Database : MEDLINE
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PMID:29505531
Author:Li Y; Ye T; Gu Q; Dong L; Chen G; Lu S
Address:Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University.
Title:Primary, cardiac, fibroblastic osteosarcoma: A case report.
Source:Medicine (Baltimore); 97(1):e9543, 2018 Jan.
ISSN:1536-5964
Country of publication:United States
Language:eng
Abstract:RATIONALE: Primary cardiac osteosarcoma is a rare tumor. To our knowledge, only 15 cases have been reported in the literature in the past 10 years. We describe a case of primary, cardiac, fibroblastic osteosarcoma in a 42-year-old woman. PATIENT CONCERNS: A 42-year-old woman with a 10-day history of chest pain. Intraoperatively, a mass was found originating from the ostium of the left inferior pulmonary vein in the left atrium, extending to the mitral orifice. Histologically, the tumor contained variable amounts of spindle cells and osseous differentiation in different areas. Primary, cardiac fibroblastic osteosarcoma had the typical appearance of interlacing hyperchromatic spindle-shaped stromal cells associated with osseous matrix. DIAGNOSES: According to the clinicopathological features, diagnosis of primary, cardiac fibroblastic osteosarcoma was made. INTERVENTIONS: Wide surgical excision of the mass was performed. OUTCOMES: Three months after the operation, transthoracic echocardiography demonstrated a 3.2 cm × 2 cm recurrent mass in the wall of the left atrium (LA). She died shortly afterwards as a result of the local disease recurrence. LESSONS: In this report, we describe a rare case of primary, cardiac fibroblastic osteosarcoma, and findings are helpful for the pathologists would like to further identify the clinicopathological features of this rare tumor.
Publication type:CASE REPORTS; JOURNAL ARTICLE


  2 / 57581 MEDLINE  
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PMID:29505526
Author:Li X; Zhao Z; Liu X; Ma G; Zhu MJ
Address:Department of Critical Care Medicine.
Title:Encephalopathy associated with propofol infusion syndrome: A case report.
Source:Medicine (Baltimore); 97(1):e9521, 2018 Jan.
ISSN:1536-5964
Country of publication:United States
Language:eng
Abstract:INTRODUCTION: Propofol infusion syndrome (PRIS) is a rare but potentially fatal complication of propofol infusion. It is clinically characterized by metabolic acidosis, refractory bradycardia, rhabdomyolysis, renal failure, hyperlipidemia, and hepatomegaly. Brain lesion was only reported once in a pediatric patient. We present the 1st adult case with colon polyp and cancer who was diagnosed with PRIS. Her brain magnetic resonance imaging (MRI) and computed tomography (CT) scans reveal prominent bilateral brain lesions, matching with the proposed pathophysiologic mechanism of the syndrome. The patient received prompt acidosis correction and cardiorespiratory support. At last, she died from refractory circulatory failure. CONCLUSION: It may be necessary to order a prompt neuroimaging examination in patients suspected with PRIS to judge whether brain lesions exist or not.
Publication type:CASE REPORTS; JOURNAL ARTICLE


  3 / 57581 MEDLINE  
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PMID:28457513
Author:Bonsignore A; Orcioni GF; Barranco R; De Stefano F; Ravetti JL; Ventura F
Address:University of Genova, Department of Legal and Forensic Medicine, Via De Toni 12, Genova 16132, Italy.
Title:Fatal disseminated histoplasmosis presenting as FUO in an immunocompetent Italian host.
Source:Leg Med (Tokyo); 25:66-70, 2017 Mar.
ISSN:1873-4162
Country of publication:Ireland
Language:eng
Abstract:Histoplasmosis is a relatively rare infectious disease endemic to certain geographic areas such as East Africa, eastern and central United States, western Mexico, Central and South America. Disseminated histoplasmosis has been reported mainly in immunocompromised hosts and in AIDS patients. In this paper we report on a fatal case of undiagnosed disseminated histoplasmosis presenting as fever of unknown origin (FUO) in a 43-year-old Italian woman who, although splenectomized 5years earlier due to a motor vehicle accident, was otherwise immunocompetent. This case report highlights the fact that, even in Europe, histoplasmosis is an emerging sporadic infection which needs be considered in the differential diagnosis of given clinical scenarios. The proposed case is of blatant forensic concern as it addresses the hypothesis of professional responsibility due to a missed diagnosis of histoplasmosis. A timely diagnosis, with appropriate therapies, could have prevented death. The role of the forensic pathologist is also crucial because the post-mortem diagnosis of histoplasmosis (never considered in the differential diagnosis during prior hospitalization) highlights the importance of a meticulous and thorough autopsy to elucidate the cause of death.
Publication type:CASE REPORTS; JOURNAL ARTICLE


  4 / 57581 MEDLINE  
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PMID:28453842
Author:Lipowski D; Popiel M; Perlejewski K; Nakamura S; Bukowska-Osko I; Rzadkiewicz E; Dzieciatkowski T; Milecka A; Wenski W; Ciszek M; Debska-Slizien A; Ignacak E; Cortes KC; Pawelczyk A; Horban A; Radkowski M; Laskus T
Address:Department of Infectious Diseases, Warsaw Medical University, Warsaw, Poland.
Title:A Cluster of Fatal Tick-borne Encephalitis Virus Infection in Organ Transplant Setting.
Source:J Infect Dis; 215(6):896-901, 2017 03 15.
ISSN:1537-6613
Country of publication:United States
Language:eng
Abstract:Background: Tick-borne encephalitis virus (TBEV) infection has become a major health problem in Europe and is currently a common cause of viral brain infection in many countries. Encephalitis in transplant recipients, althrough rare, is becoming a recognized complication. Our study provides the first description of transmission of TBEV through transplantation of solid organs. Methods: Three patients who received solid organ transplants from a single donor (2 received kidney, and 1 received liver) developed encephalitis 17-49 days after transplantation and subsequently died. Blood and autopsy tissue samples were tested by next-generation sequencing (NGS) and reverse transcription polymerase chain reaction (RT-PCR). Results: All 3 recipients were first analyzed in autopsy brain tissue samples and/or cerebrospinal fluid by NGS, which yielded 24-52 million sequences per sample and 9-988 matched TBEV sequences in each patient. The presence of TBEV was confirmed by RT-PCR in all recipients and in the donor, and direct sequencing of amplification products corroborated the presence of the same viral strain. Conclusions: We demonstrated transmission of TBEV by transplantation of solid organs. In such a setting, TBEV infection may be fatal, probably due to pharmacological immunosuppression. Organ donors should be screened for TBEV when coming from or visiting endemic areas.
Publication type:CASE REPORTS; JOURNAL ARTICLE
Name of substance:0 (RNA, Viral)


  5 / 57581 MEDLINE  
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PMID:29480860
Author:Zhu H; Zhao Y; Wang X
Address:Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China.
Title:The radiosensitive effect of apatinib for hepatocellular carcinoma patient with big paraspinal metastasis: A case report.
Source:Medicine (Baltimore); 97(2):e9598, 2018 Jan.
ISSN:1536-5964
Country of publication:United States
Language:eng
Abstract:RATIONALE: Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with great mortality rates. The prognosis of advanced HCC is very poor. PATIENT CONCERNS: Here, we report a HCC patient with a big paraspinal metastasis with 10 cm in diameter who failed the treatment of sorafenib. DIAGNOSES: Sorafenib refractory HCC with big paraspinal metastasis. INTERVENTIONS: The concurrent treatment of apatinib with stereotactic body radiotherapy (SBRT). OUTCOMES: The paraspinal metastasis with 10 cm in diameter showed nearly complete response. LESSONS: We think that the apatinib may be a good choice for HCC and it may function as a radiosensitizer of HCC. However, it warrants further investigation in the future prospective clinical studies.
Publication type:CASE REPORTS; JOURNAL ARTICLE
Name of substance:0 (Antineoplastic Agents); 0 (Pyridines); 0 (Radiation-Sensitizing Agents); 5S371K6132 (apatinib)


  6 / 57581 MEDLINE  
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PMID:29419388
Author:Ladher N; Godlee F
Address:The BMJ, London, UK nladher@bmj.com.
Title:Criminalising doctors.
Source:BMJ; 360:k479, 2018 02 01.
ISSN:1756-1833
Country of publication:England
Language:eng
Publication type:CASE REPORTS; EDITORIAL


  7 / 57581 MEDLINE  
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PMID:29256426
Author:Elfadl AK; Lee SW; Kim JH; Lee KL; Arif Ullah HM; Chung MJ; Ghim SG; Lee EJ; Kim YD; Kim SM; Jeon SG; Lim JH; Choi HJ; Park JK; Jeong KS
Address:Department of Pathology, Faculty of Veterinary Medicine, Kyungpook National University, Republic of Korea.
Title:Fatal fibrino-hemorrhagic bronchopneumonia associated with Morganella morganii in a bottlenose dolphin: a case report.
Source:Dis Aquat Organ; 127(1):41-47, 2017 Dec 19.
ISSN:0177-5103
Country of publication:Germany
Language:eng
Abstract:A 5 yr old, 184 kg, and 262 cm total length female bottlenose dolphin Tursiops truncatus was found dead in a display after bloody discharge from the blowhole was observed 3 h prior to death. Pathological examination revealed fibrinous bronchopneumonia with prominent areas of necrosis (sequestra) and numerous Gram-negative bacilli within alveoli and in blood vessels of the lungs and liver and between muscle fibers. The cause of death was attributed to septicemia. Often, cases of fibrinous bronchopneumonia are characterized by bacteremia in the latter stages of infection, resulting in the death of the animal. Septicemia likely accounts for the ecchymoses and petechiae noted on the spleen, pancreas, forestomach, lungs, visceral peritoneum, and small intestine. Additional lesions included hemothorax, stable red frothy fluid in the trachea, and lymphoid depletion in the spleen and lymph nodes. Pure growth of Morganella morganii was isolated from the lungs, blood, liver, and blowhole mucosa. Sequencing of 16s rRNA of the isolated bacteria showed more than 99.6% identity with M. morganii strain FDAARGOS_172. To our knowledge, this is the first report of fatal fibrinonecrotizing bronchopneumonia associated with M. morganii infection in a cetacean.
Publication type:CASE REPORTS; JOURNAL ARTICLE


  8 / 57581 MEDLINE  
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PMID:29216959
Author:Taxitiemuer A; Tuerdi G; Zhang Y; Wushouer F; Tao XY; Talipu J; Yimamu T; Ma HL
Address:Westen China Field Epidemiology Training Program, Beijing 100050, China; Xinjiang Uyghur Autonomous Region Centers for Disease Control and Prevention, Urumqi 830002, Xinjiang, China.
Title:An Investigation of the First Case of Human Rabies Caused by a Fox in China in May 2016.
Source:Biomed Environ Sci; 30(11):825-828, 2017 Nov.
ISSN:0895-3988
Country of publication:Netherlands
Language:eng
Abstract:This study assesses the causes and prevention measures of rabies through epidemiological investigation and analysis. A field epidemiological survey was conducted to investigate a case of rabies by fox bite. The onset of symptoms began 50 days after the bite. The patient did not receive standard treatment, rabies vaccination, or rabies immunoglobulin injection. The fox was killed on the spot. Saliva and pre-death blood samples were collected at different periods, and only blood RT-PCR tests yielded positive results. Wild fox bite is a major risk factor of rabies infection in Xinjiang Province, China.
Publication type:CASE REPORTS; JOURNAL ARTICLE


  9 / 57581 MEDLINE  
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PMID:29390362
Author:Corrias G; Horvat N; Monti S; Basturk O; Lin O; Saba L; Bodei L; Reidy DL; Mannelli L
Address:Department of Radiology, Memorial Sloan Kettering Cancer Center, NY.
Title:Malignant transformation of glucagonoma with SPECT/CT In-111 OctreoScan features: A case report.
Source:Medicine (Baltimore); 96(50):e9252, 2017 Dec.
ISSN:1536-5964
Country of publication:United States
Language:eng
Abstract:RATIONALE: Glucagonoma is an uncommon disease but it has been associated with a pattern of symptoms defined as glucagonoma syndrome. These symptoms, if promptly recognized, could help to speed up the diagnosing process. PATIENT CONCERNS: We report a case of a 68-year-old woman with a pancreatic glucagonoma. Her symptoms at the onset were typical of the glucagonoma syndrome. DIAGNOSES: After a significant weight loss, she underwent a computer tomography scan of the abdomen, which showed a hypervascular lesion of the tail of the pancreas and hypervascular lesions of the liver. An ultrasound guided biopsy was performed and pathology was consistent with glucagonoma. Her blood glucagon levels were elevated. OUTCOMES: She was treated with chemotherapy and somatostatin analogs. After 4 years, the disease had a malignant transformation, and metastases suddenly started to grow up. She stopped being responsive to treatment and eventually passed away. LESSONS: Due to its rarity, clinical diagnosis is challenging and generally it comes after a long interval since the onset of symptoms. Awareness of physicians and dermatologists of the characteristic necrolytic migratory erythema, and of the other symptoms, often leads to early diagnosis.
Publication type:CASE REPORTS; JOURNAL ARTICLE
Name of substance:0 (Radiopharmaceuticals); 0 (indium-111-octreotide); RWM8CCW8GP (Octreotide)


  10 / 57581 MEDLINE  
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PMID:29289270
Author:Lin E; Veeramachaneni H; Addissie B; Arora A
Address:Department of Internal Medicine and the Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota. Electronic address: lin.erica@mayo.edu.
Title:Squamous Cell Carcinoma of the Pancreas.
Source:Am J Med Sci; 355(1):94-96, 2018 Jan.
ISSN:1538-2990
Country of publication:United States
Language:eng
Publication type:CASE REPORTS; JOURNAL ARTICLE



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