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  1 / 8116 MEDLINE  
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[PMID]:29262274
[Au] Autor:Cunningham LL; Tucci DL
[Ad] Endereço:From the Section on Sensory Cell Biology, National Institute on Deafness and Other Communication Disorders, Bethesda, MD (L.L.C.); and the Division of Head and Neck Surgery and Communication Sciences, Duke University Medical Center, Durham, NC (D.L.T.).
[Ti] Título:Hearing Loss in Adults.
[So] Source:N Engl J Med;377(25):2465-2473, 2017 Dec 21.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Perda Auditiva
Testes Auditivos
[Mh] Termos MeSH secundário: Adulto
Implantes Cocleares
Orelha/anatomia & histologia
Predisposição Genética para Doença
Auxiliares de Audição
Perda Auditiva/classificação
Perda Auditiva/diagnóstico
Perda Auditiva/etiologia
Perda Auditiva/terapia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMra1616601


  2 / 8116 MEDLINE  
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[PMID]:29216159
[Au] Autor:Tang P; Liu S; Chen J; Yuan Z; Xie B; Zhou J; Tang Z
[Ti] Título:Cross-correlation photothermal optical coherence tomography with high effective resolution.
[So] Source:Opt Lett;42(23):4974-4977, 2017 Dec 01.
[Is] ISSN:1539-4794
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We developed a cross-correlation photothermal optical coherence tomography (CC-PTOCT) system for photothermal imaging with high lateral and axial resolution. The CC-PTOCT system consists of a phase-sensitive OCT system, a modulated pumping laser, and a digital cross-correlator. The pumping laser was used to induce the photothermal effect in the sample, causing a slight phase modulation of the OCT signals. A spatial phase differentiation method was employed to reduce phase accumulation. The noise brought by the phase differentiation method and the strong background noise were suppressed efficiently by the cross-correlator, which was utilized to extract the photothermal signals from the modulated signals. Combining the cross-correlation technique with spatial phase differentiation can improve both lateral and axial resolution of the PTOCT imaging system. Clear photothermal images of blood capillaries of a mouse ear in vivo were successfully obtained with high lateral and axial resolution. The experimental results demonstrated that this system can enhance the effective transverse resolution, effective depth resolution, and contrast of the PTOCT image effectively, aiding the ongoing development of the accurate 3D functional imaging.
[Mh] Termos MeSH primário: Razão Sinal-Ruído
Temperatura Ambiente
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Animais
Capilares/diagnóstico por imagem
Orelha/irrigação sanguínea
Imagem Tridimensional
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1364/OL.42.004974


  3 / 8116 MEDLINE  
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[PMID]:29198719
[Au] Autor:Shaffer JR; Li J; Lee MK; Roosenboom J; Orlova E; Adhikari K; Gallo C; Poletti G; Schuler-Faccini L; Bortolini MC; Canizales-Quinteros S; Rothhammer F; Bedoya G; González-José R; Pfeffer PE; Wollenschlaeger CA; Hecht JT; Wehby GL; Moreno LM; Ding A; Jin L; Yang Y; Carlson JC; Leslie EJ; Feingold E; Marazita ML; Hinds DA; Cox TC; Wang S; Ruiz-Linares A; Weinberg SM; 23andMe Research Team
[Ad] Endereço:Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
[Ti] Título:Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment.
[So] Source:Am J Hum Genet;101(6):913-924, 2017 Dec 07.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The genetic basis of earlobe attachment has been a matter of debate since the early 20 century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci associated with the trait, but large-scale analyses are still lacking. Here, we performed a genome-wide association study of lobe attachment in a multiethnic sample of 74,660 individuals from four cohorts (three with the trait scored by an expert rater and one with the trait self-reported). Meta-analysis of the three expert-rater-scored cohorts revealed six associated loci harboring numerous candidate genes, including EDAR, SP5, MRPS22, ADGRG6 (GPR126), KIAA1217, and PAX9. The large self-reported 23andMe cohort recapitulated each of these six loci. Moreover, meta-analysis across all four cohorts revealed a total of 49 significant (p < 5 × 10 ) loci. Annotation and enrichment analyses of these 49 loci showed strong evidence of genes involved in ear development and syndromes with auricular phenotypes. RNA sequencing data from both human fetal ear and mouse second branchial arch tissue confirmed that genes located among associated loci showed evidence of expression. These results provide strong evidence for the polygenic nature of earlobe attachment and offer insights into the biological basis of normal and abnormal ear development.
[Mh] Termos MeSH primário: Orelha/anatomia & histologia
Herança Multifatorial/genética
Locos de Características Quantitativas/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Região Branquial/anatomia & histologia
Criança
Pré-Escolar
Proteínas de Ligação a DNA/genética
Receptor Edar/genética
Estudo de Associação Genômica Ampla
Genótipo
Seres Humanos
Camundongos
Meia-Idade
Proteínas Mitocondriais/genética
Fator de Transcrição PAX9/genética
Proteínas/genética
Receptores Acoplados a Proteínas-G/genética
Proteínas Ribossômicas/genética
Fatores de Transcrição/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (EDAR protein, human); 0 (Edar Receptor); 0 (GPR126 protein, human); 0 (MRPS22 protein, human); 0 (Mitochondrial Proteins); 0 (PAX9 Transcription Factor); 0 (PAX9 protein, human); 0 (Proteins); 0 (Receptors, G-Protein-Coupled); 0 (Ribosomal Proteins); 0 (SKT protein, human); 0 (SP5 protein, human); 0 (Transcription Factors)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  4 / 8116 MEDLINE  
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[PMID]:29293562
[Au] Autor:Abraham U; Schlichting JK; Kramer A; Herzel H
[Ad] Endereço:Laboratory of Chronobiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Quantitative analysis of circadian single cell oscillations in response to temperature.
[So] Source:PLoS One;13(1):e0190004, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Body temperature rhythms synchronize circadian oscillations in different tissues, depending on the degree of cellular coupling: the responsiveness to temperature is higher when single circadian oscillators are uncoupled. So far, the role of coupling in temperature responsiveness has only been studied in organotypic tissue slices of the central circadian pacemaker, because it has been assumed that peripheral target organs behave like uncoupled multicellular oscillators. Since recent studies indicate that some peripheral tissues may exhibit cellular coupling as well, we asked whether peripheral network dynamics also influence temperature responsiveness. Using a novel technique for long-term, high-resolution bioluminescence imaging of primary cultured cells, exposed to repeated temperature cycles, we were able to quantitatively measure period, phase, and amplitude of central (suprachiasmatic nuclei neuron dispersals) and peripheral (mouse ear fibroblasts) single cell oscillations in response to temperature. Employing temperature cycles of different lengths, and different cell densities, we found that some circadian characteristics appear cell-autonomous, e.g. period responses, while others seem to depend on the quality/degree of cellular communication, e.g. phase relationships, robustness of the oscillation, and amplitude. Overall, our findings indicate a strong dependence on the cell's ability for intercellular communication, which is not only true for neuronal pacemakers, but, importantly, also for cells in peripheral tissues. Hence, they stress the importance of comparative studies that evaluate the degree of coupling in a given tissue, before it may be used effectively as a target for meaningful circadian manipulation.
[Mh] Termos MeSH primário: Ritmo Circadiano
Temperatura Ambiente
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Orelha
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190004


  5 / 8116 MEDLINE  
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[PMID]:29261683
[Au] Autor:Bright T; Mulwafu W; Thindwa R; Zuurmond M; Polack S
[Ad] Endereço:London School of Hygiene & Tropical Medicine, London, United Kingdom.
[Ti] Título:Reasons for low uptake of referrals to ear and hearing services for children in Malawi.
[So] Source:PLoS One;12(12):e0188703, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Early detection and appropriate intervention for children with hearing impairment is important for maximizing functioning and quality of life. The lack of ear and hearing services in low income countries is a significant challenge, however, evidence suggests that even where such services are available, and children are referred to them, uptake is low. The aim of this study was to assess uptake of and barriers to referrals to ear and hearing services for children in Thyolo District, Malawi. METHODS: This was a mixed methods study. A survey was conducted with 170 caregivers of children who were referred for ear and hearing services during community-based screening camps to assess whether they had attended their referral and reasons for non-attendance. Semi-structured interviews were conducted with 23 caregivers of children who did not take up their referral to explore in-depth the reasons for non-uptake. In addition, 15 stakeholders were interviewed. Thematic analysis of the interview data was conducted and emerging trends were analysed. RESULTS: Referral uptake was very low with only 5 out of 150 (3%) children attending. Seven main interacting themes for non-uptake of referral were identified in the semi-structured interviews: location of the hospital, lack of transport, other indirect costs of seeking care, fear and uncertainty about the referral hospital, procedural problems within the camps, awareness and understanding of hearing loss, and lack of visibility and availability of services. CONCLUSION: This study has highlighted a range of interacting challenges faced by families in accessing ear and hearing services in this setting. Understanding these context specific barriers to non-uptake of ear and hearing services is important for designing appropriate interventions to increase uptake.
[Mh] Termos MeSH primário: Orelha/fisiologia
Audição/fisiologia
Encaminhamento e Consulta
[Mh] Termos MeSH secundário: Criança
Custos e Análise de Custo
Feminino
Seguimentos
Conhecimentos, Atitudes e Prática em Saúde
Acesso aos Serviços de Saúde
Perda Auditiva/economia
Perda Auditiva/epidemiologia
Perda Auditiva/fisiopatologia
Seres Humanos
Recém-Nascido
Malaui/epidemiologia
Masculino
Inquéritos e Questionários
Transportes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188703


  6 / 8116 MEDLINE  
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[PMID]:29253030
[Au] Autor:Shim HJ; An YH; Kim DH; Yoon JE; Yoon JH
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Eulji University School of Medicine, Eulji Medical Center, Seoul, Korea.
[Ti] Título:Comparisons of auditory brainstem response and sound level tolerance in tinnitus ears and non-tinnitus ears in unilateral tinnitus patients with normal audiograms.
[So] Source:PLoS One;12(12):e0189157, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Recently, "hidden hearing loss" with cochlear synaptopathy has been suggested as a potential pathophysiology of tinnitus in individuals with a normal hearing threshold. Several studies have demonstrated that subjects with tinnitus and normal audiograms show significantly reduced auditory brainstem response (ABR) wave I amplitudes compared with control subjects, but normal wave V amplitudes, suggesting increased central auditory gain. We aimed to reconfirm the "hidden hearing loss" theory through a within-subject comparison of wave I and wave V amplitudes and uncomfortable loudness level (UCL), which might be decreased with increased central gain, in tinnitus ears (TEs) and non-tinnitus ears (NTEs). SUBJECTS AND METHODS: Human subjects included 43 unilateral tinnitus patients (19 males, 24 females) with normal and symmetric hearing thresholds and 18 control subjects with normal audiograms. The amplitudes of wave I and V from the peak to the following trough were measured twice at 90 dB nHL and we separately assessed UCLs at 500 Hz and 3000 Hz pure tones in each TE and NTE. RESULTS: The within-subject comparison between TEs and NTEs showed no significant differences in wave I and wave V amplitude, or wave V/I ratio in both the male and female groups. Individual data revealed increased V/I amplitude ratios > mean + 2 SD in 3 TEs, but not in any control ears. We found no significant differences in UCL at 500 Hz or 3000 Hz between the TEs and NTEs, but the UCLs of both TEs and NTEs were lower than those of the control ears. CONCLUSIONS: Our ABR data do not represent meaningful evidence supporting the hypothesis of cochlear synaptopathy with increased central gain in tinnitus subjects with normal audiograms. However, reduced sound level tolerance in both TEs and NTEs might reflect increased central gain consequent on hidden synaptopathy that was subsequently balanced between the ears by lateral olivocochlear efferents.
[Mh] Termos MeSH primário: Audiometria de Tons Puros
Limiar Auditivo/fisiologia
Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia
Som
Zumbido/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Orelha/fisiopatologia
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189157


  7 / 8116 MEDLINE  
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[PMID]:29078841
[Au] Autor:Levander MS; Grodzinsky E
[Ad] Endereço:Division of Nursing, Faculty of Medicine, Linköping University, Linköping, Sweden. Electronic address: martha.sund-levander@liu.se.
[Ti] Título:Variation in Normal Ear Temperature.
[So] Source:Am J Med Sci;354(4):370-378, 2017 Oct.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Variation in baseline ear temperature, taken in the unadjusted mode, has yet to be established in different age groups. Because normal body temperatures show large variations, the same may be expected for increased temperatures in fever. The aims were to study variations in normothermic body temperatures measured with an ear thermometer and to determine differences between actual and perceived body temperature during a febrile episode (referred to as difftemp) in apparently healthy children and adults. METHODS: Ear temperature was measured once in 2,006 individuals (61.7% females): 683 children aged 2 and 4 years, 492 adolescents aged 10-18 years, 685 adults aged 19-65 years and 146 elderly aged 66-89 years. Difftemp was estimated as the difference between the individual's ear body temperature, measured in the present study, and the respondent's reported temperature when feverish. RESULTS: Mean ear temperature was 36.4 ± 0.6°C overall and in the child and adult groups. In adolescents, it was 36.5 ± 0.5°C, and in elderly, 36.1 ± 0.5°C. Temperature in men was 36.3 ± 0.6°C, and in women, 36.5 ± 0.5°C. Difftemp was 1.1 ± 0.7°C in adolescents, 1.5 ± 0.7°C in children and adults, and 1.6 ± 0.7°C in those >65 years. CONCLUSIONS: Ear body temperature is lower than traditionally reported and differs with age and sex. An individual difftemp of 1.0-1.5°C along with malaise might indicate fever.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Temperatura Corporal/fisiologia
Orelha
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Fatores Sexuais
Termômetros
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE


  8 / 8116 MEDLINE  
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[PMID]:29036194
[Au] Autor:Aiglstorfer M; Costeur L; Mennecart B; Heizmann EPJ
[Ad] Endereço:Staatliches Museum für Naturkunde Stuttgart, Rosenstein 1, Stuttgart, Germany.
[Ti] Título:Micromeryx? eiselei-A new moschid species from Steinheim am Albuch, Germany, and the first comprehensive description of moschid cranial material from the Miocene of Central Europe.
[So] Source:PLoS One;12(10):e0185679, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Moschids are enigmatic pecoran ruminants whose phylogeny is still not fully understood. So far we know only little of the family's early evolutionary history and the origin of the modern genus, Moschus. Here we present a comprehensive description of cranial material, including the ear region and the dentition, of fossil moschid material from the Middle Miocene locality Steinheim am Albuch (13.5 Ma; Germany). This study provides the first exhaustive dataset for the cranial osteology of Micromeryx flourensianus, the most likely oldest true moschid. It furthermore reveals the presence of a second, so far undescribed moschid species, we here name Micromeryx? eiselei, in the abundant material from the locality. The two taxa can be clearly distinguished by characters of the skull, the ear region, the dentition, as well as by size. This evidences the sympatric occurrence of two moschid species in the locality Steinheim am Albuch.
[Mh] Termos MeSH primário: Fósseis/anatomia & histologia
Ruminantes/anatomia & histologia
Crânio/anatomia & histologia
Dente/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Orelha
Feminino
Alemanha
Imagem Tridimensional
Masculino
Modelos Anatômicos
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185679


  9 / 8116 MEDLINE  
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[PMID]:29016668
[Au] Autor:Won EJ; Choi MJ; Shin JH; Park YJ; Byun SA; Jung JS; Kim SH; Shin MG; Suh SP
[Ad] Endereço:Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
[Ti] Título:Diversity of clinical isolates of Aspergillus terreus in antifungal susceptibilities, genotypes and virulence in Galleria mellonella model: Comparison between respiratory and ear isolates.
[So] Source:PLoS One;12(10):e0186086, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We analyzed the antifungal susceptibility profiles, genotypes, and virulence of clinical Aspergillus terreus isolates from six university hospitals in South Korea. Thirty one isolates of A. terreus, comprising 15 respiratory and 16 ear isolates were assessed. Microsatellite genotyping was performed, and genetic similarity was assessed by calculating the Jaccard index. Virulence was evaluated by Galleria mellonella survival assay. All 31 isolates were susceptible to itraconazole, posaconazole, and voriconazole, while 23 (74.2%) and 6 (19.4%) showed amphotericin B (AMB) minimum inhibitory concentrations (MICs) of ≤ 1 mg/L and > 4 mg/L, respectively. Notably, respiratory isolates showed significantly higher geometric mean MICs than ear isolates to AMB (2.41 vs. 0.48 mg/L), itraconazole (0.40 vs. 0.19 mg/L), posaconazole (0.16 vs. 0.08 mg/L), and voriconazole (0.76 vs. 0.31 mg/L) (all, P <0.05). Microsatellite genotyping separated the 31 isolates into 27 types, but the dendrogram demonstrated a closer genotypic relatedness among isolates from the same body site (ear or respiratory tract); in particular, the majority of ear isolates clustered together. Individual isolates varied markedly in their ability to kill infected G. mellonella after 72 h, but virulence did not show significant differences according to source (ear or respiratory tract), genotype, or antifungal susceptibility. The current study shows the marked diversity of clinical isolates of A. terreus in terms of antifungal susceptibilities, genotypes and virulence in the G. mellonella model, and ear isolates from Korean hospitals may have lower AMB or triazole MICs than respiratory isolates.
[Mh] Termos MeSH primário: Aspergilose/genética
Aspergillus/efeitos dos fármacos
Farmacorresistência Fúngica/genética
Orelha/microbiologia
Sistema Respiratório/microbiologia
[Mh] Termos MeSH secundário: Animais
Antifúngicos/farmacologia
Aspergilose/tratamento farmacológico
Aspergilose/microbiologia
Aspergillus/patogenicidade
Orelha/patologia
Genótipo
Hospitais Universitários
Seres Humanos
Itraconazol/farmacologia
Lepidópteros/microbiologia
Repetições de Microssatélites/genética
Sistema Respiratório/patologia
Triazóis/farmacologia
Voriconazol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Triazoles); 304NUG5GF4 (Itraconazole); 6TK1G07BHZ (posaconazole); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186086


  10 / 8116 MEDLINE  
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[PMID]:28964300
[Au] Autor:Li J; Chen K; Li C; Yin D; Zhang T; Dai P
[Ad] Endereço:ENT Institute, Eye & ENT Hospital of Fudan University, China. Electronic address: ljy777@126.com.
[Ti] Título:Anatomical measurement of the ossicles in patients with congenital aural atresia and stenosis.
[So] Source:Int J Pediatr Otorhinolaryngol;101:230-234, 2017 Oct.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Our aims were to measure and compare anatomical parameters of the ossicles in normal, congenital aural stenosis (CAS), and congenital aural atresia (CAA) ears. METHODS: This retrospective study was performed using three-dimensional reconstructed images derived from computed tomography scans of 20 normal subjects, 20 CAS patients, and 20 CAA patients. RESULTS: The lengths of the malleus handle and long process of the incus were greater in normal ears than in CAS and CAA ears (all P < 0.05). The angles of the incudostapedial joint and between the short and long processes of the incus were smaller in normal ears than in CAS and CAA ears (all P < 0.05). There were no significant differences in the positions of the malleus head and incudomalleolar joint, the size of the malleus head, the length of the short process of the incus, or the angle of the incudomalleolar joint (P > 0.05). CONCLUSIONS: Anatomical parameters of the lower part, but not of the upper part, of the ossicular chain in CAS and CAA ears differed from those in normal ears. Different branchial arch origins of the upper and lower parts of the ossicular chain may explain these findings. Dysplasia of the second arch, which develops into the lower part of the ossicular chain, may contribute to ossicular malformation in CAA and CAS. Accurate radiographic measurement of malformed ossicles may be useful for reconstructive surgery of CAA and CAS using the patient's native ossicular chain and for choosing an appropriate place for active middle ear implants.
[Mh] Termos MeSH primário: Ossículos da Orelha/anormalidades
Orelha/anormalidades
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Anormalidades Congênitas/diagnóstico por imagem
Constrição Patológica
Orelha/diagnóstico por imagem
Ossículos da Orelha/diagnóstico por imagem
Feminino
Seres Humanos
Imagem Tridimensional/métodos
Masculino
Estudos Retrospectivos
Tomografia Computadorizada por Raios X/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171002
[St] Status:MEDLINE



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