Database : MEDLINE
Search on : B01.650.940.800.575.912.250.859.937.249 [DeCS Category]
References found : 128 [refine]
Displaying: 1 .. 10   in format [Large]

page 1 of 13 go to page                         

  1 / 128 MEDLINE  
              next record last record
select
to print
Photocopy
Full text
PMID:28704842
Author:Das G; Patra JK; Lee SY; Kim C; Park JG; Baek KH
Address:Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do, Republic of Korea.
Title:Analysis of metabolomic profile of fermented Orostachys japonicus A. Berger by capillary electrophoresis time of flight mass spectrometry.
Source:PLoS One; 12(7):e0181280, 2017.
ISSN:1932-6203
Country of publication:United States
Language:eng
Abstract:Microbial cell performance in food biotechnological processes has become an important concern for improving human health worldwide. Lactobacillus plantarum, which is widely distributed in nature, is a lactic acid bacterium with many industrial applications for fermented foods or functional foods (e.g., probiotics). In the present study, using capillary electrophoresis time of flight mass spectrometry, the metabolomic profile of dried Orostachys japonicus A. Berger, a perennial medicinal herb with L. plantarum was compared with that of O. japonicus fermented with L. plantarum to elucidate the metabolomic changes induced by the fermentation process. The levels of several metabolites were changed by the fermentation process, indicating their involvement in microbial performance. For example, glycolysis, the pentose phosphate pathway, the TCA cycle, the urea cycle-related metabolism, nucleotide metabolism, and lipid and amino acid metabolism were altered significantly by the fermentation process. Although the fermented metabolites were not tested using in vivo studies to increase human health benefits, our findings provide an insight into the alteration of metabolites induced by fermentation, and indicated that the metabolomic analysis for the process should be accompanied by fermenting strains and conditions.
Publication type:JOURNAL ARTICLE
Name of substance:33X04XA5AT (Lactic Acid)


  2 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PMID:27937045
Author:Uzun Y; Dalar A; Konczak I
Address:a Department of Pharmaceutical Botany, Faculty of Pharmacy , Yuzuncu Yil University , Van , Turkey.
Title:Sempervivum davisii: phytochemical composition, antioxidant and lipase-inhibitory activities.
Source:Pharm Biol; 55(1):532-540, 2017 Dec.
ISSN:1744-5116
Country of publication:England
Language:eng
Abstract:CONTEXT: Sempervivum davisii Muirhead (Crassulaceae) is a traditional medicinal herb from Eastern Anatolia. To date the composition of phytochemicals and physiological properties of this herb were not subjected to any research. OBJECTIVE: This study identifies compounds in S. davisii hydrophilic extracts and evaluates their potential biological properties. MATERIALS AND METHODS: Ethanol-based lyophilized extracts were obtained from aerial parts of plant (10 g of ground dry plant material in 200 mL of acidified aqueous ethanol, shaken for 2 h at 22 °C with supernatant collected and freeze-dried under vacuum). Phytochemical composition was investigated by liquid chromatography mass spectrometry (LC-MS/MS, phenolics) and gas chromatography mass spectrometry (GC-MS, volatiles). Phenolic compounds were quantified by high-performance liquid chromatography (HPLC) and the Folin-Ciocalteu assay. Subsequently, antioxidant capacity [ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC) assays] and enzyme inhibitory properties (isolated porcine pancreatic lipase) of the extracts were determined. RESULTS: Polyphenolic compounds were the main constituents of lyophilized extracts, among which kaempferol glycosides and quercetin hexoside dominated. The extracts exhibited potent antioxidant (FRAP values of 1925.2-5973.3 µM Fe /g DW; ORAC values of 1858.5-4208.7 µM Trolox Eq./g DW) and moderate lipase inhibitory (IC : 11.6-2.96 mg/mL) activities. Volatile compounds (nonanal, dehydroxylinalool oxide isomers, 2-decenal, 2-undecenal, 2,6-di-tetr-butylphenol) were also found. CONCLUSIONS: Phenolic compounds with the dominating kaempferol and quercetin derivatives are the sources of potent antioxidant properties of S. davisii hydrophilic extracts. The extracts exhibit moderate inhibitory properties towards isolated pancreatic lipase.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antioxidants); 0 (Enzyme Inhibitors); 0 (Kaempferols); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Solvents); 3K9958V90M (Ethanol); 9IKM0I5T1E (Quercetin); EC 3.1.1.3 (Lipase)


  3 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:27463087
Author:Cordero-Martínez J; Aguirre-Alvarado C; Guzmán-Soriano JG; Sánchez-Arroyo CE; Flores-Alonso JC; Rodríguez-Páez L
Address:a Departamento de Bioquímica , Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional , México City , Distrito Federal, México.
Title:Effects of aqueous crude extract of Echeveria gibbiflora on mouse sperm function.
Source:Syst Biol Reprod Med; 62(5):343-52, 2016 Oct.
ISSN:1939-6376
Country of publication:England
Language:eng
Abstract:UNLABELLED: The present study evaluates the possible antifertility effect of aqueous crude extract (OBACE) of Echeveria gibbiflora, a plant that belongs to the crassulaceae family, used in traditional Mexican medicine as a vaginal post coital rinse to prevent pregnancy and shown to have an immobilization/agglutination effect on sperm of different mammal species. We evaluated the effect of OBACE on functional parameters of mouse sperm, such as viability, capacitation, and acrosome reaction. In addition, due to the high concentrations of calcium bis-(hydrogen-1-malate) hexahydrate [Ca (C4H5O5)2•6H2O] present in this plant extract, we evaluated its effect on Ca(2+) influx in mouse sperm under capacitating conditions. Moreover, we determined the acute toxicity of OBACE and its in vivo effect in mouse sperm motility administering a single daily dose of 50 and 100 mg/kg during seven days, intraperitoneally. The sperm viability was not affected by the presence of different concentrations of OBACE, however, the capacitation and acrosome reaction suffered a significant decrease in a concentration-dependent manner, coinciding with the reduction of Ca(2+) influx. Furthermore, OBACE displayed an LD50 of 3,784.42 mg/kg and can be classified as a low toxic substance. Also, in vivo OBACE showed an inhibition of total and progressive motility on mouse sperm alongside a significant decrease of motility kinematic parameters and IVF rates. The results confirm the antifertility effect of this plant used in Mexican folk medicine. Further study on OBACE as a possible contraceptive treatment is warranted because of its activity and low in vivo toxicity. ABBREVIATIONS: ALH: lateral amplitude; AP: acid phosphatase; BCF: beat frequency; BSA: bovine serum albumine; CTC: chlortetracycline; FDA: fluorescein diacetate; Fura-2 AM: fura-2-acetoxymethyl ester; HIV: human immunodeficiency virus; IVF: in vitro fertilization; OBACE: aqueous crude extract of Echeveria gibbiflora; PI: propidum iodide; SN: supernatant; VAP: average path velocity; VCL: track speed; VSL: straight line velocity.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Contraceptive Agents); 0 (Plant Extracts)


  4 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
PMID:27396195
Author:Alberti Á; Riethmüller E; Béni S; Kéry Á
Title:Evaluation of Radical Scavenging Activity of Sempervivum tectorum and Corylus avellana Extracts with Different Phenolic Composition.
Source:Nat Prod Commun; 11(4):469-74, 2016 Apr.
ISSN:1934-578X
Country of publication:United States
Language:eng
Abstract:Semnpervivum tectorum L. and Corylus avellana L. are traditional herbal remedies exhibiting antioxidant activity and representing diverse phenolic composition. The aim of this study was to reveal the contribution of certain compounds to total radical scavenging activity by studying S. tectorum and C. avellana extracts prepared with solvents of different selectivity for diverse classes of phenolics. Antioxidant activity of S. tectorum and C. avellana samples was determined in the ABTS and DPPH radical scavenging assays, and phenolic composition was evaluated by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Correlations between antioxidant activity and phenolic content of houseleek extracts have been revealed. Significant differences regarding antioxidant activity have been shown between S. tectorum 80% (v/v) methanol extract and its fractions. Additionally, synergism among the constituents present together in the whole extract was assumed. Significantly higher radical scavenging activity of hazel extracts has been attributed to the differences in phenolic composition compared with houseleek extracts.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Free Radical Scavengers); 0 (Phenols); 0 (Plant Extracts)


  5 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:27341781
Author:Kim JH; Lee SH; Lee HW; Sun YN; Jang WH; Yang SY; Jang HD; Kim YH
Address:College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea; Department of Horticultural Environment, National Institute of Horticultural and Herbal Science, RDA, Wanju-gun, Jeollabuk-do 595-890, Republic of Korea.
Title:(-)-Epicatechin derivate from Orostachys japonicus as potential inhibitor of the human butyrylcholinesterase.
Source:Int J Biol Macromol; 91:1033-9, 2016 Oct.
ISSN:1879-0003
Country of publication:Netherlands
Language:eng
Abstract:Cholinesterase inhibitors block the bioconversion of neurotransmitters by cholinesterase in the nervous system. Epicatechin derivatives (1, 3 and 5), polyphenols (6 and 7) from Orostachys japonicus, and catechin derivatives (2 and 4) from our in-house library were evaluated for their inhibitory activity on cholinesterase. Compound 5 exhibited IC50 values of 58.3±2.4 and 17.8±3.8µg/mL on AChE and BuChE, respectively. Compound 5 inhibited BuChE more strongly than AChE through a competitive behavior. In silico binding positions of 5 in the active site were predicted using Autodock 4.2 and processed in a 10000-ps molecular dynamics simulation to assess the stability of compound 5 binding.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antioxidants); 0 (Cholinesterase Inhibitors); 0 (Reactive Oxygen Species); 8R1V1STN48 (Catechin); EC 3.1.1.8 (Butyrylcholinesterase)


  6 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:27230134
Author:El-Hawary SS; Mohammed R; Abouzid S; Ali ZY; Elwekeel A
Address:Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Title:Anti-arthritic activity of 11-O-(4'-O-methyl galloyl)-bergenin and Crassula capitella extract in rats.
Source:J Pharm Pharmacol; 68(6):834-44, 2016 Jun.
ISSN:2042-7158
Country of publication:England
Language:eng
Abstract:OBJECTIVES: Isolation and identification of phytochemicals of Crassula capitella (Thunberg), evaluation of the anti-arthritic potential of the extract and the major isolated compound; 11-O-(4'-O-methyl galloyl)-bergenin and underlying their mechanism on rat model of rheumatoid arthritis (RA). METHODS: Different fractions were subjected to column chromatography giving fourteen compound identified by mass and NMR spectroscopic techniques. RA was induced by intraplantar injection of complete Freund's adjuvant into the right hind paw of rats. Influence of tested samples in comparable to methotrexate on paw oedema, body weight gain, serum diagnostic markers, cartilage and bone degeneration enzymes, pro-inflammatory mediators and oxidative stress biomarkers in arthritic rats. KEY FINDINGS: Fourteen phenolic compounds were isolated and identified for the first time from C. capitella. The major compound identified as 11-O-(4'-O-methyl galloyl)-bergenin. Treatment of arthritic rats with extract or 11-O-(4'-O-methyl galloyl)-bergenin with the tested doses can reduce the progression and severity of RA. CONCLUSION: Crassula capitella is a new natural and abundant source for 11-O-(4'-O-methyl galloyl)-bergenin for resolving chronic inflammatory diseases as RA through antioxidant, anti-inflammatory and membrane stabilizing mechanism.
Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
Name of substance:0 (11-O-(4'-O-methyl galloyl)bergenin); 0 (Benzopyrans); 0 (Biomarkers); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Plant Extracts); 632XD903SP (Gallic Acid); 9007-81-2 (Freund's Adjuvant)


  7 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:27102163
Author:Botha C
Address:Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X05, Onderstepoort 0110, South Africa. christo.botha@up.ac.za.
Title:Potential Health Risks Posed by Plant-Derived Cumulative Neurotoxic Bufadienolides in South Africa.
Source:Molecules; 21(3):348, 2016 Mar 16.
ISSN:1420-3049
Country of publication:Switzerland
Language:eng
Abstract:Bufadienolide-type cardiac glycosides have a worldwide distribution and are mainly synthesized by plants, but there are also animal sources. In South Africa, members of three genera of the Crassulaceae (Cotyledon, Tylecodon and Kalanchoe) cause a unique chronic form of cardiac glycoside poisoning, predominantly in small stock. This paretic/paralytic condition is referred to as "krimpsiekte", cotyledonosis or "nenta". "Krimpsiekte" is a plant poisoning only reported from South Africa and is regarded as the most important plant poisoning of small stock in the semi-arid Little Karoo and southern fringes of the Great Karoo. The toxicosis is caused by cumulative bufadienolides which have neurotoxic properties. Four types of cumulative neurotoxic bufadienolides, namely cotyledoside, and the tyledosides, orbicusides and lanceotoxins, have been isolated. Based on the structure activity relationships and certain toxicokinetic parameters possible reasons for their accumulation are presented. Consumption of edible tissues from animals that have ingested these plants poses a potential risk to humans.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Bufanolides); 0 (Glycosides)


  8 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:26658852
Author:Jones RW
Address:USDA-ARS, Genetic improvement of Fruits and Vegetables Laboratory, 10300 Baltimore Ave, Beltsville, MD 20705, United States. Electronic address: richard.jones@ars.usda.gov.
Title:Application of succulent plant leaves for Agrobacterium infiltration-mediated protein production.
Source:J Microbiol Methods; 120:65-7, 2016 Jan.
ISSN:1872-8359
Country of publication:Netherlands
Language:eng
Abstract:When expressing plant cell wall degrading enzymes in the widely used tobacco (Nicotiana benthamiana) after Agrobacterium infiltration, difficulties arise due to the thin leaf structure. Thick leaved succulents, Kalanchoe blossfeldiana and Hylotelephium telephium, were tested as alternatives. A xyloglucanase, as well as a xyloglucanase inhibitor protein was successfully produced.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
Name of substance:0 (Bacterial Proteins); EC 3.2.1.- (Glycoside Hydrolases); EC 3.2.1.- (xyloglucan endo(1-4)-beta-D-glucanase)


  9 / 128 MEDLINE  
              first record previous record next record last record
select
to print
Photocopy
Full text
PMID:26036956
Author:Chen SJ; Yen CH; Liu JT; Tseng YF; Lin PT
Address:Department of Health Food, Chung Chou University of Science and Technology, Changhua, 51003, Taiwan.
Title:Anti-inflammatory effect of water extracts of Graptopetalum paraguayense supplementation in subjects with metabolic syndrome: a preliminary study.
Source:J Sci Food Agric; 96(5):1772-6, 2016 Mar 30.
ISSN:1097-0010
Country of publication:England
Language:eng
Abstract:BACKGROUND: Many studies have demonstrated that Graptopetalum paraguayense has good antioxidant ability; however, few studies have examined its anti-inflammatory effect. The study aimed to investigate the anti-inflammatory effects of water extracts of G. paraguayense (WGP, 4 g day(-1)) in subjects with metabolic syndrome (MS). Intervention was administered for 12 weeks. Levels of inflammatory markers [high sensitivity C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), and interleukin-6 (IL-6)] and antioxidant enzymes activities were measured. RESULTS: Forty-two subjects completed the 12 week intervention study (placebo, n = 19; WGP, n = 23). After 12 weeks supplementation, subjects in WGP group had significantly lower levels of inflammatory markers than the baseline (P < 0.05) and the placebo group (CRP, P = 0.07; TNF-α, P = 0.04; IL-6, P = 0.03). The changes in levels of the inflammatory markers were significantly decreased in WGP group (CRP, P = 0.04; TNF-α, P = 0.06; IL-6, P = 0.01) compared to the placebo group. Levels of inflammatory markers were significantly negatively correlated with the antioxidant enzymes activities after supplementation. CONCLUSION: This study demonstrated a significant reduction in inflammatory status in MS after WGP supplementation. WGP may exert an anti-inflammatory effect on MS in addition to its antioxidant ability.
Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Name of substance:0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biomarkers); 0 (Plant Extracts)


  10 / 128 MEDLINE  
              first record previous record
select
to print
Photocopy
PubMed Central Full text
Full text
PMID:26634994
Author:Yang T; Liu X
Address:Laboratory of Plant Systematics and Evolutionary Biology, College of Life Science, Wuhan University, Wuhan, Hubei 430072, China.
Title:Comparing photosynthetic characteristics of Isoetes sinensis Palmer under submerged and terrestrial conditions.
Source:Sci Rep; 5:17783, 2015 Dec 04.
ISSN:2045-2322
Country of publication:England
Language:eng
Abstract:Crassulacean acid metabolism (CAM) is widespread in terrestrial and aquatic species, plastic in response to environmental changes. Isoetes L. is one of the earliest basal vascular plants and CAM is popular in this genus. Isoetes sinensis Palmer is an amphibious species, alternating frequently between terrestrial and aquatic environments. Given this, we investigated and compared photosynthetic characteristics over a diurnal cycle under submerged condition (SC) and terrestrial condition (TC). The results suggest that I. sinensis possesses a stronger CAM capacity under SC. Compared with under TC, titratable acidity levels and organic acid concentrations were more enriched under SC, whereas soluble sugar or starch and protein levels were lower under SC. Transcript analyses for nine photosynthetic genes revealed that CAM-associated genes possessed high transcripts under SC, but C3-related transcripts were highly expressed under TC. In addition, the enzyme activity measurements demonstrated that PEPC activity over a diurnal cycle was slightly higher under SC, whereas Rubisco activity during the daytime was greater under TC. This comprehensive study probably facilitates general understandings about the CAM photosynthetic characteristics of Isoetes in response to the environmental changes.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:059QF0KO0R (Water); 142M471B3J (Carbon Dioxide); 9005-25-8 (Starch); EC 4.1.1.39 (Ribulose-Bisphosphate Carboxylase)



page 1 of 13 go to page                         
   


Refine the search
  Database : MEDLINE Advanced form   

    Search in field  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/PAHO/WHO - Latin American and Caribbean Center on Health Sciences Information