Database : MEDLINE
Search on : B01.650.940.800.575.912.063.700 [DeCS Category]
References found : 149 [refine]
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  1 / 149 MEDLINE  
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PMID:29235376
Author:Zhu LJ; Song Y; Shao P; Zhang X; Yao XS
Address:a School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
Title:Matteucens I-J, phenolics from the rhizomes of Matteuccia orientalis.
Source:J Asian Nat Prod Res; 20(1):62-66, 2018 Jan.
ISSN:1477-2213
Country of publication:England
Language:eng
Abstract:Two new phenolics, named matteucens I-J (1-2), were isolated from the 60% EtOH extract of the rhizomes of Matteuccia orientalis (HOOK.) TREV. Their structures were elucidated by means of extensive spectroscopic analysis (HRESIMS, NMR).
Publication type:JOURNAL ARTICLE
Name of substance:0 (Drugs, Chinese Herbal); 0 (Phenols)


  2 / 149 MEDLINE  
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PMID:28193278
Author:Wei X; Xu A; Shen H; Xie Y
Address:Department of Scientific Research, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, 100102, China.
Title:Qianggu capsule for the treatment of primary osteoporosis: evidence from a Chinese patent medicine.
Source:BMC Complement Altern Med; 17(1):108, 2017 Feb 13.
ISSN:1472-6882
Country of publication:England
Language:eng
Abstract:BACKGROUND: Qianggu Capsule, a Chinese patent medicine, has been widely applied in the clinical practice of primary osteoporosis (POP) in recent years. This study aims to summarize the effectiveness and safety of Qianggu Capsule in treating POP. METHODS: We searched seven electronic databases, all searches ended in 30 September, 2015. All randomised controlled trials comparing the efficacy of Qianggu Capsule treatment with no treatment, placebo or conventional therapy for POP were included. Combined therapies of Qianggu Capsule were also included. Cochrane risk of bias tool was used to assess methodological quality of primary studies. Revman 5.2.0 software was used for data analysis. RESULTS: Ten trials were enrolled. The combined effect showed that Qianggu Capsule plus Caltrate D was better than Caltrate D on lumbar spine bone mineral density (BMD) (MD = 0.05 g/cm ; 95% CI: 0.02-0.07; P = 0.0004), femoral neck BMD (MD = 0.03 g/cm ; 95% CI: 0.01-0.05; P = 0.001), femoral great trochanter BMD (MD = 0.04 g/cm ; 95% CI: 0.03-0.06; P < 0.001). Meta-analysis exhibited a significant antiosteoporosis effect of Qianggu Capsule on femoral neck BMD (MD = 0.03 g/cm ; 95% CI: 0.01-0.05; P = 0.003) and femoral trochanteric BMD (MD = 0.07 g/cm ; 95% CI: 0.02-0.12; P = 0.006) compared with α-D3 capsule. However, the methodological quality of included studies was low. Constipation and dry mouth were the most common adverse drug reactions of Qianggu Capsule. Finally the evidence level was evaluated to be low or very low. CONCLUSIONS: The effect of Qianggu Capsule for POP was supported in improving BMD. Due to the methodological drawbacks of the included studies, the conclusions should be treated with caution for future research.
Publication type:JOURNAL ARTICLE; REVIEW
Name of substance:0 (Drugs, Chinese Herbal)


  3 / 149 MEDLINE  
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PMID:27784177
Author:Song L; Cao M; Chen C; Qi P; Li N; Wu D; Peng J; Wang X; Zhang M; Hu G; Zhao J
Address:a Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry , College of Life Sciences, Sichuan University , Chengdu , P.R. China.
Title:Antibacterial activity of Pyrrosia petiolosa ethyl acetate extract against Staphylococcus aureus by decreasing hla and sea virulence genes.
Source:Nat Prod Res; 31(11):1347-1350, 2017 Jun.
ISSN:1478-6427
Country of publication:England
Language:eng
Abstract:The aim of this study was to explore the antibacterial activity of Pyrrosia petiolosa ethyl acetate extract (PPEAE) against Staphylococcus aureus in vitro and analyse its chemical components by gas chromatograph-mass spectrometry. The results of anti-microbial assay revealed that PPEAE had strong inhibitory activity against S .aureus, with MIC and MBC of 7.8 and 15.6 mg/mL, respectively. The transcriptional levels of hla and sea were reduced to 14.33 and 46.39% at the MIC compared to the control. Analysing test result exhibited that eugenol made a great contribution to antibacterial activity. This experiment indicated that PPEAE had prominent antibacterial activity against S. aureus.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Acetates); 0 (Anti-Bacterial Agents); 0 (Plant Extracts); 3T8H1794QW (Eugenol); 76845O8NMZ (ethyl acetate)


  4 / 149 MEDLINE  
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PMID:27999266
Author:Qiu ZC; Dong XL; Dai Y; Xiao GK; Wang XL; Wong KC; Wong MS; Yao XS
Address:Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China. qiu666@stu2014.jnu.edu.cn.
Title:Discovery of a New Class of Cathepsin K Inhibitors in Rhizoma Drynariae as Potential Candidates for the Treatment of Osteoporosis.
Source:Int J Mol Sci; 17(12), 2016 Dec 16.
ISSN:1422-0067
Country of publication:Switzerland
Language:eng
Abstract:(RD), as one of the most common clinically used folk medicines, has been reported to exert potent anti-osteoporotic activity. The bioactive ingredients and mechanisms that account for its bone protective effects are under active investigation. Here we adopt a novel in silico target fishing method to reveal the target profile of RD. Cathepsin K (Ctsk) is one of the cysteine proteases that is over-expressed in osteoclasts and accounts for the increase in bone resorption in metabolic bone disorders such as postmenopausal osteoporosis. It has been the focus of target based drug discovery in recent years. We have identified two components in RD, Kushennol F and Sophoraflavanone G, that can potentially interact with Ctsk. Biological studies were performed to verify the effects of these compounds on Ctsk and its related bone resorption process, which include the use of in vitro fluorescence-based Ctsk enzyme assay, bone resorption pit formation assay, as well as Receptor Activator of Nuclear factor κB (NF-κB) ligand (RANKL)-induced osteoclastogenesis using murine RAW264.7 cells. Finally, the binding mode and stability of these two compounds that interact with Ctsk were determined by molecular docking and dynamics methods. The results showed that the in silico target fishing method could successfully identify two components from RD that show inhibitory effects on the bone resorption process related to protease Ctsk.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Flavanones); 0 (Plant Preparations); 0 (RANK Ligand); 0 (Tnfsf11 protein, mouse); 97938-30-2 (vexibinol); EC 3.4.22.38 (Cathepsin K)


  5 / 149 MEDLINE  
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PMID:27794508
Author:Contreras Cárdenas AV; Hernández LR; Juárez ZN; Sánchez-Arreola E; Bach H
Address:Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada; Departamento de Ciencias Químico-Biológicas, Universidad de las Américas Puebla, Cholula, Puebla, Mexico.
Title:Antimicrobial, cytotoxic, and anti-inflammatory activities of Pleopeltis polylepis.
Source:J Ethnopharmacol; 194:981-986, 2016 Dec 24.
ISSN:1872-7573
Country of publication:Ireland
Language:eng
Abstract:AIM OF THE STUDY: Pleopeltis polylepis (Polypodaceae) is a fern used in the traditional Mexican medicine to treat fever, bleeding, typhoid, cough, pertussis, chest pain, and renal and hepatic diseases. The aim of this study was to analyze the bioactivities of different extracts, fractions and isolated compounds from this species to scientifically validate its medicinal applications. MATERIALS AND METHODS: Aerial parts of P. polylepis were macerated and extracted consecutively with hexane, chloroform, and methanol. These extracts were subsequently fractionated and compounds from hexane and methanol extracts were purified. The antimicrobial activity was assessed using a panel of eight Gram-positive and -negative bacterial and four fungal strains. The cytotoxicity of the compounds was assessed by flow cytometry using propidium iodide and the human-derived monocytic cell line THP-1. The anti-inflammatory activity was investigated by measuring the secretion of interleukin-6 and IL-10 using also the cell line THP-1. RESULTS: Various extracts, fractions and compounds obtained from this plant showed antibacterial activity against both Gram-positive and -negative strains. Antifungal activity was confirmed only in Candida albicans and Tricophyton mentagrophytes. Two fractions and two isolated compounds (butyl myristate and ß-sitosterol) showed no significant cytotoxicity and were further evaluated for their anti-inflammatory activity. All four samples tested showed an anti-inflammatory activity similar to prednisone used as a control. CONCLUSIONS: The benefit of P. polylepis as a traditional plant related to its antimicrobial and anti-inflammatory activities was confirmed by in vitro assays. To the best of our knowledge, this is the first study reporting the isolation and bioactivities of extracts, fractions or isolated compounds from P. polylepis.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Cytotoxins); 0 (Interleukin-6); 0 (Plant Extracts); 0 (Sitosterols); 0I3V7S25AW (Myristic Acid); 130068-27-8 (Interleukin-10); 5LI01C78DD (gamma-sitosterol)


  6 / 149 MEDLINE  
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PMID:27557601
Author:Musilova J; Arvay J; Vollmannova A; Toth T; Tomas J
Address:Department of Chemistry, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76, Nitra, Slovak Republic. janette.musilova@uniag.sk.
Title:Environmental Contamination by Heavy Metals in Region with Previous Mining Activity.
Source:Bull Environ Contam Toxicol; 97(4):569-75, 2016 Oct.
ISSN:1432-0800
Country of publication:United States
Language:eng
Abstract:Due to its status as one of the most contaminated regions in Slovakia, 45 soil and plant samples were collected in the Middle Spis region. In soil, the exchangeable soil reaction, humus content and heavy metals content (Zn, Cd, Cu, Pb, Hg) were determined. Total content of heavy metals (TC-HMs) and content of mobile forms (MF-HMs) in soil, as well as metal content in plants, were determined by atomic absorption spectrometry. The concentration ranges for total Zn, Cd, Cu, Pb and Hg in soil were 33.1-953, 0.65-6.73, 11.0-913, 26.5-165 and 0.28--415 mg/kg, respectively. The overall concentration ranges of these metals in plants of two types (Athyrium filix-femina L. and Poaceae herbs) were 12.4-158.6, 0.10-1.63, 3.34-85.7, 0.09-29.7 and 0.01-12.8 mg/kg, respectively. Despite the values of Zn, Cd, Cu, Pb and Hg content in the soil exceeding limit values, only the Hg content in plants presented an ecological risk.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Metals, Heavy); 0 (Soil); 0 (Soil Pollutants)


  7 / 149 MEDLINE  
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PMID:27454100
Author:Zhao L; Li T; Yu H; Zhang X; Zheng Z
Address:College of Resources and Environmental Science, Sichuan Agricultural University, 211 Huimin Road, Chengdu, Sichuan 611130, China.
Title:Effects of [S,S]-ethylenediaminedisuccinic acid and nitrilotriacetic acid on the efficiency of Pb phytostabilization by Athyrium wardii (Hook.) grown in Pb-contaminated soils.
Source:J Environ Manage; 182:94-100, 2016 Nov 01.
ISSN:1095-8630
Country of publication:England
Language:eng
Abstract:Chelate-assisted phytoextraction with biodegradable chelants has been demonstrated as an efficient method to enhance heavy metal remediation efficiency by plants, while there is little available information on phytostabilization. A pot experiment was conducted to investigate the effects of biodegradable [S,S]-ethylenediaminedisuccinic acid (EDDS) and nitrilotriacetic acid (NTA) on plant growth and Pb accumulation of Pb phytostabilizer Athyrium wardii (Hook.) grown in Pb contaminated soils and to explore the feasibility of chelate-assisted phytostabilization. Greater adverse effects on plant biomass under high EDDS treatments were observed than NTA treatments. Significant increase of shoot Pb concentrations of A. wardii was noticed with increasing NTA and EDDS dosages, while EDDS induced higher shoot Pb concentrations than NTA. Moreover, root Pb concentrations of A. wardii under NTA treatments were 1.18-1.28-time higher than EDDS treatments, and a peak value of root Pb concentrations was observed at 2 mmol kg(-1) of NTA. Shoot Pb accumulations significantly increased with increasing dosages, and EDDS treatments caused a 1.44-1.6-time increase of shoot Pb accumulation than NTA. Root Pb accumulations under NTA treatments were 1.18-1.28-time higher than EDDS treatments. Maximum root Pb accumulation (155.5 mg plant(-1)) was found at 2 mmol kg(-1) of NTA on the 14th day. Higher BCF values and lower TF values were found under NTA treatments as compared to EDDS treatments. Available Pb concentrations in soil significantly increased on the 7th day with increasing NTA and EDDS dosages, then gradually decreased on the 14th day. Soil pH slightly decreased with increasing NTA and EDDS dosages. Therefore, chelate-assisted phytostabilization could be a feasible way to enhance the efficiency of Pb phytostabilization by A. wardii.
Publication type:JOURNAL ARTICLE
Name of substance:0 ((S,S)-ethylenediaminedisuccinate); 0 (Chelating Agents); 0 (Ethylenediamines); 0 (Soil); 0 (Soil Pollutants); 0 (Succinates); 2P299V784P (Lead); KA90006V9D (Nitrilotriacetic Acid)


  8 / 149 MEDLINE  
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PMID:27378075
Author:Chaity FR; Khatun M; Rahman MS
Address:Phytochemical Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
Title:In vitro membrane stabilizing, thrombolytic and antioxidant potentials of Drynaria quercifolia L., a remedial plant of the Garo tribal people of Bangladesh.
Source:BMC Complement Altern Med; 16:184, 2016 Jul 04.
ISSN:1472-6882
Country of publication:England
Language:eng
Abstract:BACKGROUND: Drynaria quercifolia L. (Family- Polypodiaceae) is a fern grows in Bangladesh used in traditional healing by the Garo tribe of Mymensingh district. In the current study, rhizomes and fertile foliage fronds of this plant have been investigated comprehensively to assess their in vitro membrane stabilizing, thrombolytic and antioxidant properties. METHODS: Rhizomes and fertile foliage fronds of D. quercifolia were collected, dried, powdered and extracted with methanol. Later on, crude methanol extracts of the plant parts were fractionated into petroleum ether, carbon tetrachloride, chloroform and aqueous soluble fractions. The extractives were then subjected to membrane stabilizing, thrombolytic and antioxidant assays. RESULTS: In membrane stabilizing assay, crude methanol extracts of rhizomes and fertile foliage fronds and their petroleum ether fractions were found to be very effective for stabilizing erythrocyte membrane in hypotonic solution. In case of thrombolytic study, crude methanol extract of rhizomes and its aqueous fraction exhibited noticeable clot lysis. However, in antioxidant assays, crude methanol extracts of the tested plant parts and their aqueous fractions exhibited potent 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide and 2, 2'-azinobis (3-ethylbenzothiazoline sulphonic acid) (ABTS) radical scavenging activity. Besides, these extractives also displayed substantial ferric reducing potential in ferric reducing antioxidant power (FRAP) assay. Crude methanol extracts of the plant parts and their aqueous fractions were also found rich in phenolics. CONCLUSION: This study demonstrates the medicinal potentials of D. quercifolia and justifies the local uses of it by the Garo tribal people of Bangladesh for multiple disease management.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Fibrinolytic Agents); 0 (Picrates); 0 (Plant Extracts); BBX060AN9V (Hydrogen Peroxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)


  9 / 149 MEDLINE  
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PMID:27044288
Author:Mubarak M; Shaija A; Suchithra TV
Address:Mechanical Engineering Department, National Institute of Technology Calicut, Kerala, India.
Title:Optimization of lipid extraction from Salvinia molesta for biodiesel production using RSM and its FAME analysis.
Source:Environ Sci Pollut Res Int; 23(14):14047-55, 2016 Jul.
ISSN:1614-7499
Country of publication:Germany
Language:eng
Abstract:The higher areal productivity and lipid content of microalgae and aquatic weed makes them the best alternative feedstocks for biodiesel production. Hence, an efficient and economic method of extracting lipid or oil from aquatic weed, Salvinia molesta is an important step towards biodiesel production. Since Salvinia molesta is an unexplored feedstock, its total lipid content was first measured as 16 % using Bligh and Dyer's method which was quite sufficient for further investigation. For extracting more amount of lipid from Salvinia molesta, methanol: chloroform in the ratio 2:1 v/v was identified as the most suitable solvent system using Soxhlet apparatus. Based on the literature and the preliminary experimentations, parameters such as solvent to biomass ratio, temperature, and time were identified as significant for lipid extraction. These parameters were then optimized using response surface methodology with central composite design, where experiments were performed using twenty combinations of these extraction parameters with Minitab-17 software. A lipid yield of 92.4 % from Salvinia molesta was obtained with Soxhlet apparatus using methanol and chloroform (2:1 v/v) as solvent system, at the optimized conditions of temperature (85 °C), solvent to biomass ratio (20:1), and time (137 min), whereas a predicted lipid yield of 93.5 % with regression model. Fatty acid methyl ester (FAME) analysis of S. molesta lipid using gas chromatograph mass spectroscopy (GCMS) with flame ionization detector showed that fatty acids such as C16:0, C16:1, C18:1, and C18:2 contributed more than 9 % weight of total fatty acids. FAME consisted of 56.32, 28.08, and 15.59 % weight of monounsaturated, saturated, and polyunsaturated fatty acids, respectively. Higher cetane number and superior oxidation stability of S. molesta FAME could be attributed to its higher monounsaturated content and lower polyunsaturated content as compared to biodiesels produced from C. vulgaris, Sunflower, and Jatropha.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Biofuels); 0 (Fatty Acids, Nonesterified); 0 (Lipids); 0 (Solvents); 7V31YC746X (Chloroform); Y4S76JWI15 (Methanol)


  10 / 149 MEDLINE  
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PMID:26569039
Author:Luo J; Zhou W; Cao S; Jin M; Zhang C; Jin X; Cui J; Li G
Address:a Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy , Yanbian University , Yanji , P.R. China.
Title:A new biflavonoid from the whole herb of Lepisorus ussuriensis.
Source:Nat Prod Res; 30(13):1470-6, 2016 Jul.
ISSN:1478-6427
Country of publication:England
Language:eng
Abstract:A new biflavonoid, 7-O-methylnaringenin-(4'→O→6″)-scutellarein (1), together with 11 known compounds (2-12) were isolated from the whole herb of Lepisorus ussuriensis. The structure of compound 1 was elucidated by spectroscopic analyses. Amongst them, dihydroquercetin (6), diosmetin (9), baicalein (11) and 7,8-dihydroxyflavone (12) were reported from the family Polypodiaceae for the first time. Meanwhile, quercetin (7), diosmetin (9) and luteolin (10) inhibited TNF-α-induced NF-κB reporter gene expression on HeLa cells up to 30 and 100 µM.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Biflavonoids)



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