Database : MEDLINE
Search on : B01.650.940.800.575.912 [DeCS Category]
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  1 / 176 MEDLINE  
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PMID:29202741
Author:Schmidt M; Skaf J; Gavril G; Polednik C; Roller J; Kessler M; Holzgrabe U
Address:Department of Otorhinolaryngology, University of Wuerzburg, Josef-Schneider-Straße 11, D-97080, Wuerzburg, Germany. Schmidt_m2@ukw.de.
Title:The influence of Osmunda regalis root extract on head and neck cancer cell proliferation, invasion and gene expression.
Source:BMC Complement Altern Med; 17(1):518, 2017 Dec 04.
ISSN:1472-6882
Country of publication:England
Language:eng
Abstract:BACKGROUND: According to only a handful of historical sources, Osmunda regalis, the royal fern, has been used already in the middle age as an anti-cancer remedy. To examine this ancient cancer cure, an ethanolic extract of the roots was prepared and analysed in vitro on its effectiveness against head and neck cancer cell lines. METHODS: Proliferation inhibition was measured with the MTT assay. Invasion inhibition was tested in a spheroid-based 3-D migration assay on different extracellular matrix surfaces. Corresponding changes in gene expression were analysed by qRT-PCR array. Induction of apoptosis was measured by fluorescence activated cell sorting (FACS) with the Annexin V binding method. The plant extract was analysed by preliminary phytochemical tests, liquid chromatography/mass spectroscopy (LC-MS) and thin layer chromatography (TLC). Anti-angiogenetic activity was determined by the tube formation assay. RESULTS: O. regalis extract revealed a growth inhibiting effect on the head and neck carcinoma cell lines HLaC78 and FaDu. The toxic effect seems to be partially modulated by p-glycoprotein, as the MDR-1 expressing HLaC79-Tax cells were less sensitive. O. regalis extract inhibited the invasion of cell lines on diverse extracellular matrix substrates significantly. Especially the dispersion of the highly motile cell line HlaC78 on laminin was almost completely abrogated. Motility inhibition on laminin was accompanied by differential gene regulation of a variety of genes involved in cell adhesion and metastasis. Furthermore, O. regalis extract triggered apoptosis in HNSCC cell lines and inhibited tube formation of endothelial cells. Preliminary phytochemical analysis proved the presence of tannins, glycosides, steroids and saponins. Liquid chromatography/mass spectroscopy (LC-MS) revealed a major peak of an unknown substance with a molecular mass of 864.15 Da, comprising about 50% of the total extract. Thin layer chromatography identified ferulic acid to be present in the extract. CONCLUSION: The presented results justify the use of royal fern extracts as an anti-cancer remedy in history and imply a further analysis of ingredients.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Plant Extracts)


  2 / 176 MEDLINE  
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PMID:28867103
Author:Alozie YE; Ene-Obong HN
Address:Department of Human Ecology, Nutrition and Dietetics, Faculty of Agriculture, University of Uyo, Akwa Ibom State, Nigeria. Electronic address: tundealozie@yahoo.com.
Title:Recipe standardization, nutrient composition and sensory evaluation of waterleaf (Talinum triangulare) and wild spinach (Gnetum africanum) soup "afang" commonly consumed in South-south Nigeria.
Source:Food Chem; 238:65-72, 2018 Jan 01.
ISSN:0308-8146
Country of publication:England
Language:eng
Abstract:One hundred recipes of waterleaf and wild spinach soup (afang) consumed among the Ibibios in South-south Nigeria were collected through interview and questionnaire from indigenous homemakers and food sellers, harmonized, standardized, prepared and their nutrient content calculated. Mean weights of ingredients were calculated to obtain the control recipe. Major ingredients in the soup were analyzed chemically. Edible portions, retention factors to be applied in recipe calculation were determined. Sensory evaluation was conducted on five of the most preferred recipes on a nine-point hedonic scale. Edible coefficients of major foods ranged between 0.32 and 0.95. Significant changes (p<0.05) in nutrients were observed between raw and cooked ingredients and recipes. Afang soup had 67.9% moisture; protein, 12.7% and energy, 169kcal. Fat contributed 57% of the total energy. Consumption of adequate quantities of afang soup will contribute substantially to Recommended Nutrient Intake of protein and micronutrients which will further increase with additional fish/meat.
Publication type:JOURNAL ARTICLE


  3 / 176 MEDLINE  
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PMID:28476955
Author:Karthik S; Suriyaprabha R; Balu KS; Manivasakan P; Rajendran V
Address:Centre for Nano Science and Technology, K. S. Rangasamy College of Technology, Tiruchengode 637 215, Tamil Nadu, India.
Title:Influence of ball milling on the particle size and antimicrobial properties of leaf nanoparticles.
Source:IET Nanobiotechnol; 11(1):12-17, 2017 Feb.
ISSN:1751-8741
Country of publication:England
Language:eng
Abstract:The herbal nanoparticles were prepared from shade dried plant leaves employing ball milling technique using different process parameters, like ball ratio/size and milling time. The obtained nanoparticles were comprehensively characterised using X-ray diffraction, Fourier transform infrared spectroscopy, UV-visible spectroscopy, dynamic light scattering, scanning electron microscopy and antimicrobial analysis techniques. The crystallinity of the nanoparticles was retained without altering even though the particle size changes due to milling periods. The antibacterial activities of the prepared herbal nanoparticles against and were explored to understand the influence of particle size on antimicrobial activities and their functional properties. The increase in ball ratio and milling time periods leads to a decrease in nanoparticle size from 114 to 45 nm which in turn increases the antimicrobial activities. The above study confirms that antimicrobial activity relies on nanoparticle size. The observed knowledge on influence of particle size on antimicrobial activities will help to optimise the production of potential herbal nanoparticles for different biomedical applications.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Anti-Infective Agents)


  4 / 176 MEDLINE  
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PMID:28365322
Author:Shankar S; Leejae S; Jaiswal L; Voravuthikunchai SP
Address:Department of Microbiology, Faculty of Science and Natural Product Research Centre of Excellence, Prince of Songkla University, Hat Yai, 90112, Thailand; Department of Food Engineering and Bionanocomposite Research Institute, Mokpo National University, 61 Dorimri, Chungkyemyon, Muangun, 534-729, Jeo
Title:Metallic nanoparticles augmented the antibacterial potency of Rhodomyrtus tomentosa acetone extract against Escherichia coli.
Source:Microb Pathog; 107:181-184, 2017 Jun.
ISSN:1096-1208
Country of publication:England
Language:eng
Abstract:The present study was focused on the preparation of gold, silver, and gold-silver-alloy nanoparticles using Rhodomyrtus tomentosa acetone extract (RAE). The synthesized nanoparticles showed the surface plasmon resonance absorption peak corresponding to gold and silver nanoparticle. However, Au-Ag-Alloy nanoparticles showed the single peak between the peaks of AuNPs and AgNPs. TEM observation ascertained the shape and size of nanoparticles. FTIR results indicated the involvement of RAE for the synthesis and capping of nanoparticles. Study on antibacterial activity demonstrated the enhanced activity of RAE capped on silver and Au-Ag-Alloy nanoparticles against Escherichia coli.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Anti-Bacterial Agents); 0 (Drug Combinations); 0 (Plant Extracts); 1364PS73AF (Acetone); 3M4G523W1G (Silver); 7440-57-5 (Gold)


  5 / 176 MEDLINE  
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PMID:28358416
Author:Fu C; Zheng C; Lin J; Ye J; Mei Y; Pan C; Wu G; Li X; Ye H; Liu X
Address:Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
Title:Cibotium barometz polysaccharides stimulate chondrocyte proliferation in vitro by promoting G1/S cell cycle transition.
Source:Mol Med Rep; 15(5):3027-3034, 2017 May.
ISSN:1791-3004
Country of publication:Greece
Language:eng
Abstract:Cibotium barometz polysaccharides (CBPS) are one of the most important bioactive components extracted from the Cibotium barometz plant, which belongs to the Dicksoniaceae family. It has been widely used for the treatment of orthopedic diseases in traditional Chinese medicine. However, the molecular mechanisms behind the therapeutic effects of CBPS remain to be clarified. In the present study, the concentration of CBPS was detected by phenol-vitriol colorimetry. Furthermore, the effects stimulated by CBPS on the viability and G1/S cell cycle transition in primary chondrocytes from Sprague-Dawley rats were investigated. A cell viability assay demonstrated that chondrocyte proliferation may be enhanced by CBPS in a dose­ and time­dependent manner. The mechanism underlying the promotion of chondrocyte cell cycle was suggested to involve the stimulation of G1 to S phase transition. To further confirm the results, reverse transcription­quantitative polymerase chain reaction and western blot analyses were used to detect the expression of mRNA and protein levels of cyclin D1, cyclin­dependent kinase 4 and retinoblastoma protein. The results suggested that CBPS may stimulate chondrocyte proliferation via promoting G1/S cell cycle transition. Since osteoarthritis is characterized by deficient proliferation in chondrocytes, the present study indicates that CBPS may potentially serve as a novel method for the treatment of osteoarthritis.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Ccnd1 protein, rat); 0 (Drugs, Chinese Herbal); 0 (Polysaccharides); 0 (RNA, Messenger); 0 (Retinoblastoma Protein); 136601-57-5 (Cyclin D1); EC 2.7.11.22 (Cdk4 protein, rat); EC 2.7.11.22 (Cyclin-Dependent Kinase 4)


  6 / 176 MEDLINE  
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PMID:28326319
Author:Hwang SH; Kwon SH; Kim SB; Lim SS
Address:Department of Food Science and Nutrition, Hallym University, 1 Hallymdeahak-gil, Chuncheon 24252, Republic of Korea.
Title:Inhibitory Activities of Leaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant.
Source:Biomed Res Int; 2017:4273257, 2017.
ISSN:2314-6141
Country of publication:United States
Language:eng
Abstract:(Thunb.) Decne. (Lardizabalaceae) leaves (SHL) have been used traditionally as analgesics, sedatives, diuretics, and so on, in China. To date, no data have been reported on the inhibitory effect of SHL and its constituents on rat lens aldose reductase (RLAR) and advanced glycation end products (AGEs). Therefore, the inhibitory effect of compounds isolated from SHL extract on RLAR and AGEs was investigated to evaluate potential treatments of diabetic complications. The ethyl acetate (EtOAC) fraction of SHL extract showed strong inhibitory activity on RLAR and AGEs; therefore, EtOAc fraction (3.0 g) was subjected to Sephadex LH-20 column chromatography, for further fractionation, with 100% MeOH solvent system to investigate its effect on RLAR and AGEs. Phytochemical investigation of SHL led to the isolation of seven compounds. Among the isolated compounds, chlorogenic acid, calceolarioside B, luteolin-3'- - -D-glucopyranoside, quercetin-3- - -D-glucopyranoside, and luteolin-7- - -D-glucopyranoside exhibited significant inhibitory activity against RLAR with IC in the range of 7.34-23.99 M. In addition, 3-(3,4-dihydroxyphenyl) propionic acid, neochlorogenic acid, and luteolin-3'- - -D-glucopyranoside exhibited the most potent inhibitory activity against formation of AGEs, with an IC value of 115.07-184.06 M, compared to the positive control aminoguanidine (820.44 M). Based on these findings, SHL dietary supplements could be considered for the prevention and/or treatment of diabetes complication.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antioxidants); 0 (Glycation End Products, Advanced); 0 (Plant Extracts); EC 1.1.1.21 (Aldehyde Reductase)


  7 / 176 MEDLINE  
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PMID:28320315
Author:Roberts WR; Roalson EH
Address:Molecular Plant Sciences Graduate Program, Washington State University, Pullman, WA, 99164-1030, USA. wade.roberts@wsu.edu.
Title:Comparative transcriptome analyses of flower development in four species of Achimenes (Gesneriaceae).
Source:BMC Genomics; 18(1):240, 2017 03 20.
ISSN:1471-2164
Country of publication:England
Language:eng
Abstract:BACKGROUND: Flowers have an amazingly diverse display of colors and shapes, and these characteristics often vary significantly among closely related species. The evolution of diverse floral form can be thought of as an adaptive response to pollination and reproduction, but it can also be seen through the lens of morphological and developmental constraints. To explore these interactions, we use RNA-seq across species and development to investigate gene expression and sequence evolution as they relate to the evolution of the diverse flowers in a group of Neotropical plants native to Mexico-magic flowers (Achimenes, Gesneriaceae). RESULTS: The assembled transcriptomes contain between 29,000 and 42,000 genes expressed during development. We combine sequence orthology and coexpression clustering with analyses of protein evolution to identify candidate genes for roles in floral form evolution. Over 25% of transcripts captured were distinctive to Achimenes and overrepresented by genes involved in transcription factor activity. Using a model-based clustering approach we find dynamic, temporal patterns of gene expression among species. Selection tests provide evidence of positive selection in several genes with roles in pigment production, flowering time, and morphology. Combining these approaches to explore genes related to flower color and flower shape, we find distinct patterns that correspond to transitions of floral form among Achimenes species. CONCLUSIONS: The floral transcriptomes developed from four species of Achimenes provide insight into the mechanisms involved in the evolution of diverse floral form among closely related species with different pollinators. We identified several candidate genes that will serve as an important and useful resource for future research. High conservation of sequence structure, patterns of gene coexpression, and detection of positive selection acting on few genes suggests that large phenotypic differences in floral form may be caused by genetic differences in a small set of genes. Our characterized floral transcriptomes provided here should facilitate further analyses into the genomics of flower development and the mechanisms underlying the evolution of diverse flowers in Achimenes and other Neotropical Gesneriaceae.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Anthocyanins)


  8 / 176 MEDLINE  
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PMID:28289808
Author:Kumwimba MN; Zhu B
Address:Key Laboratory of Mountain Surface Processes and Ecological Regulation, Chinese Academy of Sciences, #.9, Block 4, Ren min nan Road, Chengdu, 610041, People's Republic of China.
Title:Effectiveness of Vegetated Drainage Ditches for Domestic Sewage Effluent Mitigation.
Source:Bull Environ Contam Toxicol; 98(5):682-689, 2017 May.
ISSN:1432-0800
Country of publication:United States
Language:eng
Abstract:Plant species have an important role in eco-ditches; however, the Michaelis-Menten kinetic parameters of nutrient uptake, growth rate and purification efficiency of ditch plants and their influences on domestic sewage treatment efficiency are still unclear. Growth rates of all nine species, but especially Lemna gibba, Cladophora and Myriophyllum verticillatum were best in undiluted domestic sewage as opposed to a mixture of domestic sewage. Performance of species to accumulate nutrients was not only species-specific, but was also affected by both sewage treatments. Removal efficiency of nutrients was dependent on both plant species and treatment. Uptake kinetic parameters were significantly affected by both nutrient form and plant species. The maximum uptake rate (Vmax) of NH -N was higher than NO -N. Similarly, Km values for NH -N were greater than NO -N. These results could be used to identify plants for sewage treatment efficiency and enhance water quality in eco-ditch treatment systems.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Ammonium Compounds); 0 (Nitrates); 0 (Sewage); 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen)


  9 / 176 MEDLINE  
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PMID:28278682
Author:Venditti A; Frezza C; Campanelli C; Foddai S; Bianco A; Serafini M
Address:a Dipartimento di Chimica , Università di Roma 'La Sapienza' , Rome , Italy.
Title:Phytochemical analysis of the ethanolic extract of Agathis robusta (C. Moore ex F. Muell.) F.M. Bailey.
Source:Nat Prod Res; 31(14):1604-1611, 2017 Jul.
ISSN:1478-6427
Country of publication:England
Language:eng
Abstract:This work reports the phytochemical analysis of the ethanolic extract obtained from the leaves of Agathis robusta (C. Moore ex F. Muell.) F.M. Bailey. The methodology utilised during this study comprised classical chromatographic and spectroscopic techniques. Six compounds were identified: agathisflavone (1), 7″-O-methyl-agathisflavone (2), cupressuflavone (3), rutin (4), shikimic acid (5) and (2S)-1,2-Di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-ß-d-galactopyranosyl glycerol (6). These belong to four major classes of natural compounds: bi-flavonoids (1-3); diglycosidic flavonoids (4); cycloexen-carboxylic acids (5); glycerol-glycolipids (6). To the best of our knowledge, compounds (3-6) were identified for the first time in this study as constituents of A. robusta. Anyway, the majority of these compounds has chemotaxonomic relevance and is mostly in accordance with the current botanical classification of this species. Moreover, they also present several pharmacological properties among which, the antibacterial, anti-inflammatory and protective ones are the most important and may explain why this species is used in the ethno-medicinal field.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Flavonoids); 0 (Glycolipids); 0 (Phytochemicals); 0 (Plant Extracts); 3K9958V90M (Ethanol)


  10 / 176 MEDLINE  
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PMID:28272313
Author:Li F; Mao YD; Wang YF; Raza A; Qiu LP; Xu XQ
Address:Department of Cardiothoracic Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. lifengjs@126.com.
Title:Optimization of Ultrasonic-Assisted Enzymatic Extraction Conditions for Improving Total Phenolic Content, Antioxidant and Antitumor Activities In Vitro from Trapa quadrispinosa Roxb. Residues.
Source:Molecules; 22(3), 2017 Mar 06.
ISSN:1420-3049
Country of publication:Switzerland
Language:eng
Abstract:Stems are the important residues of Roxb., which are abundant in phenolic compounds. Ultrasonic-assisted enzymatic extraction (UAEE) is confirmed as a novel extraction technology with main advantages of enhancing extraction yield and physiological activities of the extracts from various plants. In this study, UAEE was applied to obtain the highest yield of phenolic content, strongest antioxidant, and antitumor activities and to optimize the extraction conditions using response surface methodology (RSM). The extracts from the stems of were characterized by determination of their antioxidant activities through 2,2-azinobis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS), 1,1-Diphenyl-2-picrylhydrazxyl (DPPH) radical scavenging, total antioxidant capacity (TAC), ferric reducing antioxidant capacity (FRAC) methods and of their antitumor activity by MTT method. The selected key independent variables were cellulase concentration ( 1: 1.5%-2.5%), extraction time ( 2: 20-30 min) and extraction temperature ( 3: 40-60 °C). The optimal extraction conditions for total phenolic content (TPC) value of the extracts were determined as 1.74% cellulase concentration, 25.5 min ultrasonic extraction time and 49.0 °C ultrasonic temperature. Under these conditions, the highest TPC value of 53.6 ± 2.2 mg Gallic acid equivalent (GAE)/g dry weight (DW) was obtained, which agreed well with the predicted value (52.596 mg GAE/g·DW. Furthermore, the extracts obtained from UAEE presented highest antioxidant activities through ABTS, DPPH, TAC and FRAC methods were of 1.54 ± 0.09 mmol Trolox equivalent (TE)/g·DW; 1.45 ± 0.07 mmol·TE/g·DW; 45.2 ± 2.2 mg·GAE/g·DW; 50.4 ± 2.6 µmol FeSO4 equivalent/g·DW and lowest IC values of 160.4 ± 11.6 µg/mL, 126.1 ± 10.8 µg/mL, and 178.3 ± 13.1 µg/mL against Hela, HepG-2 and U251 tumor cells, respectively. The results indicated that the UAEE was an efficient alternative to improve extraction yield and enhance the antioxidant and antitumor activities of the extracts. The phenolic extracts from the stems of had significant antioxidant and antitumor activities, which could be used as a source of potential antioxidant and antitumor agents.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts)



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