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  1 / 27301 MEDLINE  
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[PMID]:29203756
[Au] Autor:Kononenko M; Vynnychenko I; Moskalenko Y; Vynnychenko O
[Ad] Endereço:Department Of Surgery And Oncology, Sumy State University, Sumy, Ukraine.
[Ti] Título:12 years of fighting liposarcoma: a case report.
[So] Source:Wiad Lek;70(5):995-997, 2017.
[Is] ISSN:0043-5147
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The proportion of liposarcoma in the structure of cancer incidence is from 10 to 35% of all mesenchymal tumors. This clinical observation describes an 12-year struggle with myxoid liposarcoma of the left upper arm, during which 17 surgeries were performed due to local recurrences, 17 radiation therapy courses and 5 chemotherapy courses were conducted. Clinical observation shows the whole complexity of myxoid liposarcoma treatment. The effectiveness of therapeutic management is determined by persistent surgery, and also by the lack of expression of Pgp, glutathione-S-transferase, metallothionein and mutant p53 in tumor structure.
[Mh] Termos MeSH primário: Braço/patologia
Lipossarcoma Mixoide/terapia
Recidiva Local de Neoplasia/terapia
[Mh] Termos MeSH secundário: Adulto
Terapia Combinada
Seres Humanos
Lipossarcoma Mixoide/tratamento farmacológico
Lipossarcoma Mixoide/radioterapia
Lipossarcoma Mixoide/cirurgia
Masculino
Recidiva Local de Neoplasia/tratamento farmacológico
Recidiva Local de Neoplasia/radioterapia
Recidiva Local de Neoplasia/cirurgia
Estadiamento de Neoplasias
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  2 / 27301 MEDLINE  
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[PMID]:29390374
[Au] Autor:Tang S; Wu X; Shen H; Wang Y; Li J; Zhang J
[Ad] Endereço:Plastic and Aesthetic Surgery Department of Hangzhou First People's Hospital.
[Ti] Título:Use of small needle knife in autologous fat grafting for the treatment of depressed scar: A case report.
[So] Source:Medicine (Baltimore);96(50):e9266, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Scars always related to functional limitations, cosmetic impairment, and social and emotional problems. Clinical improvements in scar characteristics after autologous fat grafting are well described. In this paper, we present an innovative approach to treat depressed scars. PATIENT CONCERNS: We presented a 29-year-old woman with multiple depressed scars in the left upper arm and near the elbow joint after trauma in childhood. DIAGNOSES: The patient was diagnosed as having multiple depressed scars accompanied with retraction and pain. INTERVENTIONS: We used small needle knife during fat grafting to treat the depressed scar. Vancouver Scar Scale was used to assess the effect. OUTCOMES: Aesthetic and functional improvements were observed. Resolution of pain and improvement in scar elasticity were objectively assessable. Improvement of both clinical evaluation and patient perception was obtained. LESSONS: Use of small needle knife during fat grafting is a good alternative for the treatment of depressed scars.
[Mh] Termos MeSH primário: Tecido Adiposo/transplante
Braço
Cicatriz/cirurgia
Agulhas
[Mh] Termos MeSH secundário: Adulto
Autoenxertos
Desenho de Equipamento
Feminino
Seres Humanos
Medição da Dor
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009266


  3 / 27301 MEDLINE  
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[PMID]:29352303
[Au] Autor:Gerli MFM; Guyette JP; Evangelista-Leite D; Ghoshhajra BB; Ott HC
[Ad] Endereço:Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
[Ti] Título:Perfusion decellularization of a human limb: A novel platform for composite tissue engineering and reconstructive surgery.
[So] Source:PLoS One;13(1):e0191497, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Muscle and fasciocutaneous flaps taken from autologous donor sites are currently the most utilized approach for trauma repair, accounting annually for 4.5 million procedures in the US alone. However, the donor tissue size is limited and the complications related to these surgical techniques lead to morbidities, often involving the donor sites. Alternatively, recent reports indicated that extracellular matrix (ECM) scaffolds boost the regenerative potential of the injured site, as shown in a small cohort of volumetric muscle loss patients. Perfusion decellularization is a bioengineering technology that allows the generation of clinical-scale ECM scaffolds with preserved complex architecture and with an intact vascular template, from a variety of donor organs and tissues. We recently reported that this technology is amenable to generate full composite tissue scaffolds from rat and non-human primate limbs. Translating this platform to human extremities could substantially benefit soft tissue and volumetric muscle loss patients providing tissue- and species-specific grafts. In this proof-of-concept study, we show the successful generation a large-scale, acellular composite tissue scaffold from a full cadaveric human upper extremity. This construct retained its morphological architecture and perfusable vascular conduits. Histological and biochemical validation confirmed the successful removal of nuclear and cellular components, and highlighted the preservation of the native extracellular matrix components. Our results indicate that perfusion decellularization can be applied to produce human composite tissue acellular scaffolds. With its preserved structure and vascular template, these biocompatible constructs, could have significant advantages over the currently implanted matrices by means of nutrient distribution, size-scalability and immunological response.
[Mh] Termos MeSH primário: Braço/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Engenharia Tecidual/métodos
Tecidos Suporte
[Mh] Termos MeSH secundário: Animais
Braço/anatomia & histologia
Braço/irrigação sanguínea
Reatores Biológicos
Cadáver
Matriz Extracelular/química
Seres Humanos
Imagem Tridimensional
Masculino
Meia-Idade
Perfusão
Ratos
Engenharia Tecidual/instrumentação
Tecidos Suporte/química
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191497


  4 / 27301 MEDLINE  
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[PMID]:29342217
[Au] Autor:Resnik LJ; Borgia ML; Acluche F; Cancio JM; Latlief G; Sasson N
[Ad] Endereço:Research Department, Providence VA Medical Center, Providence, Rhode Island, United States of America.
[Ti] Título:How do the outcomes of the DEKA Arm compare to conventional prostheses?
[So] Source:PLoS One;13(1):e0191326, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Objectives were to 1) compare self-reported function, dexterity, activity performance, quality of life and community integration of the DEKA Arm to conventional prostheses; and 2) examine differences in outcomes by conventional prosthesis type, terminal device type and by DEKA Arm configuration level. METHODS: This was a two-part study; Part A consisted of in-laboratory training. Part B consisted of home use. Study participants were 23 prosthesis users (mean age = 45 ± 16; 87% male) who completed Part A, and 15 (mean age = 45 ± 18; 87% male) who completed Parts A and B. Outcomes including self-report and performance measures, were collected at Baseline using participants' personal prostheses and at the End of Parts A and B. Scores were compared using paired t-tests. Wilcoxon signed-rank tests were used to compare outcomes for the full sample, and for the sample stratified by device and terminal device type. Analysis of outcomes by configuration level was performed graphically. RESULTS: At the End of Part A activity performance using the DEKA Arm and conventional prosthesis was equivalent, but slower with the DEKA Arm. After Part B, performance using the DEKA Arm surpassed conventional prosthesis scores, and speed of activity completion was equivalent. Participants reported using the DEKA Arm to perform more activities, had less perceived disability, and less difficulty in activities at the End of A and B as compared to Baseline. No differences were observed in dexterity, prosthetic skill, spontaneity, pain, community integration or quality of life. Comparisons stratified by device type revealed similar patterns. Graphic comparisons revealed variations by configuration level. CONCLUSION: Participants using the DEKA Arm had less perceived disability and more engagement of the prosthesis in everyday tasks, although activity performance was slower. After home use experience, activity performance was improved and activity speed equivalent to using conventional prostheses.
[Mh] Termos MeSH primário: Braço
Desenho de Prótese
[Mh] Termos MeSH secundário: Atividades Cotidianas
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Satisfação do Paciente
Qualidade de Vida
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191326


  5 / 27301 MEDLINE  
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[PMID]:29292975
[Au] Autor:Bryant JR; Hajjar RT; Lumley C; Chaiyasate K
[Ti] Título:Clinical Inquiry-In women who have undergone breast cancer surgery, including lymph node removal, do blood pressure measurements taken in the ipsilateral arm increase the risk of lymphedema?
[So] Source:J Okla State Med Assoc;109(12):589-91, 2016 12.
[Is] ISSN:0030-1876
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Throughout the healthcare industry fears of taking blood pressure in the arm of patients who have undergone breast cancer surgery have been propagated for decades and continue to be recommended by multiple societies and healthcare organizations. However, these precautions are not well based on evidence-based medicine and may have a more historical and traditional basis. The purpose of this study was to review current evidence-based research as well as current guidelines regarding ipsilateral arm blood pressure measurements in women who have undergone breast surgery for cancer including lymph node removal.
[Mh] Termos MeSH primário: Determinação da Pressão Arterial/efeitos adversos
Determinação da Pressão Arterial/métodos
Neoplasias da Mama/cirurgia
Excisão de Linfonodo
Linfedema/epidemiologia
Linfedema/etiologia
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/etiologia
[Mh] Termos MeSH secundário: Braço
Feminino
Seres Humanos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


  6 / 27301 MEDLINE  
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[PMID]:28281879
[Au] Autor:Jones B; Till K; Roe G; O'Hara J; Lees M; Barlow MJ; Hind K
[Ad] Endereço:a Institute for Sport, Physical Activity and Leisure , Leeds Beckett University , Leeds , UK.
[Ti] Título:Six-year body composition change in male elite senior rugby league players.
[So] Source:J Sports Sci;36(3):266-271, 2018 Feb.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the change in body composition and bone mineral content (BMC) of senior rugby league (RL) players between 2008 and 2014. Twelve male professional RL players (age, 24.6 ± 4.0 years; stature, 183.4 ± 8.4 cm) received a dual-energy X-ray absorptiometry scan during preseason in 2008 and 2014. Between 2008 and 2014, very likely increases in leg lean mass (LM), total trunk and leg BMC, and a likely increase in arm BMC and possible increases in body mass (BM), total and trunk fat mass (FM), and total, trunk and arm LM were observed. Unlikely decreases and unclear changes in leg and arm FM were also found. Large negative correlations were observed between age and BM (r = -0.72), LM (r = -0.70), FM (r = -0.61) and BMC (r = -0.84) change. Three participants (19.1 ± 1.6 years) increased LM by 7.0-9.3 kg. Younger players had the largest increases in LM during this period, although an older player (30-year old) still increased LM. Differences in body composition change were also observed for participants of the same age, thus contextual factors should be considered. This study demonstrates the individuality of body composition changes in senior professional rugby players, while considering the potential change in young athletes.
[Mh] Termos MeSH primário: Composição Corporal/fisiologia
Densidade Óssea/fisiologia
Futebol Americano/fisiologia
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adulto
Fatores Etários
Braço/anatomia & histologia
Seres Humanos
Perna (Membro)/anatomia & histologia
Estudos Longitudinais
Masculino
Fatores de Tempo
Tronco/anatomia & histologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1300313


  7 / 27301 MEDLINE  
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[PMID]:29390585
[Au] Autor:Lee SY; Jeon YT; Kim BR; Han EY
[Ad] Endereço:Department of Rehabilitation Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Republic of Korea.
[Ti] Título:Combined treatment of botulinumtoxin and robot-assisted rehabilitation therapy on poststroke, upper limb spasticity: A case report.
[So] Source:Medicine (Baltimore);96(51):e9468, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Spasticity is a major complication after stroke, and botulinumtoxin A (BoNT-A) injection is commonly used to manage focal spasticity. However, it is uncertain whether BoNT-A can improve voluntary motor control or activities of daily living function of paretic upper limbs. This study investigated whether BoNT-A injection combined with robot-assisted upper limb therapy improves voluntary motor control or functions of upper limbs after stroke. PATIENT CONCERNS: Two subacute stroke patients were transferred to the Department of Rehabilitation. DIAGNOSES: Patients demonstrated spasticity in the upper extremity on the affected side. INTERVENTIONS: BoNT-A was injected into the paretic muscles of the shoulder, arm, and forearm of the 2 patients at the subacute stage. Conventional rehabilitation therapy and robot-assisted upper limb training were performed during the rehabilitation period. OUTCOMES: Manual dexterity, grip strength, muscle tone, and activities of daily living function were improved after multidisciplinary rehabilitation treatment. LESSONS: BoNT-A injection in combination with multidisciplinary rehabilitation treatment, including robot-assisted arm training, should be recommended for subacute spastic stroke patients to enhance appropriate motor recovery.
[Mh] Termos MeSH primário: Toxinas Botulínicas/uso terapêutico
Espasticidade Muscular/etiologia
Robótica/métodos
Reabilitação do Acidente Vascular Cerebral/métodos
Acidente Vascular Cerebral/complicações
[Mh] Termos MeSH secundário: Adulto
Braço
Terapia Combinada
Feminino
Seres Humanos
Masculino
Meia-Idade
Espasticidade Muscular/reabilitação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.24.69 (Botulinum Toxins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009468


  8 / 27301 MEDLINE  
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[PMID]:29346374
[Au] Autor:Sun L; Zou T; Wang BZ; Liu F; Yuan QH; Ma YT; Ma X
[Ad] Endereço:Department of Cardiology, First Affiliated Hospital of Xingjiang Medical University, Urumqi, China.
[Ti] Título:Epidemiological investigation into the prevalence of abnormal inter-arm blood pressure differences among different ethnicities in Xinjiang, China.
[So] Source:PLoS One;13(1):e0188546, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The prevalence of and risk factors for IAD among different ethnicity groups was unknown. Our aim was to investigate the prevalence of and risk factors for IAD among Han, Uygur and Kazakh ethnicities in Xinjiang. China. METHODS: In total, 14,618 adult participants (7,799 males and 6,819 females) were recruited from the Cardiovascular Risk Survey. A 4-stage stratified cluster random sampling method was used. The participants' personal information and medical history were assessed by questionnaire. IAD was diagnosed by a noninvasive arteriosclerosis analyzer. RESULTS: The prevalence of abnormal IAD among the general population was 14.3%, with 12.5% in the Han, 14.9% in the Uygur, and 16.4% in the Kazakh populations. The prevalence of abnormal IAD among the hypertensive population was 19.4%, with 17.0% in the Han, 18.1% in the Uygur, and 22.7% in the Kazakh populations. The prevalence of abnormal IAD increased with age (all P < 0.01) but was not significantly different between the genders (all P> 0.05). Multivariate logistic regression analysis showed that age more than 45 years, obesity and hypertriglyceridemia were significantly associated with a higher prevalence of IAD. There were different risk factors for abnormal IAD in different ethnicities. Middle or old age, obesity, ABI and diabetes mellitus were risk factors for the Han population, smoking was a risk factor in the Uygur population, and obesity and PAD were risk factors in the Kazakh population. CONCLUSION: The prevalence of abnormal IAD in the Kazakh participants was higher than that in the Han and Uygur populations among both the general population and the hypertensive population in Xinjiang, China. The main risk factors of IAD were age, obesity, and triglyceride levels. Different ethnicities had different kinds of risk factors for IAD.
[Mh] Termos MeSH primário: Braço
Pressão Sanguínea
Grupos Étnicos
[Mh] Termos MeSH secundário: Adulto
Idoso
China/epidemiologia
Feminino
Seres Humanos
Hipertensão/epidemiologia
Masculino
Meia-Idade
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188546


  9 / 27301 MEDLINE  
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[PMID]:29262271
[Au] Autor:Zheng MX; Hua XY; Feng JT; Li T; Lu YC; Shen YD; Cao XH; Zhao NQ; Lyu JY; Xu JG; Gu YD; Xu WD
[Ad] Endereço:From the Department of Hand Surgery, Huashan Hospital (M.-X.Z., X.-Y.H., J.-T.F., T.L., Y.-C.L., Y.-D.S., J.-G.X., Y.-D.G., W.-D.X.), the National Clinical Research Center for Aging and Medicine (M.-X.Z., X.-Y.H., J.-T.F., T.L., Y.-C.L., Y.-D.S., J.-G.X., Y.-D.G., W.-D.X.), Department of Biostatisti
[Ti] Título:Trial of Contralateral Seventh Cervical Nerve Transfer for Spastic Arm Paralysis.
[So] Source:N Engl J Med;378(1):22-34, 2018 01 04.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Spastic limb paralysis due to injury to a cerebral hemisphere can cause long-term disability. We investigated the effect of grafting the contralateral C7 nerve from the nonparalyzed side to the paralyzed side in patients with spastic arm paralysis due to chronic cerebral injury. METHODS: We randomly assigned 36 patients who had had unilateral arm paralysis for more than 5 years to undergo C7 nerve transfer plus rehabilitation (18 patients) or to undergo rehabilitation alone (18 patients). The primary outcome was the change from baseline to month 12 in the total score on the Fugl-Meyer upper-extremity scale (scores range from 0 to 66, with higher scores indicating better function). Results The mean increase in Fugl-Meyer score in the paralyzed arm was 17.7 in the surgery group and 2.6 in the control group (difference, 15.1; 95% confidence interval, 12.2 to 17.9; P<0.001). With regard to improvements in spasticity as measured on the Modified Ashworth Scale (an assessment of five joints, each scored from 0 to 5, with higher scores indicating more spasticity), the smallest between-group difference was in the thumb, with 6, 9, and 3 patients in the surgery group having a 2-unit improvement, a 1-unit improvement, or no change, respectively, as compared with 1, 6, and 7 patients in the control group (P=0.02). Transcranial magnetic stimulation and functional imaging showed connectivity between the ipsilateral hemisphere and the paralyzed arm. There were no significant differences from baseline to month 12 in power, tactile threshold, or two-point discrimination in the hand on the side of the donor graft. RESULTS: The mean increase in Fugl-Meyer score in the paralyzed arm was 17.7 in the surgery group and 2.6 in the control group (difference, 15.1; 95% confidence interval, 12.2 to 17.9; P<0.001). With regard to improvements in spasticity as measured on the Modified Ashworth Scale (an assessment of five joints, each scored from 0 to 5, with higher scores indicating more spasticity), the smallest between-group difference was in the thumb, with 6, 9, and 3 patients in the surgery group having a 2-unit improvement, a 1-unit improvement, or no change, respectively, as compared with 1, 6, and 7 patients in the control group (P=0.02). Transcranial magnetic stimulation and functional imaging showed connectivity between the ipsilateral hemisphere and the paralyzed arm. There were no significant differences from baseline to month 12 in power, tactile threshold, or two-point discrimination in the hand on the side of the donor graft. CONCLUSIONS: In this single-center trial involving patients who had had unilateral arm paralysis due to chronic cerebral injury for more than 5 years, transfer of the C7 nerve from the nonparalyzed side to the side of the arm that was paralyzed was associated with a greater improvement in function and reduction of spasticity than rehabilitation alone over a period of 12 months. Physiological connectivity developed between the ipsilateral cerebral hemisphere and the paralyzed hand. (Funded by the National Natural Science Foundation of China and others; Chinese Clinical Trial Registry number, 13004466 .).
[Mh] Termos MeSH primário: Braço/inervação
Hemiplegia/cirurgia
Espasticidade Muscular/cirurgia
Transferência de Nervo
Nervos Periféricos/transplante
[Mh] Termos MeSH secundário: Potenciais de Ação
Adolescente
Adulto
Encéfalo/diagnóstico por imagem
Lesões Encefálicas Traumáticas/complicações
Paralisia Cerebral/complicações
Avaliação da Deficiência
Hemiplegia/etiologia
Hemiplegia/reabilitação
Seres Humanos
Masculino
Espasticidade Muscular/etiologia
Espasticidade Muscular/reabilitação
Transferência de Nervo/efeitos adversos
Nervos Periféricos/anatomia & histologia
Nervos Periféricos/fisiologia
Acidente Vascular Cerebral/complicações
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1615208


  10 / 27301 MEDLINE  
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[PMID]:29272289
[Au] Autor:Simmatis L; Krett J; Scott SH; Jin AY
[Ad] Endereço:Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
[Ti] Título:Robotic exoskeleton assessment of transient ischemic attack.
[So] Source:PLoS One;12(12):e0188786, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We used a robotic exoskeleton to quantify specific patterns of abnormal upper limb motor behaviour in people who have had transient ischemic attack (TIA). A cohort of people with TIA was recruited within two weeks of symptom onset. All individuals completed a robotic-based assessment of 8 behavioural tasks related to upper limb motor and proprioceptive function, as well as cognitive function. Robotic task performance was compared to a large cohort of controls without neurological impairments corrected for the influence of age. Impairment in people with TIA was defined as performance below the 5th percentile of controls. Participants with TIA were also assessed with the National Institutes of Health Stroke Scale (NIHSS) score, Chedoke-McMaster Stroke Assessment (CMSA) of the arm, the Behavioural Inattention Test (BIT), the Purdue pegboard test (PPB), and the Montreal Cognitive Assessment (MoCA). Age-related white matter change (ARWMC), prior infarction and cella-media index (CMI) were assessed from baseline CT scan that was performed within 24 hours of TIA. Acute infarction was assessed from diffusion-weighted imaging in a subset of people with TIA. Twenty-two people with TIA were assessed. Robotic assessment showed impaired upper limb motor function in 7/22 people with TIA patients and upper limb sensory impairment in 4/22 individuals. Cognitive tasks involving robotic assessment of the upper limb were completed in 13 participants, of whom 8 (61.5%) showed significant impairment. Abnormal performance in the CMSA arm inventory was present in 12/22 (54.5%) participants. ARWMC was 11.8 ± 6.4 and CMI was 5.4 ± 1.5. DWI was positive in 0 participants. Quantitative robotic assessment showed that people who have had a TIA display a spectrum of upper limb motor and sensory performance deficits as well as cognitive function deficits despite resolution of symptoms and no evidence of tissue infarction.
[Mh] Termos MeSH primário: Ataque Isquêmico Transitório/diagnóstico
Robótica
[Mh] Termos MeSH secundário: Braço/fisiopatologia
Feminino
Seres Humanos
Ataque Isquêmico Transitório/fisiopatologia
Masculino
Atividade Motora
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188786



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