram quanto aos hábitos de repouso e frequência de exercício físico. Os adventistas apresentaram menor prevalência de tabagismo (p=0,009) e de consumo de bebidas alcoólicas (p<0,001). Além disso, eles tinham o hábito de tomar desjejum com maior frequência (p<0,001) e comer menos entre as refeições (p<0,001) quando comparados aos não adventistas. Os adventistas também apresentaram menor idade biológica (-1,5 anos vs -0,8, p=0,001), mas não houve diferença significativa em relação ao índice de massa corporal. Entretanto, na análise por regressão linear múltipla, após controle por sexo e idade, ser adventista estava independentemente associado a um menor índice de massa corporal (p=0,03). ConclusãoOs adventistas do sétimo dia do município de Cotia apresentaram melhores hábitos e menor idade biológica quando comparados aos não adventistas.

ObjectiveTo assess and compare the lifestyles of Seventh-day Adventists and non-Adventists from the municipality of Cotia, SP. MethodsA total of 238 subjects aged 18 years or more with a mean age of 37.3 ± 11.5 years were studied, 130 (54.6%) males and 108 (45.4%) females. The subjects were selected randomly and asked to fill out a questionnaire with their demographic, anthropometric, and lifestyle data. Their body mass index and health age were calculated. ResultsAdventists (51.2%) and non-Adventists (48.8%) had similar sleeping and physical activity habits. Adventists were less likely to smoke (p=0.009) and consume alcohol (p<0.001). Additionally, they were more likely to have breakfast (p<0.001) and less likely to snack between meals (p<0.001). The health age of Adventists was also smaller (-1.5 versus -0.8 years, p=0.001), but the body mass indices of Adventists and non-Adventists did not differ. However, after controlling for sex and age, multiple linear regression showed that being an Adventist was independently associated with a smaller body mass index (p=0.03). ConclusionSeventh-day Adventists from the municipality of Cotia had better habits and smaller health age than non-Adventists.
Responsável: BR1.1 - BIREME


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Id: biblio-906384
Autor: Franklin, Thainara Araujo; Cardoso, Luisa Kecyane Batista; Veigas, Luciene Dias Bispo; Nery, Adriana Alves; Casotti, Cezar Augusto.
Título: Comportamentos de risco a saúde em adolescentes residentes em município de pequeno porte / Comportamientos de riesgo en adolescente residente de salud en pequeña ciudad porte / Health risk behaviors of adolescents living in a small municipality
Fonte: Rev. pesqui. cuid. fundam. (Online);10(3):704-710, jul.-set. 2018. tab.
Idioma: en; pt.
Resumo: Objetivo: Esse estudo tem o objetivo de identificar a prevalência de comportamentos de risco à saúde em adolescentes escolares residentes em município de pequeno porte populacional do estado da Bahia no ano de 2012. Métodos: Estudo epidemiológico transversal, censitário, de base escolar, amostra constituída por 96 adolescentes escolares matriculados no ensino médio. Resultados: No ensino médio estavam matriculados 134 adolescentes com idade entre 12 e 19 anos, 72,4% participaram do estudo, verificou-se que entre os adolescentes a média da idade foi de 16,63 anos (DP±1,63), 57,5% do sexo feminino, 78,5% não exerciam atividade remunerada, 71,1% apresentavam idade de 15 a 18 anos, 58,2% se auto-declararam de cor Parda e 49,5% reside com os pais, 60,8% não experimentaram tabaco, 90,4% consumiram algum tipo de bebida alcoólica e 77,7% foram classificados como ativos fisicamente. Conclusão: Os resultados trazem a necessidade de novas pesquisas referentes aos comportamentos de risco em adolescentes escolares

Objetivo: Este estudio tiene como objetivo identificar la prevalencia de conductas de riesgo para la salud de los adolescentes en el municipio de pequeño tamaño de la población del estado de Bahía, en 2012. Métodos: estudio transversal, censo, muestra que consta en la escuela por 96 estudiantes adolescentes inscritas en la escuela secundaria. Resultados: En la escuela secundaria se matricularon 134 adolescentes de edades comprendidas entre los 12 y los 19 años, el 72,4% participó en el estudio, se encontró que entre los adolescentes, la edad media fue de 16,63 años (DE ± 1,63), 57.5% mujeres, no se emplearon 78,5%, el 71,1% tenían entre 15-18 años de edad, el 58,2% Parda auto-declarado de color y el 49,5% vive con sus padres, 60.8% no experimentó el tabaco, el 90,4% consume algún tipo de bebida alcohólica y el 77,7% fueron clasificados como activos físicamente. Conclusión: Los resultados muestran la necesidad de una mayor investigación sobre los comportamientos de riesgo entre los estudiantes adolescentes

Objective: This study aims to identify the prevalence of health risk behaviors in schooling age adolescents that live in a small population municipality of Bahia State over 2012. Methods: It is a cohort epidemiological study, censitary, school-based, and having a sampling comprised by 96 adolescent students enrolled in high school. Results: In high school were enrolled 134 adolescents within the age group from 12 to 19 years old, where 72.4% participated in the study. It was found that among adolescent, the average age was about 16.63 years old (SD ± 1.63), where 57.5% were female, 78.5% were not employed, 71.1% were aged between 15 to 18 years old, 58.2% had self-declared brown as their skin color and 49.5% lived with their parents. It was also found that 60.8% experienced no tobacco consumption, 90.4% consumed some type of alcoholic beverage and 77.7% were classified as physically active. Conclusion: The results have shown the need for further research on risk behaviors among school adolescents
Responsável: BR1208.1 - BSEN - Biblioteca Setorial de Enfermagem e Nutrição


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Id: biblio-905200
Autor: Hirano, André Carramenha de Góes; Targueta, Eduardo Pelegrineti; Campos, Fernando Peixoto Ferraz de; Martines, João Augusto dos Santos; Andrade, Dafne; Lovisolo, Silvana Maria; Felipe-Silva, Aloisio.
Título: Severe pulmonary hypertension due to combined pulmonary fibrosis and emphysema: another cause of death among smokers
Fonte: Autops. Case Rep;7(2):15-26, Apr.-June 2017. ilus.
Idioma: en.
Resumo: In 2005, the combined pulmonary fibrosis and emphysema (CPFE) was first defined as a distinct entity, which comprised centrilobular or paraseptal emphysema in the upper pulmonary lobes, and fibrosis in the lower lobes accompanied by reduced diffused capacity of the lungs for carbon monoxide (DLCO). Recently, the fibrosis associated with the connective tissue disease was also included in the diagnosis of CPFE, although the exposure to tobacco, coal, welding, agrochemical compounds, and tire manufacturing are the most frequent causative agents. This entity characteristically presents reduced DLCO with preserved lung volumes and severe pulmonary hypertension, which is not observed in emphysema and fibrosis alone. We present the case of a 63-year-old woman with a history of heavy tobacco smoking abuse, who developed progressive dyspnea, severe pulmonary hypertension, and cor pulmonale over a 2-year period. She attended the emergency facility several times complaining of worsening dyspnea that was treated as decompensate chronic obstructive pulmonary disease (COPD). The imaging examination showed paraseptal emphysema in the upper pulmonary lobes and fibrosis in the middle and lower lobes. The echo Doppler cardiogram revealed the dilation of the right cardiac chambers and pulmonary hypertension, which was confirmed by pulmonary trunk artery pressure measurement by catheterization. During this period, she was progressively restricted to the minimal activities of daily life and dependent on caregivers. She was brought to the hospital neurologically obtunded, presenting anasarca, and respiratory failure, which led her to death. The autopsy showed signs of pulmonary hypertension and findings of fibrosis and emphysema in the histological examination of the lungs. The authors highlight the importance of the recognition of this entity in case of COPD associated with severe pulmonary hypertension of unknown cause.
Responsável: BR26.7 - Serviço de Biblioteca e Documentação Científica



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