Database : MEDLINE
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  1 / 826 MEDLINE  
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PMID:29328639
Author:Dubovina D; Mihailovic B; Bukumiric Z; Vlahovic Z; Miladinovic M; Mikovic N; Lazic Z
Title:The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis.
Source:Vojnosanit Pregl; 73(11):1010-5, 2016 Nov.
ISSN:0042-8450
Country of publication:Serbia
Language:eng
Abstract:Background/Aim: Alveolar osteitis (AO), also known as "dry socket", is relatively common post-extraction complication. It probably occurs due to excessive fibrinolytic activity in the coagulum and is characterized by intense pain sensations. The aim of this clinical study was to examine the role of hyaluronic acid and aminocaproic acid in the treatment of AO. Methods: The study included 60 patients with the clinical diagnosis of AO. All the patients were divided into two groups of 30 patients each according to the applied non-pharmacological measure: irrigation ­ irrigation of dry socket with sterile saline; curettage ­ careful curettage. Both of these groups were further divided into three subgroups regarding the applied treatment (hyaluronic acid; hyaluronic acid + aminocaproic acid; Alvogyl ®, an anesthetic and antiseptic paste), each with 10 patients, according to the following protocol: 0.2 mL of hyaluronic acid in the form of a 0.8% gel; 2 mL of aminocaproic acid and hyaluronic acid; Alvogyl®. During each visit, scheduled for every two days until complete absence of painful sensations, the patients had the therapeutic method repeated as at the first examination. At each control visit the number of present symptoms and signs of AO was recorded, as well as the level of pain (measured with a visual analogue scale). Results: With the use of hyaluronic acid, with or without aminocaproic one, a statistically significantly faster reduction in pain sensations was achieved, along with the reduction in the number of symptoms and signs of AO compared to the use of Alvogyl®. Conclusion: Hyaluronic acid, applied alone or in combination with aminocaproic acid significantly reduces pain sensation, thus it can be successfully used in the treatment of AO.
Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Name of substance:0 (Analgesics); 0 (Drug Combinations); 0 (Hydrocarbons, Iodinated); 0 (Oils, Volatile); 0 (butyl aminobenzoate, eugenol, iodoform, spearmint oil drug combinations); 0 (para-Aminobenzoates); 3T8H1794QW (Eugenol); 9004-61-9 (Hyaluronic Acid); U6F3787206 (Aminocaproic Acid)


  2 / 826 MEDLINE  
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PMID:29232553
Author:Pan R; Ruvolo V; Mu H; Leverson JD; Nichols G; Reed JC; Konopleva M; Andreeff M
Address:Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Title:Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.
Source:Cancer Cell; 32(6):748-760.e6, 2017 Dec 11.
ISSN:1878-3686
Country of publication:United States
Language:eng
Abstract:Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemia (AML). Mechanistically, p53 activation negatively regulates the Ras/Raf/MEK/ERK pathway and activates GSK3 to modulate Mcl-1 phosphorylation and promote its degradation, thus overcoming AML resistance to Bcl-2 inhibition. Moreover, Bcl-2 inhibition reciprocally overcomes apoptosis resistance to p53 activation by switching cellular response from G arrest to apoptosis. The efficacy, together with the mechanistic findings, reveals the potential of simultaneously targeting these two apoptosis regulators and provides a rational basis for clinical testing of this therapeutic approach.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Pyrrolidines); 0 (RG7388); 0 (Sulfonamides); 0 (Tumor Suppressor Protein p53); 0 (para-Aminobenzoates); N54AIC43PW (venetoclax)


  3 / 826 MEDLINE  
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PMID:28877280
Author:Epasinghe DJ; Yiu CKY; Burrow MF
Address:Prince Philip Dental Hospital, University of Hong Kong, Faculty of Dentistry, Hong Kong SAR, China.
Title:Mechanical properties, water sorption characteristics, and compound release of grape seed extract-incorporated resins.
Source:J Appl Oral Sci; 25(4):412-419, 2017 Jul-Aug.
ISSN:1678-7765
Country of publication:Brazil
Language:eng
Abstract:Objective: This study evaluated the effect of grape seed extract (GSE) incorporation on the mechanical properties, water sorption, solubility, and GSE release from the experimental adhesive resins. Material and Methods: An experimental comonomer mixture, consisting of 40% Bis-GMA, 30% Bis MP, 28% HEMA, 0.26% camphorquinone and 1% EDMAB, was used to prepare four GSE-incorporated adhesive resins at concentrations of 0.5, 1, 1.5, and 2 wt%. The neat resin without GSE was used as the control. Six resin beams (25 mm x 2 mm x 2 mm) per group were prepared for flexural strength and modulus of elasticity evaluations using a universal testing machine at a crosshead speed of 1 mm/min. Five disks (6 mm in diameter and 2 mm in thickness) per group were used for microhardness measurements using a Leitz micro-hardness tester with Leica Qgo software. Five disks (7 mm in diameter and 2 mm in thickness) per group were prepared and stored in deionized water for 28 days. Water sorption, solubility, and GSE release in deionized water were calculated for each GSE-incorporated adhesive at the end of 28th day. Data was evaluated using one-way ANOVA and Tukey multiple comparisons. Results: Flexural strength, modulus of elasticity and microhardness of GSE-incorporated adhesive decreased significantly with incorporation of 1.5% of GSE (p<0.05). Addition of GSE had no effect on the water sorption of the adhesive resins (p=0.33). The solubility of the resin also increased significantly with incorporation of 1.5% of GSE (p<0.05). Quantities of GSE release increased with increased concentration of GSE in the adhesive resin. Conclusion: Up to 1% of GSE can be incorporated into a dental adhesive resin without interfering with the mechanical properties or solubility of the resins.
Publication type:EVALUATION STUDIES; JOURNAL ARTICLE
Name of substance:0 (Grape Seed Extract); 0 (Methacrylates); 0 (Proanthocyanidins); 0 (Resin Cements); 0 (ethyl 4-N,N-dimethylaminobenzoate); 0 (para-Aminobenzoates); 059QF0KO0R (Water); 18206-61-6 (proanthocyanidin); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate); 6E1I4IV47V (hydroxyethyl methacrylate); 76-22-2 (Camphor); RAL3591W33 (camphorquinone)


  4 / 826 MEDLINE  
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PMID:28596292
Author:Kistemaker LEM; Oenema TA; Baarsma HA; Bos IST; Schmidt M; Facchinetti F; Civelli M; Villetti G; Gosens R
Address:Department of Molecular Pharmacology, University of Groningen, The Netherlands; l.e.m.kistemaker@rug.nl.
Title:The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices.
Source:Am J Physiol Lung Cell Mol Physiol; 313(3):L507-L515, 2017 Sep 01.
ISSN:1522-1504
Country of publication:United States
Language:eng
Abstract:Combination therapy of PDE4 inhibitors and anticholinergics induces bronchoprotection in COPD. Mechanical forces that arise during bronchoconstriction may contribute to airway remodeling. Therefore, we investigated the impact of PDE4 inhibitors and anticholinergics on bronchoconstriction-induced remodeling. Because of the different mechanism of action of PDE4 inhibitors and anticholinergics, we hypothesized functional interactions of these two drug classes. Guinea pig precision-cut lung slices were preincubated with the PDE4 inhibitors CHF-6001 or roflumilast and/or the anticholinergics tiotropium or glycopyorrolate, followed by stimulation with methacholine (10 µM) or TGF-ß (2 ng/ml) for 48 h. The inhibitory effects on airway smooth muscle remodeling, airway contraction, and TGF-ß release were investigated. Methacholine-induced protein expression of smooth muscle-myosin was fully inhibited by CHF-6001 (0.3-100 nM), whereas roflumilast (1 µM) had smaller effects. Tiotropium and glycopyrrolate fully inhibited methacholine-induced airway remodeling (0.1-30 nM). The combination of CHF-6001 and tiotropium or glycopyrrolate, in concentrations partially effective by themselves, fully inhibited methacholine-induced remodeling in combination. CHF-6001 did not affect airway closure and had limited effects on TGF-ß -induced remodeling, but rather, it inhibited methacholine-induced TGF-ß release. The PDE4 inhibitor CHF-6001, and to a lesser extent roflumilast, and the LAMAs tiotropium and glycopyrrolate inhibit bronchoconstriction-induced remodeling. The combination of CHF-6001 and anticholinergics was more effective than the individual compounds. This cooperativity might be explained by the distinct mechanisms of action inhibiting TGF-ß release and bronchoconstriction.
Publication type:JOURNAL ARTICLE
Name of substance:0 (3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide); 0 (Aminopyridines); 0 (Benzamides); 0 (Cholinergic Antagonists); 0 (Cyclopropanes); 0 (Phosphodiesterase 4 Inhibitors); 0 (Sulfonamides); 0 (Transforming Growth Factor beta); 0 (para-Aminobenzoates); 0P6C6ZOP5U (Roflumilast); 0W5ETF9M2K (Methacholine Chloride); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4); V92SO9WP2I (Glycopyrrolate); XX112XZP0J (Tiotropium Bromide)


  5 / 826 MEDLINE  
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PMID:28391487
Author:Giraldo A; Montes R; Rodil R; Quintana JB; Vidal-Liñán L; Beiras R
Address:Toralla Marine Station (ECIMAT), University of Vigo, 36331, Vigo, Galicia, Spain. aritzgiraldo@gmail.com.
Title:Ecotoxicological Evaluation of the UV Filters Ethylhexyl Dimethyl p-Aminobenzoic Acid and Octocrylene Using Marine Organisms Isochrysis galbana, Mytilus galloprovincialis and Paracentrotus lividus.
Source:Arch Environ Contam Toxicol; 72(4):606-611, 2017 May.
ISSN:1432-0703
Country of publication:United States
Language:eng
Abstract:The growing concern regarding the negative effects of solar radiation on the skin has led to a drastic increase in the use of sunscreens containing in its composition up to 10% of aromatic chemicals, such as ethylhexyl dimethyl p-aminobenzoic acid (OD-PABA) and octocrylene (OC). The objective of this study was to evaluate the toxicity and to assess the environmental risk posed by these two ultraviolet filters, widely used in cosmetics and as plastic additives, in the marine environment. Several ecotoxicological bioassays were performed with three model organisms belonging to different trophic levels: the microalgae Isochrysis galbana, the mussel Mytilus galloprovincialis, and the sea urchin Paracentrotus lividus. The results show remarkable toxicity to marine species for both OD-PABA (EC values range 26,5-127 µg L ) and OC (EC range 103-511 µg L ). The cell division in the microalgae I. galbana was the most sensitive endpoint tested. To determine the environmental risk of these substances, the risk coefficient (RQ) was calculated. Due to the higher concentrations reported, OC showed remarkable risk (RQ = 0.27), whereas for OD-PABA the risk was low (RQ = 0.007).
Publication type:JOURNAL ARTICLE
Name of substance:0 (Acrylates); 0 (Sunscreening Agents); 0 (Water Pollutants, Chemical); 0 (para-Aminobenzoates); 5A68WGF6WM (octocrylene); Z11006CMUZ (padimate-O)


  6 / 826 MEDLINE  
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PMID:28343007
Author:Ma B; Lu G; Liu J; Yan Z; Yang H; Pan T
Address:Key Laboratory of Integrated Regulation and Resources Development of Shallow Lakes of Ministry of Education, College of Environment, Hohai University, Nanjing 210098, China.
Title:Bioconcentration and multi-biomarkers of organic UV filters (BM-DBM and OD-PABA) in crucian carp.
Source:Ecotoxicol Environ Saf; 141:178-187, 2017 Jul.
ISSN:1090-2414
Country of publication:Netherlands
Language:eng
Abstract:Organic UV filters (OUV-Fs) are increasingly used in sunscreens and personal care products. In the present work, the bioconcentration and multi-biomarker effects of butyl methoxydibenzoylmethane (BM-DBM) and ethylhexyl dimethyl p-aminobenzoate (OD-PABA) were investigated in crucian carp (Carassius auratus). The fish were exposed to various concentrations of BM-DBM (3.88, 35.61, 181.85 and 337.15µg/L), OD-PABA (4.66, 53.83, 264.22 and 459.32µg/L) and their mixture (2.31+2.79, 23.69+26.18, 97.37+134.81 and 193.93+246.08µg/L) for 28 days. The maximal concentrations of two OUV-Fs were detected in the fish liver, followed by the brain, kidney, gill and muscle in most cases. The maximal BCF values of OD-PABA calculated in various exposure concentrations were 0.37 - 101.21 in single exposure groups and 0.11 - 31.09 in mixed exposure groups. Acetylcholinesterase (AChE) activity was significantly inhibited by BM-DBM as well as the mixtures at all of the exposure concentrations and by OD-PABA at higher concentrations (≥264.22µg/L) during 28 days of exposure. The maximal inhibition rates of AChE activity reached 64.04% for BM-DBM, 41.05% for OD-PABA and 61.50% for the mixtures at the highest concentration, which indicated that these two OUV-Fs might damage the central nervous system. Concerning oxidative stress status, BM-DBM and the mixtures significantly increased superoxide dismutase (SOD) and glutathione reductase (GR) activities and inhibited catalase (CAT) activity, while OD-PABA caused a significant increase of GR and CAT activities. AChE and GR activities seemed to be more sensitive biomarkers for BM-DBM and OD-PABA.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Alkanes); 0 (Biomarkers); 0 (Chalcones); 0 (Propiophenones); 0 (Sunscreening Agents); 0 (Water Pollutants, Chemical); 0 (para-Aminobenzoates); G63QQF2NOX (avobenzone); Z11006CMUZ (padimate-O)


  7 / 826 MEDLINE  
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PMID:28270519
Author:Honjo K; Munakata S; Tashiro Y; Salama Y; Shimazu H; Eiamboonsert S; Dhahri D; Ichimura A; Dan T; Miyata T; Takeda K; Sakamoto K; Hattori K; Heissig B
Address:Division of Stem Cell Dynamics, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Title:Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.
Source:FASEB J; 31(6):2625-2637, 2017 Jun.
ISSN:1530-6860
Country of publication:United States
Language:eng
Abstract:Adhesive small bowel obstruction remains a common problem for surgeons. After surgery, platelet aggregation contributes to coagulation cascade and fibrin clot formation. With clotting, fibrin degradation is simultaneously enhanced, driven by tissue plasminogen activator-mediated cleavage of plasminogen to form plasmin. The aim of this study was to investigate the cellular events and proteolytic responses that surround plasminogen activator inhibitor (PAI-1; ) inhibition of postoperative adhesion. Peritoneal adhesion was induced by gauze deposition in the abdominal cavity in C57BL/6 mice and those that were deficient in fibrinolytic factors, such as and In addition, C57BL/6 mice were treated with the novel PAI-1 inhibitor, TM5275. Some animals were treated with clodronate to deplete macrophages. Epidermal growth factor (EGF) experiments were performed to understand the role of macrophages and how EGF contributes to adhesion. In the early phase of adhesive small bowel obstruction, increased PAI-1 activity was observed in the peritoneal cavity. Genetic and pharmacologic PAI-1 inhibition prevented progression of adhesion and increased circulating plasmin. Whereas Serpine1 mice showed intra-abdominal bleeding, mice that were treated with TM5275 did not. Mechanistically, PAI-1, in combination with tissue plasminogen activator, served as a chemoattractant for macrophages that, in turn, secreted EGF and up-regulated the receptor, HER1, on peritoneal mesothelial cells, which led to PAI-1 secretion, further fueling the vicious cycle of impaired fibrinolysis at the adhesive site. Controlled inhibition of PAI-1 not only enhanced activation of the fibrinolytic system, but also prevented recruitment of EGF-secreting macrophages. Pharmacologic PAI-1 inhibition ameliorated adhesion formation in a macrophage-dependent manner.-Honjo, K., Munakata, S., Tashiro, Y., Salama, Y., Shimazu, H., Eiamboonsert, S., Dhahri, D., Ichimura, A., Dan, T., Miyata, T., Takeda, K., Sakamoto, K., Hattori, K., Heissig, B. Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.
Publication type:JOURNAL ARTICLE
Name of substance:0 (5-chloro-2-(((2-(4-(diphenylmethyl)piperazin-1-yl)-2-oxoethoxy)acetyl)amino)benzoate); 0 (CD11b Antigen); 0 (Piperazines); 0 (Serpin E2); 0 (Serpine2 protein, mouse); 0 (para-Aminobenzoates); 62229-50-9 (Epidermal Growth Factor); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 3.4.21.68 (Tissue Plasminogen Activator); PQX0D8J21J (Cetuximab)


  8 / 826 MEDLINE  
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PMID:28224182
Author:Zakaria EM; El-Maraghy NN; Ahmed AF; Ali AA; El-Bassossy HM
Address:Department of Pharmacology, Faculty of Pharmacy, Zagazig University, P.O. Box 44519, Zagazig, Egypt. emzakaria@zu.edu.eg.
Title:PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
Source:Naunyn Schmiedebergs Arch Pharmacol; 390(6):621-631, 2017 Jun.
ISSN:1432-1912
Country of publication:Germany
Language:eng
Abstract:Poly(ADP-ribose) polymerase (PARP) enzyme contributes to nephropathy, a serious diabetic complication which may lead to end-stage renal disease. The study aims to investigate the effect of PARP over-activation on kidney functions in a type 2 diabetic rat model. The study also tests the therapeutic use of PARP inhibitors in diabetic nephropathy. Type 2 diabetes was induced in adult male rats by high-fructose/high-fat diet and low streptozotocin dose. Then, the PARP inhibitor 4-aminobenzamide (4-AB) was administered daily for 10 weeks. At the end, urine samples were collected to measure urine creatinine, albumin, and total proteins. PARP activity, superoxide dismutase (SOD) activity, and nitrite content were measured in kidney tissue homogenate. Glucose, fructosamine, insulin, and tumor necrosis factor-alpha (TNF-α) were measured in serum. Furthermore, histological studies, collagen deposition, and immunofluorescence of nuclear factor kappa B (NFκB) and transforming growth factor beta1 (TGF-ß1) were carried out. PARP enzyme activity was significantly higher in the diabetic group and was significantly reduced by 4-AB administration. Diabetic animals had clear nephropathy indicated by proteinuria and increased albumin excretion rate (AER) which were significantly decreased by PARP inhibition. In addition, PARP inhibition increased creatinine clearance in diabetic animals and reduced renal TGF-ß1 and glomerular fibrosis. Moreover, PARP inhibition alleviated the elevated serum TNF-α level, renal NFκB, nitrite, and the decrease in SOD activity in diabetic animals. However, PARP inhibition did not significantly affect neither hyperglycemia nor insulin sensitivity. PARP enzyme inhibition alleviates diabetic nephropathy through decreasing inflammation, oxidative stress, and renal fibrosis.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Benzamides); 0 (NF-kappa B); 0 (Poly(ADP-ribose) Polymerase Inhibitors); 0 (Tumor Necrosis Factor-alpha); 0 (para-Aminobenzoates); 5W494URQ81 (Streptozocin); 77722I6PAC (4-aminobenzamide); EC 1.15.1.1 (Superoxide Dismutase); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)


  9 / 826 MEDLINE  
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PMID:28223019
Author:Wang M; Gao M; Xu Z; Zheng QH
Address:Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Title:Synthesis of [ C]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease.
Source:Bioorg Med Chem Lett; 27(6):1351-1355, 2017 03 15.
ISSN:1464-3405
Country of publication:England
Language:eng
Abstract:The reference standard (4-((5-chloro-4-(methylamino)pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone (HG-10-102-01) and its precursor (4-((5-chloro-4-(methylamino)pyrimidin-2-yl)amino)-3-hydroxyphenyl)(morpholino)methanone (desmethyl-HG-10-102-01) were synthesized from 2,4,5-trichloropyrimide and 3-methoxy-4-nitrobenzoic acid with overall chemical yield 49% in four steps and 14% in five steps, respectively. The target tracer (4-((5-chloro-4-(methylamino)pyrimidin-2-yl)amino)-3-[ C]methoxyphenyl)(morpholino)methanone ([ C]HG-10-102-01) was prepared from the precursor desmethyl-HG-10-102-01 with [ C]CH OTf through O-[ C]methylation and isolated by HPLC combined with SPE in 45-55% radiochemical yield, based on [ C]CO and decay corrected to end of bombardment (EOB). The radiochemical purity was >99%, and the specific activity (SA) at EOB was 370-1110GBq/µmol with a total synthesis time of ∼40-min from EOB.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
Name of substance:0 (HG-10-102-01); 0 (Pyrimidines); 0 (Radiopharmaceuticals); 0 (para-Aminobenzoates); EC 2.7.11.1 (LRRK2 protein, human); EC 2.7.11.1 (Leucine-Rich Repeat Serine-Threonine Protein Kinase-2)


  10 / 826 MEDLINE  
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PMID:28133704
Author:Studzinski W; Gackowska A; Przybylek M; Gaca J
Address:Faculty of Chemical Technology and Engineering, University of Technology and Life Sciences, Seminaryjna 3, 85-326, Bydgoszcz, Poland.
Title:Studies on the formation of formaldehyde during 2-ethylhexyl 4-(dimethylamino)benzoate demethylation in the presence of reactive oxygen and chlorine species.
Source:Environ Sci Pollut Res Int; 24(9):8049-8061, 2017 Mar.
ISSN:1614-7499
Country of publication:Germany
Language:eng
Abstract:In order to protect the skin from UV radiation, personal care products (PCPS) often contain chemical UV-filters. These compounds can enter the environment causing serious consequences on the water ecosystems. The aim of this study was to examine, the effect of different factors, such as UV light, the presence of NaOCl and H O on the formaldehyde formation during popular UV filter, 2-ethylhexyl 4-(dimethylamino)benzoate (ODPABA) demethylation. The concentration of formaldehyde was determined by VIS spectrophotometry after derivatization. The reaction mixtures were qualitatively analyzed using GC/MS chromatography. The highest concentration of formaldehyde was observed in the case of ODPABA/H O /UV reaction mixture. In order to describe two types of demethylation mechanisms, namely, radical and ionic, the experimental results were enriched with Fukui function analysis and thermodynamic calculations. In the case of non-irradiated system containing ODPABA and NaOCl, demethylation reaction probably proceeds via ionic mechanism. As it was established, amino nitrogen atom in the ODPABA molecule is the most susceptible site for the HOCl electrophilic attack, which is the first step of ionic demethylation mechanism. In the case of irradiated mixtures, the reaction is probably radical in nature. The results of thermodynamic calculations showed that abstraction of the hydrogen from N(CH ) group is more probable than from 2-ethylhexyl moiety, which indicates higher susceptibility of N(CH ) to the oxidation.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Sunscreening Agents); 0 (Water Pollutants, Chemical); 0 (para-Aminobenzoates); 1HG84L3525 (Formaldehyde); 4R7X1O2820 (Chlorine); BBX060AN9V (Hydrogen Peroxide); Z11006CMUZ (padimate-O)



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