Database : MEDLINE
Search on : D02.675.276.090 [DeCS Category]
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  1 / 199 MEDLINE  
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PMID:28220566
Author:Hirata Y; Yanagi T; Yamaguchi Y; Sato K; Shinkuma S; Hata H; Shimizu H
Address:Department of Dermatology, Hokkaido University Graduate School of Medicine, 060-8638 Sapporo, Japan.
Title:Ulcerative contact dermatitis caused by benzethonium chloride.
Source:Contact Dermatitis; 76(3):188-190, 2017 Mar.
ISSN:1600-0536
Country of publication:England
Language:eng
Publication type:CASE REPORTS; JOURNAL ARTICLE
Name of substance:0 (Disinfectants); 1VU15B70BP (Benzethonium)


  2 / 199 MEDLINE  
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PMID:27884428
Author:van Boxtel N; Wolfs K; Palacín MG; Van Schepdael A; Adams E
Address:KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, Herestraat 49, O&N2, PB 923, 3000 Leuven, Belgium.
Title:Headspace gas chromatography based methodology for the analysis of aromatic substituted quaternary ammonium salts.
Source:J Chromatogr A; 1476:105-113, 2016 Dec 09.
ISSN:1873-3778
Country of publication:Netherlands
Language:eng
Abstract:The analysis of quaternary ammonium salts (QAS) using GC is often performed by "in injector" pyrolysis to create volatile degradation products for quantification purposes. Besides the risk of severe system contamination, the application of this approach on aqueous samples is problematic. In this work, the sample is treated in a vial with 2,2-dimethoxypropane (DMP) under acidic catalysis. In addition to the removal of water and sample enrichment, the QAS are decomposed. As HS transfers only volatile compounds to the GC system, contamination is avoided. It was found that depending on the presence of benzyl, phenyl or methyl groups on the quaternary nitrogen; benzyl chloride, N,N-dimethylaniline or chloromethane are formed respectively in the sealed vial. All these can be used as an analytical target. A calibration curve for benzyl chloride could be derived from the pure compound. Chloromethane was generated from pure benzyldimethyldecylammonium chloride (BEDIDE), a pure QAS with benzyl and methyl groups, to construct a secondary calibration curve using a back analysis approach. It has been proven that by quantifying the formed analytical targets, the mass balance for the QAS under investigation was close to 100%. The presented procedure allows the quantification of any aromatic substituted QAS without the need for a matching reference, which is a major advantage over existing CE and LC methods The proposed methodology was validated for mouth sprays containing benzethonium chloride (BZTCl) or benzoxonium chloride (BZOCl) and for denatonium benzoate (DB) in ethylene glycol (EG) based cooling liquids. Results showed that the approach provided excellent linearity (R ≥0.999) and limits of detection around 0.01µg/vial for benzyl chloride. It was found that the reaction product of DMP and glycerol which was also present in the mouthspray and some cooling liquids, caused chromatographic interference with benzyl chloride. Treating those samples in the vial with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) after the enrichment step removes the interference and leaves a possible pathway for the simultaneous determination of glycerol in those samples.
Publication type:JOURNAL ARTICLE; VALIDATION STUDIES
Name of substance:0 (Acetamides); 0 (Benzalkonium Compounds); 0 (Benzyl Compounds); 0 (N,O-bis(trimethylsilyl)trifluoroacetamide); 0 (Quaternary Ammonium Compounds); 0 (Salts); 0 (Trimethylsilyl Compounds); 12IMO9R11X (benzoxonium chloride); 1VU15B70BP (Benzethonium); 4YK5Z54AT2 (denatonium benzoate); 83H19HW7K6 (benzyl chloride)


  3 / 199 MEDLINE  
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PMID:27533261
Author:Dzhemilev UM; D'yakonov VA; Tuktarova RA; Dzhemileva LU; Ishmukhametova SR; Yunusbaeva MM; de Meijere A
Address:Laboratory of Catalytic Synthesis, Institute of Petrochemistry and Catalysis of RAS (IPC RAS) , Prospect Octyabrya, 141, 450075, Ufa, Russian Federation.
Title:Short Route to the Total Synthesis of Natural Muricadienin and Investigation of Its Cytotoxic Properties.
Source:J Nat Prod; 79(8):2039-44, 2016 Aug 26.
ISSN:1520-6025
Country of publication:United States
Language:eng
Abstract:An original synthesis of the acetogenin muricadienin, the bioprecursor of solamin, has been developed. The key step in the five-step 41% overall yield synthesis is the catalytic cross-cyclomagnesiation reaction of functionally substituted 1,2-dienes with EtMgBr in the presence of Cp2TiCl2 and magnesium metal. It has been demonstrated for the first time that muricadienin exhibits a moderate in vitro inhibitory activity against topoisomerases I and IIα, key cell cycle enzymes. Using flow cytometry, muricadienin was shown to have high cytotoxicity toward the HEK293 kidney cancer cells (IC50 0.39 µM).
Publication type:JOURNAL ARTICLE
Name of substance:0 (Acetogenins); 0 (Antineoplastic Agents); 0 (Topoisomerase I Inhibitors); 0 (muricadienin); 1VU15B70BP (Benzethonium); EC 5.99.1.2 (DNA Topoisomerases, Type I); EC 5.99.1.2 (TOP1 protein, human); EC 5.99.1.3 (DNA Topoisomerases, Type II)


  4 / 199 MEDLINE  
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PMID:27021544
Author:Iwamura Y; Hayashi J; Sato T; Sato S; Murakami T; Fujimura T; Sasaki Y; Okada K; Takahashi E; Kikuchi T; Aino M; Noguchi T; Shimazaki Y; Mitani A; Fukuda M
Address:Department of Periodontology, School of Dentistry, Aichi Gakuin University.
Title:Assessment of oral malodor and tonsillar microbiota after gargling with benzethonium chloride.
Source:J Oral Sci; 58(1):83-91, 2016.
ISSN:1880-4926
Country of publication:Japan
Language:eng
Abstract:The oropharyngeal area can be a source of halitosis. However, the relationship between healthy tonsillar microbiota and halitosis is poorly understood. We conducted a pilot clinical study to clarify the effect of gargling with an antiseptic agent on tonsillar microbiota in patients with halitosis. Twenty-nine halitosis patients who did not have otolaryngologic disease or periodontitis were assigned randomly to one of three groups: benzethonium chloride (BZC) gargle; placebo gargle; no gargle. Concentrations of volatile sulfur compounds (VSCs) in mouth air, the organoleptic score (ORS) and tongue-coating score (TCS) were measured before and after testing. Tonsillar microbiota were assessed by detection of periodontal pathogens, and profiling with terminal-restriction fragment length polymorphism (T-RFLP) analysis and sequencing of 16SrRNA clone libraries for taxonomic assignment. Gargling with BZC reduced the concentrations of methyl mercaptan and hydrogen sulfide and the ORS, but did not affect the TCS or prevalence of periodontal pathogens. T-RFLP analyses and 16SrRNA clone sequencing showed a tendency for some candidate species to decrease in the test group. Although gargling of the oropharyngeal area with an antiseptic agent can reduce oral malodor, it appears that tonsillar microbiota are not influenced greatly. (J Oral Sci 58, 83-91, 2016).
Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Anti-Infective Agents, Local); 1VU15B70BP (Benzethonium)


  5 / 199 MEDLINE  
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PMID:26219372
Author:Mazza R; Mazzette R; McAuliffe O; Jordan K; Fox EM
Address:University of Sassari, Sassari, Italy.
Title:Differential Gene Expression of Three Gene Targets among Persistent and Nonpersistent Listeria monocytogenes Strains in the Presence or Absence of Benzethonium Chloride.
Source:J Food Prot; 78(8):1569-73, 2015 Aug.
ISSN:1944-9097
Country of publication:United States
Language:eng
Abstract:Persistence of Listeria monocytogenes strains in food processing environments remains relatively common but is difficult to control. Understanding the basis for such persistence represents an important step in the potential control or eradication of this pathogen from these environments. In this study, reverse transcription PCR was used to determine the relative and absolute expression of selected gene targets (pocR, eutJ, and qacH) among five persistent and four presumed nonpersistent L. monocytogenes strains. The quantification of these genes as markers for the persistent phenotype and the effect of benzethonium chloride (BZT) on their expression was investigated. Although no markers correlated with the ability of strains to persist in food processing facilities were found, expression of pocR was upregulated in three of the five persistent strains, in contrast to the four presumed nonpersistent strains, which showed down-regulation of this gene. These results provide further knowledge of the differential expression of genes of persistent and presumed nonpersistent strains of L. monocytogenes grown in the presence or absence of BZT and identifies upregulation of pocR as a potential response of persistent strains of L. monocytogenes to exposure to BZT.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Bacterial Proteins); 0 (Genetic Markers); 0 (RNA, Bacterial); 1VU15B70BP (Benzethonium)


  6 / 199 MEDLINE  
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PMID:26210697
Author:Rafsanjany N; Sendker J; Lechtenberg M; Petereit F; Scharf B; Hensel A
Address:University of Münster, Institute of Pharmaceutical Biology and Phytochemistry, Corrensstrasse 48, D-48149 Münster, Germany.
Title:Traditionally used medicinal plants against uncomplicated urinary tract infections: Are unusual, flavan-4-ol- and derhamnosylmaysin derivatives responsible for the antiadhesive activity of extracts obtained from stigmata of Zea mays L. against uropathogenic E. coli and Benzethonium chloride as frequent contaminant faking potential antibacterial activities?
Source:Fitoterapia; 105:246-53, 2015 Sep.
ISSN:1873-6971
Country of publication:Netherlands
Language:eng
Abstract:The dried stigmata from Zea mays L. are used traditionally for the treatment of uncomplicated urinary tract infections. A recent screening has indicated that hydroalcoholic extract of the herbal material inhibits the adhesion of uropathogenic Escherichia coli (UPEC) to T24 bladder cells. For verification of these data EtOH-water (1:1) extracts from 4 different batches of Maydis stigmata were investigated. Within an in vitro adhesion assay (UPEC strain 2980 and human T24 bladder cells) a dose-dependent antiadhesive activity against UPEC was verified (IC50 1040µg/mL). Bioassay guided fractionation of M. stigmata, batch S1, by EtOH-water extraction, followed by chromatography on Sephadex LH20 revealed two active fractions (I and XI). Further purification of fraction I and structure elucidation of the isolated compound revealed the presence of significant amounts of the biocide benzethonium chloride as contaminant. Benzethonium chloride was also identified in subsequent investigations in 2 different batches of M. stigmata. The presence of such nondeclared and illegal contaminants in the herbal raw material market has to be discussed intensively. From benzethonium-free raw material (batch S2) as well as from batch S1 fraction XI was further fractionated by MPLC and preparative HPLC, leading to a still complex subfraction XIG, which was analyzed by UHPLC/+ESI-QTOF-MS analysis. Advanced data processing and species-metabolite relationship database revealed the tentatively existence of the unusual C-glycosidic flavones derhamnosylmaysin (6), 3'-deoxyrhamnosylmaysin (4), 3'-O-methylderhamnosylmaysin (3), apiferol (2) and alternanthin (8) which might be related to the antiadhesive activity of this subfraction against UPEC.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Anti-Bacterial Agents); 0 (Flavones); 0 (Plant Extracts); 1VU15B70BP (Benzethonium)


  7 / 199 MEDLINE  
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PMID:26204005
Author:Livneh A; Youngster I; El-On Y; Berkovitch M; Abu-Kishk I
Title:The lack of effectiveness of hyperbaric oxygenation as a treatment for Leishmania major in a mouse model.
Source:Acta Parasitol; 60(2):345-9, 2015 Jun.
ISSN:1896-1851
Country of publication:Poland
Language:eng
Abstract:We aimed to study the effectiveness of hyperbaric oxygen therapy (HOT) (100% oxygen at 2 ATA for 70 minutes each session for 20 consecutive days) on BALB/c male mice infected with Leishmania major. Fifty-one mice were assigned to six groups. Group 1 was treated with HOT from 1 day after the inoculation. In Groups 2-5, treatment began when the cutaneous lesions appeared. Group 2 received HOT only, Group 3 received topical therapy with Leshcutan only, Groups 4 and 5 received a combination of HOT and Leshcutan for 5 and 10 days respectively, and Group 6 did not receive any treatment (control group). When comparing the control group with Group 1, treatment with HOT in Group 1 did not significantly affect the time of the appearance of the lesions. In contrast, mice treated with Leshcutan demonstrated a significant difference in lesion size and spleen dimensions as compared to the rest of the mice (p<0.001). The results show that HOT treatment has no positive effect on the course of Leishmaniasis in a BALB/c mice model infected with Leishmania major. Further studies are needed with a mouse model closer to humans and with different HOT protocols.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antiprotozoal Agents); 1VU15B70BP (Benzethonium); 61JJC8N5ZK (Paromomycin); WOA57K8S5V (methylbenzethonium chloride)


  8 / 199 MEDLINE  
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PMID:25979325
Author:Lee E; Oh C; Kim IS; Kwon IC; Kim S
Address:Center for Theragnosis, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Republic of Korea.
Title:Co-delivery of chemosensitizing siRNA and an anticancer agent via multiple monocomplexation-induced hydrophobic association.
Source:J Control Release; 210:105-14, 2015 Jul 28.
ISSN:1873-4995
Country of publication:Netherlands
Language:eng
Abstract:Synergistic combination of gene targeting and chemotherapy by co-delivering siRNA and anticancer drugs has widely been investigated to develop siRNA-based therapeutics for cancer treatment. Despite clinical potential of this approach, big challenges still remain such as delivery efficiency or stability/biocompatibility of the siRNA delivery system. Here we report a simple and biocompatible co-delivering formulation based on a unique complexation method, i.e., multiple monocomplexation-induced hydrophobic association between Bcl-2 targeting siRNA and a monocationic anticancer agent (benzethonium chloride, BZT). A colloidal formulation of the hydrophobically associated multiple monocomplex (HMplex) composed of siRNA, BZT and Pluronic F-68 was spontaneously constructed by physical mixing of the ternary constituents. In vitro and in vivo studies revealed that the ternary HMplex with a low charge ratio (N/P=4) possesses a tightly complexed stable nanostructure with Pluronic surface and small colloidal size less than 10nm, which allowed for 1) suitable protection of siRNA in serum-rich physiological environment, 2) efficient intracellular transfection into the cytoplasm, and 3) successful peritumoral co-delivery into the tumor tissue with dense interstitial matrix. Compared to non-targeting HMplexes between scrambled siRNA and BZT, Bcl-2 targeting HMplexes enhanced significantly both mRNA down-regulation by siRNA and apoptosis induction by BZT, and thus greatly suppressed the tumor volume when administered to highly aggressive and resistant human breast cancer xenografts (MDA-MB-231) in mice. These results elucidate that the co-complexed siRNA and BZT were liberated by intracellular decomplexation to trigger a synergistically combined therapeutic action. The successful siRNA/chemodrug co-delivery in vivo via peritumoral route and the greatly promoted therapeutic efficacy thereby represent the clinical potential of HMplexes for adjuvant locoregional cancer treatment by gene-targeted combination therapy.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Antineoplastic Agents); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (RNA, Small Interfering); 106392-12-5 (Poloxamer); 1VU15B70BP (Benzethonium)


  9 / 199 MEDLINE  
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PMID:25747761
Author:Takyi-Williams J; Dong X; Gong H; Wang Y; Jian W; Liu CF; Tang K
Address:School of Biological Sciences, Nanyang Technological University, Singapore.
Title:Application of paper spray-MS in PK studies using sunitinib and benzethonium as model compounds.
Source:Bioanalysis; 7(4):413-23, 2015.
ISSN:1757-6199
Country of publication:England
Language:eng
Abstract:AIM: Current bioanalytical methods applied in nonclinical PK studies for screening drug candidates demand significant amount of time and resources, hence, the need to develop alternative methods. RESULTS: A proof-of-concept paper spray-MS method for the detection and quantitation of small molecules in plasma has been developed and validated using sunitinib and benzethonium as model compounds. The method includes single oral or intravenous administration of sunitinib to mice and serial micro-volume (20 µl) blood collection at different time intervals. The method is rapid with overall analysis time of 1 min and a full PK profile of sunitinib was obtained from a single mouse. CONCLUSION: The paper spray-MS approach is simple, sensitive and can potentially enable significant reduction of animal use and cost.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Indoles); 0 (Pyrroles); 1VU15B70BP (Benzethonium); V99T50803M (sunitinib)


  10 / 199 MEDLINE  
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PMID:25446880
Author:Gounden V; Sacks DB; Zhao Z
Address:Department of Laboratory Medicine, NIH Clinical Center, Building 10, Room 2C-249, Bethesda, MD 20892 USA.
Title:Interference of cerebrospinal fluid total protein measurement by povidone-iodine contamination.
Source:Clin Chim Acta; 440:3-5, 2015 Feb 02.
ISSN:1873-3492
Country of publication:Netherlands
Language:eng
Abstract:BACKGROUND: A falsely high cerebrospinal fluid (CSF) total protein (TP) result measured by pyrogallol red (PGR) method was suspected to be caused by preparation of the collection site with povidone-iodine (PVP-iodine) solution. METHODS: CSF TP was evaluated for interference in samples with different final concentrations of PVP-iodine (up to 0.25% PVP and 0.025% iodine) or iodine alone (up to 0.025% iodine) using three methods: PGR, modified biuret and benzethonium chloride (BZTC). Interference exceeding ±20% of the baseline value is considered clinically significant according to the criterion defined by the College of American Pathologists. RESULTS: There were positive interference with the PGR method and negative inference for the BZTC method in CSF samples spiked with PVP-iodine. The PVP-iodine (up to 0.25% PVP and 0.025% iodine) did not cause a clinically significant interference with the modified biuret method. PVP alone without iodine caused a positive interference with the PGR method but did not interfere with the modified biuret or the BZTC method. When the samples were spiked with iodine alone, none of the three methods was affected (change<20%) by iodine concentration up to 0.025%. CONCLUSIONS: Contamination of CSF specimens with PVP-iodine can lead to interference with CSF TP measurements using PGR or BZTC methods.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL
Name of substance:0 (Cerebrospinal Fluid Proteins); 01Y4A2QXY0 (Pyrogallol); 1VU15B70BP (Benzethonium); 32638-88-3 (pyrogallol sulfonphthalein); 85H0HZU99M (Povidone-Iodine)



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