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Búsqueda : F01.100.893 [Categoria DeCS]
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  1 / 62 MEDLINE  
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PMID:28969722
Autor:Schepers R; Markus CR
Dirección:Department of Neuropsychology & Psychopharmacology, Faculty of Psychology and Neuroscience,University Maastricht,6229 ER Maastricht,The Netherlands.
Título:The interaction between 5-HTTLPR genotype and ruminative thinking on BMI.
Fuente:Br J Nutr; 118(8):629-637, 2017 Oct.
ISSN:1475-2662
País de publicación:England
Idioma:eng
Resumen:Negative affect or stress is often found to increase energy intake for high palatable energy-rich foods and hence weight gain. Reduced brain serotonin (5-HT) function is known to increase stress vulnerability and the risk for eating-related disturbances. A short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) is associated with a less efficient functioning brain serotonin system and therefore higher stress vulnerability. It has been suggested that this genotype may be directly linked to an increased risk for weight gain and/or obesity. However, a high amount of variability has been apparent in replicating such a direct gene on weight gain relationship. A most recent suggestion is that this gene by weight relationship might be moderated by an additional (cognitive) vulnerability factor involving repetitive negative thinking (rumination). Our objective was to investigate whether the S-allele of 5-HTTLPR contributes to weight gain particularly in high cognitive ruminating individuals. A total of 827 healthy young male and female college students (aged 21·3 (sd 3·0) years; BMI 16-41·7 kg/m2) were genotyped for the 5-HTTLPR polymorphism and assessed for rumination (Event Related Ruminative Index) and body weight. In line with the hypothesis, a hierarchical regression model showed that higher BMI scores were observed in specifically high ruminating S'-carriers (P=0·031, f²=0·022). These results suggest that cognitive rumination may be a critical moderator of the association between 5-HTTLPR and body mass.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (SLC6A4 protein, human); 0 (Serotonin Plasma Membrane Transport Proteins)


  2 / 62 MEDLINE  
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PMID:28686162
Autor:Rejtô N; Papp G; Molnár J
Dirección:Debreceni Egyetem Pszichologiai Intezet, Debrecen, Hungary, E-mail: mojudit@gmail.com.
Título:[The etiology of obsessive-compulsive disorder from the aspects of attachment theory, with special regard to perceived parental treatment, attachment patterns and emotion regulation difficulties].
Fuente:Psychiatr Hung; 32(2):145-157, 2017.
ISSN:0237-7896
País de publicación:Hungary
Idioma:hun
Resumen:BACKGROUND AND AIMS: The focus of our study was the etiology of obsessive-compulsive disorder from attachment aspects. Our aim was to examine the representations of perceived parental treatment, attachment patterns and the level of emotion regulation of people who suffer from obsessive-compulsive disorder. METHOD: 223 people participated in our study. The clinical group consisted of 92 persons with obsessive-compulsive symptoms, while the control group involved 131 people without OC symptoms. In the study we used the Young Parenting Inventory, the Relationship Questionnaire, and the Difficulties in Emotion Regulation Scale. Besides we compiled a questionnaire based on the DSM-5 and a demographic questionnaire. Respondents could fill the questionnaires online. RESULTS: The clinical group is characterized by significantly higher toxic frustration of each five basic emotional needs than the control group. Specifically, in the case of people with OC smptoms the toxic parental treatments for Defectiveness/ Shame, Dependence/Incompetence, Enmeshment/Undeveloped self, Entitlement/Grandiosity, Approval-seeking/ Recognition-seeking, Negativity/Pessimism, Emotional inhibition, Unrelenting standards/Hypercriticalness and Punitiveness were significantly more frequent than in the control group. The OC group is also characterized by significantly lower rate of secure attachment style, while dismissive attachment style proved to be the most frequent attachment style among them. The OC group also struggle with significantly higher level of emotion regulation difficulties.
Tipo de publicación:JOURNAL ARTICLE


  3 / 62 MEDLINE  
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PMID:28426010
Autor:Knowlton N
Dirección:Smithsonian's National Museum of Natural History and co-host of the Earth Optimism Summit in Washington DC.
Título:Doom and gloom won't save the world.
Fuente:Nature; 544(7650):271, 2017 04 18.
ISSN:1476-4687
País de publicación:England
Idioma:eng
Tipo de publicación:JOURNAL ARTICLE


  4 / 62 MEDLINE  
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PMID:28323661
Autor:Zhang X; Zhang J; Procter N; Chen X; Su Y; Lou F; Cao F
Dirección:*School of Nursing, Shandong University, Jinan, Shandong, China; †School of Nursing and Midwifery, University of South Australia, Adelaide, Australia; ‡Shandong University Center for Suicide Prevention Research, Jinan, Shandong, China; §Department of Sociology, State University of New York College at Buffalo, Buffalo, NY; and ∥School of Foreign Languages and Literature, Shandong University, Jinan, Shandong, China.
Título:Suicidal Ideation and Psychological Strain Among Patients Diagnosed With Stomach Cancer: The Mediation of Psychopathological Factors.
Fuente:J Nerv Ment Dis; 205(7):550-557, 2017 Jul.
ISSN:1539-736X
País de publicación:United States
Idioma:eng
Resumen:Patients with stomach cancer are at high risk to experience suicidal ideation. Strain theory of suicide assumes that suicide is preceded by psychological strain. Despite wide international acceptance of the theory, its use with a sample of patients with stomach cancer has not previously been reported. The aims were to examine the relationship between psychological strain and suicidal ideation among patients with stomach cancer and to determine whether psychopathological factors act as mediators. A cross-sectional study was undertaken involving subjects with no history of mental disorder, and questionnaires were administered by face-to-face interview. Patients who experienced more psychological strain, especially coping strain, are more likely to experience suicidal ideation. The mediation effects of hopelessness and psychological distress are significant. Psychological strain, hopelessness, and psychological distress may be the vital factors among patients with stomach cancer in the suicide-risk assessment interview and for care planning and psychological intervention.
Tipo de publicación:JOURNAL ARTICLE


  5 / 62 MEDLINE  
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PMID:27765413
Autor:Poelen EA; Schijven EP; Otten R; Didden R
Dirección:Research & Development Pluryn, P.O. Box 53, 6500 AB Nijmegen, The Netherlands; Behavioural Science Institute, Radboud University, P.O. Box 9104, 6500 HE Nijmegen, The Netherlands. Electronic address: epoelen01@pluryn.nl.
Título:Personality dimensions and substance use in individuals with mild to borderline intellectual disabilities.
Fuente:Res Dev Disabil; 63:142-150, 2017 Apr.
ISSN:1873-3379
País de publicación:United States
Idioma:eng
Resumen:AIMS: The aim of this study was to examine the role of the personality dimensions anxiety sensitivity, negative thinking, impulsivity and sensation seeking (as assessed by the revised version of the Substance Use Risk Profile Scale; SURPS) in substance use in individuals with mild to borderline intellectual disabilities (MBID). METHOD: We tested the relationship between level of ID and SURPS personality dimensions and the relationship between SURPS personality dimensions and severity of alcohol and drug use. Participants were 118 persons (mean age 20.5 years) with a mean IQ of 71.1 admitted to care facilities for persons with MBID and severe behavioral problems. RESULTS: We found no significant relationship between level of ID and the four personality dimensions. In addition, findings showed that individuals with lower levels of anxiety sensitivity, higher levels of negative thinking, impulsivity and sensation seeking showed more severe alcohol use. Individuals with higher levels of negative thinking and sensation seeking had more severe drug use. CONCLUSIONS AND IMPLICATIONS: The SURPS personality dimensions identify persons at increased risk for substance use disorders and might be useful in developing selective substance use interventions for individuals with MBID.
Tipo de publicación:JOURNAL ARTICLE


  6 / 62 MEDLINE  
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PMID:27749131
Autor:Kreitschmann-Andermahr I; Buchfelder M; Kleist B; Kohlmann J; Menzel C; Buslei R; Koltowska-Häggsträm M; Strasburger C; Siegel S
Título:PREDICTORS OF QUALITY OF LIFE IN 165 PATIENTS WITH ACROMEGALY: RESULTS FROM A SINGLE-CENTER STUDY.
Fuente:Endocr Pract; 23(1):79-88, 2017 Jan.
ISSN:1530-891X
País de publicación:United States
Idioma:eng
Resumen:OBJECTIVE: Even if treated, acromegaly has a considerable impact on patient quality of life (QoL); despite this, the exact clinical determinants of QoL in acromegaly are unknown. This study retrospectively examines a cohort of treated patients with acromegaly, with the aim of identifying these determinants. METHODS: Retrospective survey analysis, with 165 patients included in the study. All patients completed a survey, which included demographic data and the clinical details of their disease, the Short Form-36 Health Survey (SF-36), the revised Beck Depression Inventory (BDI-II), and the Bern Embitterment Inventory (BEI). Stepwise regression was used to identify predictors of QoL. RESULTS: The strongest predictors of the physical component score of the SF-36 were (in order of declining strength of association): Delay between first presentation of the disease and diagnosis, body mass index (BMI), number of doctors visited before the diagnosis of acromegaly, and age at diagnosis. For the mental component score, the strongest predictors were: number of doctors visited, previous radiotherapy, and age at study entry; and, for the BDI-II score: number of doctors visited, previous radiotherapy, age at study entry, and employment status at the time of diagnosis. The following were predictors of the BEI score: number of doctors visited, and age at study entry. CONCLUSION: Diagnostic delay and lack of diagnostic acumen in medical care provision are strong predictors of poor QoL in patients with acromegaly. Other identified parameters are radiotherapy, age, BMI, and employment status. An efficient acromegaly service should address these aspects when devising disease management plans. ABBREVIATIONS: BDI-II = Beck Depression Inventory II BEI = Bern Embitterment Inventory BMI = body mass index IGF-1 = insulin-like growth factor 1 MCS = mental component summary (score) PCS = physical component summary (score) QoL = quality of life SDS = standard deviation score SF-36 = Short Form-36 Health Survey.
Tipo de publicación:JOURNAL ARTICLE
Nombre de substancia:0 (Dopamine Agonists); 12629-01-5 (Human Growth Hormone); 51110-01-1 (Somatostatin); N824AOU5XV (pegvisomant)


  7 / 62 MEDLINE  
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PMID:27615793
Autor:Dlabac-de Lange JJ; Liemburg EJ; Bais L; van de Poel-Mustafayeva AT; de Lange-de Klerk ES; Knegtering H; Aleman A
Dirección:University of Groningen, University Medical Center Groningen, Department of Psychiatry, Hanzeplein 1, 9713 GZ Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Rob Giel Research Centrum, Hanzeplein 1, 9713 GZ Groningen, The Netherlands; University of Groningen
Título:Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: An Exploratory Study.
Fuente:Brain Stimul; 10(1):59-64, 2017 Jan - Feb.
ISSN:1876-4754
País de publicación:United States
Idioma:eng
Resumen:BACKGROUND: Prefrontal repetitive Transcranial Magnetic Stimulation (rTMS) may improve negative symptoms in patients with schizophrenia, but few studies have investigated the underlying neural mechanism. OBJECTIVE: This study aims to investigate changes in the levels of glutamate and glutamine (Glx, neurotransmitter and precursor) and N-Acetyl Aspartate (NAA) in the left dorsolateral prefrontal cortex of patients with schizophrenia treated with active bilateral prefrontal rTMS as compared to sham-rTMS, as measured with H-Magnetic Resonance Spectroscopy ( H-MRS). METHODS: Patients were randomized to a 3-week course of active or sham high-frequency rTMS. Pre-treatment and post-treatment H-MRS data were available for 24 patients with schizophrenia with moderate to severe negative symptoms (Positive and Negative Syndrome Scale (PANSS) negative subscale ≥ 15). Absolute metabolite concentrations were calculated using LCModel with the water peak as reference. To explore the association between treatment condition and changes in concentration of Glx and NAA, we applied a linear regression model. RESULTS: We observed an increase of Glx concentration in the active treatment group and a decrease of Glx concentration in the group receiving sham treatment. The association between changes in Glx concentration and treatment condition was significant. No significant associations between changes in NAA and treatment condition were found. CONCLUSIONS: Noninvasive neurostimulation with high-frequency bilateral prefrontal rTMS may influence Glx concentration in the prefrontal cortex of patients with schizophrenia. Larger studies are needed to confirm these findings and further elucidate the underlying neural working mechanism of rTMS.
Tipo de publicación:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Nombre de substancia:30KYC7MIAI (Aspartic Acid); 3KX376GY7L (Glutamic Acid); 997-55-7 (N-acetylaspartate)


  8 / 62 MEDLINE  
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PMID:27585982
Autor:Sydenham M; Beardwood J; Rimes KA
Dirección:Institute of Psychiatry, Psychology and Neuroscience (IoPPN),King's College London,UK.
Título:Beliefs about Emotions, Depression, Anxiety and Fatigue: A Mediational Analysis.
Fuente:Behav Cogn Psychother; 45(1):73-78, 2017 Jan.
ISSN:1469-1833
País de publicación:United States
Idioma:eng
Resumen:BACKGROUND: Beliefs that it is unacceptable to experience or express negative emotions have been found to be associated with various clinical problems. It is unclear how such beliefs, which could be viewed as a form of unhelpful perfectionism about emotions, may contribute to symptomatology. AIMS: This study investigated two hypotheses: a) greater endorsement of beliefs about the unacceptability of negative emotions will be associated with greater emotional avoidance and lower levels of support-seeking and self-compassion; b) these beliefs about emotions will be associated with higher levels of symptoms of depression, anxiety and fatigue and that this relationship will be mediated by social support-seeking, emotional avoidance and self-compassion. METHOD: Online questionnaires were completed by 451 community participants. Mediational analyses were undertaken to investigate emotional avoidance, social support-seeking and self-compassion as mediators of the relationship between beliefs about emotions and symptoms of depression, anxiety and fatigue. RESULTS: Beliefs about the unacceptability of negative emotions were significantly associated with more emotional avoidance and less self-compassion and support-seeking. The relationships between beliefs about emotions and depression, anxiety and fatigue were significantly mediated by self-compassion and emotional avoidance but not social support-seeking. CONCLUSIONS: Future research should investigate whether interventions that pay particular attention to emotional avoidance and self-compassion, such as mindfulness-based therapy or modified forms of CBT, may be beneficial in reducing distress and fatigue associated with beliefs about the unacceptability of negative emotions.
Tipo de publicación:JOURNAL ARTICLE


  9 / 62 MEDLINE  
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PMID:27457772
Autor:Yu NX; Chen L; Ye Z; Li X; Lin D
Dirección:a Department of Applied Social Sciences , City University of Hong Kong , Hong Kong , People's Republic of China.
Título:Impacts of making sense of adversity on depression, posttraumatic stress disorder, and posttraumatic growth among a sample of mainly newly diagnosed HIV-positive Chinese young homosexual men: the mediating role of resilience.
Fuente:AIDS Care; 29(1):79-85, 2017 Jan.
ISSN:1360-0451
País de publicación:England
Idioma:eng
Resumen:The experience of HIV, as a life-transforming event, might produce both negative and positive outcomes. Guided by the stress appraisal model, the present study investigated the hypothesized pathways in predicting symptomatology and posttraumatic growth (PTG) in a sample of Chinese male patients with HIV (PHIV) who were mainly newly diagnosed, young, and homosexual. In this cross-sectional study, 141 Chinese male PHIV (87.2% of them were homosexual) completed measures of making negative/positive sense of adversity, resilience, depression, posttraumatic stress disorder (PTSD), and PTG. The path analysis results showed that making negative sense of adversity was associated with depression and PTSD, partially mediated by low levels of resilience, whereas making positive sense of adversity was associated with PTG, partially mediated by resilience. The results suggest that negative and positive outcomes of trauma are impacted by making negative and positive sense of adversity, respectively, via two separate pathways, both mediated by resilience. Our findings contribute to an understanding of the cognitive process of symptomatology and PTG in the HIV context. Theoretical considerations, clinical implications, and future directions are discussed.
Tipo de publicación:JOURNAL ARTICLE


  10 / 62 MEDLINE  
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PMID:27371943
Autor:Horwitz AG; Berona J; Czyz EK; Yeguez CE; King CA
Dirección:Department of Psychology, University of Michigan, Ann Arbor, MI, USA.
Título:Positive and Negative Expectations of Hopelessness as Longitudinal Predictors of Depression, Suicidal Ideation, and Suicidal Behavior in High-Risk Adolescents.
Fuente:Suicide Life Threat Behav; 47(2):168-176, 2017 Apr.
ISSN:1943-278X
País de publicación:England
Idioma:eng
Resumen:The relationship between hopelessness and depression in predicting suicide-related outcomes varies based on the anticipation of positive versus negative events. In this prospective study of adolescents at elevated risk for suicide, we used two Beck Hopelessness Scale subscales to assess the impact of positive and negative expectations in predicting depression, suicidal ideation, and suicidal behavior over a 2- to 4-year period. In multivariate regressions controlling for depression, suicidal ideation, and negative-expectation hopelessness, positive-expectation hopelessness was the only significant predictor of depressive symptoms and suicidal behavior. Clinical interventions may benefit from bolstering positive expectations and building optimism.
Tipo de publicación:JOURNAL ARTICLE



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