Database : MEDLINE
Search on : D02.455.426.559.389 [DeCS Category]
References found : 6591 [refine]
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  1 / 6591 MEDLINE  
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PMID:29386433
Author:Hatakeyama S
Address:Graduate School of Biomedical Sciences, Nagasaki University.
Title:[Stereocontrolled Total Synthesis of Biologically Active Natural Products].
Source:Yakugaku Zasshi; 138(2):191-209, 2018.
ISSN:1347-5231
Country of publication:Japan
Language:jpn
Abstract: This review article describes the total syntheses of englerin A, ophiodilactones A and B, marinomycin A, N-methylwelwitindolinone C isothiocyanate, tirandamycins A-D, and tirandalydigin, which possess intriguing biological activities and challenging structures with characteristic ring systems. The focus is on the synthetic methodologies that lead to the highly stereocontrolled assembly of these natural products.
Publication type:JOURNAL ARTICLE; REVIEW
Name of substance:0 (Alkenes); 0 (Aminoglycosides); 0 (Benzene Derivatives); 0 (Biological Products); 0 (Indole Alkaloids); 0 (Lactones); 0 (Macrolides); 0 (N-methylwelwitindolinone B isothiocyanate); 0 (Sesquiterpenes, Guaiane); 0 (englerin A); 0 (marinomycin A); 0 (ophiodilactone A); 0 (ophiodilactone B); 0 (tirandamycin C); 0 (tirandamycin D); 114118-91-1 (tirandalydigin); 34429-70-4 (tirandamycin A); 60587-14-6 (tirandamycin B)


  2 / 6591 MEDLINE  
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PMID:29311462
Author:Takagi A
Address:Graduate School of Pharmaceutical Sciences, Osaka University.
Title:[Development of Efficient Methods for Benzyne Generation].
Source:Yakugaku Zasshi; 138(1):27-35, 2018.
ISSN:1347-5231
Country of publication:Japan
Language:jpn
Abstract:2-[(Neopentyl glycolato)boryl]phenyl triflates, readily synthesized from 2-iodophenol derivatives via halogen-magnesium exchange or Miyaura borylation, were developed as new benzyne precursors. Benzynes were generated under fluoride-ion-mediated conditions and reacted immediately with various arynophiles. Herein, we describe the generation of benzynes having reactive functional groups, such as methoxycarbonyl, acetyl, bromo, and amino groups, as well as their [4+2], (3+2), and [2+2] cycloaddition reactions which produce corresponding benzo-fused compounds.
Publication type:JOURNAL ARTICLE; REVIEW
Name of substance:0 (Benzene Derivatives); 0 (Halogens); 0 (Iodobenzenes); 0 (Ions); 0 (benzyne); F27L34A8B9 (2-iodophenol); I38ZP9992A (Magnesium); Q80VPU408O (Fluorides)


  3 / 6591 MEDLINE  
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PMID:29231935
Author:Roy S; Samanta D; Kumar P; Maji TK
Address:Molecular Materials Laboratory, Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore-560064, India. tmaji@jncasr.ac.in.
Title:Pure white light emission and charge transfer in organogels of symmetrical and unsymmetrical π-chromophoric oligo-p-(phenyleneethynylene) bola-amphiphiles.
Source:Chem Commun (Camb); 54(3):275-278, 2018 Jan 02.
ISSN:1364-548X
Country of publication:England
Language:eng
Abstract:Two novel bola-amphiphilic oligo-p-(phenyleneethynylene) (OPE) dicarboxylates have been synthesized having non-polar and mixed-polar side chains. This led to gelation in both with vesicular morphology. Upon in situ loading of a suitable dye and redox-active molecule, pure white light emitting and charge transfer (CT)-gels, respectively, were realized.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Alkynes); 0 (Azo Compounds); 0 (Benzene Derivatives); 0 (Gels); 0 (Luminescent Agents); 0 (Nitriles); 0 (Surface-Active Agents); 1518-16-7 (tetracyanoquinodimethane); 69083AX1ZX (methyl red)


  4 / 6591 MEDLINE  
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PMID:28992483
Author:Ma J; Yang Y; Jiang X; Xie Z; Li X; Chen C; Chen H
Address:State Key Laboratory of Heavy Oil Processing, State Key Laboratory of Petroleum Pollution Control, Beijing Key Lab of Oil & Gas Pollution Control, China University of Petroleum-Beijing, Beijing 102249, China. Electronic address: rubpmj@sina.com.
Title:Impacts of inorganic anions and natural organic matter on thermally activated persulfate oxidation of BTEX in water.
Source:Chemosphere; 190:296-306, 2018 Jan.
ISSN:1879-1298
Country of publication:England
Language:eng
Abstract:The present study investigated the impacts of water matrix constituents (CO , HCO , Cl , Br , PO , HPO , H PO , NO , SO and natural organic matters (NOM) on the oxidation of a mixture of benzene, toluene, ethylbenzene, and xylenes (BTEX) by thermally activated persulfate (PS). In the absence of matrix constituents, the BTEX oxidation rates decreased in the following order: xylenes > toluene ≈ ethylbenzene > benzene. HCO /CO and NOM inhibited the BTEX oxidation and the inhibiting effects became more pronounced as the HCO /CO /NOM concentration increased. SO , NO , PO and H PO did not affect the BTEX oxidation while HPO slightly inhibited the reaction. The impacts of Cl and Br were complex. Cl inhibited the benzene oxidation while 100 mM and 500 mM of Cl promoted the oxidation of m-xylene and p-xylene. Br completely suppressed the benzene oxidation while 500 mM of Br strongly promoted the oxidation of xylenes. Detailed explanations on the influence of each matrix constituent were discussed. In addition, various halogenated degradation byproducts were detected in the treatments containing Cl and Br . Overall, this study indicates that some matrix constituents such as NOM, HCO , CO , H PO , Cl and Br may reduce the BTEX removal efficiency of sulfate radical-based advanced oxidation process (SR-AOP) and the presence of Cl and Br may even lead to the formation of toxic halogenated byproducts.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Benzene Derivatives); 0 (Humic Substances); 0 (Inorganic Chemicals); 0 (Ions); 0 (Sulfates); 0 (Water Pollutants, Chemical); 0 (Xylenes); 0 (sulfate radical); 059QF0KO0R (Water); 3FPU23BG52 (Toluene); J64922108F (Benzene); L5I45M5G0O (ethylbenzene)


  5 / 6591 MEDLINE  
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PMID:28448810
Author:Doherty BT; Kwok RK; Curry MD; Ekenga C; Chambers D; Sandler DP; Engel LS
Address:Department of Epidemiology, University of North Carolina at Chapel Hill,135 Dauer Drive, 2101 McGavran-Greenberg Hall, CB #7435, Chapel Hill, NC 27599, USA; National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Title:Associations between blood BTEXS concentrations and hematologic parameters among adult residents of the U.S. Gulf States.
Source:Environ Res; 156:579-587, 2017 07.
ISSN:1096-0953
Country of publication:Netherlands
Language:eng
Abstract:BACKGROUND: Studies of workers exposed to benzene at average air concentrations below one part per million suggest that benzene, a known hematotoxin, causes hematopoietic damage even at low exposure levels. However, evidence of such effects outside of occupational settings and for other volatile organic compounds (VOCs) is limited. OBJECTIVE: To investigate associations between ambient exposures to five VOCs, including benzene, and hematologic parameters among adult residents of the U.S. Gulf Coast. MATERIALS AND METHODS: Blood concentrations of selected VOCs were measured in a sample of adult participants in the Gulf Long-term Follow-up Study (GuLF STUDY) during 2012 and 2013. Complete blood counts with differentials were also performed on a subset of participants (n=406). We used these data together with detailed questionnaire data to estimate adjusted associations between blood BTEXS (benzene, toluene, ethylbenzene, o-xylene, m/p-xylene, and styrene) concentrations and hematologic parameters using generalized linear models. RESULTS: We observed inverse associations between blood benzene concentrations and hemoglobin concentration and mean corpuscular hemoglobin concentration, and a positive association with red cell distribution width among tobacco smoke-unexposed participants (n=146). Among tobacco smoke-exposed participants (n=247), we observed positive associations between blood VOC concentrations and several hematologic parameters, including increased white blood cell and platelet counts, suggestive of hematopoietic stimulation typically associated with tobacco smoke exposure. Most associations were stronger for benzene than for the other VOCs. CONCLUSIONS: Our results suggest that ambient exposure to BTEXS, particularly benzene, may be associated with hematologic effects, including decreased hemoglobin concentration, mean corpuscular hemoglobin concentration, and increased red cell distribution width.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
Name of substance:0 (Air Pollutants); 0 (Benzene Derivatives); 0 (Volatile Organic Compounds)


  6 / 6591 MEDLINE  
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PMID:29199221
Author:Tsukano C; Suetsugu S; Muto N; Takemoto Y
Address:Graduate School of Pharmaceutical Sciences, Kyoto University.
Title:Synthesis of Tetrahydrobiphenylene via Pd(0)-Catalyzed C(sp )-H Functionalization.
Source:Chem Pharm Bull (Tokyo); 65(12):1167-1174, 2017.
ISSN:1347-5223
Country of publication:Japan
Language:eng
Abstract:Tetrahydrobiphenylene consists of cyclobutene fused with benzene and cyclohexene rings. In this paper, a direct method for synthesizing tetrahydrobiphenylenes based on a palladium (Pd)(0)-catalyzed C(sp )-H functionalization was investigated. The developed method was applied to the synthesis of several tetrahydrobiphenylenes having an oxygen functionality at the ring juncture. The derivatization of a tetrahydrobiphenylene is also reported.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Benzene Derivatives); 5TWQ1V240M (Palladium); 7440-44-0 (Carbon); 7YNJ3PO35Z (Hydrogen)


  7 / 6591 MEDLINE  
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PMID:29198609
Author:Yeon SK; Choi JW; Park JH; Lee YR; Kim HJ; Shin SJ; Jang BK; Kim S; Bahn YS; Han G; Lee YS; Pae AN; Park KD
Address:Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul, Republic of Korea; Department of Biotechnology, Yonsei University, Seoul, Republic of Korea.
Title:Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.
Source:Bioorg Med Chem; 26(1):232-244, 2018 01 01.
ISSN:1464-3391
Country of publication:England
Language:eng
Abstract:Benzyloxyphenyl moiety is a common structure of highly potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B), safinamide and sembragiline. We synthesized 4-(benzyloxy)phenyl and biphenyl-4-yl derivatives including halogen substituents on the terminal aryl unit. In addition, we modified the carbon linker between amine group and the biaryl linked unit. Among synthesized compounds, 12c exhibited the most potent and selective MAO-B inhibitory effect (hMAO-B IC : 8.9 nM; >10,000-fold selectivity over MAO-A) as a competitive inhibitor. In addition, 12c showed greater MAO-B inhibitory activity and selectivity compared to well-known MAO-B inhibitors such as selegiline, safinamide and sembragiline. In the MPTP-induced mouse model of Parkinson's disease (PD), 12c significantly protected the tyrosine hydroxylase (TH)-immunopositive DAergic neurons and attenuated the PD-associated behavioral deficits. This study suggests characteristic structures as a MAO-B inhibitor that may provide a good insight for the development of therapeutic agents for PD.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Benzene Derivatives); 0 (Monoamine Oxidase Inhibitors); 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine); EC 1.4.3.4 (Monoamine Oxidase); EC 1.4.3.4. (monoamine oxidase A, human)


  8 / 6591 MEDLINE  
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PMID:28850567
Author:Pullicin AJ; Penner MH; Lim J
Address:Department of Food Science & Technology, Oregon State University, Corvallis, Oregon, United States of America.
Title:Human taste detection of glucose oligomers with low degree of polymerization.
Source:PLoS One; 12(8):e0183008, 2017.
ISSN:1932-6203
Country of publication:United States
Language:eng
Abstract:Studies have reported that some animals, including humans, can taste mixtures of glucose oligomers (i.e., maltooligosaccharides, MOS) and that their detection is independent of the known T1R2/T1R3 sweet taste receptor. In an effort to understand potential mechanisms underlying the taste perception of glucose oligomers in humans, this study was designed to investigate: 1) the variability of taste sensitivity to MOS with low degree-of-polymerization (DP), and 2) the potential role of hT1R2/T1R3 in the MOS taste detection. To address these objectives, a series of food grade, narrow-DP-range MOS were first prepared (DP 3, 3-4, 5-6, and 6-7) by fractionating disperse saccharide mixtures. Subjects were then asked to discriminate these MOS stimuli as well as glucose (DP 1) and maltose (DP 2) from blanks after the stimuli were swabbed on the tongue. All stimuli were presented at 75 mM with and without a sweet taste inhibitor (lactisole). An α-glucosidase inhibitor (acarbose) was added to all test stimuli to prevent oral digestion of glucose oligomers. Results showed that all six stimuli were detected with similar discriminability in normal tasting conditions. When the sweet receptor was inhibited, DP 1, 2, and 3 were not discriminated from blanks. In contrast, three higher-DP paired MOS stimuli (DP 3-4, 5-6, and 6-7) were discriminated from blanks at a similar degree. Overall, these results support the presence of a sweet-independent taste perception mechanism that is stimulated by MOS greater than three units.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Benzene Derivatives); 0 (Oligosaccharides); 0 (Sweetening Agents); 0 (maltooligosaccharides); 69-79-4 (Maltose); IY9XDZ35W2 (Glucose); ZU3D90W5GZ (lactisole)


  9 / 6591 MEDLINE  
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PMID:28830789
Author:Umeokoli BO; Onyegbule FA; Okoye FBC; Wang H; Kalscheuer R; Müller WEG; Hartmann R; Liu Z; Proksch P
Address:Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany; Department of Pharmaceutical and Medicinal Chemistry, Nnamdi Azikiwe University, Awka, Nigeria.
Title:New amide and dioxopiperazine derivatives from leaves of Breynia nivosa.
Source:Fitoterapia; 122:16-19, 2017 Oct.
ISSN:1873-6971
Country of publication:Netherlands
Language:eng
Abstract:The first chemical investigation of leaves of Breynia nivosa from Nigeria resulted in the isolation of two new amide derivatives breynivosamides A and B (1 and 2) and two new dioxopiperazine derivatives breynivosines A and B (4 and 5) together with seven known compounds (3, 6-11). The structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS data as well as by comparison with the literature. All isolated compounds were tested for the cytotoxic and antimicrobial activities. Only cristatin A (6) showed cytotoxicity against the L5178Y mouse lymphoma cell line with an IC value of 13.9µM while breynivosamide A (1) exhibited moderate antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 25µM.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Amides); 0 (Anti-Infective Agents); 0 (Benzene Derivatives); 0 (breynivosamide A); 0 (cristatin A); 8DUH1N11BX (Tryptophan)


  10 / 6591 MEDLINE  
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PMID:28780260
Author:Padhi SK; Gokhale S
Address:Department of Civil Engineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.
Title:Treatment of gaseous volatile organic compounds using a rotating biological filter.
Source:Bioresour Technol; 244(Pt 1):270-280, 2017 Nov.
ISSN:1873-2976
Country of publication:England
Language:eng
Abstract:Rotating biological filter (RBF), which provides higher oxygen mass transfer has been developed for treating gaseous volatile organic compounds (VOCs) such as BTEX (Benzene, toluene, ethylbenzene and xylene) at higher concentrations. The screening of enriched cultures has been done initially to enhance the performance of RBF for treating xylene, toluene and xylene, and BTEX at various loading rates. The removal efficiency of BTEX was maximum (82%), higher than toluene and xylene (79%), and xylene (72%). The presence of xylene enhanced the removal of toluene in the mixture. In the BTEX, toluene was found to be highly biodegradable followed by ethylbenzene, benzene and xylene. The RBF also removed nutrients from wastewater along with VOCs. The stability study of RBF showed that supply of nutrient media influenced the RBF performance more. Further, the predominant strain identified in the mixed culture was Enterobacter cloacae SP4001, responsible for biodegradation of BTEX.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Benzene Derivatives); 0 (Gases); 0 (Volatile Organic Compounds); 0 (Xylenes); 3FPU23BG52 (Toluene); J64922108F (Benzene)



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