Base de dados : MEDLINE
Pesquisa : A01.456.505.631 [Categoria DeCS]
Referências encontradas : 16984 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 1699 ir para página                         

  1 / 16984 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743239
[Au] Autor:Senneby A; Davies JR; Svensäter G; Neilands J
[Ad] Endereço:Department of Oral and Maxillofacial Radiology, Malmö University, Faculty of Odontology, 205 06, Malmö, SE, Sweden.
[Ti] Título:Acid tolerance properties of dental biofilms in vivo.
[So] Source:BMC Microbiol;17(1):165, 2017 Jul 25.
[Is] ISSN:1471-2180
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The ecological plaque hypothesis explains caries development as the result of the enrichment of acid tolerant bacteria in dental biofilms in response to prolonged periods of low pH. Acid production by an acid tolerant microflora causes demineralisation of tooth enamel and thus, individuals with a greater proportion of acid tolerant bacteria would be expected to be more prone to caries development. Biofilm acid tolerance could therefore be a possible biomarker for caries prediction. However, little is known about the stability of biofilm acid tolerance over time in vivo or the distribution throughout the oral cavity. Therefore the aim of this study was to assess intra-individual differences in biofilm acid-tolerance between different tooth surfaces and inter-individual variation as well as stability of acid tolerance over time. RESULTS: The majority of the adolescents showed low scores for biofilm acid tolerance. In 14 of 20 individuals no differences were seen between the three tooth sites examined. In the remaining six, acid-tolerance at the premolar site differed from one of the other sites. At 51 of 60 tooth sites, acid-tolerance at baseline was unchanged after 1 month. However, acid tolerance values changed over a 1-year period in 50% of the individuals. CONCLUSIONS: Biofilm acid tolerance showed short-term stability and low variation between different sites in the same individual suggesting that the acid tolerance could be a promising biological biomarker candidate for caries prediction. Further evaluation is however needed and prospective clinical trials are called for to evaluate the diagnostic accuracy.
[Mh] Termos MeSH primário: Ácidos/farmacologia
Biofilmes/efeitos dos fármacos
Placa Dentária/microbiologia
[Mh] Termos MeSH secundário: Adolescente
Bactérias/classificação
Bactérias/isolamento & purificação
Fenômenos Fisiológicos Bacterianos/efeitos dos fármacos
Criança
Feminino
Seres Humanos
Masculino
Boca/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1186/s12866-017-1074-7


  2 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29480881
[Au] Autor:Wu YH; Liu KT; Yeh IJ; Chang CW
[Ad] Endereço:Department of Emergency Medicine, Kaohsiung Medical University Hospital.
[Ti] Título:Cheiro-Oral syndrome caused by thalamus hemorrhage: A case report.
[So] Source:Medicine (Baltimore);97(2):e9652, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cheiro-Oral syndrome (COS) is a pure sensory deficit confined to the perioral area and ipsilateral distal fingers or hand. Owing to relatively minor clinical findings and various presentations in different cases, the insidious and severe illness it implies may be overlooked at acute settings. PATIENT CONCERNS: A 70-year-old man with history of hypertension and type II diabetes mellitus under regular medication control came to our emergency department with chief complaint of sudden onset of right perioral region and right upper limb numbness. General physical and neurological examinations were normal except for subtle hypoesthesia to light touch, and pinprick in the right corner of mouth and right forearm to distal fingers. DIAGNOSES: Routine blood analysis was all in normal range including white blood cell count, hemocrit platelet, renal and liver function, and electrolytes such as sodium and potassium. Noncontrast brain computed tomography showed abnormal high-attenuation collection in the left thalamus. INTERVENTION: Follow-up computed tomography showed absorption of the hemorrhage after strict control of his blood pressure. OUTCOMES: The patient was discharged 7 days later from our hospital with stable condition. LESSONS: We demonstrated type I COS associated with thalamic hemorrhage to highlight the neurological implication of COS. It is crucial for emergency clinicians to recognize the symptoms and promptly order a neuroimaging study to exclude large infarction/hemorrhage, which would deeply affect the disposition and following treatment of the patient.
[Mh] Termos MeSH primário: Hemorragia Cerebral/complicações
Transtornos das Sensações/etiologia
[Mh] Termos MeSH secundário: Idoso
Hemorragia Cerebral/diagnóstico por imagem
Hemorragia Cerebral/terapia
Diagnóstico Diferencial
Seres Humanos
Masculino
Boca
Transtornos das Sensações/diagnóstico por imagem
Transtornos das Sensações/terapia
Síndrome
Tálamo/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Extremidade Superior
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009652


  3 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29241039
[Au] Autor:Inohara N
[Ad] Endereço:Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: ino@umich.edu.
[Ti] Título:Route Connection: Mouth to Intestine in Colitis.
[So] Source:Cell Host Microbe;22(6):730-731, 2017 12 13.
[Is] ISSN:1934-6069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In a recent study published in Science, Atarashi et al. (2017) showed that Klebsiella strains isolated from the saliva of Crohn's disease patients can induce Th1 cell responses to promote colitis. Their findings highlight the importance of the oral cavity as a potential reservoir for bacteria that can promote intestinal disease.
[Mh] Termos MeSH primário: Colite Ulcerativa
Colite
[Mh] Termos MeSH secundário: Doença de Crohn
Seres Humanos
Intestinos
Boca/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


  4 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28469101
[Au] Autor:Wang L; Mei XL
[Ad] Endereço:Department of Dermatology, Allergy and Clinical Immunology Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
[Ti] Título:Retrospective Analysis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in 88 Chinese Patients.
[So] Source:Chin Med J (Engl);130(9):1062-1068, 2017 May 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases with high mortality rates. This study was designed to analyze the pathogenic factors, clinical manifestations, complications, treatment, and prognosis of SJS/TEN and to explore the differences between surviving and deceased patients. METHODS: SJS/TEN patients admitted to Beijing Friendship Hospital from January 2006 to December 2015 were included in the study. Patients' data were retrospectively analyzed. Comparative studies were performed on the survival group and the deceased group, and Fisher's exact probability test was used for statistical analysis. RESULTS: Among the 88 patients included, 40 (45.5%) were male with a mean age of 45 ± 18 years. Forty-eight (54.5%) had SJS, 34 (38.6%) had SJS/TEN, and 6 (6.8%) had TEN. Fifty-three (60.2%) cases were caused by medications, mainly antibiotics (n = 24) followed by traditional Chinese medicines (n = 7). Forty-two cases (47.7%) developed visceral damage. Eighty-two patients improved or recovered and were discharged from hospital, and six patients died. Comparative studies on the survival group and the deceased group showed that the presence of malignant tumor ( χ2 = 27.969,P < 0.001), connective tissue diseases ( χ2 = 9.187, P= 0.002), previous abnormal liver/kidney functions ( χ2 = 6.006, P= 0.014), heart rate >100 times/min ( χ2 = 6.347, P= 0.012), detached skin area >20% ( χ2 = 5.594, P= 0.018), concurrent mucosal involvement at the mouth, eyes, and external genitals ( χ2 = 4.945, P= 0.026), subsequent accompanying liver/kidney damage ( χ2 = 11.839, P= 0.001, and χ2 = 36.302,P < 0.001, respectively), and SCORTEN score >2 ( χ2 = 37.148,P < 0.001) increased the risk of death. CONCLUSIONS: SJS/TEN is mainly caused by medications, and nearly half of patients develop visceral damage. Multiple factors increase the mortality risk.
[Mh] Termos MeSH primário: Síndrome de Stevens-Johnson/metabolismo
Síndrome de Stevens-Johnson/patologia
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Doenças do Tecido Conjuntivo/metabolismo
Doenças do Tecido Conjuntivo/patologia
Olho/patologia
Feminino
Genitália/patologia
Seres Humanos
Rim/metabolismo
Rim/patologia
Fígado/metabolismo
Fígado/patologia
Masculino
Meia-Idade
Boca/patologia
Estudos Retrospectivos
Pele/metabolismo
Pele/patologia
Síndrome de Stevens-Johnson/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.204929


  5 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28468163
[Au] Autor:Abukawa H; Kono M; Hamada H; Okamoto A; Satomi T; Chikazu D
[Ad] Endereço:*Oral and Maxillofacial Surgery Service, Tokyo Medical University Hachioji Medical Center †Department of Oral and Maxillofacial Surgery, Tokyo Medical University Hospital, Tokyo ‡Oral and Maxillofacial Surgery Service, Tokyo Medical University Ibaraki Medical Center, Ibaraki §Department of Oral and Maxillofacial Surgery, Tokyo Medical University, Tokyo, Japan.
[Ti] Título:Indications of Potassium Titanyl Phosphate Laser Therapy for Slow-Flow Vascular Malformations in Oral Region.
[So] Source:J Craniofac Surg;28(3):771-774, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Indications for laser therapy for slow-flow vascular malformations in the oral and maxillofacial regions have not been clearly documented. The authors aimed to estimate the frequency of resolution of slow-flow vascular malformations and to identify risk and prognostic factors associated with resolution in potassium titanyl phosphate (KTP) laser treatment. METHODS: This study was designed as a prospective cohort study. Patients who had diagnosed slow-flow vascular malformations were continuously assigned to receive KTP laser therapy. All patients had intralesional laser photocoagulation performed under local anesthesia. Administered power of the KTP laser was fixed at 2 watts throughout the procedure in all patients. The primary endpoint was to understand the frequency of resolution of slow-flow vascular malformations in KTP laser treatment. Secondary endpoints were: treatment outcomes based on lesion size; treatment outcomes based on location; treatment outcomes based on total energy in joules; types of complications. Treatment outcomes were judged by a clinical assessment as well as reduction in lesion size on magnetic resonance imaging. RESULTS: Data were obtained from 26 patients (9 men, 17 women) with 38 lesions. The average lesion size was 13.5 ±â€Š7.7 mm. Treatment outcomes based on lesion size showed that cure and regression were obtained in lesions less than 30 mm in size. However, lesions larger than 30 mm showed no response. Lesions in the tongue and lips showed higher cure rates than in other areas. Treatment outcomes based on administered total energy in joules showed that 68% of lesions were treated and responded well at less than 400 joules. Complication rate was relatively high in the buccal mucosal lesions. Immediate postoperative complications such as necrosis were more common in high-energy administration than in low-energy administration. CONCLUSION: Our results indicated that KTP laser therapy was effective for slow-flow vascular malformations less than 30 mm in size without significant side effects.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/fisiologia
Terapia a Laser/métodos
Lasers de Estado Sólido/uso terapêutico
Boca/irrigação sanguínea
Fosfatos
Cirurgia Bucal/métodos
Titânio
Malformações Vasculares/cirurgia
[Mh] Termos MeSH secundário: Feminino
Seguimentos
Hemodinâmica
Seres Humanos
Terapia com Luz de Baixa Intensidade/métodos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Estudos Prospectivos
Resultado do Tratamento
Ultrassonografia Doppler em Cores
Malformações Vasculares/diagnóstico
Malformações Vasculares/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphates); 12690-20-9 (potassium titanylphosphate); D1JT611TNE (Titanium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003445


  6 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29194752
[Au] Autor:Engen SA; Schreurs O; Petersen F; Blix IJS; Baekkevold ES; Schenck K
[Ad] Endereço:Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
[Ti] Título:The Regulatory Role of the Oral Commensal Streptococcus mitis on Human Monocytes.
[So] Source:Scand J Immunol;87(2):80-87, 2018 Feb.
[Is] ISSN:1365-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Streptococcus mitis colonizes all niches of the human oral cavity from early infancy and throughout life. Monocytes patrol blood vessels, lymphoid and non-lymphoid tissues and migrate into infected tissue where they participate in the inflammatory cascade and immune regulation. Here, we studied the effect of S. mitis on monocytes. Transcriptome analysis of monocytes exposed to S. mitis (SmMo) revealed increased transcription of chemotactic factors (CCL2, CCL3, CCL20, CXCL1, CXCL2) and cytokines (IL1A, IL1B, IL6, IL23, IL36G, TNF), indicating that S. mitis may trigger recruitment of leucocytes and initiate inflammation. Increased transcription in SmMo of IL1B, IL6 and IL23 indicated that S. mitis may participate in the induction of Th17 responses and agreed with our earlier findings of S. mitis-mediated memory Th17 reactivity. Furthermore, S. mitis inhibited tetanus toxoid-specific CD4 T cell proliferation. This can be due to the increased secretion of IL-10 and expression of PD-L1 that was observed in SmMo. PGE2 can modulate IL-10 and PD-L1 expression, concomitant with that of CCR7, IL-12 and IL-23 that also were changed. This, along with increased SmMo transcription of PTGS2 (COX2) and PTGER4 (EP4), pointed to a role of PGE2. Measurement of PGE2 secretion by SmMo showed indeed a marked increase, and chemical inhibition of PGE2 production lowered the PD-L1 expression on SmMo. In conclusion, our findings show that S. mitis may trigger immune modulation by recruiting immune cells to the site of infection, while at the same time dampening the severity of the response through expression of IL-10, PGE2 and PD-L1.
[Mh] Termos MeSH primário: Monócitos/imunologia
Boca/microbiologia
Infecções Estreptocócicas/imunologia
Streptococcus mitis/imunologia
[Mh] Termos MeSH secundário: Antígeno B7-H1/metabolismo
Células Cultivadas
Quimiotaxia
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Citocinas/genética
Citocinas/metabolismo
Dinoprostona/metabolismo
Perfilação da Expressão Gênica
Regulação da Expressão Gênica
Seres Humanos
Imunomodulação
Mediadores da Inflamação/metabolismo
Monócitos/microbiologia
Receptores de Prostaglandina E Subtipo EP4/genética
Receptores de Prostaglandina E Subtipo EP4/metabolismo
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-H1 Antigen); 0 (Cytokines); 0 (Inflammation Mediators); 0 (PTGER4 protein, human); 0 (Receptors, Prostaglandin E, EP4 Subtype); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (PTGS2 protein, human); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12636


  7 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29320551
[Au] Autor:Navarro-Lozano A; Sánchez-Domene D; Rossa-Feres DC; Bosch J; Sawaya RJ
[Ad] Endereço:Departamento de Zoologia e Botânica. Universidade Estadual Paulista, São José do Rio Preto, São Paulo, Brazil.
[Ti] Título:Are oral deformities in tadpoles accurate indicators of anuran chytridiomycosis?
[So] Source:PLoS One;13(1):e0190955, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We evaluated the use of oral deformities as reliable proxies for determining Batrachochytrium dendrobatidis (Bd) infection in tadpoles of six anuran species of the Atlantic Forest in southeastern Brazil. We examined oral discs of 2156 tadpoles of six species of anurans collected in 2016: Aplastodiscus albosignatus, Boana albopunctata, Boana faber, Scinax hayii, Crossodactylus caramaschii, and Physalaemus cuvieri. Three oral deformities were recognized: lack of keratinization only in upper and/or lower jaw sheaths, lack of keratinization only in upper or lower tooth rows, and both deformities together. A subsample composed of all the individuals possessing oral deformities (N = 195) plus randomly selected individuals without oral deformities (N = 184) were tested for Bd via qPCR. Oral deformities were observed in all six species, but only five were infected with Bd. Since we found that dekeratinization of tooth rows was not associated with the presence of Bd in any of the studied species we used a new proxy (jaw sheaths dekeratinization with or without dekeratinization in tooth rows: JSD-proxy) for Bd detection. Our results showed a nonrandom relationship between Bd infection and JSD-proxy in three species of the family Hylidae. However, the use of JSD-proxy for Bd detection in these species resulted in up to 30.8% false positives and up to 29.3% false negatives. The use of the JSD-proxy in species for which no relationship was found reached 100% of false positives. We conclude that the use of oral dekeratinization as a generalized proxy for Bd detection in tadpoles should not be used as a single diagnosis technique.
[Mh] Termos MeSH primário: Anuros/microbiologia
Quitridiomicetos
Larva/microbiologia
Boca/patologia
Micoses/veterinária
[Mh] Termos MeSH secundário: Animais
Reações Falso-Negativas
Reações Falso-Positivas
Queratinas
Micoses/diagnóstico
Micoses/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
68238-35-7 (Keratins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190955


  8 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28468190
[Au] Autor:Aldelaimi TN; Boskani SW; Ali SM; Mahmud PK
[Ad] Endereço:*Department of Oral and Maxillofacial Surgery, College of Dentistry, Anbar University, Ramadi City, Anbar Province †Department of Oral and Maxillofacial Surgery, Sulaimaniyah Teaching Hospital, Kurdistan Region, Iraq.
[Ti] Título:Eagle Syndrome: An Unusual Cause Limited Mouth Opening and Surgical Management.
[So] Source:J Craniofac Surg;28(3):e214-e216, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eagle syndrome, defined "stylalgia," occurs when an elongated styloid process or calcified stylohyoid ligament causes dysphagia, facial pain recurrent throat pain or foreign body sensation, also associated symptoms such as neck or throat pain with radiation to the ear. The symptoms related to this condition can be confused or misdiagnosed to a wide variety of facial neuralgias. The incidence of Eagle syndrome varies among population. Usually asymptomatic, it occurs in adult patients, and can be diagnosed by physical examination and radiologically. A 30-year-old male patient presented to the maxillofacial unit of Sulaimaniyah Teaching Hospital with a complaint of pain in the right side of face interfering with mouth opening and causing deviation to the right side of mouth for 6 months duration. The elongated styloid process of the right side was resected surgically by the intra-oral approach. The patient was asymptomatic and comfortably followed up for 5 months.
[Mh] Termos MeSH primário: Transtornos de Deglutição/etiologia
Neuralgia Facial/complicações
Boca/fisiopatologia
Procedimentos Neurocirúrgicos/métodos
Ossificação Heterotópica/complicações
Osso Temporal/anormalidades
[Mh] Termos MeSH secundário: Adulto
Transtornos de Deglutição/diagnóstico
Transtornos de Deglutição/cirurgia
Neuralgia Facial/diagnóstico
Neuralgia Facial/cirurgia
Seres Humanos
Masculino
Ossificação Heterotópica/diagnóstico
Ossificação Heterotópica/cirurgia
Osso Temporal/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003399


  9 / 16984 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28459758
[Au] Autor:Dawson C; Al-Qamachi L; Martin T
[Ad] Endereço:OMFS Department, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
[Ti] Título:Speech and swallowing outcomes following oral cavity reconstruction.
[So] Source:Curr Opin Otolaryngol Head Neck Surg;25(3):200-204, 2017 Jun.
[Is] ISSN:1531-6998
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: This review explores speech and swallowing outcomes following oral cavity reconstruction for treatment of head and neck cancer, with focus on articles published within 2015-2016. RECENT FINDINGS: There is limited recent evidence that explores functional outcomes following oral cavity surgery in the literature; therefore, an overview of the literature describing surgical interventions and their associated functional outcomes is timely. SUMMARY: We discuss the challenges associated with achieving adequate surgical margins, alongside optimal functional outcomes. The correlation between the size, site and type of reconstruction with speech and swallowing function are described, along with novel surgical and therapeutic interventions that may reduce treatment morbidity and have the potential to impact positively on quality of life.
[Mh] Termos MeSH primário: Transtornos de Deglutição/etiologia
Neoplasias Bucais/cirurgia
Boca/cirurgia
Complicações Pós-Operatórias/etiologia
Qualidade de Vida
Procedimentos Cirúrgicos Reconstrutivos
Distúrbios da Fala/etiologia
[Mh] Termos MeSH secundário: Deglutição
Seres Humanos
Fala
Retalhos Cirúrgicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1097/MOO.0000000000000359


  10 / 16984 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29172516
[Au] Autor:Rybakovsky E; Valenzano MC; Deis R; DiGuilio KM; Thomas S; Mullin JM
[Ad] Endereço:Lankenau Institute for Medical Research , 100 East Lancaster Avenue, Wynnewood, Pennsylvania 19096 United States.
[Ti] Título:Improvement of Human-Oral-Epithelial-Barrier Function and of Tight Junctions by Micronutrients.
[So] Source:J Agric Food Chem;65(50):10950-10958, 2017 Dec 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The oral epithelium represents a major interface between an organism and its external environment. Improving this barrier at the molecular level can provide an organism added protection from microbial-based diseases. Barrier function of the Gie-3B11-human-gingival-epithelial-cell-culture model is enhanced by the micronutrients zinc, quercetin, retinoic acid, and acetyl-11-keto-ß-boswellic acid, as observed by a concentration-dependent increase in transepithelial electrical resistance and a decrease in transepithelial C-d-mannitol permeability. With this improvement of tight-junction (TJ)-barrier function (reduced leak) comes a pattern of micronutrient-induced changes in TJ claudin abundance that is specific to each individual micronutrient, along with changes in claudin subcellular localization. These micronutrients were effective not only when administered to both cell surfaces simultaneously but also when administered to the apical surface alone, the surface to which the micronutrients would be presented in routine clinical use. The biomedical implications of micronutrient enhancement of the oral-epithelial barrier are discussed.
[Mh] Termos MeSH primário: Células Epiteliais/metabolismo
Micronutrientes/metabolismo
Boca/metabolismo
Junções Íntimas/metabolismo
[Mh] Termos MeSH secundário: Células CACO-2
Seres Humanos
Mucosa Intestinal/citologia
Mucosa Intestinal/metabolismo
Permeabilidade
Quercetina/metabolismo
Tretinoína/metabolismo
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Micronutrients); 5688UTC01R (Tretinoin); 9IKM0I5T1E (Quercetin); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04203



página 1 de 1699 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde