Base de dados : LILACS
Pesquisa : F02.463.425.097 [Categoria DeCS]
Referências encontradas : 127 [refinar]
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Id: biblio-1000805
Autor: Beigbeder de Agosta, Carolina; Colombo, Rosa Inés.
Título: Mi cuerpo me pertenece / My body belongs to me.
Fonte: Buenos Aires; Cauquen; 2005. 37 p.
Idioma: es.
Responsável: AR338.1 - Biblioteca
AR338.1; 159.922.7, B20, 07/4229


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Id: biblio-1000732
Autor: Ruiz, Franco.
Título: El sida en la Plata: testimonios del VIH en la ciudad, aportes para su análisis y prevención / AIDS in La Plata: testimonies of HIV in the city, contributions for its analysis and prevention.
Fonte: La Plata; La comuna ediciones; 2006. 127 p.
Idioma: es.
Responsável: AR338.1 - Biblioteca
AR338.1; 616.90, R87%07/4286


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Texto completo SciELO Brasil
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Id: lil-702549
Autor: Mendes-da-Silva, Cristiano; Giriko, Catherine Assuka; Mennitti, Lais Vales; Hosoume, Lilian Fazion; Souto, Tayane dos Santos; Silva, Alexandre Valotta da.
Título: Maternal high-fat diet during pregnancy or lactation changes the somatic and neurological development of the offspring / Dieta materna rica em gordura durante a gravidez ou lactacao altera o desenvolvimento somatico e neurologico da prole
Fonte: Arq. neuropsiquiatr;72(2):136-144, 02/2014. tab, graf.
Idioma: en.
Projeto: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo.
Resumo: The maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, during pregnancy or lactation. Indicators of the body growth, physical maturation, and reflex ontogeny were evaluated. Offspring of dams fed a HFD showed reduced weight and body growth, delayed physical maturation, and delayed maturation of the physiological reflexes, such as vibrissa placing, auditory startle response, and free-fall righting. Our findings suggest that maternal HFD during pregnancy or lactation modifies somatic and neurological development of the offspring, possibly increasing the risk of neuroendocrine and neuropsychiatric disorders later in life.

A exposição materna a dieta rica em gordura (DRG) durante a gravidez e a amamentação tem sido considerada um importante indutor de alterações da programação normal da prole, em animais e humanos, e pode atrapalhar o desenvolvimento do cérebro. No presente estudo, investigamos o desenvolvimento somático e sensório-motor da prole de ratas alimentadas com uma DRG, em comparação com ratas alimentadas com uma dieta controle, durante a gravidez ou lactação. Foram avaliados indicadores de crescimento corporal, maturação física e ontogênese de reflexos. A prole de ratas alimentadas com DRG mostrou redução de peso e crescimento do corpo, atraso da maturação física e maturação tardia de reflexos fisiológicos, tais como colocação pelas vibrissas, resposta ao susto e reação de aceleração. Nossos resultados sugerem que DRG materna durante a gravidez ou lactação modifica desenvolvimento somático e neurológico da prole, possivelmente aumentando o risco para distúrbios neuroendócrinos e neuropsiquiátricos mais tarde na vida.
Responsável: BR1.1 - BIREME


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Id: lil-659643
Autor: Cassilhas, R.C.; Lee, K.S.; Venâncio, D.P.; Oliveira, M.G.M.; Tufik, S.; Mello, M.T..
Título: Resistance exercise improves hippocampus-dependent memory
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(12):1215-1220, Dec. 2012. ilus.
Idioma: en.
Resumo: It has been demonstrated that resistance exercise improves cognitive functions in humans. Thus, an animal model that mimics this phenomenon can be an important tool for studying the underlying neurophysiological mechanisms. Here, we tested if an animal model for resistance exercise was able to improve the performance in a hippocampus-dependent memory task. In addition, we also evaluated the level of insulin-like growth factor 1/insulin growth factor receptor (IGF-1/IGF-1R), which plays pleiotropic roles in the nervous system. Adult male Wistar rats were divided into three groups (N = 10 for each group): control, SHAM, and resistance exercise (RES). The RES group was submitted to 8 weeks of progressive resistance exercise in a vertical ladder apparatus, while the SHAM group was left in the same apparatus without exercising. Analysis of a cross-sectional area of the flexor digitorum longus muscle indicated that this training period was sufficient to cause muscle fiber hypertrophy. In a step-through passive avoidance task (PA), the RES group presented a longer latency than the other groups on the test day. We also observed an increase of 43 and 94% for systemic and hippocampal IGF-1 concentration, respectively, in the RES group compared to the others. A positive correlation was established between PA performance and systemic IGF-1 (r = 0.46, P < 0.05). Taken together, our data indicate that resistance exercise improves the hippocampus-dependent memory task with a concomitant increase of IGF-1 level in the rat model. This model can be further explored to better understand the effects of resistance exercise on brain functions.
Responsável: BR1.1 - BIREME


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Texto completo SciELO Costa Rica
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Id: lil-648413
Autor: Flores Sandí, Grettchen.
Título: Síndrome de Cronos / Cronos syndrome
Fonte: Acta méd. costarric;53(3):121-128, jul.-sept. 2011.
Idioma: es.
Resumo: La salud ocupacional tiene como finalidad promover y mantener el más alto grado de bienestar físico, mental y social de los trabajadores. En los últimos años se presenta un nuevo tipo de riesgos ocupacionales que tienen que ver con factores psicosociales y que se están convirtiendo en problemáticas muy importantes en el ámbito laboral, por las patologías concomitantes. En términos generales, el Síndrome de Cronos se refiere al miedo patológico de la persona que ocupa un puesto superior, de promover a sus subalternos por temor a ser desplazado o sustituido; su diagnóstico se basa en características de desempeño, temor a delegar, relaciones sociales patológicas, egocentrismo, autoengaño y desarrollo limitado. Esta patología puede tener comorbilidad con otro tipo de trastornos asociados a la cultura organizacional como ocurre en el acoso laboral, la adicción laboral y el presentismo. El tratamiento puede requerir un abordaje en dos sentidos, y además de proveer tratamiento para los síntomas psicofísicos que lo acompañan, que se incluya la ayuda al trabajador para que desarrolle mecanismos eficaces de respuesta en el trabajo, comprendiendo una adecuada gestión de la cultura organizacional, un diagnóstico del clima laboral, el fomento de la comunicación y la prevención de riesgos laborales.
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Texto completo SciELO Brasil
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Id: lil-622750
Autor: Brenes, J.C.; Broiz, A.C.; Bassi, G.S.; Schwarting, R.K.W.; Brandão, M.L..
Título: Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(4):349-356, Apr. 2012. ilus.
Idioma: en.
Resumo: Electrical stimulation of midbrain tectum structures, particularly the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), produces defensive responses, such as freezing and escape behavior. Freezing also ensues after termination of dPAG stimulation (post-stimulation freezing). These defensive reaction responses are critically mediated by γ-aminobutyric acid and 5-hydroxytryptamine mechanisms in the midbrain tectum. Neurokinins (NKs) also play a role in the mediation of dPAG stimulation-evoked fear, but how NK receptors are involved in the global processing and expression of fear at the level of the midbrain tectum is yet unclear. The present study investigated the role of NK-1 receptors in unconditioned defensive behavior induced by electrical stimulation of the dPAG and IC of male Wistar rats. Spantide (100 pmol/0.2 μL), a selective NK-1 antagonist, injected into these midbrain structures had anti-aversive effects on defensive responses and distress ultrasonic vocalizations induced by stimulation of the dPAG but not of the IC. Moreover, intra-dPAG injections of spantide did not influence post-stimulation freezing or alter exploratory behavior in rats subjected to the elevated plus maze. These results suggest that NK-1 receptors are mainly involved in the mediation of defensive behavior organized in the dPAG. Dorsal periaqueductal gray-evoked post-stimulation freezing was not affected by intra-dPAG injections of spantide, suggesting that NK-1-mediated mechanisms are only involved in the output mechanisms of defensive behavior and not involved in the processing of ascending aversive information from the dPAG.
Responsável: BR1.1 - BIREME


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Id: lil-618055
Autor: Hatano, V. Y; Torricelli, A. S; Giassi, A. C. C; Coslope, L. A; Viana, M. B.
Título: Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(-)-carvone in the elevated T-maze
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(3):238-243, Mar. 2012. ilus, tab.
Idioma: en.
Resumo: Lippia alba (Mill.) N.E. Brown (Verbenaceae) is widely used in different regions of Central and South America as a tranquilizer. The plant’s anxiolytic properties, however, merit investigation. The present study evaluated the effects of repeated daily (14 days) intraperitoneal (ip) treatment with an essential oil (EO) from a chemotype of L. alba (LA, chemotype II, 12.5 and 25 mg/kg; N = 6-8) and (R)-(-)-carvone (25 mg/kg; N = 8-12), the main constituent of this chemotype, on male Wistar rats (weighing 250 g at the beginning of the experiments) submitted to the elevated T-maze (ETM). The ETM allows the measurement of two defensive responses: inhibitory avoidance and one-way escape. In terms of psychopathology, these responses have been related to generalized anxiety and panic disorder, respectively. Treatment with the EO impaired ETM avoidance latencies, without altering escape, in a way similar to the reference drug diazepam (P < 0.05) (avoidance 2: control = 84.6 ± 35.2; EO 12.5 mg/kg = 11.8 ± 3.8; EO 25 mg/kg = 14.6 ± 2.7; diazepam = 7 ± 2.1). (R)-(-)-carvone also significantly altered this same response (P < 0.05; avoidance 1: control = 91.9 ± 31.5; carvone = 11.6 ± 1.8; diazepam = 8.1 ± 3.3). These results were not due to motor changes since no significant effects were detected in an open field. These observations suggest that LA exerts anxiolytic-like effects on a specific subset of defensive behaviors that have been implicated in generalized anxiety disorder, and suggest that carvone is one of the constituents of LA responsible for its action as a tranquilizer.
Responsável: BR1.1 - BIREME


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Id: lil-612637
Autor: Rodrigues, David Henrique; Vilela, Márcia de Carvalho; Lacerda-Queiroz, Norinne; Miranda, Aline Silva de; Sousa, Larissa Fonseca da Cunha; Reis, Helton José dos; Teixeira, Antônio Lúcio.
Título: Behavioral investigation of mice with experimental autoimmune encephalomyelitis / Investigação comportamental de camundongos com encefalomielite autoimune experimental
Fonte: Arq. neuropsiquiatr;69(6):938-942, Dec. 2011. graf.
Idioma: en.
Resumo: Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG35-55 model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG35-55 are probably subtle or absent.

Esclerose múltipla é uma doença neuroinflamatória que resulta em séria incapacidade neurológica. Além do comprometimento físico, sintomas comportamentais também são comuns em pacientes com esclerose múltipla. A encefalomielite autoimune experimental (EAE) é considerada um modelo de esclerose múltipla e mimetiza as principais caracte-rísticas da doença, como a desmielinização e a fraqueza motora. Neste trabalho, objetivamos estudar parâmetros comportamentais em animais com EAE usando o modelo de MOG35-55 em camundongos C57BL/6. Analisamos memória e ansiedade em animais utilizando o labirinto em cruz elevado, o teste da esquiva inibitória e o teste de memória de reconhecimento. Nenhuma diferença em quaisquer dos testes foi encontrada comparando animais controles e animais induzidos com EAE. Assim, concluímos que alterações comportamentais em animais com EAE induzidos com MOG35-55 são provavelmente sutis ou ausentes.
Responsável: BR1.1 - BIREME


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Id: lil-607432
Autor: Fiorenza, Natália G; Sartor, Dagieli; Myskiw, Jociane C; Izquierdo, Iván.
Título: Treatment of fear memories: interactions between extinction and reconsolidation
Fonte: An. acad. bras. ciênc;83(4):1363-1372, Dec. 2011.
Idioma: en.
Resumo: Retrieval labilizes memory traces and these gates two protein synthesis-dependent processes in the brain: extinction, which inhibits further retrieval, and reconsolidation, which may enhance retrieval or change its content. Extinction may itself suffer reconsolidation. Interactions among these processes may be applied to treatments of fear memories, such as those underlying post-traumatic stress disorders.

A evocação labiliza os arquivos de memória, e isto permite dois processos dependentes de síntese protéica no cérebro: a extinção, que inibe a evocação ulterior, e a reconsolidação, que pode aumentar a evocação ou mudar seu conteúdo. A extinção pode por sua vez sofrer reconsolidação. Interações entre estes dois processos podem ser aplicados ao tratamento das memórias de medo, tais como aquelas em que se baseia o estresse pós-traumático.
Responsável: BR1.1 - BIREME


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Id: lil-604543
Autor: Foroozandeh, Elham; Ahadi, Hassan; Askari, Parviz; Naeini, Manoochehr Sattari.
Título: Effects of single, brief exposure to an 8 mT electromagnetic field on avoidance learning in male and female mice
Fonte: Psychol. neurosci. (Impr.);4(1):143-148, Jan.-June 2011. ilus, graf.
Idioma: en.
Resumo: The present study investigated the effect of extremely low frequency (8 mT, 50 Hz) electromagnetic fields (ELF-EMF) on avoidance learning in mice and compared the effect of an ELF-EMF in adult male and female mice. Learning was evaluated using a passive avoidance learning procedure in a standard wooden box, in which, despite their instinctive tendencies, mice learn to stay on a small platform to avoidant an electric shock. Before each learning session, the animals were exposed to an 8 mT, 50 Hz ELF created by a round coil. Immediately after 60 min exposure to the ELF-EMF, the mice were subjected to avoidance learning. The animals in the sham-exposed control group were placed in the coil for 60 min but were not exposed to the EMF and were subjected to the same behavioral procedures as the experimental group. The comparison of learned behaviors in the experimental and control groups showed that exposure to an 8 mT, 50 Hz ELF for 60 min significantly affected passive avoidance learning in both male (p < .023) and female (p < .015) mice.
Responsável: BR85.1 - Biblioteca Dante Moreira Leite



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