Database : MEDLINE
Search on : B01.650.940.800.575.912.063.700.666 [DeCS Category]
References found : 63 [refine]
Displaying: 1 .. 10   in format [Large]

page 1 of 7 go to page                  

  1 / 63 MEDLINE  
              next record last record
select
to print
Photocopy
Full text
PMID:28341348
Author:Kohli I; Shafi R; Isedeh P; Griffith JL; Al-Jamal MS; Silpa-Archa N; Jackson B; Athar M; Kollias N; Elmets CA; Lim HW; Hamzavi IH
Address:Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Title:The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study.
Source:J Am Acad Dermatol; 77(1):33-41.e1, 2017 Jul.
ISSN:1097-6787
Country of publication:United States
Language:eng
Abstract:BACKGROUND: There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. OBJECTIVE: This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). METHODS: In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE. RESULTS: Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects. LIMITATIONS: Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied. CONCLUSION: The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.
Publication type:CLINICAL STUDY; JOURNAL ARTICLE
Name of substance:0 (Plant Extracts)


  2 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PMID:27665299
Author:Mounessa J; Buntinx-Krieg T; Qin R; Dunnick CA; Dellavalle RP
Address:Stony Brook University School of Medicine, 101 Nicolls Road, Stony Brook, NY, 11794, USA.
Title:Primary and Secondary Chemoprevention of Malignant Melanoma.
Source:Am J Clin Dermatol; 17(6):625-634, 2016 Dec.
ISSN:1179-1888
Country of publication:New Zealand
Language:eng
Abstract:The incidence of malignant melanoma (MM) continues to rise in the United States. While sun protection and full body skin examinations remain the mainstay of preventative care, chemoprevention of the deadly disease has become an increasingly popular field of study. In this focused review, we discuss current findings and analyze the risks and benefits of various agents investigated for the primary and secondary chemoprevention of MM. Such agents include topical retinoids, vitamins, and supplements, Polypodium leucotomas extracts, non-steroidal anti-inflammatory agents (NSAIDs), statins, sunscreens, and field therapy with topical imiquimod for primary and secondary chemoprevention. We further identify a need for expanded high quality human research on the topic.
Publication type:JOURNAL ARTICLE; REVIEW
Name of substance:0 (Adjuvants, Immunologic); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Micronutrients); 0 (Plant Extracts); 0 (Sunscreening Agents)


  3 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text
PMID:27367679
Author:Parrado C; Mascaraque M; Gilaberte Y; Juarranz A; Gonzalez S
Address:Pathology Department, School of Medicine, Universidad de Málaga, Malaga 29071, Spain. cparrado@uma.es.
Title:Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review.
Source:Int J Mol Sci; 17(7), 2016 Jun 29.
ISSN:1422-0067
Country of publication:Switzerland
Language:eng
Abstract:Healthier life styles include increased outdoors time practicing sports and walking. This means increased exposure to the sun, leading to higher risk of sunburn, photoaging and skin cancer. In addition to topical barrier products, oral supplementations of various botanicals endowed with antioxidant activity are emerging as novel method of photoprotection. Polypodium leucotomos extract (PL, commercial name Fernblock(®), IFC Group, Spain) is a powerful antioxidant due to its high content of phenolic compounds. PL is administered orally, with proven safety, and it can also be used topically. Its mechanisms include inhibition of the generation and release of reactive oxygen species (ROS) by ultraviolet (UV) light. It also prevents UV- and ROS-induced DNA damage with inhibition of AP1 and NF-κB and protection of natural antioxidant enzyme systems. At the cellular level, PL decreases cellular apoptosis and necrosis mediated UV and inhibits abnormal extracellular matrix remodeling. PL reduces inflammation, prevents immunosuppression, activates tumor suppressor p53 and inhibits UV-induced cyclooxygenase-2 (COX-2) enzyme expression. In agreement with increased p53 activity, PL decreased UV radiation-induced cell proliferation. PL also prevents common deletions mitochondrial DNA damage induced by UVA, and MMP-1 expression induced Visible Light and Infrared Radiation. These cellular and molecular effects are reflected in inhibitions of carcinogenesis and photoaging.
Publication type:JOURNAL ARTICLE; REVIEW
Name of substance:0 (Plant Extracts); 0 (fernblock)


  4 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PMID:26885792
Author:Berman B; Ellis C; Elmets C
Title:Polypodium Leucotomos--An Overview of Basic Investigative Findings.
Source:J Drugs Dermatol; 15(2):224-8, 2016 Feb.
ISSN:1545-9616
Country of publication:United States
Language:eng
Abstract:The use of Polypodium leucotomos, a species of fern, has been reported to be beneficial in the treatment of atopic dermatitis, vitiligo, and psoriasis, and for prevention of polymorphic light eruption, sunburn, and squamous cell carcinoma. We review the in vivo animal, in vitro human, and human clinical studies performed to help elucidate the actions of and biologic pathways affected by P. leucotomos. These results serve as the scientific rationale and basis for the protection and effectiveness afforded by P. leucotomos in cutaneous diseases.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
Name of substance:0 (Antioxidants); 0 (Dermatologic Agents); 0 (Plant Extracts)


  5 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:26763327
Author:Llorens C; Argentina M; Rojas N; Westbrook J; Dumais J; Noblin X
Address:Laboratoire de Physique de la Matière Condensée, Université Nice Sophia-Antipolis, CNRS UMR 7336, Parc Valrose, Nice Cedex 2 06108, France Institut Non Linéaire de Nice, Université Nice Sophia-Antipolis, CNRS UMR 7335, 1361 Route des Lucioles, Valbonne 06560, France.
Title:The fern cavitation catapult: mechanism and design principles.
Source:J R Soc Interface; 13(114):20150930, 2016 Jan.
ISSN:1742-5662
Country of publication:England
Language:eng
Abstract:Leptosporangiate ferns have evolved an ingenious cavitation catapult to disperse their spores. The mechanism relies almost entirely on the annulus, a row of 12-25 cells, which successively: (i) stores energy by evaporation of the cells' content, (ii) triggers the catapult by internal cavitation, and (iii) controls the time scales of energy release to ensure efficient spore ejection. The confluence of these three biomechanical functions within the confines of a single structure suggests a level of sophistication that goes beyond most man-made devices where specific structures or parts rarely serve more than one function. Here, we study in detail the three phases of spore ejection in the sporangia of the fern Polypodium aureum. For each of these phases, we have written the governing equations and measured the key parameters. For the opening of the sporangium, we show that the structural design of the annulus is particularly well suited to inducing bending deformations in response to osmotic volume changes. Moreover, the measured parameters for the osmoelastic design lead to a near-optimal speed of spore ejection (approx. 10 m s(-1)). Our analysis of the trigger mechanism by cavitation points to a critical cavitation pressure of approximately -100 ± 14 bar, a value that matches the most negative pressures recorded in the xylem of plants. Finally, using high-speed imaging, we elucidated the physics leading to the sharp separation of time scales (30 versus 5000 µs) in the closing dynamics. Our results highlight the importance of the precise tuning of the parameters without which the function of the leptosporangium as a catapult would be severely compromised.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T


  6 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PMID:26767294
Author:Zhang WT; Zhao YX; Meng AG; Liu CY; Duan JY; Yao HK; Li Y
Title:[Analysis of Volatile Components of Polypodium hastatum by GC-MS].
Source:Zhong Yao Cai; 38(5):992-4, 2015 May.
ISSN:1001-4454
Country of publication:China
Language:chi
Abstract:OBJECTIVE: To further reveal the chemical constituents of Polypodium hastatum, volatile components from this plant were investigated. METHODS: The volatile components were extracted under reflux from the whole plant of Polypodium hastatum, and then analyzed qualitatively and quantitatively by GC-MS. RESULTS: 60 volatile components were detected and of all components detected, the structures and relative contents of 34 volatile compounds were elucidated. CONCLUSION: In the volatile components identified, most are fatty acid esters, especially methyl and ethyl esters, which compose the major volatile chemical constituents of Polypodium hastatum.
Publication type:ENGLISH ABSTRACT; JOURNAL ARTICLE
Name of substance:0 (Fatty Acids); 0 (Oils, Volatile); 0 (Plant Oils)


  7 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PubMed Central Full text
Full text
PMID:26627241
Author:Chang ES; Neuhof M; Rubinstein ND; Diamant A; Philippe H; Huchon D; Cartwright P
Address:Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS 66045;
Title:Genomic insights into the evolutionary origin of Myxozoa within Cnidaria.
Source:Proc Natl Acad Sci U S A; 112(48):14912-7, 2015 Dec 01.
ISSN:1091-6490
Country of publication:United States
Language:eng
Abstract:The Myxozoa comprise over 2,000 species of microscopic obligate parasites that use both invertebrate and vertebrate hosts as part of their life cycle. Although the evolutionary origin of myxozoans has been elusive, a close relationship with cnidarians, a group that includes corals, sea anemones, jellyfish, and hydroids, is supported by some phylogenetic studies and the observation that the distinctive myxozoan structure, the polar capsule, is remarkably similar to the stinging structures (nematocysts) in cnidarians. To gain insight into the extreme evolutionary transition from a free-living cnidarian to a microscopic endoparasite, we analyzed genomic and transcriptomic assemblies from two distantly related myxozoan species, Kudoa iwatai and Myxobolus cerebralis, and compared these to the transcriptome and genome of the less reduced cnidarian parasite, Polypodium hydriforme. A phylogenomic analysis, using for the first time to our knowledge, a taxonomic sampling that represents the breadth of myxozoan diversity, including four newly generated myxozoan assemblies, confirms that myxozoans are cnidarians and are a sister taxon to P. hydriforme. Estimations of genome size reveal that myxozoans have one of the smallest reported animal genomes. Gene enrichment analyses show depletion of expressed genes in categories related to development, cell differentiation, and cell-cell communication. In addition, a search for candidate genes indicates that myxozoans lack key elements of signaling pathways and transcriptional factors important for multicellular development. Our results suggest that the degeneration of the myxozoan body plan from a free-living cnidarian to a microscopic parasitic cnidarian was accompanied by extreme reduction in genome size and gene content.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.


  8 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:26585922
Author:Murbach TS; Béres E; Vértesi A; Glávits R; Hirka G; Endres JR; Clewell AE; Szakonyiné IP
Address:AIBMR Life Sciences, Inc., 4117 South Meridian, Puyallup, WA 98373, USA. Electronic address: tim@aibmr.com.
Title:A comprehensive toxicological safety assessment of an aqueous extract of Polypodium leucotomos (Fernblock(®)).
Source:Food Chem Toxicol; 86:328-41, 2015 Dec.
ISSN:1873-6351
Country of publication:England
Language:eng
Abstract:A battery of toxicological studies was conducted in accordance with internationally accepted standards to investigate the genotoxicity and repeated-dose oral toxicity of Fernblock(®), a commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos used for its oral and topical photoprotective properties. No evidence of mutagenicity was observed in a bacterial reverse mutation test or in vitro mammalian chromosomal aberration test nor was any genotoxic activity observed in an in vivo mouse micronucleus test. Two repeated-dose oral toxicity studies were conducted in male and female Wistar rats. In the first study, no mortality or toxic effects were observed and no target organs were identified at doses administered for 14 days by gavage up to the maximum dose of 5000 mg/kg bw/day. Based on these results, a 90-day study was conducted at 0, 300, 600, and 1200 mg/kg bw/day. No mortality or treatment-related adverse effects were observed and no target organs were identified. The NOAEL from the 90-day study was determined to be 1200 mg/kg bw/day, the highest dose tested.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Plant Extracts); 0 (fernblock)


  9 / 63 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:26218723
Author:Auriemma M; Di Nicola M; Gonzalez S; Piaserico S; Capo A; Amerio P
Address:*Department of Medicine and Aging Science, Dermatologic Clinic, University "G. d'Annunzio," Chieti-Pescara, Italy; †Department of Experimental and Clinical Science, University "G. d'Annunzio," Chieti-Pescara, Italy; ‡Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York; §Dermatology Service, Ramon y Cajal Hospital, Madrid, Spain; ‖Dermatologic Department, University of Padua, Padua, Italy.
Title:Polypodium leucotomos supplementation in the treatment of scalp actinic keratosis: could it improve the efficacy of photodynamic therapy?
Source:Dermatol Surg; 41(8):898-902, 2015 Aug.
ISSN:1524-4725
Country of publication:United States
Language:eng
Abstract:BACKGROUND: Actinic keratoses (AKs) are a common premalignant skin condition. Many treatments are available for AKs. Photodynamic therapy (PDT) is one of the most effective treatments. However, major concerns exist on the possibility of PDT-induced DNA-mutagenesis/immunosuppression, leading to AKs recurrence/treatment failure. An extract (PLE) from the fern polypodium leucotomos reduces UV-induced immunosuppression and mutagenesis. OBJECTIVE: To assess the ability of PLE to enhance the efficacy of PDT treatment, reducing AKs recurrence on the scalp. MATERIALS AND METHODS: Thirty-four bald patients presenting at least two AKs on the scalp were alternatively assigned to two groups. Both groups underwent two PDT-sessions one-week apart. The first group began oral PLE supplementation one week after the last PDT session. Evaluation of the effect of PLE supplementation was performed by direct inspection of the bald areas, lesions count, and photodynamic diagnosis assessment at 2 and 6 months. RESULTS: Both groups were homogeneous in terms of skin phototype and previous UV exposure. Mean age was 75.7 ± 7.8 years and 76.5 ± 5.5 years, respectively. Both treatment modalities were successful in reducing AKs number (p < .001). However, PLE supplementation increased clearance rate compared with PDT alone (p = .040). CONCLUSION: Polypodium leucotomos improves PDT clearance and decreases AK recurrence rate at 6 months, suggesting its use as a complementary agent in the treatment of field cancerization.
Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Name of substance:0 (Photosensitizing Agents); 0 (Plant Extracts); 585NM85KYM (methyl 5-aminolevulinate); 88755TAZ87 (Aminolevulinic Acid)


  10 / 63 MEDLINE  
              first record previous record
select
to print
Photocopy
PMID:25738847
Author:Winkelmann RR; Del Rosso J; Rigel DS
Title:Polypodium leucotomos extract: a status report on clinical efficacy and safety.
Source:J Drugs Dermatol; 14(3):254-61, 2015 Mar.
ISSN:1545-9616
Country of publication:United States
Language:eng
Abstract:Various extracts of polypodium leucotomos (PLE) applied topically or taken orally have been shown to have several beneficial antioxidant, photoprotectant, antimutagenic, and immunoregulatory effects. Modern studies have evaluated the efficacy of PLE orally as a photoprotective agent and for use in several photo-aggravated dermatologic disorders such as polymorphous light eruption, other photodermatoses, and melasma. No articles have been published evaluating the safety of PLE. We performed a PUBMED search for any randomized clinical trials related to PLE, or anapsos, a synonym. The primary safety endpoint of the review was any mention of an adverse event, side effect, or toxicity. Overall, 19 human and 6 basic science studies were included spanning over 40 years of research. Oral PLE was administered at daily doses ranging from 120 mg to 1080 mg. No adverse effects were reported in laboratory studies. In humans, side effects (gastrointestinal complaints and pruritus) were mild to moderate and found only in very small numbers of patients overall (16/1016 [2%]). This review concludes PLE is well tolerated at all doses administered and associated with a negligible risk of side effects.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
Name of substance:0 (Dermatologic Agents); 0 (Plant Extracts)



page 1 of 7 go to page                  
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information