Database : MEDLINE
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  1 / 5306 MEDLINE  
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PMID:29121567
Author:Li Y; Li L; Chen ZX; Zhang J; Gong L; Wang YX; Zhao HQ; Mu Y
Address:CAS Key Laboratory of Urban Pollutant Conversion, Collaborative Innovation Centre of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei, China.
Title:Carbonate-activated hydrogen peroxide oxidation process for azo dye decolorization: Process, kinetics, and mechanisms.
Source:Chemosphere; 192:372-378, 2018 Feb.
ISSN:1879-1298
Country of publication:England
Language:eng
Abstract:Advanced oxidation processes offer effective solutions in treating wastewater from various industries. This study is the first time to investigate the potential of carbonate-activated hydrogen peroxide (CAP) oxidation process for the removal of organic pollutant from highly alkaline wastewaters. Azo dye acid orange 7 (AO7) was selected as a model pollutant. The influences of various parameters on AO7 decolorization by the CAP oxidation were evaluated. Furthermore, the active species involved in AO7 degradation were explored using scavenger experiments and electron spin resonance analysis. Additionally, AO7 degradation products by the CAP oxidation were identified to elucidate possible transformation pathways. Results showed that the CAP oxidation had better AO7 decolorization performance compared to bicarbonate-activated hydrogen peroxide method. The AO7 decolorization efficiency augmented from 3.70 ± 0.76% to 54.27 ± 2.65% when carbonate concentration was increased from 0 to 50 mM at pH 13.0, and then changed slightly with further increasing carbonate concentration to 70 mM. It increased almost linearly from 5.95 ± 0.32% to 94.03 ± 0.39% as H O concentration was increased from 5 to 50 mM. Moreover, trace amount of Co(II) could facilitate AO7 decolorization by the CAP reaction. Superoxide and carbonate radicals might be the main reactive oxygen species involved in the CAP process. Finally, a possible degradation pathway of AO7 by the CAP oxidation was proposed based on the identified products.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Azo Compounds); 0 (Benzenesulfonates); 0 (Bicarbonates); 0 (Carbonates); 0 (Coloring Agents); 0 (Environmental Pollutants); 0 (Peroxides); BBX060AN9V (Hydrogen Peroxide); Q1LIY3BO0U (2-naphthol orange)


  2 / 5306 MEDLINE  
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PMID:27773252
Author:Bahrani S; Ghaedi M; Mansoorkhani MJ; Asfaram A; Bazrafshan AA; Purkait MK
Address:Departmentof Chemistry, Yasouj University, Yasouj 75918-74831, Iran.
Title:Ultrasonic assisted dispersive solid-phase microextraction of Eriochrome Cyanine R from water sample on ultrasonically synthesized lead (II) dioxide nanoparticles loaded on activated carbon: Experimental design methodology.
Source:Ultrason Sonochem; 34:317-324, 2017 01.
ISSN:1873-2828
Country of publication:Netherlands
Language:eng
Abstract:The present research focus on designing an appropriate dispersive solid-phase microextraction (UA-DSPME) for preconcentration and determination of Eriochrome Cyanine R (ECR) in aqueous solutions with aid of sonication using lead (II) dioxide nanoparticles loaded on activated carbon (PbO-NPs-AC). This material was fully identified with XRD and SEM. Influence of pH, amounts of sorbent, type and volume of eluent, and sonication time on response properties were investigated and optimized by central composite design (CCD) combined with surface response methodology using STATISTICA. Among different solvents, dimethyl sulfoxide (DMSO) was selected as an efficient eluent, which its combination by present nanoparticles and application of ultrasound waves led to enhancement in mass transfer. The predicted maximum extraction (100%) under the optimum conditions of the process variables viz. pH 4.5, eluent 200µL, adsorbent dosage 2.5mg and 5min sonication was close to the experimental value (99.50%). at optimum conditions some experimental features like wide 5-2000ngmL ECR, low detection limit (0.43ngmL , S/N=3:1) and good repeatability and reproducibility (relative standard deviation, <5.5%, n=12) indicate versatility in successful applicability of present method for real sample analysis. Investigation of accuracy by spiking known concentration of ECR over 200-600ngmL gave mean recoveries from 94.850% to 101.42% under optimal conditions. The procedure was also applied for the pre-concentration and subsequent determination of ECR in tap and waste waters.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Benzenesulfonates); 0 (Oxides); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 16291-96-6 (Charcoal); 2P299V784P (Lead); 3564-18-9 (solochrome cyanine R); 4IN6FN8492 (lead oxide)


  3 / 5306 MEDLINE  
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PMID:28463583
Author:Yang SO; Sodaneath H; Lee JI; Jung H; Choi JH; Ryu HW; Cho KS
Address:a Department of Environmental Science and Engineering , Ewha Womans University , Seoul , Republic of Korea.
Title:Decolorization of acid, disperse and reactive dyes by Trametes versicolor CBR43.
Source:J Environ Sci Health A Tox Hazard Subst Environ Eng; 52(9):862-872, 2017 Jul 29.
ISSN:1532-4117
Country of publication:England
Language:eng
Abstract:The mycoremediation has been considered as a promising method for decolorizing dye wastewater. To explore new bioresource for mycoremediation, a new white-rot fungus that could decolorize various dyes commonly used in textile industries was isolated, and its ligninolytic enzyme activity and decolorization capacity were characterized. The isolated CBR43 was identified as Trametes versicolor based on the morphological properties of its fruit body and spores, as well as through partial 18S rDNA gene sequences. Isolated CBR43 displayed high activities of laccase and Mn-dependent peroxidase, whereas its lignin peroxidase activity was relatively low. These ligninolytic enzyme activities in potato dextrose broth (PDB) medium were enhanced by the addition of yeast extract (1-10 g L ). In particular, lignin peroxidase activity was increased more than 5 times in the PDB medium amended with 10 g L of yeast extract. The CBR43 decolorized more than 90% of 200 mg L acid dyes (red 114, blue 62 and black 172) and reactive dyes (red 120, blue 4, orange 16 and black 5) within 6 days in the PDB medium. CBR43 decolorized 67% of 200 mg L acid orange 7 within 9 days. The decolorization efficiencies for disperse dyes (red 1, orange 3 and black 1) were 51-80% within 9 days. The CBR43 could effectively decolorize high concentrations of acid blue 62 and acid black 172 (500-700 mg L ). The maximum dye decolorization rate was obtained at 28°C, pH 5, and 150 rpm in the PDB medium. T. versicolor CBR43 had high laccase and Mn-dependent peroxidase activities, and could decolorize a wide variety of dyes such as acid, disperse and reactive textile dyes. This fungus had decolorizing activities of azo-type dyes as well as anthraquinone-type dyes. T. versicolor CBR43 is one of promising bioresources for the decolorization of textile wastewater including various dyes.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Azo Compounds); 0 (Benzenesulfonates); 0 (Coordination Complexes); 0 (Naphthalenesulfonates); 0 (Waste Water); 0 (Water Pollutants, Chemical); 0 (acid black 172); EC 1.10.3.2 (Laccase); EC 1.11.1.- (Peroxidases); EC 1.11.1.13 (manganese peroxidase); Q1LIY3BO0U (2-naphthol orange)


  4 / 5306 MEDLINE  
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PMID:28902856
Author:Weber IP; Rana M; Thomas PBM; Dimov IB; Franze K; Rajan MS
Address:Department of Physiology, Development and Neuroscience, Anatomy Building, University of Cambridge, Cambridge, United Kingdom.
Title:Effect of vital dyes on human corneal endothelium and elasticity of Descemet's membrane.
Source:PLoS One; 12(9):e0184375, 2017.
ISSN:1932-6203
Country of publication:United States
Language:eng
Abstract:The purpose of this study was to evaluate the effects of vital dyes on human Descemet's membranes (DMs) and endothelia. DMs of 25 human cadaveric corneas with research consent were treated with dyes routinely used in Descemet membrane endothelial keratoplasty (DMEK), 0.05% Trypan blue (TB) or a combination of 0.15% Trypan blue, 0.025% Brilliant blue and 4% Polyethylene glycol (commercial name Membrane Blue Dual; MB). The effects of these two dyes on (i) endothelial cell viability, (ii) DM mechanical properties as assessed by atomic force microscopy, and iii) qualitative DM dye retention were tested for two varying exposure times (one or four minutes). No significant differences in cell toxicity were observed between treatments with TB and MB at the two different exposure times (P = 0.21). Further, both dyes led to a significant increase in DM stiffness: exposure to TB and MB for one minute increased the apparent elastic modulus of the DM by 11.2% (P = 8*10-3) and 17.7%, respectively (P = 4*10-6). A four-minute exposure led to an increase of 8.6% for TB (P = 0.004) and 13.6% for MB (P = 0.03). Finally, at 25 minutes, the dye retention of the DM was considerably better for MB compared to TB. Taken together, a one-minute exposure to MB was found to improve DM visibility compared to TB, with a significant increase in DM stiffness and without detrimental effects on endothelial cell viability. The use of MB could therefore improve (i) visibility of the DM scroll, and (ii) intraoperative unfolding, enhancing the probability of successful DMEK surgery.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Benzenesulfonates); 0 (Coloring Agents); 30IQX730WE (Polyethylene Glycols); H3R47K3TBD (brilliant blue); I2ZWO3LS3M (Trypan Blue)


  5 / 5306 MEDLINE  
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PMID:28832600
Author:Ewert D; Hu N; Du X; Li W; West MB; Choi CH; Floyd R; Kopke RD
Address:Hough Ear Institute, Oklahoma City, OK, United States of America.
Title:HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma.
Source:PLoS One; 12(8):e0183089, 2017.
ISSN:1932-6203
Country of publication:United States
Language:eng
Abstract:Oxidative stress is considered a major cause of the structural and functional changes associated with auditory pathologies induced by exposure to acute acoustic trauma AAT). In the present study, we examined the otoprotective effects of 2,4-disulfophenyl-N-tert-butylnitrone (HPN-07), a nitrone-based free radical trap, on the physiological and cellular changes in the auditory system of chinchilla following a six-hour exposure to 4 kHz octave band noise at 105 dB SPL. HPN-07 has been shown to suppress oxidative stress in biological models of a variety of disorders. Our results show that administration of HPN-07 beginning four hours after acoustic trauma accelerated and enhanced auditory/cochlear functional recovery, as measured by auditory brainstem responses (ABR), distortion product otoacoustic emissions (DPOAE), compound action potentials (CAP), and cochlear microphonics (CM). The normally tight correlation between the endocochlear potential (EP) and evoked potentials of CAP and CM were persistently disrupted after noise trauma in untreated animals but returned to homeostatic conditions in HPN-07 treated animals. Histological analyses revealed several therapeutic advantages associated with HPN-07 treatment following AAT, including reductions in inner and outer hair cell loss; reductions in AAT-induced loss of calretinin-positive afferent nerve fibers in the spiral lamina; and reductions in fibrocyte loss within the spiral ligament. These findings support the conclusion that early intervention with HPN-07 following an AAT efficiently blocks the propagative ototoxic effects of oxidative stress, thereby preserving the homeostatic and functional integrity of the cochlea.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Benzenesulfonates); 0 (Free Radical Scavengers); 7M1J3HN9VO (disufenton sodium)


  6 / 5306 MEDLINE  
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PMID:28764060
Author:Tatebe C; Ohtsuki T; Fujita T; Nishiyama K; Itoh S; Sugimoto N; Kubota H; Tada A; Sato K; Akiyama H
Address:National Institute of Health Sciences, 1-18-1, Kami-yoga, Setagaya-ku, Tokyo 158-8501, Japan. Electronic address: c-sasaki@nihs.go.jp.
Title:Determination of starting materials, intermediates, and subsidiary colors in the color additive Food Red No. 106 (Sulforhodamine B) using high-performance liquid chromatography.
Source:Food Chem; 237:733-742, 2017 Dec 15.
ISSN:0308-8146
Country of publication:England
Language:eng
Abstract:The main subsidiary color of structure in Food Red No. 106 (R106) was identified to be a desethyl derivative (R106-SubA). High-performance liquid chromatography (HPLC) was performed for the quantitative determination of benzaldehyde-2,4-disulfonic acid, N,N-diethyl-m-aminophenol, leuco acid, pyrone acid, R106-SubA, etc. in R106. An ammonium acetate solution (20mM) and acetonitrile:water (7:3) were used to stabilize the retention time of the HPLC analytes. The linearity of the calibration curves was in the range of 0.05-10µg/mL, with good correlation coefficients (R >0.9983). The recoveries of impurities at levels 0.1%, 0.5% and 1% ranged from 94.2% to 106.6% with relative standard deviations of 0.1%-1.0%. While surveying commercial R106, the amounts obtained by area% determination were similar to those obtained by the calibration-curve determination. The area% determination by HPLC for the determinations of impurities in R106 is a simple and reliable method and can be applied in routine analysis.
Publication type:JOURNAL ARTICLE
Name of substance:0 (2,4-disulfonic acid benzaldehyde); 0 (Benzaldehydes); 0 (Benzenesulfonates); 0 (Food Coloring Agents); 0 (Rhodamines); 2609-88-3 (lissamine rhodamine B)


  7 / 5306 MEDLINE  
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PMID:28624143
Author:Berg A; Berg T
Address:Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany.
Title:A small-molecule screen identifies the antitrypanosomal agent suramin and analogues NF023 and NF449 as inhibitors of STAT5a/b.
Source:Bioorg Med Chem Lett; 27(15):3349-3352, 2017 08 01.
ISSN:1464-3405
Country of publication:England
Language:eng
Abstract:The transcription factor STAT5a is a potential target for tumor therapy. We present a fluorescence polarization-based, high-throughput screen of chemical libraries containing natural products and known bioactive molecules, for the identification of small-molecule inhibitors of the STAT5a SH2 domain. This screen identified suramin, a drug used to treat African trypanosomiasis, and its analogues NF023 and NF449 as inhibitors of the SH2 domains of STAT5a/b. Our data extend the known in vitro targets of suramin and analogues to include members of the STAT protein family.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate)); 0 (Benzenesulfonates); 0 (STAT5 Transcription Factor); 0 (STAT5A protein, human); 0 (STAT5B protein, human); 0 (Small Molecule Libraries); 0 (Tumor Suppressor Proteins); 6032D45BEM (Suramin)


  8 / 5306 MEDLINE  
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PMID:28535350
Author:Fortin S; Charest-Morin X; Turcotte V; Lauvaux C; Lacroix J; Côté MF; Gobeil S; C-Gaudreault R
Address:CHU de Québec Research Centre, Oncology Division, Hôpital Saint-François d'Assise , 10 rue de l'Espinay, Quebec City, Quebec, Canada G1L 3L5.
Title:Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.
Source:J Med Chem; 60(12):4963-4982, 2017 Jun 22.
ISSN:1520-4804
Country of publication:United States
Language:eng
Abstract:Prodrug-mediated utilization of the cytochrome P450 (CYP) 1A1 to obtain the selective release of potent anticancer products within cancer tissues is a promising approach in chemotherapy. We herein report the rationale, preparation, biological evaluation, and mechanism of action of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs) that are antimicrotubule prodrugs activated by CYP1A1. Although PAIB-SOs are inert in most cells tested, they are highly cytocidal toward several human breast cancer cells, including hormone-independent and chemoresistant types. PAIB-SOs are N-dealkylated into cytotoxic phenyl 4-(2-oxo-3-imidazolidin-1-yl)benzenesulfonates (PIB-SOs) in CYP1A1-positive cancer cells, both in vitro and in vivo. In conclusion, PAIB-SOs are novel chemotherapeutic prodrugs with no equivalent among current antineoplastics and whose selective action toward breast cancer is tailored to the characteristic pattern of CYP1A1 expression observed in a large percentage of human breast tumors.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antimitotic Agents); 0 (Benzenesulfonates); 0 (Prodrugs); EC 1.14.14.1 (CYP1A1 protein, human); EC 1.14.14.1 (Cytochrome P-450 CYP1A1)


  9 / 5306 MEDLINE  
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PMID:28506753
Author:Vuorinen A; Engeli RT; Leugger S; Kreutz CR; Schuster D; Odermatt A; Matuszczak B
Address:Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056
Title:Phenylbenzenesulfonates and -sulfonamides as 17ß-hydroxysteroid dehydrogenase type 2 inhibitors: Synthesis and SAR-analysis.
Source:Bioorg Med Chem Lett; 27(13):2982-2985, 2017 07 01.
ISSN:1464-3405
Country of publication:England
Language:eng
Abstract:17ß-Hydroxysteroid dehydrogenase type 2 (17ß-HSD2) converts the potent estrogen estradiol into the weakly active keto form estrone. Because of its expression in bone, inhibition of 17ß-HSD2 provides an attractive strategy for the treatment of osteoporosis, a condition that is often caused by a decrease of the active sex steroids. Currently, there are no drugs on the market targeting 17ß-HSD2, but in multiple studies, synthesis and biological evaluation of promising 17ß-HSD2 inhibitors have been reported. Our previous work led to the identification of phenylbenzenesulfonamides and -sulfonates as new 17ß-HSD2 inhibitors by ligand-based pharmacophore modeling and virtual screening. In this study, new molecules representing this scaffold were synthesized and tested in vitro for their 17ß-HSD2 activity to derive more profound structure-activity relationship rules.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Benzenesulfonates); 0 (Enzyme Inhibitors); 0 (Sulfonamides); 0 (phenylbenzenesulfonate); EC 1.1.1.62 (Estradiol Dehydrogenases); EC 1.1.1.62 (HSD17B2 protein, human)


  10 / 5306 MEDLINE  
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PMID:28505578
Author:Shen JH; Horng JJ; Wang YS; Zeng YR
Address:Graduate School of Engineering Science and Technology, National Yunlin University of Science and Technology (YunTech), Douliou, Yunlin 64002, Taiwan, ROC.
Title:The use of reactive index of hydroxyl radicals to investigate the degradation of acid orange 7 by Fenton process.
Source:Chemosphere; 182:364-372, 2017 Sep.
ISSN:1879-1298
Country of publication:England
Language:eng
Abstract:This study suggested the amount of hydroxyl radicals (OH) reacting with organics as a new index to evaluate the reaction efficiency (RE) of Fenton process, and used it to investigate the degradation mechanism of target pollution, Acid Orange 7 (AO7). The effects of initial concentrations of Fe(II), H O , and AO7 on RE were quantified by using response surface methodology (RSM). The main factors affecting RE were Fe(II), H O , and their interaction, and their percentage effects were 65.75, 11.99 and 22.23%, respectively. Moreover, based on the analysis result of RSM, a condition for good RE was proposed that it should ensure a higher amount of OH reacted with organics, and reduce the amount of OH scavenged by Fe(II). Liquid chromatography-mass spectrometry (LC/MS) analysis was used to identify the products of AO7 degradation in Fenton process, and there were three possible mechanisms to be observed, such as azo bond cleavage, hydroxylation, and oxidation of naphthalene ring. The trend of mechanisms might vary with the amount of OH attacks, and therefore the use of estimated RE could provide more particular information to better understand the relationship between organic degradation and OH attacks.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Azo Compounds); 0 (Benzenesulfonates); 0 (Ferrous Compounds); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron); Q1LIY3BO0U (2-naphthol orange)



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