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  1 / 28491 MEDLINE  
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PMID:28991557
Autor:Niell BL; Freer PE; Weinfurtner RJ; Arleo EK; Drukteinis JS
Dirección:Division of Breast Imaging, Department of Diagnostic Imaging, H. Lee Moffitt Cancer Center and Research Institute, 12902 USF Magnolia Drive, Tampa, FL 33612-9416, USA. Electronic address: bethany.niell@moffitt.org.
Título:Screening for Breast Cancer.
Fuente:Radiol Clin North Am; 55(6):1145-1162, 2017 Nov.
ISSN:1557-8275
País de publicación:United States
Idioma:eng
Resumen:The goal of screening is to detect breast cancers when still curable to decrease breast cancer-specific mortality. Breast cancer screening in the United States is routinely performed with mammography, supplemental digital breast tomosynthesis, ultrasound, and/or MR imaging. This article aims to review the most commonly used breast imaging modalities for screening, discuss how often and when to begin screening with specific imaging modalities, and examine the pros and cons of screening. By the article's end, the reader will be better equipped to have informed discussions with patients and medical professionals regarding the benefits and disadvantages of breast cancer screening.
Tipo de publicación:JOURNAL ARTICLE; REVIEW


  2 / 28491 MEDLINE  
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PMID:28143431
Autor:Vierkant RA; Degnim AC; Radisky DC; Visscher DW; Heinzen EP; Frank RD; Winham SJ; Frost MH; Scott CG; Jensen MR; Ghosh K; Manduca A; Brandt KR; Whaley DH; Hartmann LC; Vachon CM
Dirección:Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Título:Mammographic breast density and risk of breast cancer in women with atypical hyperplasia: an observational cohort study from the Mayo Clinic Benign Breast Disease (BBD) cohort.
Fuente:BMC Cancer; 17(1):84, 2017 Jan 31.
ISSN:1471-2407
País de publicación:England
Idioma:eng
Resumen:BACKGROUND: Atypical hyperplasia (AH) and mammographic breast density (MBD) are established risk factors for breast cancer (BC), but their joint contributions are not well understood. We examine associations of MBD and BC by histologic impression, including AH, in a subcohort of women from the Mayo Clinic Benign Breast Disease Cohort. METHODS: Women with a diagnosis of BBD and mammogram between 1985 and 2001 were eligible. Histologic impression was assessed via pathology review and coded as non-proliferative disease (NP), proliferative disease without atypia (PDWA) and AH. MBD was assessed clinically using parenchymal pattern (PP) or BI-RADS criteria and categorized as low, moderate or high. Percent density (PD) was also available for a subset of women. BC and clinical information were obtained by questionnaires, medical records and the Mayo Clinic Tumor Registry. Women were followed from date of benign biopsy to BC, death or last contact. Standardized incidence ratios (SIRs) compared the observed number of BCs to expected counts. Cox regression estimated multivariate-adjusted MBD hazard ratios. RESULTS: Of the 6271 women included in the study, 1132 (18.0%) had low MBD, 2921 (46.6%) had moderate MBD, and 2218 (35.4%) had high MBD. A total of 3532 women (56.3%) had NP, 2269 (36.2%) had PDWA and 470 (7.5%) had AH. Over a median follow-up of 14.3 years, 528 BCs were observed. The association of MBD and BC risk differed by histologic impression (p-interaction = 0.03), such that there was a strong MBD and BC association among NP (p < 0.001) but non-significant associations for PDWA (p = 0.27) and AH (p = 0.96). MBD and BC associations for AH women were not significant within subsets defined by type of MBD measure (PP vs. BI-RADS), age at biopsy, number of foci of AH, type of AH (lobular vs. ductal) and body mass index, and after adjustment for potential confounding variables. Women with atypia who also had high PD (>50%) demonstrated marginal evidence of increased BC risk (SIR 4.98), but results were not statistically significant. CONCLUSION: We found no evidence of an association between MBD and subsequent BC risk in women with AH.
Tipo de publicación:JOURNAL ARTICLE; OBSERVATIONAL STUDY


  3 / 28491 MEDLINE  
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PMID:28109009
Autor:Shia WC; Huang YL; Wu HK; Chen DR
Dirección:Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan.
Título:Using Flow Characteristics in Three-Dimensional Power Doppler Ultrasound Imaging to Predict Complete Responses in Patients Undergoing Neoadjuvant Chemotherapy.
Fuente:J Ultrasound Med; 36(5):887-900, 2017 May.
ISSN:1550-9613
País de publicación:England
Idioma:eng
Resumen:OBJECTIVES: Strategies are needed for the identification of a poor response to treatment and determination of appropriate chemotherapy strategies for patients in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize that power Doppler ultrasound imaging can provide useful information on predicting response to neoadjuvant chemotherapy. METHODS: The solid directional flow of vessels in breast tumors was used as a marker of pathologic complete responses (pCR) in patients undergoing neoadjuvant chemotherapy. Thirty-one breast cancer patients who received neoadjuvant chemotherapy and had tumors of 2 to 5 cm were recruited. Three-dimensional power Doppler ultrasound with high-definition flow imaging technology was used to acquire the indices of tumor blood flow/volume, and the chemotherapy response prediction was established, followed by support vector machine classification. RESULTS: The accuracy of pCR prediction before the first chemotherapy treatment was 83.87% (area under the ROC curve [AUC] = 0.6957). After the second chemotherapy treatment, the accuracy of was 87.9% (AUC = 0.756). Trend analysis showed that good and poor responders exhibited different trends in vascular flow during chemotherapy. CONCLUSIONS: This preliminary study demonstrates the feasibility of using the vascular flow in breast tumors to predict chemotherapeutic efficacy.
Tipo de publicación:JOURNAL ARTICLE


  4 / 28491 MEDLINE  
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PMID:28946143
Autor:Wang J; Zeng H; Li H; Chen T; Wang L; Zhang K; Chen J; Wang R; Li Q; Wang S
Dirección:Department of General Surgery, Jinling Hospital, Medical school of Nanjing University, Nanjing, China.
Título:MicroRNA-101 Inhibits Growth, Proliferation and Migration and Induces Apoptosis of Breast Cancer Cells by Targeting Sex-Determining Region Y-Box 2.
Fuente:Cell Physiol Biochem; 43(2):717-732, 2017.
ISSN:1421-9778
País de publicación:Switzerland
Idioma:eng
Resumen:BACKGROUND: Increasing evidence has demonstrated that microRNAs play a critical role in breast cancer (BC) progression. microRNA-101 (miR-101) has been considered a tumor suppressive miRNA in different cancer types. This study aimed to investigate miR-101 expression in BC tissues and to investigate its roles in BC progression that are mediated by Sex-determining region Y-box 2 (SOX2), a critical oncogene in various cancers. METHODS: qRT-PCR and immunohistochemistry were performed to detect miR-101 and SOX2 expression in BC tissues and paired normal tissues or BC cell lines. MTT, transwell migration, wound healing, colony formation, flow cytometric and xenograft assays were performed to determine the influence of miR-101 and SOX2 on the malignant behaviors of BC cells in vitro and in vivo. RESULTS: miR-101 was significantly downregulated in BC tissues and cell lines. miR-101 overexpression inhibited the malignant behaviors of BC cells, both in vitro and in vivo. miR-101 downregulation had the converse effect. A miR-101 binding site was identified by luciferase reporter assay in the 3'UTR of SOX2. SOX2 was upregulated in BC tissues and cell lines, and its upregulation was associated with lymph node metastasis, pathological grade and TNM classification. SOX2 knockdown mimicked the effects of miR-101 overexpression on the malignant behaviors of BC cells, while SOX2 overexpression mitigated the miR-101-induced inhibition of these effects. CONCLUSIONS: Our study revealed that miR-101 plays a critical role in suppressing tumor progression by directly targeting SOX2.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (MIRN101 microRNA, human); 0 (MicroRNAs); 0 (SOX2 protein, human); 0 (SOXB1 Transcription Factors)


  5 / 28491 MEDLINE  
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PMID:28930757
Autor:Li X; Sun S; Li N; Gao J; Yu J; Zhao J; Li M; Zhao Z
Dirección:Department of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian, China.
Título:High Expression of CCR7 Predicts Lymph Node Metastasis and Good Prognosis in Triple Negative Breast Cancer.
Fuente:Cell Physiol Biochem; 43(2):531-539, 2017.
ISSN:1421-9778
País de publicación:Switzerland
Idioma:eng
Resumen:BACKGROUND/AIMS: Previous preclinical and clinical studies have reported a positive correlation between the expression of the C-C chemokine receptor 7 (CCR7) and the incidence of lymph node metastasis in breast cancer. However, the prognostic relevance of CCR7 expression in breast cancer remains contradictory till now. The aim of this study is to assess the correlation of the CCR7 expression with other clinicopathological features and prognosis in breast cancer. METHODS: The CCR7 gene amplification and mRNA expression levels from approximately 3,000 patients were retrieved from human breast cancer databases and analyzed. Furthermore, a total of 188 primary triple negative breast cancer patients were enrolled in this study (diagnosed since January 2009 to January 2013 from the Second Hospital of Dalian Medical University). The protein levels of CCR7 were examined by immunohistochemistry using paraffin-embedded tumor tissues. RESULTS: The analysis of gene amplification and mRNA levels showed the expression of CCR7 in breast cancer correlated with better prognosis. When we compared the CCR7 expressions in different subtypes, the basal-like group showed the highest expression of CCR7 and exhibited a better prognosis. Consistently, Kaplan-Meier analysis of 188 triple negative breast cancer patients showed that the prognosis of patients with positive CCR7 expression was significantly better than those with negative expression (HR=0.642, p=0.0275). Additionally, we also observed a positive correlation between lymph node metastasis and the CCR7 expression (p=0.0096). CONCLUSIONS: Our results indicated that elevated CCR7 expression as a marker for increased lymph node metastasis, in addition to serve as an independent prognostic indicator for better overall survival in triple negative breast cancer patients.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (CCR7 protein, human); 0 (Receptors, CCR7)


  6 / 28491 MEDLINE  
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PMID:28914475
Autor:Lee AY; Joe BN; Price ER
Dirección:Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California.
Título:The Predicament of the Probably Benign Breast MRI: Should We Rely on Intuition?
Fuente:Breast J; 23(5):501-503, 2017 09.
ISSN:1524-4741
País de publicación:United States
Idioma:eng
Tipo de publicación:EDITORIAL; COMMENT


  7 / 28491 MEDLINE  
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PMID:28558811
Autor:Coufal O; Ostrízek T; Krsicka P; Lzicarová E; Nenutil R; Procházková M; Bencsiková B; Grell P; Sefr R
Dirección:Department of Surgical Oncology, Masaryk Memorial Cancer Institute, Zluty kopec, 7, 656 53, Brno, Czech Republic.
Título:Focal necrosis mimicking breast cancer following coronary bypass grafting.
Fuente:World J Surg Oncol; 15(1):111, 2017 May 30.
ISSN:1477-7819
País de publicación:England
Idioma:eng
Resumen:BACKGROUND: Breast cancer can be diagnosed easily in most cases. However, occasionally, we are faced with some conditions that can mimic it. These may include inflammations, benign tumors, cysts, hematomas, or, more rarely, focal necrosis. CASE PRESENTATION: This report presents a case of focal breast necrosis following myocardial revascularization with the left internal mammary artery, which is a very rare condition, with only few cases described in the literature. The necrosis becomes usually apparent a few days or weeks after the surgery and is often coincidental with the dehiscence of sternotomy with necrosis of wound edges. As it mostly affects the skin, it can be easily recognized. Also, our patient developed a dehisced sternotomy shortly after the surgery but there were no obvious objective changes on the breast. The condition was first dominated only by non-specific subjective symptom-pain. Later, a lump in the breast occurred, when the sternotomy had already healed. Moreover, an enlarged lymph node was palpable in the axilla. Because of non-typical symptoms, the condition was suggestive of breast cancer for a relatively long time. The patient had suffered from a very strong pain until she was treated by mastectomy with a good clinical result. CONCLUSIONS: Mammary necrosis following the coronary artery bypass is rare. In most cases, it manifests on the skin shortly after the surgery concurrently with dehisced sternotomy, so it can be easily diagnosed. However, in sporadic cases, the symptoms may occur later and may mimic breast cancer. Our objective is to raise awareness of this rare condition.
Tipo de publicación:CASE REPORTS; JOURNAL ARTICLE


  8 / 28491 MEDLINE  
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PMID:28438385
Autor:Zhou D; Springer MZ; Xu D; Liu D; Hudmon A; Macleod KF; Meroueh SO
Dirección:Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, United States.
Título:Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth.
Fuente:Bioorg Med Chem; 25(12):2995-3005, 2017 Jun 15.
ISSN:1464-3391
País de publicación:England
Idioma:eng
Resumen:Triple-negative breast cancers (TNBCs) lack the signature targets of other breast tumors, such as HER2, estrogen receptor, and progesterone receptor. These aggressive basal-like tumors are driven by a complex array of signaling pathways that are activated by multiple driver mutations. Here we report the discovery of 6 (KIN-281), a small molecule that inhibits multiple kinases including maternal leucine zipper kinase (MELK) and the non-receptor tyrosine kinase bone marrow X-linked (BMX) with single-digit micromolar IC s. Several derivatives of 6 were synthesized to gain insight into the binding mode of the compound to the ATP binding pocket. Compound 6 was tested for its effect on anchorage-dependent and independent growth of MDA-MB-231 and MDA-MB-468 breast cancer cells. The effect of 6 on BMX prompted us to evaluate its effect on STAT3 phosphorylation and DNA binding. The compound's inhibition of cell growth led to measurements of survivin, Bcl-X , p21 , and cyclin A2 levels. Finally, LC3B-II levels were quantified following treatment of cells with 6 to determine whether the compound affected autophagy, a process that is known to be activated by STAT3. Compound 6 provides a starting point for the development of small molecules with polypharmacology that can suppress TNBC growth and metastasis.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Antineoplastic Agents); 0 (Protein Kinase Inhibitors); 0 (STAT3 Transcription Factor); 0 (Small Molecule Libraries); 0 (Tumor Suppressor Protein p53)


  9 / 28491 MEDLINE  
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PMID:28205064
Autor:Jaber S; Rogers C; Sunderland B; Parsons R; MacKenzie S; Seet J; Czarniak P
Dirección:Curtin University, Bentley, WA, Australia.
Título:Appropriateness of surgical antibiotic prophylaxis for breast surgery procedures.
Fuente:Int J Clin Pharm; 39(2):483-486, 2017 Apr.
ISSN:2210-7711
País de publicación:Netherlands
Idioma:eng
Resumen:Background Guidelines for the appropriate use of antibiotic prophylaxis are provided in the Therapeutic Guidelines: Antibiotics (eTG) in Australia. Inappropriate use of antibiotics is problematic. Objective To examine adherence with therapeutic guidelines (eTG) in breast surgery and trends in non-adherence dependent on the type of breast surgery performed. Setting Major Western Australian teaching hospital. Method A retrospective cross-sectional study reviewed a random sample of 150 from 1049 eligible medical records of patients who underwent a breast surgical procedure in 2013 or 2014. Main outcome measure Adherence to the eTG. Results Antibiotic prophylaxis was prescribed for 139 (92.7%) operations. Adherence to the eTG occurred in 20 (13.3%) operations, whilst 11 (7.3%) did not adhere to any element of the eTG. Appropriate timing was the main factor not adhered to. Postoperative antibiotics were prescribed following 35 (23.3%) operations, with 32 (91.4%) administered beyond 24 h. Length of stay was significantly different (p = 0.0036) between surgical groups. There was a tendency for risk of an infection to be decreased with adherence (odds ratio: 0.23; 95% CI: 0.05, 1.07; p = 0.06). Conclusion Adherence to the eTG was low (13.3%), despite a decreased risk of SSI when guidelines were followed.
Tipo de publicación:JOURNAL ARTICLE


  10 / 28491 MEDLINE  
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PMID:29049174
Autor:Xue Y; Yao S; Li X; Zhang H
Dirección:aDepartment of Ultrasonography, Linyi People's Hospital, Linyi City, Shandong bDepartment of Ultrasonography, Heze Municipal Hospital, Heze City, Shandong cDepartment of Radiology, Linyi People's Hospital, Linyi City, Shandong, China.
Título:Value of shear wave elastography in discriminating malignant and benign breast lesions: A meta-analysis.
Fuente:Medicine (Baltimore); 96(42):e7412, 2017 Oct.
ISSN:1536-5964
País de publicación:United States
Idioma:eng
Resumen:The analysis was aimed to evaluate the diagnostic accuracy of shear wave elastography (SWE) for malignant breast lesions through a meta-analysis.Related articles were searched from Pubmed, Embase, and Cochrane library. Overall sensitivity and specificity were analyzed with DerSimonian and Laird random effects model. Area under curve with corresponding 95% confidence interval (were calculated to evaluate the diagnostic accuracy of SWE. Sensitivity and publication bias were assessed as well.A total of 25 articles including 4128 patients and 4546 breast lesions were included in the pooled analysis. In the subgroup analysis, diagnostic sensitivity and specificity of SWE in Asian population were 0.84 (0.79-0.88) and 0.87 (0.84-0.90), respectively, whereas they were 0.92 (0.86-0.96) and 0.89 (0.84-0.92) in Caucasian population. The diagnostic accuracy of SWE was a little higher for Caucasians than for Asians (0.95 vs. 0.92). The diagnostic sensitivity and specificity of virtual touch tissue quantification were 0.85 (0.77-0.91) and 0.93 (0.88-0.96), respectively. It showed a little higher value in specificity and summary ROC curve than SWE (0.93 vs. 0.87; 0.95 vs. 0.93). In addition, maximum stiffness exhibited higher detection sensitivity than that of mean stiffness (0.91 vs. 0.85).SWE serves as an accurate diagnostic technology for discriminating between malignant and benign breast lesions.
Tipo de publicación:JOURNAL ARTICLE; META-ANALYSIS; REVIEW



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