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  1 / 5374 MEDLINE  
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PMID:29220436
Autor:Ni Y; Jensen K; Kouskoumvekaki I; Panagiotou G
Dirección:Systems Biology & Bioinformatics Group, School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong.
Título:NutriChem 2.0: exploring the effect of plant-based foods on human health and drug efficacy.
Fuente:Database (Oxford); 2017, 2017 Jan 01.
ISSN:1758-0463
País de publicación:England
Idioma:eng
Resumen:Database URL: http://sbb.hku.hk/services/NutriChem-2.0/.
Tipo de publicación:JOURNAL ARTICLE


  2 / 5374 MEDLINE  
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PMID:29240794
Autor:Tsuchiya R; Taira Y; Orita M; Fukushima Y; Endo Y; Yamashita S; Takamura N
Dirección:Department of Global Health, Medicine and Welfare, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Título:Radiocesium contamination and estimated internal exposure doses in edible wild plants in Kawauchi Village following the Fukushima nuclear disaster.
Fuente:PLoS One; 12(12):e0189398, 2017.
ISSN:1932-6203
País de publicación:United States
Idioma:eng
Resumen:Kawauchi Village, in Fukushima Prefecture, is located within a 30-km radius of the nuclear disaster site of the Fukushima Daiichi Nuclear Power Plant (FDNPP). "Sansai" (edible wild plants) in this village have been evaluated by gamma spectrometry after the residents had returned to their homes, to determine the residents' risk of internal exposure to artificial radionuclides due to consumption of these plants. The concentrations of radiocesium (cesium-134 and cesium-137) were measured in all 364 samples collected in spring 2015. Overall, 34 (9.3%) samples exceeded the regulatory limit of 100 Bq/kg established by Japanese guidelines, 80 (22.0%) samples registered between 100 Bq/kg and 20 Bq/kg, and 250 (68.7%) registered below 20 Bq/kg (the detection limit). The internal effective doses from edible wild plants were sufficiently low (less than 1 mSv/y), at 3.5±1.2 µSv/y for males and 3.2±0.9 µSv/y for females (2.7±1.5 µSv/y for children and 3.7±0.7 µSv/y for adults in 2015). Thus, the potential internal exposure doses due to consumption of these edible wild plants were below the applicable radiological standard limits for foods. However, high radiocesium levels were confirmed in specific species, such as Eleutherococcus sciadophylloides ("Koshiabura") and Osmunda japonica (Asian royal fern, "Zenmai"). Consequently, a need still might exist for long-term follow-up such as environmental monitoring, physical and mental support to avoid unnecessary radiation exposure and to remove anxiety about adverse health effects due to radiation. The customs of residents, especially the "satoyama" (countryside) culture of ingesting "sansai," also require consideration in the further reconstruction of areas such as Kawauchi Village that were affected by the nuclear disaster.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Cesium Radioisotopes)


  3 / 5374 MEDLINE  
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PMID:28855423
Autor:Yao Y; Chen Y; Adili R; McKeown T; Chen P; Zhu G; Li D; Ling W; Ni H; Yang Y
Dirección:Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Título:Plant-based Food Cyanidin-3-Glucoside Modulates Human Platelet Glycoprotein VI Signaling and Inhibits Platelet Activation and Thrombus Formation.
Fuente:J Nutr; 147(10):1917-1925, 2017 Oct.
ISSN:1541-6100
País de publicación:United States
Idioma:eng
Resumen:Platelets play an important role in hemostasis, thrombosis, and atherosclerosis. Glycoprotein VI (GPVI) is a major platelet receptor that interacts with exposed collagen on injured vessel walls. Our previous studies have shown that anthocyanins (a type of natural plant pigment) attenuate platelet function; however, whether anthocyanins affect collagen-induced GPVI signaling remains unknown. The objective of this study was to explore the effects of cyanidin-3-glucoside (Cy-3-g, one of the major bioactive compounds in anthocyanins) on platelet activation and thrombosis and the GPVI signaling pathway. Platelets from healthy men and women were isolated and incubated with different concentrations (0, 0.5, 5, and 50 µM) of Cy-3-g. The expression of activated integrin αIIbß3, P-selectin, CD63, and CD40L, fibrinogen binding to platelets, and platelet aggregation were evaluated in vitro. Platelet adhesion and aggregation in whole blood under flow conditions were assessed in collagen-coated perfusion chambers. Thrombosis and hemostasis were assessed in 3-4-wk-old male C57BL/6J mice through FeCl -induced intravital microscopy and tail bleeding time. The effect of Cy-3-g on collagen-induced human platelet GPVI signaling was explored with Western blot. Cy-3-g attenuated platelet function in a dose-dependent manner. The 0.5-µM dose of Cy-3-g inhibited ( < 0.05) human platelet adhesion and aggregation to collagen at both venous (-54.02%) and arterial (-22.90%) shear stresses. The 5-µM dose inhibited ( < 0.05) collagen-induced human platelet activation (PAC-1: -48.21%, P-selectin: -50.63%), secretion (CD63: -73.89%, CD40L: -43.70%), fibrinogen binding (-56.79%), and aggregation (-17.81%). The 5-µM dose attenuated ( < 0.01) thrombus growth (-66.67%) without prolonging bleeding time in mice. The 50-µM dose downregulated ( < 0.05) collagen-induced GPVI signaling in human platelets and significantly decreased phosphorylation of Syk-linker for activation of T cells (LAT)-SLP76 (Syk: -39.08%, LAT: -32.25%, SLP76: -40.00%) and the expression of Lyn (-31.89%), Fyn (-36.27%), and phospholipase C-γ2 (-39.08%). Cy-3-g inhibits human platelet activation, aggregation, secretion, and thrombus formation, and downregulates the collagen-GPVI signaling pathway. Supplementation of Cy-3-g may have protective effects against atherothrombosis.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Adaptor Proteins, Signal Transducing); 0 (Anthocyanins); 0 (Antigens, CD); 0 (Glucosides); 0 (P-Selectin); 0 (Phosphoproteins); 0 (Plant Extracts); 0 (Platelet Membrane Glycoproteins); 0 (SELP protein, human); 0 (SLP-76 signal Transducing adaptor proteins); 0 (platelet membrane glycoprotein VI); 7084-24-4 (cyanidin 3-O-glucoside); 9007-34-5 (Collagen)


  4 / 5374 MEDLINE  
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PMID:28783000
Autor:Eom T; Cho HD; Kim J; Park M; An J; Kim M; Kim SH; Han SB
Dirección:a Department of Pharmaceutical Analysis, College of Pharmacy , Chung-Ang University , Dongjak-gu , Seoul , Republic of Korea.
Título:Multiclass mycotoxin analysis in edible oils using a simple solvent extraction method and liquid chromatography with tandem mass spectrometry.
Fuente:Food Addit Contam Part A Chem Anal Control Expo Risk Assess; 34(11):2011-2022, 2017 Nov.
ISSN:1944-0057
País de publicación:England
Idioma:eng
Resumen:A simple and rapid method for the simultaneous determination of 11 mycotoxins - aflatoxins B , B , G and G ; fumonisins B , B and B ; ochratoxin A; zearalenone; deoxynivalenol; and T-2 toxin - in edible oils was established using liquid chromatography tandem mass spectrometry (LC-MS/MS). In this study, QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe), QuEChERS with dispersive liquid-liquid microextraction, and solvent extraction were examined for sample preparation. Among these methods, solvent extraction with a mixture of formic acid/acetonitrile (5/95, v/v) successfully extracted all target mycotoxins. Subsequently, a defatting process using n-hexane was employed to remove the fats present in the edible oil samples. Mass spectrometry was carried out using electrospray ionisation in polarity switching mode with multiple reaction monitoring. The developed LC-MS/MS method was validated by assessing the specificity, linearity, recovery, limit of quantification (LOQ), accuracy and precision with reference to Commission Regulation (EC) 401/2006. Mycotoxin recoveries of 51.6-82.8% were achieved in addition to LOQs ranging from 0.025 ng/g to 1 ng/g. The edible oils proved to be relatively uncomplicated matrices and the developed method was applied to 9 edible oil samples, including soybean oil, corn oil and rice bran oil, to evaluate potential mycotoxin contamination. The levels of detection were significantly lower than the international regulatory standards. Therefore, we expect that our developed method, based on simple, two-step sample preparation process, will be suitable for the large-scale screening of mycotoxin contamination in edible oils.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Mycotoxins); 0 (Plant Oils); 0 (Solvents)


  5 / 5374 MEDLINE  
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PMID:28712477
Autor:Momtazi AA; Askari-Khorasgani O; Abdollahi E; Sadeghi-Aliabadi H; Mortazaeinezhad F; Sahebkar A
Dirección:Nanotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: abbasmomtazi@yahoo.com.
Título:Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia odoratissima Mozaff.
Fuente:J Acupunct Meridian Stud; 10(3):180-186, 2017 Jun.
ISSN:2093-8152
País de publicación:Korea (South)
Idioma:eng
Resumen:BACKGROUND: Kelussia odoratissima Mozaff. (Apiaceae) is an edible, indigenous, and ethnomedicinal plant that grows only in Iran. Although antioxidant and anti-inflammatory properties of K. odoratissima have been reported, cytotoxic activity of this plant has not been investigated previously. OBJECTIVE: This study aims to evaluate the cytotoxicity of K. odoratissima leaf extract against a panel of human cancer cell lines. A secondary aim was to perform a phytochemical analysis of the plant's leaf oil. METHODS: To extract the plant oil, dried leaves were subjected to hydrodistillation using a Clevenger-type apparatus for up to 3 hours. For the phytochemical analysis, essential oil was subjected to gas chromatography/mass spectrometry. Plant extraction was performed by macerating leaf powder of K. odoratissima (50 g) in 70% methanol (500 mL) at room temperature (25-28°C) for 24 hours. To perform cytotoxicity assays, methanolic extract of K. odoratissima was tested against a panel of cell lines including MDA-MB468 (human breast cancer cell line), K562 (human leukemia cell line), SKOV3 (human ovarian cancer cell line), Y79 (human eye cancer cell line), A549 (lung cancer cell line), and HEK 293 (normal human embryonic kidney cell line). RESULTS: Gas chromatography/mass spectrometry analysis revealed that sesquiterpens are dominant volatile components of the plant, followed by phthalides comprising 3-butyldine phthalide and 3-n-butyl phthalide, the latter compound being the major component of the leaf oil (25.1%). The leaf extract showed selective and dose-dependent cytotoxicity against MDA-MB468, K562, SKOV3, Y79, and A549 cancer cell lines with IC values (concentration that inhibits cell growth by 50%) of 85 µg/mL, 70 µg/mL, 120 µg/mL, 82 µg/mL, and145 µg/mL, respectively. CONCLUSIONS: The present results suggest a direct cytotoxic activity of K. odoratissima leaf extract against human cancer cell lines. This activity of K. odoratissima may find application in combination with traditional herbal medicines to develop a new anticancer pharmacopuncture therapy.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Antineoplastic Agents); 0 (Plant Extracts)


  6 / 5374 MEDLINE  
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PMID:28700665
Autor:Roy A; Lim L; Srivastava S; Lu Y; Song J
Dirección:Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.
Título:Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plants.
Fuente:PLoS One; 12(7):e0180632, 2017.
ISSN:1932-6203
País de publicación:United States
Idioma:eng
Resumen:The recent Zika viral (ZIKV) epidemic has been associated with severe neurological pathologies such as neonatal microcephaly and Guillain-Barre syndrome but unfortunately no vaccine or medication is effectively available yet. Zika NS2B-NS3pro is essential for the proteolysis of the viral polyprotein and thereby viral replication. Thus NS2B-NS3pro represents an attractive target for anti-Zika drug discovery/design. Here, we have characterized the solution conformations and catalytic parameters of both linked and unlinked Zika NS2B-NS3pro complexes and found that the unlinked complex manifested well-dispersed NMR spectra. Subsequently with selective isotope-labeling using NMR spectroscopy, we demonstrated that C-terminal residues (R73-K100) of NS2B is highly disordered without any stable tertiary and secondary structures in the Zika NS2B-NS3pro complex in the free state. Upon binding to the well-characterized serine protease inhibitor, bovine pancreatic trypsin inhibitor (BPTI), only the extreme C-terminal residues (L86-K100) remain disordered. Additionally, we have identified five flavonoids and one natural phenol rich in edible plants including fruits and vegetables, which inhibit Zika NS2B-NS3pro in a non-competitive mode, with Ki ranging from 770 nM for Myricetin to 34.02 µM for Apigenin. Molecular docking showed that they all bind to a pocket on the back of the active site and their structure-activity relationship was elucidated. Our study provides valuable insights into the solution conformation of Zika NS2B-NS3pro and further deciphers its susceptibility towards allosteric inhibition by natural products. As these natural product inhibitors fundamentally differ from the currently-known active site inhibitors in terms of both inhibitory mode and chemical scaffold, our finding might open a new avenue for development of better allosteric inhibitors to fight ZIKV infection.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Biological Products); 0 (Buffers); 0 (NS2B protein, flavivirus); 0 (NS3 protein, flavivirus); 0 (Solutions); 0 (Viral Nonstructural Proteins); EC 3.4.21.- (Serine Endopeptidases); EC 3.6.4.13 (RNA Helicases)


  7 / 5374 MEDLINE  
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PMID:28685577
Autor:Lin L; Zheng F; Zhou H; Li S
Dirección:Fujian Province Key Laboratory of Modern Analytical Science and Separation Technology and §College of Chemistry and Environmental Science, Minnan Normal University , Zhangzhou, Fujian 363000, People's Republic of China.
Título:Biomimetic Gastrointestinal Tract Functions for Metal Absorption Assessment in Edible Plants: Comparison to In Vivo Absorption.
Fuente:J Agric Food Chem; 65(30):6282-6287, 2017 Aug 02.
ISSN:1520-5118
País de publicación:United States
Idioma:eng
Resumen:A biomimetic gastrointestinal tract, including in vitro digestion and biomimetic biomembrane extraction, has been proposed for absorption assessment of metals from edible plants. However, its validity is still unknown. Herein, two species of edible plants, Anoectochilus roxburghii and Radix astragali, were selected and digested in a bionic mouth, stomach, and intestine, and then trace metals (Cr, Mn, Fe, Ni, Cu, Zn, Se, Sr, As, and Pb) were transformed to their final metal species. To check model predictability, in vitro and in vivo metal absorption were imitated and tested by monolayer liposome extraction and rat stomach or single-pass duodenal intestine, respectively. A strong correlation was established between in vivo and in vitro metal absorption ratios, with 0.89 > R > 0.66, and a significant relationship (p < 0.05) was exhibited for stomach, intestine, two plant species, and 10 metal species. Our biomimetic system could be used as low-cost alternatives to animal and clinical studies for multi-metal absorption.
Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
Nombre de substancia:0 (Drugs, Chinese Herbal); 0 (Metals); 922OP8YUPF (Huang Qi)


  8 / 5374 MEDLINE  
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PMID:28558360
Autor:Zhang C; Wang X; Ashraf U; Qiu B; Ali S
Dirección:Key Laboratory of Bio-Pesticide Innovation and Application, Engineering Research Centre of Biological Control, South China Agricultural University, Guangzhou 510642, P.R. China. Electronic address: zhangcanmail@163.com.
Título:Transfer of lead (Pb) in the soil-plant-mealybug-ladybird beetle food chain, a comparison between two host plants.
Fuente:Ecotoxicol Environ Saf; 143:289-295, 2017 Sep.
ISSN:1090-2414
País de publicación:Netherlands
Idioma:eng
Resumen:Contamination of soil with heavy metals has become an issue of concern on global scale. This study investigates the translocation of lead (Pb) along the soil - plant (eggplant and tomato) - mealybug (Dysmicoccus neobrevipes) - ladybird beetle (Cryptolaemus montrouzieri) food chain. Soil amendments used for this study were adjusted to 0, 25, 50 and 100mg/kg of Pb (w/w). The results revealed significantly higher transfer of Pb in tomato when compared to eggplant. Bio-magnification of Pb (2-4 times) was observed for soil - root transfer whereas Pb was bio-minimized in later part of food chain (shoot - mealybug - ladybird transfer). A dose dependent increase in transfer of Pb across the multi-trophic food chain was observed for both host plants. A decrease in coefficients of Pb transfer (from root - shoot and shoot - mealybug) was observed with increase in Pb concentrations. Our results also showed removal of Pb from the bodies of ladybird beetle during metamorphosis. Further studies are required to explain the mechanisms or physiological pathways involved in the bio-minimization of Pb across the food chain.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Soil); 0 (Soil Pollutants); 2P299V784P (Lead)


  9 / 5374 MEDLINE  
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PMID:28494204
Autor:Medyk M; Grembecka M; Brzezicha-Cirocka J; Falandysz J
Dirección:a Laboratory of Environmental Chemistry & Ecotoxicology , Gdansk University , Gdansk , Poland.
Título:Bio- and toxic elements in mushrooms from the city of Umeå and outskirts, Sweden.
Fuente:J Environ Sci Health B; 52(8):577-583, 2017 Aug 03.
ISSN:1532-4109
País de publicación:England
Idioma:eng
Resumen:Edible mushrooms (Albatrellus ovinus, Boletus edulis, Clitocybe odora, Gomphidius glutinosus, Leccinum scabrum, Leccinum versipelle, Lycoperdon perlatum, Suillus bovinus, Suillus luteus, and Xerocomus subtomentosus) collected from unpolluted areas of the city of Umeå and its outskirts in the northern part of Sweden were examined for contents of toxic metallic elements (Cd, Pb, and Ag) and essential macro- and microelements (K, Na, Ca, Mg, Cu, Fe, Mn, and Zn) using a validated method and a final measurement by flame atomic absorption spectroscopy (F-AAS). The median values of the toxic metallic element concentrations (in mg kg dry biomass, db) ranged from: 0.12-3.9, 0.46-5.1, and 0.91-6.2 for Ag, Cd and Pb, respectively. For the essential metallic elements, the median values of concentrations ranged from: 24000-58000, 15-2000, 59-610, 520-1900, 2.0-97, 16-150, 15-120, and 4.3-26 mg kg db for K, Na, Ca, Mg, Cu, Zn, Fe, and Mn, respectively. The baseline concentrations of the metallic elements determined in mushrooms were mainly affected by the fungal species. The assessed probable maximal dietary intake of Cd (0.002 mg kg body mass) solely from a mushroom meal was only slightly below a revised value of the tolerable weekly intake for this element, while for Pb (0.003 mg kg body mass) it was tenfold below the provisionally tolerable weekly intake.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Metals)


  10 / 5374 MEDLINE  
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PMID:28382889
Autor:Mathai JK; Liu Y; Stein HH
Dirección:1Division of Nutritional Sciences,University of Illinois,Urbana,IL 61801,USA.
Título:Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein digestibility-corrected amino acid scores (PDCAAS).
Fuente:Br J Nutr; 117(4):490-499, 2017 Feb.
ISSN:1475-2662
País de publicación:England
Idioma:eng
Resumen:An experiment was conducted to compare values for digestible indispensable amino acid scores (DIAAS) for four animal proteins and four plant proteins with values calculated as recommended for protein digestibility-corrected amino acid scores (PDCAAS), but determined in pigs instead of in rats. Values for standardised total tract digestibility (STTD) of crude protein (CP) and standardised ileal digestibility (SID) of amino acids (AA) were calculated for whey protein isolate (WPI), whey protein concentrate (WPC), milk protein concentrate (MPC), skimmed milk powder (SMP), pea protein concentrate (PPC), soya protein isolate (SPI), soya flour and whole-grain wheat. The PDCAAS-like values were calculated using the STTD of CP to estimate AA digestibility and values for DIAAS were calculated from values for SID of AA. Results indicated that values for SID of most indispensable AA in WPI, WPC and MPC were greater (P<0·05) than for SMP, PPC, SPI, soya flour and wheat. With the exception of arginine and tryptophan, the SID of all indispensable AA in SPI was greater (P<0·05) than in soya flour, and with the exception of threonine, the SID of all indispensable AA in wheat was less (P<0·05) than in all other ingredients. If the same scoring pattern for children between 6 and 36 months was used to calculate PDCAAS-like values and DIAAS, PDCAAS-like values were greater (P<0·05) than DIAAS values for SMP, PPC, SPI, soya flour and wheat indicating that PDCAAS-like values estimated in pigs may overestimate the quality of these proteins.
Tipo de publicación:COMPARATIVE STUDY; JOURNAL ARTICLE
Nombre de substancia:0 (Amino Acids, Essential); 0 (Dietary Proteins); 0 (Milk Proteins); 0 (Plant Proteins); 0 (Soybean Proteins); 0 (Whey Proteins)



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