Database : MEDLINE
Search on : C10.177.575.600.625 [DeCS Category]
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PMID:28526222
Author:Lu W; Yan H; Wu S; Xu W; Jin H; Du J
Address:Department of Pediatrics, Peking University First Hospital, Beijing, China.
Title:Hemocytometric Measures Predict the Efficacy of Oral Rehydration for Children with Postural Tachycardia Syndrome.
Source:J Pediatr; 187:220-224, 2017 Aug.
ISSN:1097-6833
Country of publication:United States
Language:eng
Abstract:OBJECTIVE: To explore whether hemocytometric measures could be qualified predictors for the effect of oral rehydration salts (ORS) in children with postural tachycardia syndrome (POTS). STUDY DESIGN: Thirty-five children with POTS and 29 healthy children were enrolled. General information, hemodynamic status, and baseline hemocytometric variables were collected. Children with POTS received ORS therapy and were followed up for 3 months. The independent risk factors of developing POTS were explored. A receiver-operating characteristic curve was used to evaluate predictive value of hemocytometric variables for therapeutic effectiveness of ORS therapy. RESULTS: Children with POTS had larger mean corpuscular volume (MCV) and lower mean corpuscular hemoglobin concentration (MCHC) values than controls (P < .05). The baseline MCV values positively correlated with heart rate elevation from supine to upright (r = 0.294, P < .05). Both larger MCV and lower MCHC values were independent risk factors of developing POTS (for MCV, P < .05, OR 1.222; for MCHC, P < .05, OR 0.936). In children with POTS, responders to ORS had baseline lower MCV and higher MCHC than nonresponders (P < .05). The receiver-operating characteristic curve for the predictive value of MCHC showed that area under the curve was 0.73. CONCLUSIONS: MCHC values could be used to predict the effectiveness of ORS for treating POTS in children.
Publication type:JOURNAL ARTICLE


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PMID:28429690
Author:Ugan Atik S; Dedeoglu R; Koka A; Öztunç F
Address:Department of Pediatric Cardiology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. sezenugan@hotmail.com.
Title:Çocuklarda postüral ortostatik tasikardi sendromu, uygunsuz sinüs tasikardisi ve vazovagal senkop tani ve tedavisindeki deneyimlerimiz. [Our experience in the diagnosis and treatment of postural orthostatic tachycardia syndrome, vasovagal syncope, and inappropriate sinus tachycardia in children].
Source:Turk Kardiyol Dern Ars; 45(3):227-234, 2017 Apr.
ISSN:1308-4488
Country of publication:Turkey
Language:tur
Abstract:OBJECTIVES: The aim of this study was to share our experience in the diagnosis and treatment of patients who presented at our clinic with syncope, pre-syncope, dizziness, and palpitations. STUDY DESIGN: Patients who were treated at pediatric cardiology clinic for complaints of syncope, dizziness, and palpitations between 2014 and 2016 were enrolled in the study. Detailed history of the patients, physical examination findings, laboratory and electrocardiogram results were recorded. Tilt table test, 24-hour Holter rhythm monitoring, and exercise test were performed, as required. Patients were diagnosed as vasovagal syncope, postural orthostatic tachycardia syndrome (POTS), or inappropriate sinus tachycardia based on these findings. Treatment of the patients was evaluated. RESULTS: Thirty patients were diagnosed as vasovagal syncope, 7 patients as POTS, and 2 as inappropriate sinus tachycardia. POTS accompanied Raynaud's phenomenon in 1 patient, hypertrophic cardiomyopathy in 1 patient, and homocystinuria in another patient. Complaints of patients with vasovagal syncope improved with non-medical therapy. Medical treatment was administered to the patients with diagnosis of POTS and inappropriate sinus tachycardia. CONCLUSION: In patients with complaints of syncope, pre-syncope, dizziness, and palpitations without structural heart disease or non-rhythm problems, cardiovascular autonomic disorders, such as POTS and inappropriate sinus tachycardia should be kept in mind, as well as vasovagal syncope.
Publication type:JOURNAL ARTICLE


  3 / 317 MEDLINE  
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PMID:28429687
Author:Aliyev F
Address:Azerbaijan Medical University, Cardiovascular Center, Baku, Azerbaijan. drfaridaliyev@yahoo.com.tr.
Title:Postural orthostatic tachycardia: A syndrome requiring detailed search for associated conditions.
Source:Turk Kardiyol Dern Ars; 45(3):214-216, 2017 04.
ISSN:1308-4488
Country of publication:Turkey
Language:eng
Publication type:EDITORIAL; COMMENT


  4 / 317 MEDLINE  
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PMID:28414396
Author:Heyer GL
Title:Postural Tachycardia Syndrome: Diagnosis and Management in Adolescents and Young Adults.
Source:Pediatr Ann; 46(4):e145-e154, 2017 Apr 01.
ISSN:1938-2359
Country of publication:United States
Language:eng
Abstract:Postural tachycardia syndrome (POTS) represents a common form of orthostatic intolerance that disproportionately affects young women from puberty through adulthood. Patients with POTS have day-to-day orthostatic symptoms with the hallmark feature of an excessive, sustained, and symptomatic rise in heart rate during orthostatic testing. Although considerable overlap exists, three subtypes of POTS have been described: neuropathic, hyperadrenergic, and hypovolemic forms. The wide spectrum of symptoms and comorbidities can make treatment particularly challenging. Volume expansion with fluid and salt, exercise, and education constitute a reasonable initial therapy for most patients. Several medicines are also available to treat orthostatic intolerance and the associated comorbidities. Defining the POTS subtypes clinically in each patient may help to guide medicine choices. A multidisciplinary approach to overall management of the patient with POTS is advised. This review highlights several aspects of POTS with a specific focus on adolescent and young adult patients. [Pediatr Ann. 2017;46(4):e145-e154.].
Publication type:JOURNAL ARTICLE; REVIEW


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PMID:28362251
Author:Fant C; Cohen A
Address:Department of Emergency Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.
Title:Syncope In Pediatric Patients: A Practical Approach To Differential Diagnosis And Management In The Emergency Department.
Source:Pediatr Emerg Med Pract; 14(4):1-28, 2017 04.
ISSN:1549-9650
Country of publication:United States
Language:eng
Abstract:Syncope is a condition that is often seen in the emergency department. Most syncope is benign, but it can be a symptom of a life-threatening condition. While syncope often requires an extensive workup in adults, in the pediatric population, critical questioning and simple, noninvasive testing is usually sufficient to exclude significant or life-threatening causes. For low-risk patients, resource-intensive workups are rarely diagnostic, and add significant cost to medical care. This issue will highlight critical diseases that cause syncope, identify high-risk "red flags," and enable the emergency clinician to develop a cost-effective, minimally invasive algorithm for the diagnosis and treatment of pediatric syncope.
Publication type:JOURNAL ARTICLE


  6 / 317 MEDLINE  
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PMID:28351847
Author:Anderson JB; Willis MW
Address:Department of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio jeffrey.anderson@cchmc.org.
Title:Differentiating Between Postural Tachycardia Syndrome and Vasovagal Syncope.
Source:Pediatrics; 139(4), 2017 04.
ISSN:1098-4275
Country of publication:United States
Language:eng
Publication type:JOURNAL ARTICLE; COMMENT


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PMID:28286774
Author:Celletti C; Camerota F; Castori M; Censi F; Gioffrè L; Calcagnini G; Strano S
Address:Physical Medicine and Rehabilitation, Umberto I Hospital, Rome, Italy.
Title:Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure?
Source:Biomed Res Int; 2017:9161865, 2017.
ISSN:2314-6141
Country of publication:United States
Language:eng
Abstract:. Joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type (JHS/EDS-HT), is a hereditary connective tissue disorder mainly characterized by generalized joint hypermobility, skin texture abnormalities, and visceral and vascular dysfunctions, also comprising symptoms of autonomic dysfunction. This study aims to further evaluate cardiovascular autonomic involvement in JHS/EDS-HT by a battery of functional tests. . The response to cardiovascular reflex tests comprising deep breathing, Valsalva maneuver, 30/15 ratio, handgrip test, and head-up tilt test was studied in 35 JHS/EDS-HT adults. Heart rate and blood pressure variability was also investigated by spectral analysis in comparison to age and sex healthy matched group. . Valsalva ratio was normal in all patients, but 37.2% of them were not able to finish the test. At tilt, 48.6% patients showed postural orthostatic tachycardia, 31.4% orthostatic intolerance, 20% normal results. Only one patient had orthostatic hypotension. Spectral analysis showed significant higher baroreflex sensitivity values at rest compared to controls. This study confirms the abnormal cardiovascular autonomic profile in adults with JHS/EDS-HT and found the higher baroreflex sensitivity as a potential disease marker and clue for future research.
Publication type:CLINICAL TRIAL; JOURNAL ARTICLE


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PMID:28185102
Author:Ruzieh M; Baugh A; Dasa O; Parker RL; Perrault JT; Renno A; Karabin BL; Grubb B
Address:University of Toledo, Toledo, OH, USA. mohammed.ruzieh@utoledo.edu.
Title:Effects of intermittent intravenous saline infusions in patients with medication-refractory postural tachycardia syndrome.
Source:J Interv Card Electrophysiol; 48(3):255-260, 2017 Apr.
ISSN:1572-8595
Country of publication:Netherlands
Language:eng
Abstract:BACKGROUND: The postural tachycardia syndrome (POTS) is a heterogeneous group of disorders that results in symptoms of orthostatic intolerance. Excess blood pooling has been observed to cause low effective circulating volume in the central vasculature. Consequently, acute volume loading with IV saline has emerged as a potential strategy for clinical intervention. We evaluated the impact of acute volume loading on both the signs and symptoms of patients suffering from POTS. METHODS: Fifty-seven subjects screened from our population of POTS patients and assenting to participation were administered the two surveys by telephone. Subjects completed each survey twice, before, and after initiating IV hydration therapy. The Orthostatic Hypotension Questionnaire (OHQ) was used to assess change in clinical symptomatology, while the short form 36 health survey (SF-36) was employed to assess the impact of IV saline infusion on quality of life. RESULTS: Fifty-seven patients were included in the analysis. The average number of medications trialed before referral for IV hydration was 3.6 ± 1.7 medications. Saline infusions occurred with mean frequency of 11.3 ± 8.5 days and at a mean volume of 1.5 ± 0.6 l per infusion. The mean change of the OHQ was 3.1 ± 0.3 (95% CI 2.6-3.7; P < 0.001), with significant improvement in all the composite scores. The mean change in the SF-36 form was 19.1 ± 2.7 (95% CI -24.6 to -13.6; P < 0.001). CONCLUSIONS: Intermittent IV infusions of saline dramatically reduce symptoms and improve quality of life in patients suffering from POTS. Further work should explore its efficacy as a bridge study for patients of high symptomatic severity.
Publication type:JOURNAL ARTICLE; OBSERVATIONAL STUDY
Name of substance:0 (Anti-Arrhythmia Agents); 451W47IQ8X (Sodium Chloride)


  9 / 317 MEDLINE  
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PMID:28073220
Author:Gøtzsche PC
Title:Hvad ved vi om sikkerheden af HPV-vaccinerne? What do we know about the safety of the HPV vaccines?
Source:Tidsskr Nor Laegeforen; 137(1):11-12, 2017 Jan.
ISSN:0807-7096
Country of publication:Norway
Language:eng; nor
Publication type:JOURNAL ARTICLE
Name of substance:0 (Papillomavirus Vaccines)


  10 / 317 MEDLINE  
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PMID:27941082
Author:Keating EM; Antiel RM; Weiss KE; Wallace D; Antiel SJ; Fischer PR; Junghans-Rutelonis AN; Harbeck-Weber C
Address:1 Mayo Clinic, Rochester, MN, USA.
Title:Parental Perceptions of Pediatric Pain and POTS-Related Disability.
Source:Clin Pediatr (Phila); 56(13):1185-1192, 2017 Nov.
ISSN:1938-2707
Country of publication:United States
Language:eng
Abstract:Adolescents with postural orthostatic tachycardia syndrome (POTS) often have pain and functional impairment. This study evaluated how parental attributions of children's symptoms relate to child functional impairment. Adolescents with chronic pain and clinical symptoms suggestive of autonomic dysfunction (fatigue, dizziness, nausea) that attended a multidisciplinary chronic pain clinic completed measures of depression, anxiety, and functioning (n = 141). Parents of 114 of these patients completed the Parent Pain Attribution Questionnaire (PPAQ), a measure indicating the extent they believe physical and psychosocial factors account for their child's health condition. Patients were retrospectively grouped as to whether or not they had significant POTS on tilt table testing (n = 37). Greater parental attribution to physical causes was associated with increased levels of functional disability whether patients had POTS ( r = 0.45, P = .006) or not ( r = 0.25, P = .03). These results suggest that providers should advocate a more comprehensive family-oriented rehabilitative approach to treatment.
Publication type:JOURNAL ARTICLE



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