Database : MEDLINE
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  1 / 84 MEDLINE  
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PMID:28325830
Author:Sessa EB; Juslén A; Väre H; Chambers SM
Address:Department of Biology, University of Florida, Gainesville, Florida 32611 USA emilysessa@ufl.edu.
Title:Into Africa: Molecular phylogenetics and historical biogeography of sub-Saharan African woodferns ( ).
Source:Am J Bot; 104(3):477-486, 2017 Mar.
ISSN:1537-2197
Country of publication:United States
Language:eng
Abstract:PREMISE OF THE STUDY: Our goal was to infer the phylogenetic relationships and historical biogeography of the genus with a focus on taxa in sub-Saharan Africa and neighboring islands. In general, little is known about the relationships between African fern species and their congeners in other geographic regions, and our aim was to determine whether the sub-Saharan African species of are monophyletic and evolved within Africa or arrived there via repeated dispersals into Africa from other regions. METHODS: We obtained sequence data for five chloroplast markers from 214 species of and 18 outgroups. We performed phylogenetic and molecular dating analyses using a Bayesian relaxed clock method in BEAST with fossil and secondary calibration points and estimated ancestral ranges for the genus globally by comparing multiple models in BioGeoBEARS. KEY RESULTS: We found that 22 of 27 accessions of sub-Saharan African belong to a large clade of 31 accessions that also includes taxa from Indian and Atlantic Ocean islands. Additional accessions of taxa from our regions of interest have Asian, Hawaiian, European, or North American species as their closest relatives. CONCLUSIONS: The majority of sub-Saharan African species are descended from a shared common ancestor that dispersed to Africa from Asia approximately 10 Ma. There have been subsequent dispersal events from the African mainland to islands in the Atlantic and Indian Oceans, including Madagascar. Several additional species are estimated to have descended from ancestors that reached Africa via separate events over the last roughly 20 million years.
Publication type:JOURNAL ARTICLE


  2 / 84 MEDLINE  
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PMID:28323385
Author:Chen NH; Qian YR; Li W; Zhang YB; Zhou YD; Li GQ; Li YL; Wang GC
Address:Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Title:Six New Acylphloroglucinols from Dryopteris championii.
Source:Chem Biodivers; 14(7), 2017 Jul.
ISSN:1612-1880
Country of publication:Switzerland
Language:eng
Abstract:Six new acylphloroglucinols (1 - 6) were isolated from Dryopteris championii. Their structures were established on the basis of extensive analysis of spectroscopic data and comparison with reported data. The antibacterial activities of the isolates were evaluated against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Dickeya zeae.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Anti-Bacterial Agents); 0 (Plant Extracts); DHD7FFG6YS (Phloroglucinol)


  3 / 84 MEDLINE  
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PMID:28282885
Author:Wang J; Yan YT; Fu SZ; Peng B; Bao LL; Zhang YL; Hu JH; Zeng ZP; Geng DH; Gao ZP
Address:School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. juan_wangli@163.com.
Title:Anti-Influenza Virus (H5N1) Activity Screening on the Phloroglucinols from Rhizomes of Dryopteris crassirhizoma.
Source:Molecules; 22(3), 2017 Mar 08.
ISSN:1420-3049
Country of publication:Switzerland
Language:eng
Abstract:For screening the active phloroglucinols on influenza virus (H5N1) from NaKai, a database was established including twenty-three phloroglucinols that had been isolated from . Their inhibitory effect on the neuraminidase (NA) of influenza virus H5N1 was screened by molecular docking. As a result, three candidates were selected. The rhizomes of were subjected to isolation and purification processes to obtain the inhibitor candidates. Thirteen phloroglucinols were obtained, including three selected candidates and two new phloroglucinols. The five phloroglucinols were investigated for their inhibitory activity on NA in vitro. The results showed that dryocrassin ABBA and filixic acid ABA exhibited inhibitory effects on NA with IC as 18.59 ± 4.53 and 29.57 ± 2.48 µM, respectively, and the other three phloroglucinols showed moderate inhibitory activity. Moreover, the anti-influenza virus (H5N1) activity and cytotoxicity of dryocrassin ABBA and filixic acid ABA were tested on Madin-Darby canine kidney (MDCK) cells with the cell counting kit-8 (CCK8) method. The results confirmed that dryocrassin ABBA exhibited an inhibitory activity with low cytotoxicity (TC > 400 µM) against influenza virus (H5N1) which will have to be investigated in further detail. In conclusion, phloroglucinols from were shown to have anti-influenza virus activity, and especially dryocrassin ABBA, one of the phloroglucinols, may have the potential to control influenza virus (H5N1) infection.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antiviral Agents); 0 (Viral Proteins); DHD7FFG6YS (Phloroglucinol); EC 3.2.1.18 (NA protein, influenza A virus); EC 3.2.1.18 (Neuraminidase)


  4 / 84 MEDLINE  
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PMID:28117728
Author:Zhong ZC; Zhao DD; Liu ZD; Jiang S; Zhang YL
Address:Food Science Department of XiZang Agriculture and Animal Husbandry College, Xizang 860000, China. zxzzc@163.com.
Title:A New Human Cancer Cell Proliferation Inhibition Sesquiterpene, Dryofraterpene A, from Medicinal Plant Dryopteris fragrans (L.) Schott.
Source:Molecules; 22(1), 2017 Jan 21.
ISSN:1420-3049
Country of publication:Switzerland
Language:eng
Abstract:The global burden of cancer continues to increase largely with the aging and growth of the world population. The purpose of the present work was to find new anticancer molecules from a natural source. We utilized chromatographic methods to isolate compounds from medicinal plant (L.) Schott. The structure of the new compounds was determined by spectroscopic and spectrometric data (1D NMR, 2D NMR, and EMI-MS). Their anti-proliferation effects against five human cancer cell lines including A549, MCF7, HepG2, HeLa, and PC-3 were evaluated by CCK-8 andlactate dehydrogenase (LDH) assay. A new sesquiterpene, (7 , 10 )-2,3-dihydroxy-calamenene-15-carboxylic acid methyl ester ( ), and two known compounds ( and ) were isolated. The new sesquiterpene was named dryofraterpene A and significantly inhibited cancer cell proliferation without any obvious necrosis below a 10 µM concentration. In conclusion, a novel anticancer sesquiterpene together with two known compounds was isolated, which might be a promising lead compound for the treatment of cancer.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (dryofraterpene A)


  5 / 84 MEDLINE  
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PMID:27558683
Author:Ali M; Rauf A; Hadda TB; Bawazeer S; Abu-Izneid T; Khan H; Raza M; Khan SA; Shah SU; Pervez S; Patel S; Orhan IE
Title:Mechanisms Underlying Anti-hyperalgesic Properties of Kaempferol-3,7- di-O-α-L-rhamnopyranoside Isolated from Dryopteris cycadina.
Source:Curr Top Med Chem; 17(4):383-390, 2017.
ISSN:1873-4294
Country of publication:Netherlands
Language:eng
Abstract:BACKGROUND: The present study was designed to evaluate the anti-hyperalgesic effect of kaempferol-3,7-di-O-α-L-rhamnopyranoside isolated from the ethyl acetate soluble part of Dryopteris cycadina. Pretreatment of the compound at the doses of 2.5, 5, and 10 mg/kg caused a significant reduction in abdominal constrictions in acetic acid-induced writhing test with maximum effect of 63.03% (P < 0.001) at 10 mg/kg i.p. When subjected in formalin test, it evoked a marked antinociceptive effect in both phases in a dose-dependent manner. The maximum (p < 0.01) pain-inhibiting effects were 61.36% and 65.89% in 1st and 2nd phases at 10 mg/kg i.p., respectively. Administration of atropine (non-selective cholinergic receptor antagonist) significantly (p < 0.05) antagonized the antihyperalgesic effect of the compound, while glibenclamide and naloxone did not alter the induced antinociceptive effect and thus, antinociceptive activity of the compound is mediated, at least in part, through cholinergic system antagonism; independent of calcium channel and opioidergic receptor participation. Furthermore, docking studies underlined strong COX-2 inhibitory activity of the compound. RESULT: Our data concluded that overall analgesic activity of the compound seems to involve COX-2 inhibition and activation of cholinergic receptors. However, further detailed studies are required in this direction to confirm the analgesic effect of the compound for its possible clinical utility.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Analgesics); 0 (Kaempferols)


  6 / 84 MEDLINE  
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PMID:27294155
Author:Chi C; Giri SS; Jun JW; Kim HJ; Yun S; Kim SG; Park SC
Address:Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151742, Republic of Korea.
Title:Immunomodulatory Effects of a Bioactive Compound Isolated from Dryopteris crassirhizoma on the Grass Carp Ctenopharyngodon idella.
Source:J Immunol Res; 2016:3068913, 2016.
ISSN:2314-7156
Country of publication:Egypt
Language:eng
Abstract:In the present study, we investigated effects of compound kaempferol 3-a-L-(4-O-acetyl)rhamnopyranoside-7-a-L-rhamnopyranoside (SA) isolated from Dryopteris crassirhizoma during immune-related gene expression in Ctenopharyngodon idella head kidney macrophages (CIHKM). The expression of immune-related genes (IL-1ß, TNF-α, MyD88, and Mx1) were investigated using real-time PCR at 2 h, 8 h, 12 h, and 24 h after incubation with 1, 10, and 50 µg mL(-1) of SA. Furthermore, fish were injected intraperitoneally with 100 µL of SA, and immune parameters such as lysozyme activity, complement C3, SOD, phagocytic activity, and IgM level were examined at 1, 2, and 3 weeks after injection. The differential expression of cytokines was observed after exposure to SA. IL-1ß genes displayed significant expression at 2 and 8 h after exposure to 1-10 µg mL(-1) of SA. SA also induced gene expression of cytokines such as MyD88, Mx1, and TNF-α. Furthermore, enhanced immune parameters in grass carp confirmed the immunomodulatory activity of SA. Interestingly, this compound has no toxic effect on CIHKM cells as tested by MTT assay. In addition, fish immunised with 10 µg mL(-1) of SA exhibited maximum resistance against Aeromonas hydrophila infection. These results suggest that SA has the potential to stimulate immune responses in grass carp.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Biological Products); 0 (Plant Extracts)


  7 / 84 MEDLINE  
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PMID:27243922
Author:Su Y; Wan D; Song W
Address:aDepartment of Orthopaedics, Shanghai Jiaotong University Affiliated Sixth People's Hospital bDepartment of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Title:Dryofragin inhibits the migration and invasion of human osteosarcoma U2OS cells by suppressing MMP-2/9 and elevating TIMP-1/2 through PI3K/AKT and p38 MAPK signaling pathways.
Source:Anticancer Drugs; 27(7):660-8, 2016 Aug.
ISSN:1473-5741
Country of publication:England
Language:eng
Abstract:Dryofragin, a phloroglucinol derivative extracted from Dryopteris fragrans (L.) Schott, was found to inhibit proliferation and induce apoptosis of tumor cells. However, the mechanism involved in the suppression of cancer cell metastasis by dryofragin remains unclear. Our study investigated the mechanisms for the antitumor properties of dryofragin on the migration and invasion of human osteosarcoma U2OS cells. Dryofragin suppressed the migration and invasive ability of U2OS cells, and it decreased the expression of MMP-2 and MMP-9 and elevated the expression of TIMP-1 and TIMP-2. Western blotting assays indicated that dryofragin was effective in suppressing the phosphorylation of phosphatidylinositide-3 kinase (PI3K), Akt, and p38 MAPK. These results suggest that dryofragin inhibited U2OS cell migration and invasion by reducing the expression of MMP-2 and MMP-9 and elevating the expression of TIMP-1 and TIMP-2 through the PI3K/AKT and p38 MAPK signaling pathways. Above all, we conclude that dryofragin represents an anti-invasive agent and may potentially be applicable in osteosarcoma therapy.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Matrix Metalloproteinase Inhibitors); 0 (Plant Extracts); 0 (TIMP1 protein, human); 0 (TIMP2 protein, human); 0 (Tissue Inhibitor of Metalloproteinase-1); 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.4.24.24 (MMP2 protein, human); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9)


  8 / 84 MEDLINE  
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PMID:26700189
Author:Peng B; Bai RF; Li P; Han XY; Wang H; Zhu CC; Zeng ZP; Chai XY
Address:a Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine , Beijing 100010 , China.
Title:Two new glycosides from Dryopteris fragrans with anti-inflammatory activities.
Source:J Asian Nat Prod Res; 18(1):59-64, 2016.
ISSN:1477-2213
Country of publication:England
Language:eng
Abstract:Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis. Compounds 1-3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 µM, respectively.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Anti-Inflammatory Agents); 0 (Chromones); 0 (Coumarins); 0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (dryofracoulin A); 0 (frachromone C); 31C4KY9ESH (Nitric Oxide)


  9 / 84 MEDLINE  
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PMID:26596576
Author:Gao C; Guo N; Li N; Peng X; Wang P; Wang W; Luo M; Fu YJ
Address:College of Basic Medical Science, Peking University Health Science Center, Beijing, 100083, People's Republic of China.
Title:Investigation of antibacterial activity of aspidin BB against Propionibacterium acnes.
Source:Arch Dermatol Res; 308(2):79-86, 2016 Mar.
ISSN:1432-069X
Country of publication:Germany
Language:eng
Abstract:In the present study, antibacterial activity of four kinds of phloroglucinol derivatives extracted from Dryopteris fragrans (L.) Schott against S. aureus, S. epidermidis and P. acnes has been tested. Aspidin BB exerted the strongest antibacterial activity with minimal inhibition concentration (MIC) values ranging from 7.81 to 15.63 µg/mL. The time-kill assay indicated that aspidin BB could kill P. acnes completely at 2 MIC (MBC) within 4 h. By using AFM, we demonstrated extensive cell surface alterations of aspidin BB-treated P. acnes. SDS-PAGE of supernatant proteins and lipid peroxidation results showed that aspidin BB dose-dependently affected membrane permeability of P. acnes. DNA damage and protein degradation of P. acnes were also verified. SDS-PAGE of precipitated proteins revealed possible targets of aspidin BB, i.e., heat shock proteins (26 kDa) and lipase (33 kDa) which could all cause inflammation. Aspidin BB also seriously increased the inhibition rate of lipase activity from 10.20 to 65.20 % to possibly inhibit the inflammation. In conclusions, the effective constituents of D. fragrans (L.) Schott to treat acne might be phloroglucinol derivatives including aspidin BB, aspidin PB, aspidinol and dryofragin. Among this, aspidin BB inhibited the growth of P. acnes by disrupting their membrane, DNA and proteins and finally leaded to the cell death. The obtained data highlighted the potential of using aspidin BB as an alternative treatment for acne vulgaris.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Plant Extracts); DHD7FFG6YS (Phloroglucinol); EC 3.1.1.3 (Lipase); N21SD2R570 (aspidin BB)


  10 / 84 MEDLINE  
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PMID:26476395
Author:Ekrt L; Koutecký P
Address:Department of Botany, Faculty of Science, University of South Bohemia, Branisovská 1760, CZ-370 05 Ceské Budejovice, Czech Republic libor.ekrt@gmail.com.
Title:Between sexual and apomictic: unexpectedly variable sporogenesis and production of viable polyhaploids in the pentaploid fern of the Dryopteris affinis agg. (Dryopteridaceae).
Source:Ann Bot; 117(1):97-106, 2016 Jan.
ISSN:1095-8290
Country of publication:England
Language:eng
Abstract:BACKGROUND AND AIMS: In ferns, apomixis is an important mode of asexual reproduction. Although the mechanisms of fern reproduction have been studied thoroughly, most previous work has focused on cases in which ferns reproduce either exclusively sexually or exclusively asexually. Reproduction of ferns with potentially mixed systems and inheritance of apomixis remains largely unknown. This study addresses reproduction of the pentaploid Dryopteris × critica, a hybrid of triploid apomictic D. borreri and tetraploid sexual D. filix-mas. METHODS: Spore size, abortion percentage and number of spores per sporangium were examined in pentaploid plants of D. × critica grown in an experimental garden. The sporangial content of leaf segments was cultivated on an agar medium, and DNA ploidy levels were estimated by DAPI flow cytometry in 259 gametophytes or sporophytes arising from the F2 generation of the pentaploid hybrid. KEY RESULTS: The hybrid is partly fertile (89-94% of aborted spores) and shows unstable sporogenesis with sexual and apomictic reproduction combined. The number of spores per sporangium varied from approx. 31 to 64. Within a single sporangium it was possible to detect formation of either only aborted spores or various mixtures of aborted and well-developed reduced spores and unreduced diplospores. The spores germinated in viable gametophytes with two ploidy levels: pentaploid (5x, from unreduced spores) and half of that (approx. 2·5x, from reduced spores). Moreover, 2-15% of gametophytes (both 2·5x and 5x) formed a viable sporophyte of the same ploidy level due to apogamy. CONCLUSIONS: This study documents the mixed reproductive mode of a hybrid between apomictic and sexual ferns. Both sexual reduced and apomictic unreduced spores can be produced by a single individual, and even within a single sporangium. Both types of spores give rise to viable F2 generation gametophytes and sporophytes.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (DNA, Plant)



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