Database : MEDLINE
Search on : D02.675.276.136.500 [DeCS Category]
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  1 / 123 MEDLINE  
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PMID:29248772
Author:Spórna-Kucab A; Milo A; Kumorkiewicz A; Wybraniec S
Address:Department of Analytical Chemistry, Institute C-1, Faculty of Chemical Engineering and Technology, Cracow University of Technology, ul. Warszawska 24, Cracow 31-155, Poland. Electronic address: anetasporna@chemia.pk.edu.pl.
Title:Studies on polar high-speed counter-current chromatographic systems in separation of amaranthine-type betacyanins from Celosia species.
Source:J Chromatogr B Analyt Technol Biomed Life Sci; 1073:96-103, 2018 Jan 15.
ISSN:1873-376X
Country of publication:Netherlands
Language:eng
Abstract:Betacyanins, natural plant pigments exhibiting antioxidant and chemopreventive properties, were extracted from Celosia spicata (Thouars) Spreng. inflorescences and separated by high-speed counter-current chromatography (HSCCC) in two polar solvent systems composed of: TBME - 1-BuOH - ACN - H O (0.7% HFBA, 2:2:1:5, v/v/v/v) (system I) and EtOH - ACN - 1-PrOH - (NH ) SO - H O (0.5:0.5:0.5:1.2:1, v/v/v/v/v) (system II). The systems were used in the head-to-tail (system I) and tail-to-head (system II) mode. The flow rate of the mobile phase was 2.0 ml/min and the column rotation speed was 860 rpm. The retention of the stationary phase was 73.5% (system I) and 80.0% (system II). For the identification of separated betacyanins in the crude extract as well as in the HSCCC fractions, LC-DAD-ESI-MS/MS analyses were performed. Depending on the target compounds, each of the systems exhibit meaningfully different selectivity and applicability. For the pairs of amaranthines (1/1') and betanins (2/2'), the best choice is the system II, but the acylated amaranthine pairs (3/3' and 4/4') can be resolved only in the ion-pair system I. For the indication of the most suitable solvent system for Celosia plumosa hort., Celosia cristata L. and Celosia spicata (Thouars) Spreng. species, the profiles of betacyanins in different plant parts were studied.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Betacyanins); 0 (Plant Extracts); 15167-84-7 (amaranthin betacyanin)


  2 / 123 MEDLINE  
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PMID:29317207
Author:Imamura T; Takagi H; Miyazato A; Ohki S; Mizukoshi H; Mori M
Address:Ishikawa Prefectural University, Nonoichi, Ishikawa, 921-8836, Japan. Electronic address: timamura@ishikawa-up.ac.jp.
Title:Isolation and characterization of the betalain biosynthesis gene involved in hypocotyl pigmentation of the allotetraploid Chenopodium quinoa.
Source:Biochem Biophys Res Commun; 496(2):280-286, 2018 02 05.
ISSN:1090-2104
Country of publication:United States
Language:eng
Abstract:In quinoa seedlings, the pigment betalain accumulates in the hypocotyl. To isolate the genes involved in betalain biosynthesis in the hypocotyl, we performed ethyl methanesulfonate (EMS) mutagenesis on the CQ127 variety of quinoa seedlings. While putative amaranthin and celosianin II primarily accumulate in the hypocotyls, this process produced a green hypocotyl mutant (ghy). This MutMap+ method using the quinoa draft genome revealed that the causative gene of the mutant is CqCYP76AD1-1. Our results indicated that the expression of CqCYP76AD1-1 was light-dependent. In addition, the transient expression of CqCYP76AD1-1 in Nicotiana benthamiana leaves resulted in the accumulation of betanin but not isobetanin, and the presence of a polymorphism in CqCYP76A1-2 in the CQ127 variety was shown to have resulted in its loss of function. These findings suggested that CqCYP76AD1-1 is involved in betalain biosynthesis during the hypocotyl pigmentation process in quinoa. To our knowledge, CqCYP76AD1-1 is the first quinoa gene identified by EMS mutagenesis using a draft gene sequence.
Publication type:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
Name of substance:0 (Betacyanins); 0 (Mutagens); 15167-84-7 (amaranthin betacyanin); 37279-84-8 (Betalains); 5YJC992ZP6 (betanin); 9H154DI0UP (Ethyl Methanesulfonate); EC 1.14.13.- (7-Alkoxycoumarin O-Dealkylase); EC 1.14.13.- (cytochrome P-450 CYP76B1 (Helianthus tuberosus))


  3 / 123 MEDLINE  
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PMID:28624090
Author:Nistor OV; Seremet Ceclu L; Andronoiu DG; Rudi L; Botez E
Address:Food Science and Engineering Faculty "Dunarea de Jos" University of Galati, 111 Domneasca Street, 800201, Romania.
Title:Influence of different drying methods on the physicochemical properties of red beetroot (Beta vulgaris L. var. Cylindra).
Source:Food Chem; 236:59-67, 2017 Dec 01.
ISSN:0308-8146
Country of publication:England
Language:eng
Abstract:There is an increased interest in preserving fruits and vegetables by drying. The novelty of this study consists in the combination of the following three drying methods: free convection (at 50, 60, and 70°C), forced convection at 40°C and 315W microwave power. The aim of this study was to investigate the effects of the drying conditions on red beetroot (Beta vulgaris L.) in terms of betalain variance, and polyphenol, microstructure changes (SEM). A strong thermal shock, provided by convection at 60° followed by microwave wattage 315W/9min, leads to a better preservation of bioactive compounds content (0.631±0.0042mg/g of betacyanin and 0.795±0.0019mg/g betaxanthin) when compared to convection at 50, 60 and 70°C. The results showed that combined drying methods led to a significant preservation of the phytochemical content as compared to the traditional methods.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Betacyanins); 0 (Polyphenols); 37279-84-8 (Betalains)


  4 / 123 MEDLINE  
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PMID:28372168
Author:Roriz CL; Barros L; Prieto MA; Morales P; Ferreira IC
Address:Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, Apartado 1172, 5300-253 Bragança, Portugal; Dpto. Nutrición y Bromatología II, Facultad de Farmacia, Universidad Complutense de Madrid (UCM), Plaza Ramón y Cajal, s/n, E-28040 Madrid, Spain.
Title:Floral parts of Gomphrena globosa L. as a novel alternative source of betacyanins: Optimization of the extraction using response surface methodology.
Source:Food Chem; 229:223-234, 2017 Aug 15.
ISSN:0308-8146
Country of publication:England
Language:eng
Abstract:The present study describes a novel mechanical process for the pigmented parts of Gomphrena globosa L. The effects of the variables of the maceration extraction of betacyanins have not been properly described. Therefore, this study also aims to optimize the conditions that maximize betacyanins extraction from G. globosa as an alternative source. Assisted by response surface methodology, an experimental design was developed for testing the extraction variables (time, temperature, ethanol-water proportion and solid-liquid ratio). The responses used were betacyanins quantification (by HPLC-PDA-MS/ESI and spectrophotometric analysis), the extraction-yield and the colour intensity of the produced powder. The betacyanins identified were gomphrenin and isogomphrenin II and III. The highest betacyanins content (∼45mg/g) was obtained by 165min, 25°C, 0% of ethanol and 5g/L of solid-liquid ratio. The betacyanins content from the floral parts of G. globosa is higher than those normally found in other sources highlighting its industrial application.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Betacyanins); 0 (Plant Extracts)


  5 / 123 MEDLINE  
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PMID:28192880
Author:Dhananjayan I; Kathiroli S; Subramani S; Veerasamy V
Address:Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidhambaram, 608 002 Tamilnadu, India.
Title:Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats.
Source:Biomed Pharmacother; 88:1069-1079, 2017 Apr.
ISSN:1950-6007
Country of publication:France
Language:eng
Abstract:Betanin, a chromoalkaloid of beetroot, has shown significant biological effects of antioxidants, anti-inflammatory and anticarcinogenic activities. So, we attempted to determine whether betanin (a natural pigment) would be protective against hyperglycemia in streptozotocin (STZ) - nicotinamide (NA) induced diabetic rats. Rats were injected with STZ (40mg/kgb.w.) 15 mins after the administration of NA (110mg/kgb.w.) by intraperitonially (i.p.) 30days for the induction of experimental diabetes mellitus. After 72h diabetic rats were treated with betanin orally at a doses of 10, 20 and 40mg/kg b.w., respectively in a dose dependent manner and glibenclamide (600µg/kgb.w.). The promising character of betanin against diabetic rats was evaluated by performing the various biochemical parameters and histomorphological changes in liver and pancreas. Among the three doses, 20mg/kgb.w. of betanin was able to positively regulate plasma glucose, insulin, glycosylated hemoglobin (HbA ) and hemoglobin (Hb) levels by significantly increasing the activity of glycolytic enzyme (glucokinase and pyruvate kinase), glucose-6-phosphate dehydrogenase and significantly decreasing the activity of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) thereby increasing the glycogen content in the liver. We put forward that betanin could significantly restore the levels of carbohydrate metabolic key enzymes to near normal in diabetic rat. Immunohistochemical observation of pancreas revealed that betanin treated diabetic rats showed increased insulin immunoreactive ß-cells, which confirmed the biochemical findings. Taken together, present study suggests that betanin modulates the carbohydrate metabolism and has beneficial effects in glucose homeostasis.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Betacyanins); 0 (Biomarkers); 0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (Insulin); 25X51I8RD4 (Niacinamide); 5W494URQ81 (Streptozocin); 5YJC992ZP6 (betanin); 9005-79-2 (Glycogen)


  6 / 123 MEDLINE  
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PMID:28190594
Author:Spórna-Kucab A; Jagodzinska J; Wybraniec S
Address:Department of Analytical Chemistry, Institute C-1, Faculty of Chemical Engineering and Technology, Cracow University of Technology, ul. Warszawska 24, Cracow 31-155, Poland. Electronic address: anetasporna@chemia.pk.edu.pl.
Title:Separation of betacyanins from purple flowers of Gomphrena globosa L. by ion-pair high-speed counter-current chromatography.
Source:J Chromatogr A; 1489:51-57, 2017 Mar 17.
ISSN:1873-3778
Country of publication:Netherlands
Language:eng
Abstract:Betacyanins, known as antioxidants and chemopreventive natural compounds with colourful properties, were extracted from purple flowers of Gomphrena globosa L. belonging to the Amaranthaceae family and separated for the first time by ion-pair high-speed counter-current chromatography (HSCCC). The pigments were detected by LC-DAD-ESI-MS/MS technique. Separation of betacyanins (300mg) by HSCCC was accomplished in four solvent systems: tert-butyl methyl ether - butanol - acetonitrile - water (0.7% and 1.0% HFBA - heptafluorobutyric acid - system I and III) and tert-butyl methyl ether - butanol - methanol - water (0.7% and 1.0% HFBA - system II and IV) (2:2:1:5, v/v/v/v) in the head-to-tail mode. The mobile phase (aqueous phase) was run at 2.0ml/min and the column rotation speed was 860rpm. The applied systems enabled to study the influence of HFBA concentration as well as systems polarity on betacyanins separation. Comparison of the systems containing 0.7% HFBA (systems I-II) demonstrates that the replacement of acetonitrile by methanol increases the resolution (R ) between all betacyanins and does not influence the retention of the stationary phase (S =76%). Higher concentration of the acid in systems III-IV slightly decreases S to 71% in the systems with 1.0% HFBA. Comparison of the resolution values for betacyanins in the systems with 0.7% and 1.0% HFBA demonstrates that higher concentration of the acid improves the separation effectiveness for all betacyanins as a result of increasing of the chemical affinity of the pigments to the organic stationary phase in HSCCC. The systems III-IV with 1% HFBA are the most effective for the separation of all the studied betacyanins.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Betacyanins); 0 (Solvents)


  7 / 123 MEDLINE  
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PMID:28111218
Author:Sutariya B; Saraf M
Address:Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (East), Mumbai 400068, Maharashtra, India.
Title:Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-ß pathway.
Source:J Ethnopharmacol; 198:432-443, 2017 Feb 23.
ISSN:1872-7573
Country of publication:Ireland
Language:eng
Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Opuntia elatior Mill are being used traditionally in different disease condition like diabetes, obesity, asthma, inflammatory disorders, and anemia. Betanin, a compound isolated from fruits of Opuntia elatior Mill has potent anti-oxidative and anti-inflammatory activity. Recent study from our lab indicated the protective effect of betanin against high glucose induced rat renal epithelial cell fibrosis and matrix accumulation, major features of diabetic nephropathy (DN). However the molecular mechanism of betanin in DN has not yet been fully elucidated. AIM OF THE STUDY: The aim of the present study was to further investigate the anti-fibrotic mechanisms of betanin against streptozotocin (STZ) induced DN. MATERIALS AND METHODS: Betanin was isolated from fruits of Opuntia elatior Mill (Cactaceae) and structure was elucidated using spectroscopy (UV, IR, 1H-NMR and mass). STZ was injected intraperitoneally with single dose of 50mg/kg for diabetes induction. In order to develop DN the animals were left in diabetes condition without any treatment during the following 4 weeks. Betanin (25, 50 and 100mg/kg/day) and lisinopril (5mg/kg/day, reference compound) were orally administered for 8 weeks after the induction of DN. Renal function, blood glucose, serum creatinine, blood urea nitrogen (BUN) and antioxidant enzyme activities in the kidney tissue were measured. Kidney tissue samples were used for glomerulosclerosis, tubulointerstitial fibrosis and morphometric studies. The expression of transforming growth factor-beta (TGF-ß), type IV collagen, alpha-smooth muscle actin (α-SMA) and E-cadherin in kidney tissue were evaluated using reverse transcription-polymerase chain reaction, and immunohistochemistry. RESULTS: Betanin was successfully isolated from fruits of Opuntia elatior Mill (Cactaceae) and purified by column chromatography. The results showed that betanin attenuated diabetic kidney injury by significantly inhibiting proteinuria, blood glucose, serum creatinine and BUN levels and restored antioxidant enzyme activities in kidney tissue. Histological studies exhibited that betanin treatment reduced the glomerular surface area, glomerulosclerosis and tubulointerstitial fibrosis. Furthermore, betanin modulated mRNA and protein expression of TGF-ß, type IV collagen, α-SMA and E-cadherin in kidney. CONCLUSIONS: The results conclude that betanin can effectively suppress renal fibrosis in DN, and may slow down the progression to end-stage renal disease by regulating TGF-ß signal pathway.
Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
Name of substance:0 (Betacyanins); 0 (Blood Glucose); 0 (Transforming Growth Factor beta); 5W494URQ81 (Streptozocin); 5YJC992ZP6 (betanin); AYI8EX34EU (Creatinine); E7199S1YWR (Lisinopril)


  8 / 123 MEDLINE  
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PMID:27917454
Author:Yong YY; Dykes G; Lee SM; Choo WS
Address:School of Science, Monash University Malaysia, 47500, Bandar Sunway, Selangor, Malaysia.
Title:Comparative Study of Betacyanin Profile and Antimicrobial Activity of Red Pitahaya (Hylocereus polyrhizus) and Red Spinach (Amaranthus dubius).
Source:Plant Foods Hum Nutr; 72(1):41-47, 2017 Mar.
ISSN:1573-9104
Country of publication:Netherlands
Language:eng
Abstract:Betacyanins are reddish to violet pigments that can be found in red pitahaya (Hylocereus polyrhizus) and red spinach (Amaranthus dubius). This study investigated the impact of sub-fractionation (solvent partitioning) on betacyanin content in both plants. Characterization of betacyanins and evaluation of their antimicrobial activities were also carried out. Betanin was found in both plants. In addition, isobetanin, phyllocactin and hylocerenin were found in red pitahaya whereas amaranthine and decarboxy-amaranthine were found in red spinach. Sub-fractionated red pitahaya and red spinach had 23.5 and 121.5 % more betacyanin content, respectively, than those without sub-fractionation. Sub-fractionation increased the betanin and decarboxy-amaranthine content in red pitahaya and red spinach, respectively. The betacyanin fraction from red spinach (minimum inhibitory concentration [MIC] values: 0.78-3.13 mg/mL) demonstrated a better antimicrobial activity profile than that of red pitahaya (MIC values: 3.13-6.25 mg/mL) against nine Gram-positive bacterial strains. Similarly, the red spinach fraction (MIC values: 1.56-3.13 mg/mL) was more active than the red pitahaya fraction (MIC values: 3.13-6.25 mg/mL) against five Gram-negative bacterial strains. This could be because of a higher amount of betacyanin, particularly amaranthine in the red spinach.
Publication type:COMPARATIVE STUDY; JOURNAL ARTICLE
Name of substance:0 (Anti-Infective Agents); 0 (Betacyanins); 0 (Plant Extracts); 0 (hylocerenin); 0 (phyllocactin); 5YJC992ZP6 (betanin)


  9 / 123 MEDLINE  
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PMID:27596427
Author:Tran TN; Athanassiou A; Basit A; Bayer IS
Address:Smart Materials, Istituto Italiano di Tecnologia, Via Morego, 30, Genova 16163, Italy. Electronic address: thi-nga.tran@iit.it.
Title:Starch-based bio-elastomers functionalized with red beetroot natural antioxidant.
Source:Food Chem; 216:324-33, 2017 Feb 01.
ISSN:0308-8146
Country of publication:England
Language:eng
Abstract:Red beetroot (RB) powder was incorporated into starch-based bio-elastomers to obtain flexible biocomposites with tunable antioxidant properties. Starch granules within the bio-elastomers affected the release of the antioxidant molecule betanin in the RB powder. The bio-elastomers were hydrophobic and resisted dissolution in water, hence the release of betanin was due to diffusion rather than polymer matrix disintegration. Hydrophobicity was maintained even after water immersion. Released betanin demonstrated highly efficient antioxidant scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+)). RB powder was also found to increase the Young's modulus of the bio-elastomers without compromising their elongation ability. Infrared spectral analysis indicated weak interactions through hydrogen bonding among starch granules, RB powder and PDMS polymer within the bio-elastomers. Hence, as a simple but intelligent biomaterial consisting of mainly edible starch and RB powder the present bio-elastomers can be used in active packaging for a variety of pharmaceutical, medical, and food applications.
Publication type:JOURNAL ARTICLE
Name of substance:0 (Antioxidants); 0 (Benzothiazoles); 0 (Betacyanins); 0 (Biphenyl Compounds); 0 (Elastomers); 0 (Free Radicals); 0 (Picrates); 0 (Plant Preparations); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 5YJC992ZP6 (betanin); 9005-25-8 (Starch); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)


  10 / 123 MEDLINE  
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PMID:26873098
Author:Clifford T; Constantinou CM; Keane KM; West DJ; Howatson G; Stevenson EJ
Address:Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK. tom.clifford@northumbria.ac.uk.
Title:The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans.
Source:Eur J Nutr; 56(3):1245-1254, 2017 Apr.
ISSN:1436-6215
Country of publication:Germany
Language:eng
Abstract:PURPOSE: To evaluate the plasma bioavailability of betanin and nitric oxide (NOx) after consuming beetroot juice (BTJ) and whole beetroot (BF). BTJ and BF were also analysed for antioxidant capacity, polyphenol content (TPC) and betalain content. METHODS: Ten healthy males consumed either 250 ml of BTJ, 300 g of BF or a placebo drink, in a randomised, crossover design. Venous plasma samples were collected pre (baseline), 1, 2, 3, 5 and 8 h post-ingestion. Betanin content in BTJ, BF and plasma was analysed with reverse-phase high-performance liquid chromatography (HPLC) and mass spectrometry detection (LCMS). Antioxidant capacity was estimated using the Trolox equivalent antioxidant capacity (TEAC) and polyphenol content using Folin-Ciocalteu colorimetric methods [gallic acid equivalents (GAE)] and betalain content spectrophotometrically. RESULTS: TEAC was 11.4 ± 0.2 mmol/L for BTJ and 3.4 ± 0.4 µmol/g for BF. Both BTJ and BF contained a number of polyphenols (1606.9 ± 151 mg/GAE/L and 1.67 ± 0.1 mg/GAE/g, respectively), betacyanins (68.2 ± 0.4 mg/betanin equivalents/L and 19.6 ± 0.6 mg/betanin equivalents/100 g, respectively) and betaxanthins (41.7 ± 0.7 mg/indicaxanthin equivalents/L and 7.5 ± 0.2 mg/indicaxanthin equivalents/100 g, respectively). Despite high betanin contents in both BTJ (~194 mg) and BF (~66 mg), betanin could not be detected in the plasma at any time point post-ingestion. Plasma NOx was elevated above baseline for 8 h after consuming BTJ and 5 h after BF (P < 0.05). CONCLUSIONS: These data reveal that BTJ and BF are rich in phytonutrients and may provide a useful means of increasing plasma NOx bioavailability. However, betanin, the major betalain in beetroot, showed poor bioavailability in plasma.
Publication type:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
Name of substance:0 (Antioxidants); 0 (Betacyanins); 0 (Betaxanthins); 0 (Nitrates); 0 (Polyphenols); 0 (Pyridines); 0 (indicaxanthin); 31C4KY9ESH (Nitric Oxide); 37279-84-8 (Betalains)



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